Discovery of N‑(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro‑1H‑pyrrolo[2,3‑c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Br... von McDaniel, Keith F, Wang, Le, Soltwedel, Todd, Fidanze, Steven D, Hasvold, Lisa A, Liu, Dachun, Mantei, Robert A, Pratt, John K, Sheppard, George S, Bui, Mai H, Faivre, Emily J, Huang, Xiaoli, Li, Leiming, Lin, Xiaoyu, Wang, Rongqi, Warder, Scott E, Wilcox, Denise, Albert, Daniel H, Magoc, Terrance J, Rajaraman, Ganesh, Park, Chang H, Hutchins, Charles W, Shen, Jianwei J, Edalji, Rohinton P, Sun, Chaohong C, Martin, Ruth, Gao, Wenqing, Wong, Shekman, Fang, Guowei, Elmore, Steven W, Shen, Yu, Kati, Warren M

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Enabling, Decagram-Scale Synthesis of Macrocyclic MCL‑1 Inhibitor ABBV-467 von Brady, Patrick B., Sorensen, Bryan K., Risi, Roberto M., Curtin, Michael L., Mantei, Robert A., Florjancic, Alan S., Mastracchio, Anthony, Ji, Cheng, Kunzer, Aaron R., Lai, Chunqiu, Storer, Gregory E., Chan, Vincent S., Henry, Rodger F., Souers, Andrew J., Michaelides, Michael R., Judd, Andrew S., Hansen, T. Matthew

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Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors von Wang, Le, Pratt, John K, Soltwedel, Todd, Sheppard, George S, Fidanze, Steven D, Liu, Dachun, Hasvold, Lisa A, Mantei, Robert A, Holms, James H, McClellan, William J, Wendt, Michael D, Wada, Carol, Frey, Robin, Hansen, T. Matthew, Hubbard, Robert, Park, Chang H, Li, Leiming, Magoc, Terrance J, Albert, Daniel H, Lin, Xiaoyu, Warder, Scott E, Kovar, Peter, Huang, Xiaoli, Wilcox, Denise, Wang, Rongqi, Rajaraman, Ganesh, Petros, Andrew M, Hutchins, Charles W, Panchal, Sanjay C, Sun, Chaohong, Elmore, Steven W, Shen, Yu, Kati, Warren M, McDaniel, Keith F

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Discovery and optimization of novel constrained pyrrolopyridone BET family inhibitors von Fidanze, Steven D., Liu, Dachun, Mantei, Robert A., Hasvold, Lisa A., Pratt, John K., Sheppard, George S., Wang, Le, Holms, James H., Dai, Yujia, Aguirre, Ana, Bogdan, Andrew, Dietrich, Justin D., Marjanovic, Jasmina, Park, Chang H., Hutchins, Charles W., Lin, Xiaoyu, Bui, Mai H., Huang, Xiaoli, Wilcox, Denise, Li, Leiming, Wang, Rongqi, Kovar, Peter, Magoc, Terrance J., Rajaraman, Ganesh, Albert, Daniel H., Shen, Yu, Kati, Warren M., McDaniel, Keith F.

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Methylpyrrole inhibitors of BET bromodomains von Hasvold, Lisa A., Sheppard, George S., Wang, Le, Fidanze, Steven D., Liu, Dachun, Pratt, John K., Mantei, Robert A., Wada, Carol K., Hubbard, Robbert, Shen, Yu, Lin, Xiaoyu, Huang, Xiaoli, Warder, Scott E., Wilcox, Denise, Li, Leiming, Buchanan, F. Greg, Smithee, Lauren, Albert, Daniel H., Magoc, Terrance J., Park, Chang H., Petros, Andrew M., Panchal, Sanjay C., Sun, Chaohong, Kovar, Peter, Soni, Nirupama B., Elmore, Steven W., Kati, Warren M., McDaniel, Keith F.

