Angiogenic factors in bone local environment von Chim, Shek Man, Tickner, Jennifer, Chow, Siu To, Kuek, Vincent, Guo, Baosheng, Zhang, Ge, Rosen, Vicki, Erber, Wendy, Xu, Jiake

Volltext

A Human Brain-Chip for Modeling Brain Pathologies and Screening Blood-Brain Barrier Crossing Therapeutic Strategies von Chim, Shek Man, Howell, Kristen, Kokkosis, Alexandros, Zambrowicz, Brian, Karalis, Katia, Pavlopoulos, Elias

Volltext

EGFL6 Promotes Endothelial Cell Migration and Angiogenesis through the Activation of Extracellular Signal-regulated Kinase von Chim, Shek Man, Qin, An, Tickner, Jennifer, Pavlos, Nathan, Davey, Tamara, Wang, Hao, Guo, Yajun, Zheng, Ming Hao, Xu, Jiake

Volltext

Neurotrophin‐3 Induces BMP‐2 and VEGF Activities and Promotes the Bony Repair of Injured Growth Plate Cartilage and Bone in Rats von Su, Yu‐Wen, Chung, Rosa, Ruan, Chun‐Sheng, Chim, Shek Man, Kuek, Vincent, Dwivedi, Prem P, Hassanshahi, Mohammadhossein, Chen, Ke‐Ming, Xie, Yangli, Chen, Lin, Foster, Bruce K, Rosen, Vicki, Zhou, Xin‐Fu, Xu, Jiake, Xian, Cory J

Volltext

Functional biology of the Steel syndrome founder allele and evidence for clan genomics derivation of COL27A1 pathogenic alleles worldwide von Gonzaga-Jauregui, Claudia, Yesil, Gozde, Nistala, Harikiran, Gezdirici, Alper, Bayram, Yavuz, Nannuru, Kalyan C, Pehlivan, Davut, Yuan, Bo, Jimenez, Johanna, Sahin, Yavuz, Paine, Ingrid S, Akdemir, Zeynep Coban, Rajamani, Saathyaki, Staples, Jeffrey, Dronzek, John, Howell, Kristen, Fatih, Jawid M, Smaldone, Silvia, Schlesinger, Alan E, Ramírez, Norman, Cornier, Alberto S, Kelly, Melissa A, Haber, Robert, Chim, Shek Man, Nieman, Kristy, Wu, Nan, Walls, Johnathon, Poueymirou, William, Siao, Chia-Jen, Sutton, V Reid, Williams, Marc S, Posey, Jennifer E, Gibbs, Richard A, Carlo, Simon, Tegay, David H, Economides, Aris N, Lupski, James R

Volltext

Cerebral Vein Malformations Result from Loss of Twist1 Expression and BMP Signaling from Skull Progenitor Cells and Dura von Tischfield, Max A., Robson, Caroline D., Gilette, Nicole M., Chim, Shek Man, Sofela, Folasade A., DeLisle, Michelle M., Gelber, Alon, Barry, Brenda J., MacKinnon, Sarah, Dagi, Linda R., Nathans, Jeremy, Engle, Elizabeth C.

Volltext

Genetic inactivation of zinc transporter SLC39A5 improves liver function and hyperglycemia in obesogenic settings von Chim, Shek Man, Howell, Kristen, Dronzek, John, Wu, Weizhen, Van Hout, Cristopher, Ferreira, Manuel A R, Ye, Bin, Li, Alexander, Brydges, Susannah, Arunachalam, Vinayagam, Marcketta, Anthony, Locke, Adam E, Bovijn, Jonas, Verweij, Niek, De, Tanima, Lotta, Luca, Mitnaul, Lyndon, LeBlanc, Michelle, Center, Regeneron Genetics, Carey, David J, Melander, Olle, Shuldiner, Alan, Karalis, Katia, Economides, Aris N, Nistala, Harikiran

