The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor von Manfredi, James J

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p53/HMGB1 Complexes Regulate Autophagy and Apoptosis von LIVESEY, Kristen M, RUI KANG, LOTZE, Michael T, DAOLIN TANG, VERNON, Philip, BUCHSER, William, LOUGHRAN, Patricia, WATKINS, Simon C, LIN ZHANG, MANFREDI, James J, ZEH, Herbert J, LUYUAN LI

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The p53 tumor suppressor participates in multiple cell cycle checkpoints von Giono, Luciana E., Manfredi, James J.

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In vivo RNA-seq and ChIP-seq analyses show an obligatory role for the C terminus of p53 in conferring tissue-specific radiation sensitivity von Resnick-Silverman, Lois, Zhou, Royce, Campbell, Moray J., Leibling, Ian, Parsons, Ramon, Manfredi, James J.

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E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression von Carvajal, Luis A, Hamard, Pierre-Jacques, Tonnessen, Crystal, Manfredi, James J

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Distinct mechanisms control genome recognition by p53 at its target genes linked to different cell fates von Farkas, Marina, Hashimoto, Hideharu, Bi, Yingtao, Davuluri, Ramana V., Resnick-Silverman, Lois, Manfredi, James J., Debler, Erik W., McMahon, Steven B.

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Mdm2-RNA Interactions as a Target for Cancer Therapy: It’s Not All About p53 von Bohlman, Stephen, Manfredi, James J.

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USP7 Enforces Heterochromatinization of p53 Target Promoters by Protecting SUV39H1 from MDM2-Mediated Degradation von Mungamuri, Sathish Kumar, Qiao, Rui F., Yao, Shen, Manfredi, James J., Gu, Wei, Aaronson, Stuart A.

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Mdm2 and MdmX: Partners in p53 Destruction von Manfredi, James J.

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p53 Promotes cell survival due to the reversibility of its cell-cycle checkpoints von Lukin, Dana J, Carvajal, Luis A, Liu, Wen-jun, Resnick-Silverman, Lois, Manfredi, James J

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TP53 Alterations in Myelodysplastic Syndromes and Acute Myeloid Leukemia von Rahmé, Ramy, Braun, Thorsten, Manfredi, James J, Fenaux, Pierre

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The C terminus of p53 regulates gene expression by multiple mechanisms in a target- and tissue-specific manner in vivo von Hamard, Pierre-Jacques, Barthelery, Nicolas, Hogstad, Brandon, Mungamuri, Sathish Kumar, Tonnessen, Crystal A, Carvajal, Luis A, Senturk, Emir, Gillespie, Virginia, Aaronson, Stuart A, Merad, Miriam, Manfredi, James J

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Skp2B overexpression alters a prohibitin-p53 axis and the transcription of PAPP-A, the protease of insulin-like growth factor binding protein 4 von Chander, Harish, Halpern, Max, Resnick-Silverman, Lois, Manfredi, James J, Germain, Doris

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p53 Basic C Terminus Regulates p53 Functions through DNA Binding Modulation of Subset of Target Genes von Hamard, Pierre-Jacques, Lukin, Dana J., Manfredi, James J.

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Inactivation of Wild-Type p53 by Asparagine Endopeptidase in Glioblastoma: An Opportunity to Target the “Undruggable” von Manfredi, James J

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p53 and Development: Shedding Light on an Evolutionary Enigma von Manfredi, James J.

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p53 defies convention again: a p53 mutant that has lost tumor suppression but still can kill von Manfredi, James J

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Mdm2 Is Required for Inhibition of Cdk2 Activity by p21, Thereby Contributing to p53-Dependent Cell Cycle Arrest von Giono, Luciana E., Manfredi, James J.

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Another fork in the road-life or death decisions by the tumour suppressor p53 von Carvajal, Luis A, Manfredi, James J

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Robust p53 Stabilization Is Dispensable for Its Activation and Tumor Suppressor Function von Kon, Ning, Churchill, Michael, Li, Huan, Mukherjee, Siddhartha, Manfredi, James J., Gu, Wei

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