Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Abeta, tau, immunity and lipid processing von Kunkle, B. W., Grenier-Boley, B., Sims, R., Bis, J. C., Damotte, V., Naj, A. C., Boland, A., Vronskaya, M., van Der Lee, S. J., Amlie-Wolf, A., Bellenguez, C., Frizatti, A., Chouraki, V., Martin, E. R., Sleegers, K., Badarinarayan, N., Jakobsdottir, J., Hamilton-Nelson, K. L., Moreno-Grau, S., Olaso, R., Raybould, R., Chen, Y., Kuzma, A. B., Hiltunen, M., Morgan, T., Ahmad, S., Vardarajan, B. N., Epelbaum, J., Hoffmann, P., Boada, M., Beecham, G. W., Garnier, J. G., Harold, D., Fitzpatrick, A. L., Valladares, O., Moutet, M. L., Gerrish, A., Qu, L., Bacq, D., Denning, N., Jian, X., Zhao, Y., del Zompo, M., Fox, N. C., Choi, S. H., Mateo, I., Hughes, J. T., Adams, H. H., Malamon, J., Sanchez-Garcia, F., Patel, Y., Brody, J. A., Dombroski, B. A., Naranjo, M. C. D., Daniilidou, M., Eiriksdottir, G., Mukherjee, S., Wallon, D., Uphill, J., Aspelund, T., Cantwell, L. B., Garzia, F., Galimberti, D., Hofer, E., Butkiewicz, M., Fin, B., Scarpini, E., Sarnowski, C., Bush, W. S., Meslage, S., Kornhuber, J., White, C. C., Song, Y., Barber, R. C., Engelborghs, S., Sordon, S., Voijnovic, D., Adams, P. M., Vandenberghe, R., Mayhaus, M., Cupples, L. A., Albert, M. S., de Deyn, P. P., Gu, W., Himali, J. J., Beekly, D., Squassina, A., Hartmann, A. M., Orellana, A., Blacker, D., Rodriguez-Rodriguez, E., Lovestone, S., Garcia, M. E., Doody, R. S., Munoz-Fernadez, C., Sussams, R., Lin, H., Fairchild, T. J., Benito, Y. A., Holmes, C.

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Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease von Jakobsdottir, J., Raybould, R., Vronskaya, M., White, C.C., Herms, S., Smith, A.V., Funk, C.C., Sánchez-Juan, P., Wolters, F.J., Zhao, Y., Malamon, J., Dombroski, B., Whitehead, P., Cantwell, L.B., Burgess, J.D., Adams, H.H., Chakrabarty, P., Beiser, A.S., Lannfelt, L., Mecocci, P., Eiriksdottir, G., Henández, I., Tarraga, L., Albert, M.S., Emilsson, V., Doody, R.S., Spalletta, G., Frosch, M.P., Kamboh, M.I., Marshall, R., Fairén, M.D., Uphill, J., Hughes, J.T., Orfei, M.D., Ciaramella, A., Mayhaus, M., Brookes, K., Cupidi, C., Gill, M., Apostolova, L.G., Asthana, S., Boeve, B.F., Burke, J.R., Buxbaum, J.D., Cairns, N.J., Chui, H.C., Gearing, M., Harrell, L.E., Jarvik, G.P., Leverenz, J.B., Li, G., Lieberman, A.P., McCormick, W.C., Miller, C.A., Pankratz, V.S., Raskind, M., Tanzi, R.E., Troncoso, J.C., Wingo, T.S., Garzia, F., Vandenberghe, R., Fernadez, C.M., Lilius, L., Koivisto, A.M., Dermecourt, V., Fievet, N., Brice, A., Ritchie, K., Dubois, B., Himali, J.J., Tschanz, J., Fitzpatrick, A.L., Kukull, W.A., Larson, E.B., Rotter, J.I., Coto, E., Gallo, M., Galimberti, D., Tsuang, D.W., Daniele, A., Nacmias, B., Rubinsztein, D.C., Bras, J., Collinge, J., Tsolaki, M., Uitterlinden, A.G., Powell, J., Golde, T.E., De Jager, P.L., Ertekin-Taner, N., Passmore, P., Younkin, S.G., Ortega-Cubero, S., Jones, L., Mayeux, R., Amin, N., Holmans, P.A., Pericak-Vance, M.A., Lambert, J.C., Destefano, Anita L.