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Substituted 4-amino-1H-pyrazolo[3,4-d]pyrimidines as multi-targeted inhibitors of insulin-like growth factor-1 receptor (IGF1R) and members of ErbB-family receptor kinases von WANG, Gary T, MANTEI, Robert A, BOUSKA, Jennifer, JIEYI WANG, DAVIDSEN, Steven K, BELL, Randy L, SHEPPARD, George S, HUBBARD, Robert D, WILSBACHER, Julie L, QIAN ZHANG, TUCKER, Lora, XIAOMING HU, KOVAR, Peter, JOHNSON, Eric F, OSTERLING, Donald J

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Discovery and Optimization of Anthranilic Acid Sulfonamides as Inhibitors of Methionine Aminopeptidase-2:  A Structural Basis for the Reduction of Albumin Binding von Sheppard, George S, Wang, Jieyi, Kawai, Megumi, Fidanze, Steve D, BaMaung, Nwe Y, Erickson, Scott A, Barnes, David M, Tedrow, Jason S, Kolaczkowski, Lawrence, Vasudevan, Anil, Park, David C, Wang, Gary T, Sanders, William J, Mantei, Robert A, Palazzo, Fabio, Tucker-Garcia, Lora, Lou, Pingping, Zhang, Qian, Park, Chang H, Kim, Ki H, Petros, Andrew, Olejniczak, Edward, Nettesheim, David, Hajduk, Phillip, Henkin, Jack, Lesniewski, Richard, Davidsen, Steven K, Bell, Randy L

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1-(5-Chloro-2-alkoxyphenyl)-3-(5-cyano- pyrazi-2-yl)ureas as Potent and Selective Inhibitors of Chk1 Kinase:  Synthesis, Preliminary SAR, and Biological Activities von Wang, Gary T, Li, Gaoquan, Mantei, Robert A, Chen, Zehan, Kovar, Peter, Gu, Wendy, Xiao, Zhan, Zhang, Haiying, Sham, Hing L, Sowin, Thomas, Rosenberg, Saul H, Lin, Nan-Horng

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Lead optimization of methionine aminopeptidase-2 (MetAP2) inhibitors containing sulfonamides of 5,6-disubstituted anthranilic acids von Wang, Gary T., Mantei, Robert A., Kawai, Megumi, Tedrow, Jason S., Barnes, David M., Wang, Jieyi, Zhang, Qian, Lou, Pingping, Garcia, Lora A., Bouska, Jennifer, Yates, Melinda, Park, Chang, Judge, Russell A., Lesniewski, Richard, Sheppard, George S., Bell, Randy L.

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2,4-Diarylpyrrolidine-3-carboxylic AcidsPotent ETA Selective Endothelin Receptor Antagonists. 1. Discovery of A-127722 von Winn, Martin, von Geldern, Thomas W, Opgenorth, Terry J, Jae, Hwan-Soo, Tasker, Andrew S, Boyd, Steven A, Kester, Jeffrey A, Mantei, Robert A, Bal, Radhika, Sorensen, Bryan K, Wu-Wong, Jinshyun R, Chiou, William J, Dixon, Douglas B, Novosad, Eugene I, Hernandez, Lisa, Marsh, Kennan C

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Discovery of Spiro Oxazolidinediones as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases von Michaelides, Michael R, Kluge, Arthur, Patane, Michael, Van Drie, John H, Wang, Ce, Hansen, T. Matthew, Risi, Roberto M, Mantei, Robert, Hertel, Carmen, Karukurichi, Kannan, Nesterov, Alexandre, McElligott, David, de Vries, Peter, Langston, J. William, Cole, Philip A, Marmorstein, Ronen, Liu, Hong, Lasko, Loren, Bromberg, Kenneth D, Lai, Albert, Kesicki, Edward A

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Pyridone-Containing farnesyltransferase inhibitors: synthesis and biological evaluation von Hasvold, Lisa A., Wang, Weibo, Gwaltney, Stephen L., Rockway, Todd W., Nelson, Lissa T.J., Mantei, Robert A., Fakhoury, Stephen A., Sullivan, Gerard M., Li, Qun, Lin, Nan-Horng, Wang, Le, Zhang, Haiying, Cohen, Jerome, Gu, Wen-Zhen, Marsh, Kennan, Bauch, Joy, Rosenberg, Saul, Sham, Hing L.

