T cell-engaging BiTE antibodies specific for EGFR potently eliminate KRAS- and BRAF-mutated colorectal cancer cells von Lutterbuese, Ralf, Raum, Tobias, Kischel, Roman, Hoffmann, Patrick, Mangold, Susanne, Rattel, Benno, Friedrich, Matthias, Thomas, Oliver, Lorenczewski, Grit, Rau, Doris, Schaller, Evelyne, Herrmann, Ines, Wolf, Andreas, Urbig, Thomas, Baeuerle, Patrick A., Kufer, Peter, Ravetch, Jeffrey V.

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Side-by-side analysis of five clinically tested anti-EpCAM monoclonal antibodies von Münz, Markus, Murr, Alexander, Kvesic, Majk, Rau, Doris, Mangold, Susanne, Pflanz, Stefan, Lumsden, John, Volkland, Jörg, Fagerberg, Jan, Riethmüller, Gert, Rüttinger, Dominik, Kufer, Peter, Baeuerle, Patrick A, Raum, Tobias

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Abstract 3251: Fibroblast activation protein (FAP)-selective delivery of CD40 agonistic DARPin®molecule for tumor-localized immune activation von Rigamonti, Nicolo, Schlegel, Anja, Barsin, Sophie, Schwestermann, Jonas, Mangold, Susanne, Kaufmann, Yvonne, Zitt, Christof, Veitonmäki, Niina, Levitsky, Victor, Metz, Clara

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Abstract 1890: A solution to T-cell engager toxicity: An anti-CD3 Prodrug DARPin (CD3-PDD) shows no toxicity, but potent anti-tumor activity in a humanized mouse model von Bosshart, Andreas, Ahlskog, Julia Katharina, Eggenschwiler, Aline, Schiegg, Dieter, Grübler, Yvonne, Wandel, Sandra, Fontaine, Simon, Paladino, Maria, Mangold, Susanne, Hospodarsch, Tanja, Neculcea, Alexandra, Iss, Chloé, Herzog, Christel, Schlereth, Bernd

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Human IgG1 antibodies antagonizing activating receptor NKG2D on natural killer cells von Steigerwald, Jutta, Raum, Tobias, Pflanz, Stefan, Cierpka, Ronny, Mangold, Susanne, Rau, Doris, Hoffmann, Patrick, Kvesic, Majk, Zube, Christina, Linnerbauer, Stefanie, Lumsden, John, Sriskandarajah, Mirnaalini, Kufer, Peter, Baeuerle, Patrick A., Volkland, Jörg

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Abstract 1073: A tumor-targeted CD40 agonistic DARPin® molecule leading to antitumor activity with limited systemic toxicity von Rigamonti, Nicolo, Jetzer, Sarah, Van der Velden, Niels, Abdelmotaleb, Omar, Barsin, Sophie, Schwestermann, Jonas, Mangold, Susanne, Kaufmann, Yvonne, Bessey, Ralph, Valeri, Andrea, Poulet, Heidi, Zitt, Christof, Trail, Pamela A., Levitsky, Victor, Veitonmäki, Niina, Metz, Clara

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The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants von Rothenberger, Sylvia, Hurdiss, Daniel L, Walser, Marcel, Malvezzi, Francesca, Mayor, Jennifer, Ryter, Sarah, Moreno, Hector, Liechti, Nicole, Bosshart, Andreas, Iss, Chloé, Calabro, Valérie, Cornelius, Andreas, Hospodarsch, Tanja, Neculcea, Alexandra, Looser, Thamar, Schlegel, Anja, Fontaine, Simon, Villemagne, Denis, Paladino, Maria, Schiegg, Dieter, Mangold, Susanne, Reichen, Christian, Radom, Filip, Kaufmann, Yvonne, Schaible, Doris, Schlegel, Iris, Zitt, Christof, Sigrist, Gabriel, Straumann, Marcel, Wolter, Julia, Comby, Marco, Sacarcelik, Feyza, Drulyte, Ieva, Lyoo, Heyrhyoung, Wang, Chunyan, Li, Wentao, Du, Wenjuan, Binz, H Kaspar, Herrup, Rachel, Lusvarghi, Sabrina, Neerukonda, Sabari Nath, Vassell, Russell, Wang, Wei, Adler, Julia M, Eschke, Kathrin, Nascimento, Mariana, Abdelgawad, Azza, Gruber, Achim D, Bushe, Judith, Kershaw, Olivia, Knutson, Charles G, Balavenkatraman, Kamal K, Ramanathan, Krishnan, Wyler, Emanuel, Teixeira Alves, Luiz Gustavo, Lewis, Seth, Watson, Randall, Haeuptle, Micha A, Zürcher, Alexander, Dawson, Keith M, Steiner, Daniel, Weiss, Carol D, Amstutz, Patrick, van Kuppeveld, Frank J M, Stumpp, Michael T, Bosch, Berend-Jan, Engler, Olivier, Trimpert, Jakob