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A statistical framework for cross-tissue transcriptome-wide association analysis von Li, M, Lu, Q, Wang, J, Zekavat, SM, Yu, Z, Gu, J, Mukherjee, S, Natarajan, P, Kuzma, A, Crane, PK, Lu, H, Zhao, H, Albert, MS, Arnold, SE, Asthana, S, Beach, TG, Beekly, D, Bigio, EH, Bowen, JD, Boxer, A, Burke, JR, Cairns, NJ, Cantwell, LB, Cao, C, Carlson, CS, Carney, RM, Chui, HC, Cribbs, DH, Crocco, EA, De Jager, PL, DeCarli, C, Dick, M, Doody, RS, Faber, KM, Fallon, KB, Farlow, MR, Farrer, LA, Ferris, S, Frosch, MP, Gearing, M, Geschwind, DH, Goate, AM, Graff-Radford, NR, Green, RC, Growdon, JH, Haines, JL, Hardy, J, Huentelman, MJ, Hyman, BT, Jun, G, Kamboh, MI, Karydas, A, Kauwe, JSK, Kaye, JA, Kim, R, Kowall, NW, Kukull, WA, Martiniuk, F, Mash, DC, McCurry, SM, Mesulam, M, Miller, BL, Miller, CA, Miller, JW, Montine, TJ, Morris, JC, Naj, AC, O'Bryant, S, Olichney, JM, Parisi, JE, Paulson, HL, Pericak-Vance, MA, Peskind, E, Pierce, A, Potter, H, Reiman, EM, Reisberg, B, Reisch, JS, Ringman, JM, Roberson, ED, Rogaeva, E, Saykin, AJ, Schellenberg, GD, Schneider, JA, Schneider, LS, Sonnen, JA, Spina, S, Trojanowski, JQ, Troncoso, JC, Van Eldik, LJ, Vinters, HV, Weintraub, S, Welsh-Bohmer, KA, Wilhelmsen, KC, Williamson, J, Wingo, TS, Wright, CB, Younkin, SG, Yu, C-E, Yu, L

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Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing von Naj, AC, van der Lee, SJ, Bellenguez, C, Badarinarayan, N, Vardarajan, BN, Fitzpatrick, AL, Denning, N, Zhao, Y, Fox, NC, Sanchez-Garcia, F, Scarpini, E, Meslage, S, White, CC, Voijnovic, D, Adams, PM, Himali, JJ, Orellana, A, Lin, H, Giedraitis, V, Helisalmi, S, Lynch, A, Tarraga, L, Lipton, RB, Frisardi, V, Rotter, J, Royall, DR, Maletta, RG, Dubois, B, Fratiglioni, L, Barnes, LL, Froelich, L, McGuinness, B, Bird, TD, Warren, JD, Boeve, BF, Bowen, JD, Proitsi, P, Burke, JR, Kauwe, JSK, McQuillin, A, Carlson, CS, Carlsson, CM, Allen, M, Masullo, C, Crocco, EA, Fallon, KB, Farlow, MR, Koelsch, H, Leber, M, Galasko, DR, Gilbert, JR, Growdon, JH, Feulner, T, Honig, LS, Hollingworth, P, Jun, GR, Jessen, F, LaFerla, FM, Joeckel, K-H, Leverenz, JB, Pickering-Brown, S, Lieberman, AP, Wichmann, H-E, Marson, DC, Martiniuk, F, Bayer, A, McDavid, AN, Al-Chalabi, A, Myers, AJ, Mead, S, Sorbi, S, Quinn, JF, Smith, AD, Rosen, HJ, Rosenberg, RN, Saykin, AJ, Vance, JM, Schneider, LS, Slifer, S, Sonnen, JA, Van Eldik, LJ, Vinters, HV, Weintraub, S, Williamson, J, Saba, Y, Peters, O, Crane, PK, De Jager, PL, Gwilliam, R, Fornage, M, Ertekin-Taner, N, Love, S, Nicolas, G, Munger, R, O'Donovan, MC, Ramirez, A, Wang, L-S, Holmans, PA, Seshadri, S, Lambert, J-C

