Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design von Tsao, Désirée H.H., Sutherland, Alan G., Jennings, Lee. D., Li, Yuanhong, Rush, Thomas S., Alvarez, Juan C., Ding, Weidong, Dushin, Elizabeth G., Dushin, Russell G., Haney, Steve A., Kenny, Cynthia H., Karl Malakian, A., Nilakantan, Ramaswamy, Mosyak, Lidia

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Structural Basis for the Immunogenic Properties of the Meningococcal Vaccine Candidate LP2086 von Mascioni, Alessandro, Bentley, Breagh E., Camarda, Rosaria, Dilts, Deborah A., Fink, Pamela, Gusarova, Viktoria, Hoiseth, Susan K., Jacob, Jaison, Lin, Shuo L., Malakian, Karl, McNeil, Lisa K., Mininni, Terri, Moy, Franklin, Murphy, Ellen, Novikova, Elena, Sigethy, Scott, Wen, Yingxia, Zlotnick, Gary W., Tsao, Désirée H.H.

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Synthesis and Structure−Activity Relationship of Novel 6-Aryl-1,4- dihydrobenzo[d][1,3]oxazine-2-thiones as Progesterone Receptor Modulators Leading to the Potent and Selective Non... von Fensome, Andrew, Bender, Reinhold, Chopra, Rajiv, Cohen, Jeff, Collins, Mark A, Hudak, Valerie, Malakian, Karl, Lockhead, Susan, Olland, Andrea, Svenson, Kristine, Terefenko, Eugene A, Unwalla, Ray J, Wilhelm, James M, Wolfrom, Scott, Zhu, Yuan, Zhang, Zhiming, Zhang, Puwen, Winneker, Richard C, Wrobel, Jay

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Two N-Terminal Domains of Kv4 K + Channels Regulate Binding to and Modulation by KChIP1 von Scannevin, Robert H, Wang, KeWei, Jow, Flora, Megules, Jennifer, Kopsco, David C, Edris, Wade, Carroll, Karen C, Lü, Qiang, Xu, Weixin, Xu, Zhangbao, Katz, Alan H, Olland, Stephane, Lin, Laura, Taylor, Meggin, Stahl, Mark, Malakian, Karl, Somers, Will, Mosyak, Lydia, Bowlby, Mark R, Chanda, Pranab, Rhodes, Kenneth J

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Abstract 2904: CAT-179, an allogeneic NK cell product expressing HER2-CAR, IL-15 and TGFβ dominant negative receptor, durably regresses HER2-expressing xenograft tumors in mice von Hamza, Bashar, Nunez, Angela, Marques, Marilyn, Barandiaran, Alexia, Moreno, Henry, Moore, Finola, Walsh, Meghan, Choi, Eugene, Pradhan, Kisha, Daniel, Krista, Johnson, Jennifer, Franco, Charlotte, Alvarez, Andres, Malakian, Karl, Wong, Keith H., Gold, Joseph, Suri, Vipin, Picarella, Dominic

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Structure-Based Design of Estrogen Receptor-β Selective Ligands von Manas, Eric S, Unwalla, Rayomand J, Xu, Zhang B, Malamas, Michael S, Miller, Chris P, Harris, Heather A, Hsiao, Chulai, Akopian, Tatos, Hum, Wah-Tung, Malakian, Karl, Wolfrom, Scott, Bapat, Ashok, Bhat, Ramesh A, Stahl, Mark L, Somers, William S, Alvarez, Juan C

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Catalytic Domain Crystal Structure of Protein Kinase C-θ (PKCθ) von Xu, Zhang-Bao, Chaudhary, Divya, Olland, Stephane, Wolfrom, Scott, Czerwinski, Robert, Malakian, Karl, Lin, Laura, Stahl, Mark L., Joseph-McCarthy, Diane, Benander, Christina, Fitz, Lori, Greco, Rita, Somers, William S., Mosyak, Lidia

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Abstract 2898: CAT-248, an allogeneic CD70-directed CAR-NK cell therapy effectively controls CD70-positive tumor xenografts von Hamza, Bashar, Choi, Eugene, Picarella, Dominic, Moore, Finola, Nunez, Angela, Moreno, Henry, Marques, Marilyn, Barandiaran, Alexia, Walsh, Meghan, Pradhan, Kisha, Daniel, Krista, Becker, Kelly, Johnson, Jennifer, Malakian, Karl, Wong, Keith H., Omobono, Mark A., Franco, Charlotte, Alvarez, Andres, Nguyen, Jenna, Blanco, Billy, Khurana, Priya, Marques, Beatriz, Rivera, Adriana, McAuliffe, Michele, Chang, Jae-Woong, Krueger, Joshua, Webber, Beau R., Moriarity, Branden S., Gold, Joseph, Thomas, Cherry, Suri, Vipin

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NMR dynamics and antibody recognition of the meningococcal lipidated outer membrane protein LP2086 in micellar solution von Mascioni, Alessandro, Moy, Franklin J., McNeil, Lisa K., Murphy, Ellen, Bentley, Breagh E., Camarda, Rosaria, Dilts, Deborah A., Fink, Pamela S., Gusarova, Viktoria, Hoiseth, Susan K., Malakian, Karl, Mininni, Terri, Novikova, Elena, Lin, Shuo, Sigethy, Scott, Zlotnick, Gary W., Tsao, Désirée H.H.