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The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants von Rothenberger, Sylvia, Hurdiss, Daniel L, Walser, Marcel, Malvezzi, Francesca, Mayor, Jennifer, Ryter, Sarah, Moreno, Hector, Liechti, Nicole, Bosshart, Andreas, Iss, Chloe, Calabro, Valerie, Cornelius, Andreas, Hospodarsch, Tanja, Neculcea, Alexandra, Looser, Thamar, Schlegel, Anja, Fontaine, Simon, Villemagne, Denis, Paladino, Maria, Schiegg, Dieter, Mangold, Susanne, Reichen, Christian, Radom, Filip, Kaufmann, Yvonne, Schaible, Doris, Schlegel, Iris, Zitt, Christof, Sigrist, Gabriel, Straumann, Marcel, Wolter, Julia, Comby, Marco, Sacarcelik, Feyza, Drulyte, Ieva, Lyoo, Heyrhyoung, Wang, Chunyan, Li, Wentao, Du, Wenjuan, Binz, H. Kaspar, Herrup, Rachel, Lusvarghi, Sabrina, Neerukonda, Sabari Nath, Vassell, Russell, Wang, Wei, Adler, Julia M, Eschke, Kathrin, Nascimento, Mariana, Abdelgawad, Azza, Gruber, Achim D, Bushe, Judith, Kershaw, Olivia, Knutson, Charles G, Balavenkatraman, Kamal K, Ramanathan, Krishnan, Wyler, Emanuel, Alves, Luiz Gustavo Teixeira, Lewis, Seth, Watson, Randall, Haeuptle, Micha A, Zuercher, Alexander, Dawson, Keith M, Steiner, Daniel, Weiss, Carol D, Amstutz, Patrick, van Kuppeveld, Frank J.M, Stumpp, Michael T, Bosch, Berend-Jan, Engler, Olivier, Trimpert, Jakob

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Potent Control of Tumor Growth by CEA/CD3-bispecific Single-chain Antibody Constructs That Are Not Competitively Inhibited by Soluble CEA von LUTTERBUESE, Ralf, RAUM, Tobias, MULGREW, Kathy, OBERST, Michael D, HAMMOND, Scott A, BAEUERLE, Patrick A, KUFER, Peter, KISCHEL, Roman, LUTTERBUESE, Petra, SCHLERETH, Bernd, SCHALLER, Evelyne, MANGOLD, Susanne, RAU, Doris, MEIER, Petra, KIENER, Peter A

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Antitumor Activity of an EpCAM/CD3-bispecific BiTE Antibody During Long-term Treatment of Mice in the Absence of T-cell Anergy and Sustained Cytokine Release von AMANN, Maria, DARGOUGES, Sandrine, RAUM, Tobias, MÜNZ, Markus, KUFER, Peter, SCHLERETH, Bernd, BAEUERLE, Patrick A, FRIEDRICH, Matthias, LORENCZEWSKI, Grit, BRISCHWEIN, Klaus, KISCHEL, Roman, LUTTERBUESE, Ralf, MANGOLD, Susanne, RAY, Doris, VOLKLAND, Jörg, PFLANZ, Stefan

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Mining the human autoantibody repertoire: isolation of potent IL17A-neutralizing monoclonal antibodies from a patient with thymoma von Beerli, Roger R, Bauer, Monika, Fritzer, Andrea, Rosen, Lindsey B, Buser, Regula B, Hanner, Markus, Maudrich, Melanie, Nebenfuehr, Mario, Toepfer, Jorge Alejandro Sepulveda, Mangold, Susanne, Bauer, Anton, Holland, Steven M, Browne, Sarah K, Meinke, Andreas