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Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease von Peloso, GM, van der Lee, SJ, Sims, R, Naj, AC, Bellenguez, C, Badarinarayan, N, Jakobsdottir, J, Kunkle, BW, Boland, A, Raybould, R, Bis, JC, Martin, ER, Grenier-Boley, B, Heilmann-Heimbach, S, Chouraki, V, Kuzma, AB, Sleegers, K, Vronskaya, M, Ruiz, A, Graham, RR, Olaso, R, Hoffmann, P, Grove, ML, Vardarajan, BN, Hiltunen, M, Nöthen, MM, White, CC, Hamilton-Nelson, KL, Epelbaum, J, Maier, W, Choi, SH, Beecham, GW, Dulary, C, Herms, S, Smith, AV, Funk, CC, Derbois, Forstner, AJ, Ahmad, S, Li, H, Bacq, D, Harold, D, Satizabal, CL, Valladares, O, Squassina, A, Thomas, R, Brody, JA, Qu, L, Sánchez-Juan, P, Morgan, T, Wolters, FJ, Zhao, Y, Garcia, FS, Denning, N, Fornage, M, Malamon, J, Naranjo, MCD, Majounie, E, Mosley, TH, Dombroski, B, Wallon, D, Lupton, MK, Dupuis, J, Whitehead, P, Fratiglioni, L, Medway, C, Jian, X, Mukherjee, S, Keller, L, Brown, K, Lin, H, Cantwell, LB, Panza, F, McGuinness, B, Moreno-Grau, S, Burgess, JD, Solfrizzi, V, Proitsi, P, Adams, HH, Allen, M, Seripa, D, Pastor, P, Cupples, LA, Price, ND, Hannequin, D, Frank-García, A, Levy, D, Chakrabarty, P, Caffarra, P, Giegling, I, Beiser, AS, Giedraitis, V, Hampel, H, Garcia, ME, Wang, X, Lannfelt, L, Mecocci, P, Eiriksdottir, G, Crane, PK

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Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease von Badarinarayan, N, Jakobsdottir, J, Grenier-Boley, B, Heilmann-Heimbach, S, Kuzma, AB, Sleegers, K, White, CC, Hamilton-Nelson, KL, Choi, S-H, Dulary, C, Ahmad, S, Li, H, Squassina, A, Brody, JA, Qu, L, Sánchez-Juan, P, Wolters, FJ, Dombroski, B, Fratiglioni, L, Medway, C, Keller, L, Seripa, D, Levy, D, Chakrabarty, P, Hampel, H, Wang, X, Crane, PK, Barber, RC, Scherer, M, Emilsson, V, Braae, A, Blacker, D, Doody, RS, Spalletta, G, Bossù, P, Yang, Q, Jessen, F, Sotolongo-Grau, O, Braddel, A, Soininen, H, Orfei, MD, Lleó, A, Barber, IS, Cupidi, C, Fox, NC, Baldwin, CT, Barral, S, Bird, TD, Boeve, BF, Bowen, JD, Evans, DA, Galasko, DR, Harrell, LE, Huentelman, MJ, Hulette, CM, Jun, G, Kowall, NW, Lieberman, AP, Martiniuk, F, Mash, DC, McCormick, WC, McCurry, SM, McKee, AC, Pankratz, VS, Potter, H, Roberson, ED, Rogaeva, E, Schneider, LS, Stern, RA, Troncoso, JC, Van Eldik, LJ, Vinters, HV, Vonsattel, JP, Wilhelmsen, KC, Septier, G, Fernadez, CM, Thonberg, H, Kinhult-Stählbom, A, Fievet, N, Himali, JJ, Keene, CD, Fitzpatrick, AL, Kukull, WA, Larson, EB, Alvarez, V, Rivadeneira, F, Royall, DR, Winslow, AR, Behrens, TW, Uitterlinden, AG, Holmes, C, Ingelsson, M, Powell, J, Morgan, K, DeStefano, AL, Campion, D, Ikram, MA, Jones, L, Haines, JL, Wang, L-S

