Commercial Route Research and Development for SGLT2 Inhibitor Candidate Ertugliflozin von Bowles, Paul, Brenek, Steven J, Caron, Stéphane, Do, Nga M, Drexler, Michele T, Duan, Shengquan, Dubé, Pascal, Hansen, Eric C, Jones, Brian P, Jones, Kris N, Ljubicic, Tomislav A, Makowski, Teresa W, Mustakis, Jason, Nelson, Jade D, Olivier, Mark, Peng, Zhihui, Perfect, Hahdi H, Place, David W, Ragan, John A, Salisbury, John J, Stanchina, Corey L, Vanderplas, Brian C, Webster, Mark E, Weekly, R. Matt

Volltext

Multikilogram Synthesis of a Hepatoselective Glucokinase Activator von Dunetz, Joshua R, Berliner, Martin A, Xiang, Yanqiao, Houck, Timothy L, Salingue, Fabrice H, Chao, Wang, Yuandong, Chen, Shenghua, Wang, Huang, Yun, Farrand, Douglas, Boucher, Steven J, Damon, David B, Makowski, Teresa W, Barrila, Mark T, Chen, Raymond, Martínez, Isamir

Volltext

Synthesis of 1,2,3,4-Tetrahydroisoquinolines Containing Electron-Withdrawing Groups von Quallich, George J, Makowski, Teresa W, Sanders, Andrew F, Urban, Frank J, Vazquez, Enrique

Volltext

Enantioselective Synthesis of Nicotinic Receptor Probe 7,8-Difluoro-1,2,3,4,5,6- hexahydro-1,5-methano-3-benzazocine von Bashore, Crystal G, Vetelino, Michael G, Wirtz, Michael C, Brooks, Paige R, Frost, Heather N, McDermott, Ruth E, Whritenour, David C, Ragan, John A, Rutherford, Jennifer L, Makowski, Teresa W, Brenek, Steven J, Coe, Jotham W

Volltext

Synthesis and Purification of 6-Ethoxy-4-oxo-1,4-dihydro-[1,5]naphthyridine-3-carboxylic Acid Benzylamide von Beaudin, Justin, Bourassa, Dennis E, Bowles, Paul, Castaldi, Michael J, Clay, Ronald, Couturier, Michel A, Karrick, Gregory, Makowski, Teresa W, McDermott, Ruth E, Meltz, Clifford N, Meltz, Morgan, Phillips, James E, Ragan, John A, Ripin, David H. Brown, Singer, Robert A, Tucker, John L, Wei, Lulin

Volltext

Investigation of Methods for Seven-Membered Ring Synthesis:  A Practical Synthesis of 4-Oxo-5,6,7,8-tetrahydro-4H-cyclohepta[b]furan-3-carboxylic Acid von Ragan, John A, Murry, Jerry A, Castaldi, Michael J, Conrad, Alyson K, Jones, Brian P, Li, Bryan, Makowski, Teresa W, McDermott, Ruth, Sitter, Barb J, White, Timothy D, Young, Gregory R

Volltext

A Practical Synthesis of Cycloheptane-1,3-dione von Ragan, John A, Makowski, Teresa W, am Ende, David J, Clifford, Pamela J, Young, Gregory R, Conrad, Alyson K, Eisenbeis, Shane A

Volltext

Optimizing Selective Partial Hydrogenations of 4-Nitroacetophenone via Parallel Reaction Screening von Hawkins, Joel M., Makowski, Teresa W.

Volltext

2,5-Dimethylpyrrole Protection Facilitates Copper(I)-Mediated Methoxylations of Aryl Iodides in the Presence of Anilines von Ragan, John A., Makowski, Teresa W., Castaldi, Michael J., Hill, Paul D.

Volltext

ULLMAN METHOXYLATION IN THE PRESENCE OF A 2,5-DIMETHYLPYRROLE-BLOCKED ANILINE: PREPARATION OF 2-FLUORO-4-METHOXYANILINE

Volltext

Synthetic, Structural, and Mechanistic Issues in the Development of a Subtype Selective GABA Partial Agonist Hypnotic Agent von Ragan, John A., Murry, Jerry A., Castaldi, Michael J., Conrad, Alyson K., Hill, Paul D., Jones, Brian P., Kasthurikrishnan, Narasimhan, Li, Bryan, Makowski, Teresa W., McDermott, Ruth, ., et al

Volltext

ChemInform Abstract: A Practical Synthesis of Cycloheptane-1,3-dione von Ragan, John A., Makowski, Teresa W., am Ende, David J., Clifford, Pamela J., Young, Gregory R., Conrad, Alyson K., Eisenbeis, Shane A.