Volltext

EGFL7 Is Expressed in Bone Microenvironment and Promotes Angiogenesis via ERK, STAT3, and Integrin Signaling Cascades von Chim, Shek Man, Kuek, Vincent, Chow, Siu To, Lim, Bay Sie, Tickner, Jennifer, Zhao, Jinmin, Chung, Rosa, Su, Yu-Wen, Zhang, Ge, Erber, Wendy, Xian, Cory J., Rosen, Vicki, Xu, Jiake

Volltext

HtrA1 is upregulated during RANKL-induced osteoclastogenesis, and negatively regulates osteoblast differentiation and BMP2-induced Smad1/5/8, ERK and p38 phosphorylation von Wu, Xinghuo, Chim, Shek Man, Kuek, Vincent, Lim, Bay Sie, Chow, Siu To, Zhao, Jinmin, Yang, Shuhua, Rosen, Vicki, Tickner, Jennifer, Xu, Jiake

Volltext

Loss of protein kinase C-δ protects against LPS-induced osteolysis owing to an intrinsic defect in osteoclastic bone resorption von Khor, Ee Cheng, Abel, Tamara, Tickner, Jennifer, Chim, Shek Man, Wang, Cathy, Cheng, Taksum, Ng, Benjamin, Ng, Pei Ying, Teguh, Dian Astari, Kenny, Jacob, Yang, Xiaohong, Chen, Honghui, Nakayama, Keiichi I, Nakayama, Keiko, Pavlos, Nathan, Zheng, Ming H, Xu, Jiake

Volltext

miR-764-5p promotes osteoblast differentiation through inhibition of CHIP/STUB1 expression von Guo, Junwei, Ren, Fangli, Wang, Yinyin, Li, Shan, Gao, Zhengrong, Wang, Xiaoyan, Ning, Hongxiu, Wu, Jianguo, Li, Yi, Wang, Zhao, Chim, Shek Man, Xu, Jiake, Chang, Zhijie

Volltext

An overview of the regulation of bone remodelling at the cellular level von Kular, Jasreen, Tickner, Jennifer, Chim, Shek Man, Xu, Jiake

Volltext

Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease von Horowitz, Julie E., Kosmicki, Jack A., Damask, Amy, Sharma, Deepika, Roberts, Genevieve H. L., Justice, Anne E., Banerjee, Nilanjana, Coignet, Marie V., Yadav, Ashish, Leader, Joseph B., Marcketta, Anthony, Park, Danny S., Lanche, Rouel, Maxwell, Evan, Knight, Spencer C., Bai, Xiaodong, Guturu, Harendra, Sun, Dylan, Baltzell, Asher, Kury, Fabricio S. P., Backman, Joshua D., Girshick, Ahna R., O’Dushlaine, Colm, McCurdy, Shannon R., Partha, Raghavendran, Mansfield, Adam J., Turissini, David A., Li, Alexander H., Zhang, Miao, Mbatchou, Joelle, Watanabe, Kyoko, Gurski, Lauren, McCarthy, Shane E., Kang, Hyun M., Dobbyn, Lee, Stahl, Eli, Verma, Anurag, Sirugo, Giorgio, Ritchie, Marylyn D., Jones, Marcus, Balasubramanian, Suganthi, Siminovitch, Katherine, Salerno, William J., Shuldiner, Alan R., Rader, Daniel J., Mirshahi, Tooraj, Locke, Adam E., Marchini, Jonathan, Overton, John D., Carey, David J., Habegger, Lukas, Cantor, Michael N., Rand, Kristin A., Hong, Eurie L., Reid, Jeffrey G., Ball, Catherine A., Baras, Aris, Abecasis, Gonçalo R., Ferreira, Manuel A. R.