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Survival Benefit of Living-Donor Liver Transplant von Jackson, Whitney E, Malamon, John S, Kaplan, Bruce, Saben, Jessica L, Schold, Jesse D, Pomposelli, James J, Pomfret, Elizabeth A

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Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau von Hohman, Timothy J, Dumitrescu, Logan, Barnes, Lisa L, Thambisetty, Madhav, Beecham, Gary, Kunkle, Brian, Gifford, Katherine A, Bush, William S, Chibnik, Lori B, Mukherjee, Shubhabrata, De Jager, Philip L, Kukull, Walter, Crane, Paul K, Resnick, Susan M, Keene, C. Dirk, Montine, Thomas J, Schellenberg, Gerard D, Haines, Jonathan L, Zetterberg, Henrik, Blennow, Kaj, Larson, Eric B, Johnson, Sterling C, Albert, Marilyn, Bennett, David A, Schneider, Julie A, Jefferson, Angela L

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Reassessing the survival benefit of deceased donor liver transplantation - retrospective cohort study von Malamon, John S, Kaplan, Bruce, Jackson, Whitney E, Saben, Jessica L, Schold, Jesse D, Pomfret, Elizabeth A, Pomposelli, James J

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Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study von Reiman, Eric M., Arboleda-Velasquez, Joseph F., Quiroz, Yakeel T., Huentelman, Matthew J., Beach, Thomas G., Caselli, Richard J., Chen, Yinghua, Su, Yi, Myers, Amanda J., Hardy, John, Paul Vonsattel, Jean, Younkin, Steven G., Bennett, David A., De Jager, Philip L., Larson, Eric B., Crane, Paul K., Keene, C. Dirk, Kamboh, M. Ilyas, Kofler, Julia K., Duque, Linda, Gilbert, John R., Gwirtsman, Harry E., Buxbaum, Joseph D., Dickson, Dennis W., Frosch, Matthew P., Ghetti, Bernardino F., Lunetta, Kathryn L., Wang, Li-San, Hyman, Bradley T., Kukull, Walter A., Foroud, Tatiana, Haines, Jonathan L., Mayeux, Richard P., Pericak-Vance, Margaret A., Schneider, Julie A., Trojanowski, John Q., Farrer, Lindsay A., Schellenberg, Gerard D., Beecham, Gary W., Montine, Thomas J., Jun, Gyungah R.

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An evaluation of the organ procurement and transplantation network's expanded post-transplant performance metrics von Malamon, John S, Ho, Bing, Jackson, Whitney E, Saben, Jessica L, Schold, Jesse D, Pomposelli, James J, Pomfret, Elizabeth A, Kaplan, Bruce

