Dual mTORC1/2 inhibition compromises cell defenses against exogenous stress potentiating Obatoclax-induced cytotoxicity in atypical teratoid/rhabdoid tumors von Parkhurst, Ashlyn, Wang, Sabrina Z., Findlay, Tyler R., Malebranche, Kristen J., Odabas, Arman, Alt, Jesse, Maxwell, Micah J., Kaur, Harpreet, Peer, Cody J., Figg, William D., Warren, Katherine E., Slusher, Barbara S., Eberhart, Charles G., Raabe, Eric H., Rubens, Jeffrey A.

Volltext

Epigenetic upregulation of Schlafen11 renders 
WNT- and SHH-activated medulloblastomas sensitive to cisplatin von Nakata, Satoshi, Murai, Junko, Okada, Masayasu, Takahashi, Haruhiko, Findlay, Tyler H, Malebranche, Kristen, Parthasarathy, Akhila, Miyashita, Satoshi, Gabdulkhaev, Ramil, Benkimoun, Ilan, Druillennec, Sabine, Chabi, Sara, Hawkins, Eleanor, Miyahara, Hiroaki, Tateishi, Kensuke, Yamashita, Shinji, Yamada, Shiori, Saito, Taiki, On, Jotaro, Watanabe, Jun, Tsukamoto, Yoshihiro, Yoshimura, Junichi, Oishi, Makoto, Nakano, Toshimichi, Imamura, Masaru, Imai, Chihaya, Yamamoto, Tetsuya, Takeshima, Hideo, Sasaki, Atsuo T, Rodriguez, Fausto J, Nobusawa, Sumihito, Varlet, Pascale, Pouponnot, Celio, Osuka, Satoru, Pommier, Yves, Kakita, Akiyoshi, Fujii, Yukihiko, Raabe, Eric H, Eberhart, Charles G, Natsumeda, Manabu

Volltext

ATRT-09. COMBINATION OF THE PI3K INHIBITOR PAXALISIB WITH THE NUCLEOSIDE ANALOG GEMCITABINE ACTIVATES THE INTEGRATED STRESS RESPONSE AND EXTENDS SURVIVAL IN ORTHOTOPIC MODELS OF AT... von Findlay, Tyler, Malebranche, Kristen, Geethadevi, Anupa, Eberhart, Charles, Raabe, Eric, Rubens, Jeffrey

Volltext

ATRT-04. TARGETING THE COREST COMPLEX HELPS REPROGRAM AT/RT’S ABNORMAL EPIGENETIC LANDSCAPE TOWARD A DIFFERENTIATION PHENOTYPE von Geethadevi, Anupa, Collard, Marianne, Vaidya, Nikhil, Findlay, Tyler, Malebranche, Kristen, Eberhart, Charles, Raabe, Eric, Cole, Philip, Alani, Rhoda, Rubens, Jeffrey

Volltext

Abstract 5226: The PI3K inhibitor Paxalisib combines synergistically with the pan-Raf inhibitor TAK580 (DAY 101) to extend survival in orthotopic xenograft models of atypical terat... von Malebranche, Kristen, Findlay, Tyler, Eberhart, Charles, Raabe, Eric, Rubens, Jeffrey

Volltext

Abstract 5509: The PI3K inhibitor Paxalisib combines synergistically with the MEK inhibitor Mirdametinib to target atypical teratoid/rhabdoid tumors von Malebranche, Kristen J., Findlay, Tyler, Geethadevi, Anupa, Eberhart, Charles, Raabe, Eric, Rubens, Jeffrey

Volltext

Abstract 5490: Combination of the PI3k inhibitor Paxalisib with the nucleoside analog Gemcitabine over-activates the integrated stress response and induces atypical teratoid/rhabdo... von Findlay, Tyler, Malebranche, Kristen, Geethadevi, Anupa, Raabe, Eric, Eberhart, Charles, Rubens, Jeffrey

Volltext

Abstract 1141: The CoREST complex as a novel target to disrupt AT/RT’s abnormal epigenetic landscape von Geethadevi, Anupa, Collard, Marianne, Vaidya, Nikhil, Findlay, Tyler, Malebranche, Kristen, Eberhart, Charles, Raabe, Eric, Cole, Philip, Alani, Rhoda, Rubens, Jeffrey

Volltext