5-Azacitidine Exerts Prolonged Pro-Apoptotic Effects and Overcomes Cisplatin-Resistance in Non-Seminomatous Germ Cell Tumor Cells von Oing, Christoph, Verem, Izudin, Mansour, Wael Y, Bokemeyer, Carsten, Dyshlovoy, Sergey, Honecker, Friedemann

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alternative end-joining pathway for repair of DNA double-strand breaks requires PARP1 but is not dependent upon microhomologies von Mansour, Wael Y, Rhein, Tim, Dahm-Daphi, Jochen

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DNA Damage Repair Deficiency in Prostate Cancer von Burdak-Rothkamm, Susanne, Mansour, Wael Y., Rothkamm, Kai

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BCL2-overexpressing prostate cancer cells rely on PARP1-dependent end-joining and are sensitive to combined PARP inhibitor and radiation therapy von Oing, Christoph, Tennstedt, Pierre, Simon, Ronald, Volquardsen, Jennifer, Borgmann, Kerstin, Bokemeyer, Carsten, Petersen, Cordula, Dikomey, Ekkehard, Rothkamm, Kai, Mansour, Wael Y.

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Synthesis and new DNA targeting activity of 6- and 7-tert-butylfascaplysins von Dyshlovoy, Sergey A., Mansour, Wael Y., Ramm, Natalia A., Hauschild, Jessica, Zhidkov, Maxim E., Kriegs, Malte, Zielinski, Alexandra, Hoffer, Konstantin, Busenbender, Tobias, Glumakova, Ksenia A., Spirin, Pavel V., Prassolov, Vladimir S., Tilki, Derya, Graefen, Markus, Bokemeyer, Carsten, von Amsberg, Gunhild

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Depletion of Histone Demethylase Jarid1A Resulting in Histone Hyperacetylation and Radiation Sensitivity Does Not Affect DNA Double-Strand Break Repair von Penterling, Corina, Drexler, Guido A, Böhland, Claudia, Stamp, Ramona, Wilke, Christina, Braselmann, Herbert, Caldwell, Randolph B, Reindl, Judith, Girst, Stefanie, Greubel, Christoph, Siebenwirth, Christian, Mansour, Wael Y, Borgmann, Kerstin, Dollinger, Günther, Unger, Kristian, Friedl, Anna A

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X-ray Fluorescence Uptake Measurement of Functionalized Gold Nanoparticles in Tumor Cell Microsamples von Schmutzler, Oliver, Graf, Sebastian, Behm, Nils, Mansour, Wael Y., Blumendorf, Florian, Staufer, Theresa, Koernig, Christian, Salah, Dina, Kang, Yanan, Peters, Jan N., Liu, Yang, Feliu, Neus, Parak, Wolfgang J., Burkhardt, Anja, Gargioni, Elisabetta, Gennis, Sabrina, Chandralingam, Sharah, Hoeeg, Finn, Maison, Wolfgang, Rothkamm, Kai, Schulz, Florian, Gruener, Florian

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Preclinical patient‐derived modeling of castration‐resistant prostate cancer facilitates individualized assessment of homologous recombination repair deficient disease von Elsesy, Mohamed E., Oh‐Hohenhorst, Su Jung, Oing, Christoph, Eckhardt, Alicia, Burdak‐Rothkamm, Susanne, Alawi, Malik, Müller, Christian, Schüller, Ulrich, Maurer, Tobias, Amsberg, Gunhild, Petersen, Cordula, Rothkamm, Kai, Mansour, Wael Y.

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The absence of Ku but not defects in classical non-homologous end-joining is required to trigger PARP1-dependent end-joining von Mansour, Wael Y., Borgmann, K., Petersen, C., Dikomey, Ekkehard, Dahm-Daphi, Jochen

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Impaired 53BP1/RIF1 DSB mediated end-protection stimulates CtIP-dependent end resection and switches the repair to PARP1-dependent end joining in G1 von Bakr, Ali, Köcher, Sabrina, Volquardsen, Jennifer, Petersen, Cordula, Borgmann, Kerstin, Dikomey, Ekkehard, Rothkamm, Kai, Mansour, Wael Y

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Induction of DNA damage, apoptosis and cell cycle perturbation mediate cytotoxic activity of new 5-aminosalicylate–4-thiazolinone hybrid derivatives von S Ramadan, Wafaa, Saleh, Ekram M, Menon, Varsha, Vazhappilly, Cijo George, Abdu-Allah, Hajjaj H.M., El-Shorbagi, Abdel-Nasser A., Mansour, Wael, El-Awady, Raafat

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Inhibition of PARP1-dependent end-joining contributes to Olaparib-mediated radiosensitization in tumor cells von Kötter, Annika, Cornils, Kerstin, Borgmann, Kerstin, Dahm-Daphi, Jochen, Petersen, Cordula, Dikomey, Ekkehard, Mansour, Wael Y.