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Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis von Kunkle, Brian W, Schmidt, Michael, Klein, Hans-Ulrich, Naj, Adam C, Hamilton-Nelson, Kara L, Larson, Eric B, Evans, Denis A, De Jager, Phil L, Crane, Paul K, Buxbaum, Joe D, Ertekin-Taner, Nilufer, Barnes, Lisa L, Fallin, M. Daniele, Manly, Jennifer J, Go, Rodney C. P, Obisesan, Thomas O, Kamboh, M. Ilyas, Bennett, David A, Hall, Kathleen S, Goate, Alison M, Foroud, Tatiana M, Martin, Eden R, Wang, Li-San, Byrd, Goldie S, Farrer, Lindsay A, Haines, Jonathan L, Schellenberg, Gerard D, Mayeux, Richard, Pericak-Vance, Margaret A, Reitz, Christiane, Graff-Radford, Neill R, Martinez, Izri, Ayodele, Temitope, Logue, Mark W, Cantwell, Laura B, Jean-Francois, Melissa, Kuzma, Amanda B, Adams, L.D, Vance, Jeffery M, Cuccaro, Michael L, Chung, Jaeyoon, Mez, Jesse, Lunetta, Kathryn L, Jun, Gyungah R, Lopez, Oscar L, Hendrie, Hugh C, Reiman, Eric M, Kowall, Neil W, Leverenz, James B, Small, Scott A, Levey, Allan I, Golde, Todd E, Saykin, Andrew J, Starks, Takiyah D, Albert, Marilyn S, Hyman, Bradley T, Petersen, Ronald C, Sano, Mary, Wisniewski, Thomas, Vassar, Robert, Kaye, Jeffrey A, Henderson, Victor W, DeCarli, Charles, LaFerla, Frank M, Brewer, James B, Miller, Bruce L, Swerdlow, Russell H, Van Eldik, Linda J, Paulson, Henry L, Trojanowski, John Q, Chui, Helena C, Rosenberg, Roger N, Craft, Suzanne, Grabowski, Thomas J, Asthana, Sanjay, Morris, John C, Strittmatter, Stephen M, Kukull, Walter A

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A model for calculating the long-term estimated post-transplant survival of deceased donor liver transplant patients von Malamon, John S., Jackson, Whitney E., Saben, Jessica L., Conzen, Kendra, Schold, Jesse D., Pomposelli, James J., Pomfret, Elizabeth A., Kaplan, Bruce

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A comparative study of structural variant calling in WGS from Alzheimer's disease families von Malamon, John S, Farrell, John J, Xia, Li Charlie, Dombroski, Beth A, Das, Rueben G, Way, Jessica, Kuzma, Amanda B, Valladares, Otto, Leung, Yuk Yee, Scanlon, Allison J, Lopez, Irving Antonio Barrera, Brehony, Jack, Worley, Kim C, Zhang, Nancy R, Wang, Li-San, Farrer, Lindsay A, Schellenberg, Gerard D, Lee, Wan-Ping, Vardarajan, Badri N

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Human whole-exome genotype data for Alzheimer’s disease von Leung, Yuk Yee, Naj, Adam C., Chou, Yi-Fan, Valladares, Otto, Schmidt, Michael, Hamilton-Nelson, Kara, Wheeler, Nicholas, Lin, Honghuang, Gangadharan, Prabhakaran, Qu, Liming, Clark, Kaylyn, Kuzma, Amanda B., Lee, Wan-Ping, Cantwell, Laura, Nicaretta, Heather, Haines, Jonathan, Farrer, Lindsay, Seshadri, Sudha, Brkanac, Zoran, Cruchaga, Carlos, Pericak-Vance, Margaret, Mayeux, Richard P., Bush, William S., Destefano, Anita, Martin, Eden, Schellenberg, Gerard D., Wang, Li-San

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Quality control and integration of genotypes from two calling pipelines for whole genome sequence data in the Alzheimer's disease sequencing project von Naj, Adam C., Lin, Honghuang, Vardarajan, Badri N., White, Simon, Lancour, Daniel, Ma, Yiyi, Schmidt, Michael, Sun, Fangui, Butkiewicz, Mariusz, Bush, William S., Kunkle, Brian W., Malamon, John, Amin, Najaf, Choi, Seung Hoan, Hamilton-Nelson, Kara L., van der Lee, Sven J., Gupta, Namrata, Koboldt, Daniel C., Saad, Mohamad, Wang, Bowen, Nato, Alejandro Q., Sohi, Harkirat K., Kuzma, Amanda, Wang, Li-San, Cupples, L. Adrienne, van Duijn, Cornelia, Seshadri, Sudha, Schellenberg, Gerard D., Boerwinkle, Eric, Bis, Joshua C., Dupuis, Josée, Salerno, William J., Wijsman, Ellen M., Martin, Eden R., DeStefano, Anita L.