Volltext

METHOD OF SYNTHESIS OF PYRROLE AMIDES von MAKOWSKI, TERESA W, CLIFFORD, PAMELA J, MELDRUM ALLEN, DOUGLAS JOHN, RAGAN, JOHN A, EISENBEIS, SHANE A, QUALLICH, GEORGE J, CONRAD, ALYSON K, YOUNG, GREGORY R, AM ENDE, DAVID J

Volltext bestellen

An mRNA Vaccine against SARS-CoV-2 — Preliminary Report von Jackson, Lisa A, Anderson, Evan J, Rouphael, Nadine G, Roberts, Paul C, Makhene, Mamodikoe, Coler, Rhea N, McCullough, Michele P, Chappell, James D, Denison, Mark R, Stevens, Laura J, Pruijssers, Andrea J, McDermott, Adrian, Flach, Britta, Doria-Rose, Nicole A, Corbett, Kizzmekia S, Morabito, Kaitlyn M, O’Dell, Sijy, Schmidt, Stephen D, Swanson, Phillip A, Padilla, Marcelino, Mascola, John R, Neuzil, Kathleen M, Bennett, Hamilton, Sun, Wellington, Peters, Etza, Makowski, Mat, Albert, Jim, Cross, Kaitlyn, Buchanan, Wendy, Pikaart-Tautges, Rhonda, Ledgerwood, Julie E, Graham, Barney S, Beigel, John H

Volltext

Process Development and Scale Up of a Selective JAK3 Covalent Inhibitor PF-06651600 von Tao, Yong, McWilliams, J. Christopher, Wiglesworth, Kristin E, Girard, Kevin P, Makowski, Teresa M, Sach, Neal W, Mustakis, Jason G, Mehta, Ruchi, Trujillo, John I, Chen, Xiaofeng, Li, Tangqing, Shi, Feng, Xie, Chengfu, Zhang, Qing

Volltext

Synthesis of Enantiopure Fluoropiperidines via Biocatalytic Desymmetrization and Flow Photochemical Decarboxylative Fluorination von Blakemore, Caroline A., Humphrey, John M., Yang, Eddie, Kohrt, Jeffrey T., Morse, Peter Daniel, Howard, Roger M., Yayla, Hatice G., Knauber, Thomas, Xie, Longfei, Makowski, Teresa, Raggon, Jeffrey W., Watson, Rebecca B., am Ende, Christopher W., Ryder, Tim, White, Ormacinda, Koos, Martin R. M., Kumar, Rajesh, Shi, Feng, Li, Jie, Wang, Huan, Chen, Like, Wang, Julai

Volltext

Developing an Asymmetric Transfer Hydrogenation Process for (S)‑5-Fluoro-3-methylisobenzofuran-1(3H)‑one, a Key Intermediate to Lorlatinib von Duan, Shengquan, Li, Bryan, Dugger, Robert W, Conway, Brian, Kumar, Rajesh, Martinez, Carlos, Makowski, Teresa, Pearson, Robert, Olivier, Mark, Colon-Cruz, Roberto

Volltext

Correction: Publisher correction: Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148 von Fang, Jun, Jia, Jinping, Makowski, Matthew, Xu, Mai, Wang, Zhaoming, Zhang, Tongwu, Hoskins, Jason W., Choi, Jiyeon, Han, Younghun, Zhang, Mingfeng, Thomas, Janelle, Kovacs, Michael, Collins, Irene, Dzyadyk, Marta, Thompson, Abbey, O'Neill, Maura, Das, Sudipto, Lan, Qi, Koster, Roelof, Stolzenberg-Solomon, Rachael S., Kraft, Peter, Wolpin, Brian M., Jansen, Pascal W. T. C., Olson, Sara, McGlynn, Katherine A., Kanetsky, Peter A., Chatterjee, Nilanjan, Barrett, Jennifer H., Dunning, Alison M., Taylor, John C., Newton-Bishop, Julia A., Timothy Bishop, D, Andresson, Thorkell, Petersen, Gloria M., Amos, Christopher I., Iles, Mark M., Nathanson, Katherine L., Teresa Landi, Maria, Vermeulen, Michiel, Brown, Kevin M., Amundadottir, Laufey T.

Volltext

Process Development of a Second Generation β‑Amyloid-Cleaving Enzyme InhibitorImproving the Robustness of a Halogen-Metal Exchange Using Continuous Stirred-Tank Reactors von Li, Bryan, Barnhart, Richard W, Dion, Amelie, Guinness, Steven, Happe, Alan, Hayward, Cheryl M, Kohrt, Jeffrey, Makowski, Teresa, Maloney, Mark, Nelson, Jade D, Nematalla, Asaad, McWilliams, J. Christopher, Peng, Zhihui, Raggon, Jeffrey, Sagal, John, Weisenburger, Gerald A, Bao, Denghui, Gonzalez, Miguel, Lu, Jiangping, McLaws, Mark D, Tao, Jian, Wu, Baolin

Volltext

Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148 von Fang, Jun, Jia, Jinping, Makowski, Matthew, Xu, Mai, Wang, Zhaoming, Zhang, Tongwu, Hoskins, Jason W., Choi, Jiyeon, Han, Younghun, Zhang, Mingfeng, Thomas, Janelle, Kovacs, Michael, Collins, Irene, Dzyadyk, Marta, Thompson, Abbey, O'Neill, Maura, Das, Sudipto, Lan, Qi, Koster, Roelof, Stolzenberg-Solomon, Rachael S., Kraft, Peter, Wolpin, Brian M., Jansen, Pascal W. T. C., Olson, Sara, McGlynn, Katherine A., Kanetsky, Peter A., Chatterjee, Nilanjan, Barrett, Jennifer H., Dunning, Alison M., Taylor, John C., Newton-Bishop, Julia A., Bishop, D. Timothy, Andresson, Thorkell, Petersen, Gloria M., Amos, Christopher I., Iles, Mark M., Nathanson, Katherine L., Landi, Maria Teresa, Vermeulen, Michiel, Brown, Kevin M., Amundadottir, Laufey T.

Volltext