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Functional crosstalk between DNA damage response proteins 53BP1 and BRCA1 regulates double strand break repair choice von Bakr, Ali, Köcher, Sabrina, Volquardsen, Jennifer, Reimer, Rudolph, Borgmann, Kerstin, Dikomey, Ekkehard, Rothkamm, Kai, Mansour, Wael Y

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Radiation-induced double-strand breaks require ATM but not Artemis for homologous recombination during S-phase von Köcher, Sabrina, Rieckmann, Thorsten, Rohaly, Gabor, Mansour, Wael Y, Dikomey, Ekkehard, Dornreiter, Irena, Dahm-Daphi, Jochen

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5-Fluorouracil sensitizes colorectal tumor cells towards double stranded DNA breaks by interfering with homologous recombination repair von Srinivas, Upadhyayula Sai, Dyczkowski, Jerzy, Beißbarth, Tim, Gaedcke, Jochen, Mansour, Wael Y, Borgmann, Kerstin, Dobbelstein, Matthias

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Hierarchy of nonhomologous end-joining, single-strand annealing and gene conversion at site-directed DNA double-strand breaks von Mansour, Wael Y., Schumacher, Sabine, Rosskopf, Raphael, Rhein, Tim, Schmidt-Petersen, Filip, Gatzemeier, Fruszina, Haag, Friedrich, Borgmann, Kerstin, Willers, Henning, Dahm-Daphi, Jochen

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Emerging Insights into Keratin 16 Expression during Metastatic Progression of Breast Cancer von Elazezy, Maha, Schwentesius, Sandra, Stegat, Luisa, Wikman, Harriet, Werner, Stefan, Mansour, Wael Y., Failla, Antonio Virgilio, Peine, Sven, Mueller, Volkmar, Thiery, Jean Paul, Warkiani, Majid Ebrahimi, Pantel, Klaus, Joosse, Simon A.

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Aberrant overexpression of miR-421 downregulates ATM and leads to a pronounced DSB repair defect and clinical hypersensitivity in SKX squamous cell carcinoma von Mansour, Wael Y, Bogdanova, Natalia V, Kasten-Pisula, Ulla, Rieckmann, Thorsten, Köcher, Sabrina, Borgmann, Kerstin, Baumann, Michael, Krause, Mechtild, Petersen, Cordula, Hu, Hailiang, Gatti, Richard A, Dikomey, Ekkehard, Dörk, Thilo, Dahm-Daphi, Jochen

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Loss of CHD1 causes DNA repair defects and enhances prostate cancer therapeutic responsiveness von Kari, Vijayalakshmi, Mansour, Wael Yassin, Raul, Sanjay Kumar, Baumgart, Simon J, Mund, Andreas, Grade, Marian, Sirma, Hüseyin, Simon, Ronald, Will, Hans, Dobbelstein, Matthias, Dikomey, Ekkehard, Johnsen, Steven A

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Salvage Chemotherapy with Cisplatin, Ifosfamide, and Paclitaxel in Aggressive Variant of Metastatic Castration-Resistant Prostate Cancer von von Amsberg, Gunhild, Zilles, Mirjam, Mansour, Wael, Gild, Philipp, Alsdorf, Winfried, Kaune, Moritz, Böckelmann, Lukas, Hauschild, Jessica, Krisp, Christoph, Rohlfing, Tina, Saygi, Ceren, Alawi, Malik, Zielinski, Alexandra, Langebrake, Claudia, Oh-Hohenhorst, Su Jung, Perner, Sven, Tilki, Derya, Schlüter, Hartmut, Graefen, Markus, Dyshlovoy, Sergey A, Bokemeyer, Carsten

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