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A model for calculating the long-term estimated post-transplant survival of deceased donor liver transplant patientsResearch in context von John S. Malamon, Whitney E. Jackson, Jessica L. Saben, Kendra Conzen, Jesse D. Schold, James J. Pomposelli, Elizabeth A. Pomfret, Bruce Kaplan

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A rare missense variant of CASP7 is associated with familial late-onset Alzheimer's disease von Zhang, Xiaoling, Ma, Yiyi, Lancour, Daniel, Farrell, John J., Chung, Jaeyoon, Dinh, Huyen, Doddapeneni, Harsha, English, Adam, Gibbs, Richard A., Han, Yi, Jayaseelan, Joy, Kalra, Divya, Khan, Ziad, Lee, Sandra, Liu, Yue, Muzny, Donna, Nasser, Waleed, White, Simon, Worley, Kim, Zhu, Yiming, Beiser, Alexa, Chen, Yuning, Chung, Jaeyoon, Cupples, L. Adrienne, DeStefano, Anita, Dupuis, Josee, Farrell, John, Farrer, Lindsay, Lancour, Daniel, Lin, Honghuang, Sarnowski, Chloe, Zhang, Xiaoling, Choi, Seung Hoan, Gabriel, Stacey, Butkiewicz, Mariusz, Haines, Jonathan, Song, Yeunjoo, Barral, Sandra, Reitz, Christiane, Reyes, Dolly, Tosto, Giuseppe, Vardarajan, Badri, Amad, Shahzad, Amin, Najaf, Ikram, M. Afran, van Duijn, Cornelia, Vanderspek, Ashley, Schmidt, Helena, Goate, Alison, Marcora, Edoardo, Foroud, Tatiana, Feolo, Michael, Launer, Lenore J., Bennett, David A., Xia, Li Charlie, Beecham, Gary, Hamilton-Nelson, Kara, Jaworski, James, Martin, Eden, Pericak-Vance, Margaret, Rajabli, Farid, Schmidt, Michael, Cantwell, Laura, Childress, Micah, Chou, Yi-Fan, Cweibel, Rebecca, Leung, Yuk Yee, Lin, Han-Jen, Malamon, John, Naj, Adam, Valladares, Otto, Wang, Li-San, Wang, Weixin, Zhang, Nancy, Boerwinkle, Eric, Bressler, Jan, Fornage, Myriam, Jian, Xueqiu, Liu, Xiaoming, Blue, Elizabeth, Brown, Lisa, Day, Tyler, Dorschner, Michael, Horimoto, Andrea R., Nato, Alejandro Q., Navas, Pat, Nguyen, Hiep, Rice, Kenneth, Sohi, Harkirat, Thornton, Timothy, Tsuang, Debby, Cruchaga, Carlos, Fulton, Robert S., Koboldt, Daniel C., Larson, David E., Waligorski, Jason, Wilson, Richard K., Haines, Jonathan L., Pericak-Vance, Margaret A., Lunetta, Kathryn L.

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NIAGADS: The NIA Genetics of Alzheimer's Disease Data Storage Site von Partch, Amanda, Valladares, Otto, Cweibel, Rebecca, Greenfest-Allen, Emily, Childress, Micah, Malamon, John, Gangadharan, Prabhakaran, Zhao, Yi, Qu, Liming, Leung, Yuk Yee, Naj, Adam C, Stoeckert, Christian J, Schellenberg, Gerard D, Wang, Li-San

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P4‐044: THE GCAD CLOUD‐BASED WORKFLOW FOR PROCESSING WHOLE EXOME AND WHOLE GENOME DATA FROM THE ALZHEIMER'S DISEASE SEQUENCING PROJECT von Gangadharan, Prabhakaran, Leung, Yuk Yee, Valladares, Otto, Chou, Yi-Fan, Kuzma, Amanda B., Cantwell, Laura B., Qu, Liming, Lin, Han-Jen, Zhao, Yi, Malamon, John Stephen, Naj, Adam C., Salerno, William J., Schellenberg, Gerard D., Wang, Li-San

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