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Abstract 2434: Novel primate-crossreactive BiTE antibodies that eliminate cancer cells expressing cMet, IGFR-1, FAP-alpha, PSCA, Endosialin, CAIX or Her2/neu von Raum, Tobias J., Rau, Doris, Kischel, Roman, Bluemel, Claudia, Hausmann, Susanne, Steiger, Carola, Meier, Petra, Ebert, Evelyn, Mangold, Susanne, Hoffmann, Patrick, Strasser, Susanne, Cierpka, Ronny, Kvesic, Majk, Baeuerle, Patrick A., Kufer, Peter

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Abstract 2435: Validation of Cynomolgus monkeys as relevant species for safety assessment of a novel human BiTE antibody platform for cancer therapy von Rattel, Benno, Kischel, Roman, Thomas, Oliver, Friedrich, Matthias, Rau, Doris, Ebert, Evelyn, Raum, Tobias, Wolf, Andreas, Mangold, Susanne, Kvesic, Majk, Baeuerle, Patrick A., Kufer, Peter

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Abstract 2429: Evidence of a therapeutic window with a T cell-engaging BiTE antibody based on monoclonal antibody cetuximab von Lutterbuese, Ralf, Thomas, Oliver, Raum, Tobias, Kischel, Roman, Hoffmann, Patrick, Friedrich, Matthias, Lorenczweski, Grit, Wolf, Andreas, Urbig, Thomas, Schaller, Evelyn, Rau, Doris, Mangold, Susanne, Baeuerle, Patrick A., Kufer, Peter, Rattel, Benno

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Abstract 5339: Inhibition of breast cancer cell proliferation and unique epitope recognition by EpCAM-specific human monoclonal antibody adecatumumab von Münz, Markus, Murr, Alexander, Kvesic, Majk, Rau, Doris, Mangold, Susanne, Pflanz, Stefan, Lumsden, John, Volkland, Jörg, Fagerberg, Jan, Riethmüller, Gert, Rüttinger, Dominik, Kufer, Peter, Baeuerle, Patrick A., Raum, Tobias

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A METHOD FOR PREPARING A PURIFIED CYCLIC COMPOUND COMPOSITION von DISTANTE, Francesco, KEHRER, Florian, LUK, Harris Ho Ting, MANGOLD, Susanne

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A highly stable polyethylene glycol-conjugated human single-chain antibody neutralizing granulocyte-macrophage colony stimulating factor at low nanomolar concentration von Krinner, Eva-Maria, Hepp, Julia, Hoffmann, Patrick, Bruckmaier, Sandra, Petersen, Laetitia, Petsch, Silke, Parr, Larissa, Schuster, Ioana, Mangold, Susanne, Lorenczewski, Grit, Lutterbüse, Petra, Buziol, Stefan, Hochheim, Inessa, Volkland, Jörg, Mølhøj, Michael, Sriskandarajah, Mirnalini, Strasser, Markus, Itin, Christian, Wolf, Andreas, Basu, Amartya, Yang, Karen, Filpula, David, Sørensen, Poul, Kufer, Peter, Baeuerle, Patrick, Raum, Tobias

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Cross-species-specific single domain bispecific single chain antibody von Raum, Tobias, Rau, Doris, Mangold, Susanne, Kufer, Peter, Hoffmann, Patrick, Klinger, Matthias, Kischel, Roman, Lutterbüse, Ralf

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CROSS-SPECIES-SPECIFIC BINDING DOMAIN von Raum, Tobias, Rau, Doris, Mangold, Susanne, Kufer, Peter, Hoffmann, Patrick, Klinger, Matthias, Kischel, Roman, Lutterbüse, Ralf

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CROSS-SPECIES-SPECIFIC CD3-EPSILON BINDING DOMAIN von RAU, DORIS, MANGOLD, SUSANNE, KUFER, PETER, HOFFMANN, PATRICK, KISCHEL, ROMAN, RAUM, TOBIAS, KLINGER, MATTHIAS, LUTTERBÜSE, RALF

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