Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl von Weisberg, Ellen, Manley, Paul W., Breitenstein, Werner, Brüggen, Josef, Cowan-Jacob, Sandra W., Ray, Arghya, Huntly, Brian, Fabbro, Doriano, Fendrich, Gabriele, Hall-Meyers, Elizabeth, Kung, Andrew L., Mestan, Jürgen, Daley, George Q., Callahan, Linda, Catley, Laurie, Cavazza, Cara, Mohammed, Azam, Neuberg, Donna, Wright, Renee D., Gilliland, D. Gary, Griffin, James D.

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In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants von O'HARE, Thomas, WALTERS, Denise K, DRUKER, Brian J, STOFFREGEN, Eric P, TAIPING JIA, MANLEY, Paul W, MESTAN, Jürgen, COWAN-JACOB, Sandra W, LEE, Francis Y, HEINRICH, Michael C, DEININGER, Michael W. N

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The Crystal Structure of a c-Src Complex in an Active Conformation Suggests Possible Steps in c-Src Activation von Cowan-Jacob, Sandra W., Fendrich, Gabriele, Manley, Paul W., Jahnke, Wolfgang, Fabbro, Doriano, Liebetanz, Janis, Meyer, Thomas

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PKC412 inhibits in vitro growth of neoplastic human mast cells expressing the D816V-mutated variant of KIT: comparison with AMN107, imatinib, and cladribine (2CdA) and evaluation o... von Gleixner, Karoline V., Mayerhofer, Matthias, Aichberger, Karl J., Derdak, Sophia, Sonneck, Karoline, Böhm, Alexandra, Gruze, Alexander, Samorapoompichit, Puchit, Manley, Paul W., Fabbro, Doriano, Pickl, Winfried F., Sillaber, Christian, Valent, Peter

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Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog von Boggon, Titus J., Li, Yiqun, Manley, Paul W., Eck, Michael J.

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Advances in the structural biology, design and clinical development of Bcr-Abl kinase inhibitors for the treatment of chronic myeloid leukaemia von Manley, Paul William, Cowan-Jacob, Sandra W., Mestan, Jürgen

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AMN107, a Novel Aminopyrimidine Inhibitor of Bcr-Abl, Has In vitro Activity against Imatinib-Resistant Chronic Myeloid Leukemia von GOLEMOVIC, Mirna, VERSTOVSEK, Srdan, ARLINGHAUS, Ralph B, TONG SUN, KANTARJIAN, Hagop, BERAN, Miloslav, GILES, Francis, CORTES, Jorge, MANSHOURI, Taghi, MANLEY, Paul W, MESTAN, Jürgen, DUGAN, Margaret, ALLAND, Leila, GRIFFIN, James D

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Imatinib: a selective tyrosine kinase inhibitor von Manley, P.W., Cowan-Jacob, S.W., Buchdunger, E., Fabbro, D., Fendrich, G., Furet, P., Meyer, T., Zimmermann, J.

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Protein kinases as targets for anticancer agents: from inhibitors to useful drugs von Fabbro, Doriano, Ruetz, Stephan, Buchdunger, Elisabeth, Cowan-Jacob, Sandra W, Fendrich, Gabriele, Liebetanz, Janis, Mestan, Jürgen, O'Reilly, Terence, Traxler, Peter, Chaudhuri, Bhabatosh, Fretz, Heinz, Zimmermann, Jürg, Meyer, Thomas, Caravatti, Giorgio, Furet, Pascal, Manley, Paul W

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The small molecule tyrosine kinase inhibitor AMN107 inhibits TEL-PDGFRβ and FIP1L1-PDGFRα in vitro and in vivo von Stover, Elizabeth H., Chen, Jing, Lee, Benjamin H., Cools, Jan, McDowell, Elizabeth, Adelsperger, Jennifer, Cullen, Dana, Coburn, Allison, Moore, Sandra A., Okabe, Rachel, Fabbro, Doriano, Manley, Paul W., Griffin, James D., Gilliland, D. Gary