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Characterization of Protein Kinase C θ Activation Loop Autophosphorylation and the Kinase Domain Catalytic Mechanism von Czerwinski, Robert, Aulabaugh, Ann, Greco, Rita M, Olland, Stephane, Malakian, Karl, Wolfrom, Scott, Lin, Laura, Kriz, Ron, Stahl, Mark, Huang, Ying, Liu, Lin, Chaudhary, Divya

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Catalytically Active MAP KAP Kinase 2 Structures in Complex with Staurosporine and ADP Reveal Differences with the Autoinhibited Enzyme von Underwood, Kathryn W., Parris, Kevin D., Federico, Elizabeth, Mosyak, Lidia, Czerwinski, Robert M., Shane, Tania, Taylor, Meggin, Svenson, Kristine, Liu, Yan, Hsiao, Chu-Lai, Wolfrom, Scott, Maguire, Michelle, Malakian, Karl, Telliez, Jean-Baptiste, Lin, Lih-Ling, Kriz, Ronald W., Seehra, Jasbir, Somers, William S., Stahl, Mark L.

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Solution structure of wild-type human matrix metalloproteinase 12 (MMP-12) in complex with a tight-binding inhibitor von Markus, Michelle A, Dwyer, Brian, Wolfrom, Scott, Li, Jianchang, Li, Wei, Malakian, Karl, Wilhelm, James, Tsao, Désirée H. H

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Structural Basis for the Immunogenic Properties of the Meningococcal Vaccine Candidate LP2086S von Mascioni, Alessandro, Bentley, Breagh E., Camarda, Rosaria, Dilts, Deborah A., Fink, Pamela, Gusarova, Viktoria, Hoiseth, Susan K., Jacob, Jaison, Lin, Shuo L., Malakian, Karl, McNeil, Lisa K., Mininni, Terri, Moy, Franklin, Murphy, Ellen, Novikova, Elena, Sigethy, Scott, Wen, Yingxia, Zlotnick, Gary W., Tsao, Désirée H. H.

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Solution structure of the tumor necrosis factor receptor-1 death domain von Sukits, Steven F, Lin, Lih-Ling, Hsu, Sang, Malakian, Karl, Powers, Robert, Xu, Guang-Yi

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Purification and Characterization of Active Plk‐1 Produced in E. coli and Baculovirus‐Infected Sf9 Insect Cells von Tam, Amy Sze Pui, Malakian, Karl, Benard, Susan, Kelleher, Kerry, Liu, Yan, Tan, Xingzhi, Loganzo, Frank, Siegel, Marshall, Kriz, Ron, Somers, Will, Stahl, Mark, Lin, Laura

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Purification and Characterization of Phosphodiesterase 4B von Tam, May S.K., Liu, Yan, Malakian, Karl, Aulabaugh, Ann, Johnson, Mark, Svenson, Kristine, Ghavami, Afshin, Parris, Kevin, Failli, Amedeo, Kriz, Ron, Stahl, Mark, Lin, Laura, Wen, Yingxia

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The NMR structure of the TRADD death domain, a key protein in the TNF signaling pathway von Tsao, Désirée H H, Hum, Wah-Tung, Hsu, Sang, Malakian, Karl, Lin, Lih-Ling

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Solution Structure of N-TRADD and Characterization of the Interaction of N-TRADD and C-TRAF2, a Key Step in the TNFR1 Signaling Pathway von Tsao, Désirée H.H., McDonagh, Thomas, Telliez, Jean-Baptiste, Hsu, Sang, Malakian, Karl, Xu, Guang-Yi, Lin, Lih-Ling

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A homogeneous time-resolved fluorescence resonance energy transfer assay for IL-13/IL-13Rα1 interaction von Yang, Xiaoke, Capotosto, Rita, DiBlasio, Elizabeth, Hu, Zhixiang, Kriz, Ron, Lorenzo, Maria, Malakian, Karl, Wolfrom, Scott, Wilhelm, James, Wolf, Stanley F.

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Expression and purification of active protein kinase Cd (PKCd) kinase domain from E. coli von Strand, James Lloyd, Lin, Laura, Chaudhary, Divya, Czerwinski, Robert, Tsao, Desiree, Li, Yuanhong, Malakian, Karl, Wolfrom, Scott, Liu, Yan, Siegel, Marshall, Kriz, Ron, Stahl, Mark, Somers, Will

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