Volltext

Genetic inactivation of zinc transporter SLC39A5 improves liver function and hyperglycemia in obesogenic settings von Chim, Shek Man, Howell, Kristen, Dronzek, John, Wu, Weizhen, Van Hout, Cristopher, Ferreira, Manuel AR, Ye, Bin, Li, Alexander, Brydges, Susannah, Arunachalam, Vinayagam, Marcketta, Anthony, Locke, Adam E, Bovijn, Jonas, Verweij, Niek, De, Tanima, Lotta, Luca, Mitnaul, Lyndon, LeBlanc, Michelle, Center, Regeneron Genetics, Carey, David J, Melander, Olle, Shuldiner, Alan, Karalis, Katia, Economides, Aris N, Nistala, Harikiran

Volltext

Osteoblast-derived EGFL6 couples angiogenesis to osteogenesis during bone repair von Chen, Kai, Liao, Shijie, Li, Yicheng, Jiang, Haibo, Liu, Yun, Wang, Chao, Kuek, Vincent, Kenny, Jacob, Li, Boxiang, Huang, Qian, Hong, Jianxin, Huang, Yan, Chim, Shek Man, Tickner, Jennifer, Pavlos, Nathan J, Zhao, Jinmin, Liu, Qian, Qin, An, Xu, Jiake

Volltext

SC-514, a selective inhibitor of IKKβ attenuates RANKL-induced osteoclastogenesis and NF-κB activation von Liu, Qian, Wu, Huafei, Chim, Shek Man, Zhou, Lin, Zhao, Jinmin, Feng, Haotian, Wei, Qingli, Wang, Qing, Zheng, Ming H., Tan, Ren Xiang, Gu, Qiong, Xu, Jun, Pavlos, Nathan, Tickner, Jennifer, Xu, Jiake

Volltext

NMIHBA results from hypomorphic PRUNE1 variants that lack short-chain exopolyphosphatase activity von Nistala, Harikiran, Dronzek, John, Gonzaga-Jauregui, Claudia, Chim, Shek Man, Rajamani, Saathyaki, Nuwayhid, Samer, Delgado, Dennis, Burke, Elizabeth, Karaca, Ender, Franklin, Matthew C, Sarangapani, Prasad, Podgorski, Michael, Tang, Yajun, Dominguez, Melissa G, Withers, Marjorie, Deckelbaum, Ron A, Scheonherr, Christopher J, Gahl, William A, Malicdan, May C, Zambrowicz, Brian, Gale, Nicholas W, Gibbs, Richard A, Chung, Wendy K, Lupski, James R, Economides, Aris N

Volltext

Osteoblast derived-neurotrophin‑3 induces cartilage removal proteases and osteoclast-mediated function at injured growth plate in rats von Su, Yu-Wen, Chim, Shek Man, Zhou, Lin, Hassanshahi, Mohammadhossein, Chung, Rosa, Fan, Chiaming, Song, Yunmei, Foster, Bruce K., Prestidge, Clive A., Peymanfar, Yaser, Tang, Qian, Butler, Lisa M., Gronthos, Stan, Chen, Di, Xie, Yangli, Chen, Lin, Zhou, Xin-Fu, Xu, Jiake, Xian, Cory J.

Volltext

NPNT is Expressed by Osteoblasts and Mediates Angiogenesis via the Activation of Extracellular Signal-regulated Kinase von Kuek, Vincent, Yang, Zhifan, Chim, Shek Man, Zhu, Sipin, Xu, Huazi, Chow, Siu To, Tickner, Jennifer, Rosen, Vicki, Erber, Wendy, Li, Xiucheng, Qin, An, Qian, Yu, Xu, Jiake

Volltext

Novel vertebrate- and brain-specific driver of neuronal outgrowth von Jansen, Eric J.R., van Bakel, Nick H.M., Benedict, Bente, Olde Loohuis, Nikkie F.M., Hafmans, Theo G.M., Chim, Shek Man, Xu, Jiake, Kolk, Sharon M., Martens, Gerard J.M.

Volltext