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PKC412 overcomes resistance to imatinib in a murine model of FIP1L1-PDGFRα-induced myeloproliferative disease von Cools, Jan, Stover, Elizabeth H, Boulton, Christina L, Gotlib, Jason, Legare, Robert D, Amaral, Sonia M, Curley, David P, Duclos, Nicole, Rowan, Rebecca, Kutok, Jeffery L, Lee, Benjamin H, Williams, Ifor R, Coutre, Steven E, Stone, Richard M, DeAngelo, Daniel J, Marynen, Peter, Manley, Paul W, Meyer, Thomas, Fabbro, Doriano, Neuberg, Donna, Weisberg, Ellen, Griffin, James D, Gilliland, D.Gary

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New Anilinophthalazines as Potent and Orally Well Absorbed Inhibitors of the VEGF Receptor Tyrosine Kinases Useful as Antagonists of Tumor-Driven Angiogenesis von Bold, Guido, Altmann, Karl-Heinz, Frei, Jörg, Lang, Marc, Manley, Paul W, Traxler, Peter, Wietfeld, Bernhard, Brüggen, Josef, Buchdunger, Elisabeth, Cozens, Robert, Ferrari, Stefano, Furet, Pascal, Hofmann, Francesco, Martiny-Baron, Georg, Mestan, Jürgen, Rösel, Johannes, Sills, Matthew, Stover, David, Acemoglu, Figan, Boss, Eugen, Emmenegger, René, Lässer, Laurent, Masso, Elvira, Roth, Rosemarie, Schlachter, Christian, Vetterli, Werner, Wyss, Dominique, Wood, Jeanette M

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Dual-specific Src and Abl kinase inhibitors, PP1 and CGP76030, inhibit growth and survival of cells expressing imatinib mesylate–resistant Bcr-Abl kinases von Warmuth, Markus, Simon, Nicola, Mitina, Olga, Mathes, Ruth, Fabbro, Doriano, Manley, Paul W., Buchdunger, Elisabeth, Forster, Karin, Moarefi, Ismail, Hallek, Michael

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Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia von Irvine, DA, Zhang, B, Kinstrie, R, Tarafdar, A, Morrison, H, Campbell, VL, Moka, HA, Ho, Y, Nixon, C, Manley, PW, Wheadon, H, Goodlad, JR, Holyoake, TL, Bhatia, R, Copland, M

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Anthranilic Acid Amides:  A Novel Class of Antiangiogenic VEGF Receptor Kinase Inhibitors von Manley, Paul W, Furet, Pascal, Bold, Guido, Brüggen, Josef, Mestan, Jürgen, Meyer, Thomas, Schnell, Christian R, Wood, Jeanette, Haberey, Martin, Huth, Andreas, Krüger, Martin, Menrad, Andreas, Ottow, Eckhard, Seidelmann, Dieter, Siemeister, Gerhard, Thierauch, Karl-Heinz

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Therapies directed at vascular endothelial growth factor von Manley, Paul W, Martiny-Baron, Georg, Schlaeppi, Jean-Marc, Wood, Jeanette M

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Synthesis and characterization of a novel tritiated K ATP channel opener with a benzopyran structure von Manley, Paul W, Löffler‐Walz, Cornelia, Russ, Ulrich, Hambrock, Annette, Moenius, Thomas, Quast, Ulrich

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Large-Scale Negishi Coupling as Applied to the Synthesis of PDE472, an Inhibitor of Phosphodiesterase Type 4D von Manley, Paul W, Acemoglu, Murat, Marterer, Wolfgang, Pachinger, Werner

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NMR resonance assignment of selectively labeled proteins by the use of paramagnetic ligands von Cutting, Brian, Strauss, André, Fendrich, Gabriele, Manley, Paul W, Jahnke, Wolfgang

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Structure-activity studies of potassium channel opening in pinacidil-type cyanoguanidines, nitroethenediamines, thioureas, and ureas von Manley, Paul W, Quast, Ulrich

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