Design, Synthesis, and Evaluation of Piperazinyl Pyrrolidin-2-ones as a Novel Series of Reversible Monoacylglycerol Lipase Inhibitors von Aida, Jumpei, Fushimi, Makoto, Kusumoto, Tomokazu, Sugiyama, Hideyuki, Arimura, Naoto, Ikeda, Shuhei, Sasaki, Masako, Sogabe, Satoshi, Aoyama, Kazunobu, Koike, Tatsuki

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Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization von Balbach, Melanie, Ghanem, Lubna, Rossetti, Thomas, Kaur, Navpreet, Ritagliati, Carla, Ferreira, Jacob, Krapf, Dario, Puga Molina, Lis C, Santi, Celia Maria, Hansen, Jan Niklas, Wachten, Dagmar, Fushimi, Makoto, Meinke, Peter T, Buck, Jochen, Levin, Lonny R

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Discovery of a Novel and Brain-Penetrant O‑GlcNAcase Inhibitor via Virtual Screening, Structure-Based Analysis, and Rational Lead Optimization von Tawada, Michiko, Fushimi, Makoto, Masuda, Kei, Sun, Huikai, Uchiyama, Noriko, Kosugi, Yohei, Lane, Weston, Tjhen, Richard, Endo, Satoshi, Koike, Tatsuki

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Asymmetric intramolecular Cannizzaro reaction of anhydrous phenylglyoxal von Ishihara, Kazuaki, Yano, Takayuki, Fushimi, Makoto

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Prediction of Compound Bioactivities Using Heat-Diffusion Equation von Hidaka, Tadashi, Imamura, Keiko, Hioki, Takeshi, Takagi, Terufumi, Giga, Yoshikazu, Giga, Mi-Ho, Nishimura, Yoshiteru, Kawahara, Yoshinobu, Hayashi, Satoru, Niki, Takeshi, Fushimi, Makoto, Inoue, Haruhisa

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Catalytic Enantioselective [2 + 4] and [2 + 2] Cycloaddition Reactions with Propiolamides von Ishihara, Kazuaki, Fushimi, Makoto

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T‐495, a novel low cooperative M1 receptor positive allosteric modulator, improves memory deficits associated with cholinergic dysfunction and is characterized by low gastrointesti... von Mandai, Takao, Sako, Yuu, Kurimoto, Emi, Shimizu, Yuji, Nakamura, Minoru, Fushimi, Makoto, Maeda, Ryouta, Miyamoto, Maki, Kimura, Haruhide

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Synthesis of Hydroxylated Bicyclic Amino Acids from l-Tyrosine: Octahydro-1H-indole Carboxylates von Pierce, Joshua G, Kasi, Dhanalakshmi, Fushimi, Makoto, Cuzzupe, Anthony, Wipf, Peter

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Catalytic Enantioselective 1,3-Dipolar Cycloadditions of Nitrones with Propioloylpyrazoles and Acryloylpyrazoles Induced by Chiral π-Cation Catalysts von Sakakura, Akira, Hori, Masahiro, Fushimi, Makoto, Ishihara, Kazuaki

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Rational Design of Minimal Artificial Diels–Alderases Based on the Copper(II) Cation–Aromatic π Attractive Interaction von Ishihara, Kazuaki, Fushimi, Makoto, Akakura, Matsujiro

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Design of Brønsted Acid-Assisted Chiral Brønsted Acid Catalyst Bearing a Bis(triflyl)methyl Group for a Mannich-Type Reaction von Hasegawa, Aiko, Naganawa, Yuki, Fushimi, Makoto, Ishihara, Kazuaki, Yamamoto, Hisashi

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Optimization of lead compounds into on-demand, nonhormonal contraceptives: leveraging a public–private drug discovery institute collaboration von Balbach, Melanie, Fushimi, Makoto, Huggins, David J, Steegborn, Clemens, Meinke, Peter T, Levin, Lonny R, Buck, Jochen

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Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates von Miller, Michael, Rossetti, Thomas, Ferreira, Jacob, Ghanem, Lubna, Balbach, Melanie, Kaur, Navpreet, Levin, Lonny R., Buck, Jochen, Kehr, Maria, Coquille, Sandrine, van den Heuvel, Joop, Steegborn, Clemens, Fushimi, Makoto, Finkin-Groner, Efrat, Myers, Robert W., Kargman, Stacia, Liverton, Nigel J., Huggins, David J., Meinke, Peter T.