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Abstract 4695: Functional group elaboration of a low molecular weight fragment to yield the novel BET family bromodomain inhibitor ABBV-075 von McDaniel, Keith, Wang, Le, Sheppard, George, Fidanze, Steve, Pratt, John, Liu, Dachun, Hasvold, Lisa, Mantei, Robert, Park, Chang, Sarthy, Aparna, Li, Leiming, Albert, Daniel H., Lin, Xiaoyu, Warder, Scott, Faivre, Emily, Bui, Mai H., Huang, Xiaoli, Wilcox, Denise, Wang, Rongqi, Magoc, Terry, Rajaraman, Ganesh, Petros, Andrew, Panchal, Sanjay, Sun, Chaohong, Fang, Guowei, Elmore, Steven W., Rosenberg, Saul, Shen, Yu, Kati, Warren

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Methylpyrrole inhibitors of BET bromodomains von Hasvold, Lisa A., Sheppard, George S., Wang, Le, Fidanze, Steven D., Liu, Dachun, Pratt, John K., Mantei, Robert A., Wada, Carol K., Hubbard, Robbert, Shen, Yu, Lin, Xiaoyu, Huang, Xiaoli, Warder, Scott E., Wilcox, Denise, Li, Leiming, Buchanan, F. Greg, Smithee, Lauren, Albert, Daniel H., Magoc, Terrance J., Park, Chang H., Petros, Andrew M., Panchal, Sanjay C., Sun, Chaohong, Kovar, Peter, Soni, Nirupama B., Elmore, Steven W., Kati, Warren M., McDaniel, Keith F.

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Imidazo[2,1- b]thiazoles: Multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases von Fidanze, Steve D., Erickson, Scott A., Wang, Gary T., Mantei, Robert, Clark, Richard F., Sorensen, Bryan K., Bamaung, Nwe Y., Kovar, Peter, Johnson, Eric F., Swinger, Kerren K., Stewart, Kent D., Zhang, Qian, Tucker, Lora A., Pappano, William N., Wilsbacher, Julie L., Wang, Jieyi, Sheppard, George S., Bell, Randy L., Davidsen, Steven K., Hubbard, Robert D.

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Discovery of a series of pyrrolidine-based endothelin receptor antagonists with enhanced ET A receptor selectivity von Boyd, Steven A, Mantei, Robert A, Tasker, Andrew S, Liu, Gang, Sorensen, Bryan K, Henry Jr, Kenneth J, von Geldern, Thomas W, Winn, Martin, Wu-Wong, Jinshyun R, Chiou, William J, Dixon, Douglas B, Hutchins, Charles W, Marsh, Kennan C, Nguyen, Bach, Opgenorth, Terry J

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Identification of Novel Binding Interactions in the Development of Potent, Selective 2-Naphthamidine Inhibitors of Urokinase. Synthesis, Structural Analysis, and SAR of N-Phenyl Am... von Wendt, Michael D, Rockway, Todd W, Geyer, Andrew, McClellan, William, Weitzberg, Moshe, Zhao, Xumiao, Mantei, Robert, Nienaber, Vicki L, Stewart, Kent, Klinghofer, Vered, Giranda, Vincent L

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Nonpeptide Renin Inhibitors with Good Intraduodenal Bioavailability and Efficacy in Dog von Boyd, Steven A, Fung, Anthony K. L, Baker, William R, Mantei, Robert A, Stein, Herman H, Cohen, Jerome, Barlow, Jennifer L, Klinghofer, Vered, Wessale, Jerry L

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C-Terminal modifications of nonpeptide renin inhibitors: improved oral bioavailability via modification of physicochemical properties von Boyd, Steven A, Fung, Anthony K. L, Baker, William R, Mantei, Robert A, Armiger, Yoek Lin, Stein, Herman H, Cohen, Jerome, Egan, David A, Barlow, Jennifer L

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Abstract A248: Substituted 4-amino-1 H -pyrazolo[3,4- d ]pyrimidines as multitargeted inhibitors targeting insulin-like growth factor-1 receptor (IGF1R) and members of ErbB-family... von Wang, Gary T., Mantei, Robert A., Hubbard, Robert D., Wilsbacher, Julie L., Zhang, Qian, Tucker, Lora, Hu, Xiaoming, Kovar, Peter, Johson, Erick F., Osterling, Donald J., Bouska, Jennifer, Wang, Jieyi, Bell, Randy L., Davidsen, Steven K., Sheppard, George S.

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