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Design of a Small-Molecule Catalyst Using Intramolecular Cation−π Interactions for Enantioselective Diels−Alder and Mukaiyama−Michael Reactions:  l-DOPA-Derived Monopeptide·Cu(II)... von Ishihara, Kazuaki, Fushimi, Makoto

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Regiodivergent Nucleophilic Fluorination under Hydrogen Bonding Catalysis: A Computational and Experimental Study von Horwitz, Matthew A., Dürr, Alexander B., Afratis, Konstantinos, Chen, Zijun, Soika, Julia, Christensen, Kirsten E., Fushimi, Makoto, Paton, Robert S., Gouverneur, Véronique

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Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation von Sun, Shan, Fushimi, Makoto, Rossetti, Thomas, Kaur, Navpreet, Ferreira, Jacob, Miller, Michael, Quast, Jonathan, van den Heuvel, Joop, Steegborn, Clemens, Levin, Lonny R., Buck, Jochen, Myers, Robert W., Kargman, Stacia, Liverton, Nigel, Meinke, Peter T., Huggins, David J.

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Addition to “Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation” von Sun, Shan, Fushimi, Makoto, Rossetti, Thomas, Kaur, Navpreet, Ferreira, Jacob, Miller, Michael, Quast, Jonathan, van den Heuvel, Joop, Steegborn, Clemens, Levin, Lonny R., Buck, Jochen, Myers, Robert W., Kargman, Stacia, Liverton, Nigel, Meinke, Peter T., Huggins, David J.

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Discovery of Potent, Selective, and Brain-Penetrant 1H‑Pyrazol-5-yl‑1H‑pyrrolo[2,3‑b]pyridines as Anaplastic Lymphoma Kinase (ALK) Inhibitors von Fushimi, Makoto, Fujimori, Ikuo, Wakabayashi, Takeshi, Hasui, Tomoaki, Kawakita, Youichi, Imamura, Keisuke, Kato, Tomoko, Murakami, Morio, Ishii, Tsuyoshi, Kikko, Yorifumi, Kasahara, Maki, Nakatani, Atsushi, Hiura, Yuto, Miyamoto, Maki, Saikatendu, Kumar, Zou, Hua, Lane, Scott Weston, Lawson, J. David, Imoto, Hiroshi

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Discovery of 1‑[2-Fluoro-4-(1H‑pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl‑1H‑pyrazol-5-yl)pyridazin-4(1H)‑one (TAK-063), a Highly Potent, Selective, and Orally Active Phosphodieste... von Kunitomo, Jun, Yoshikawa, Masato, Fushimi, Makoto, Kawada, Akira, Quinn, John F, Oki, Hideyuki, Kokubo, Hironori, Kondo, Mitsuyo, Nakashima, Kosuke, Kamiguchi, Naomi, Suzuki, Kazunori, Kimura, Haruhide, Taniguchi, Takahiko

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Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10) von Fushimi, Makoto, Buck, Hannes, Balbach, Melanie, Gorovyy, Anna, Ferreira, Jacob, Rossetti, Thomas, Kaur, Navpreet, Levin, Lonny R, Buck, Jochen, Quast, Jonathan, van den Heuvel, Joop, Steegborn, Clemens, Finkin-Groner, Efrat, Kargman, Stacia, Michino, Mayako, Foley, Michael A, Miller, Michael, Liverton, Nigel J, Huggins, David J, Meinke, Peter T

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