P706: ASCIMINIB USE IN CML: THE UK EXPERIENCE von Innes, A., Orovboni, V., Claudiani, S., Fernando, F., Khan, A., Byrne, J., Gallipoli, P., Copland, M., Horne, G., Arnold, C., Collins, A., Cunningham, N., Danga, A., Frewin, R., Garland, P., Hannah, G., Hassan, S., Makkuni, S., Rothwell, K., Foroni, L., Hayden, C., Apperley, J., Milojkovic, D.

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Impact of BCR::ABL1 single nucleotide variants on 1 asciminib efficacy von Innes, A, Hayden, C, Orovboni, V, Claudiani, S, Fernando, F, Khan, A, Rees, D, Byrne, J, Gallipoli, P, Francis, S, Copland, M, Horne, G, Raghavan, M, Arnold, C, Collins, A, Cranfield, T, Cunningham, N, Danga, A, Forsyth, P, Frewin, R, Garland, P, Hannah, G, Avenoso, D, Hassan, S, Huntly, B, Husain, J, Makkuni, S, Rothwell, K, Khorashad, J, Apperley, J, Milojkovic, D

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Efficacy and safety of baricitinib or ravulizumab in adult patients with severe COVID-19 (TACTIC-R): a randomised, parallel-arm, open-label, phase 4 trial von Hall, Frances C, Cheriyan, Joseph, Galloway, James, Bond, Simon, Norton, Sam, Kostapanos, Michalis, Nodale, Marianna, Jayne, David R, Galloway, James, Wilkinson, Ian, Banham-Hall, Edward, Bayes, Hannah, Kostapanos, Michalis, Nodale, Marianna, Petchey, William, Nagra, Deepak, Bird, Georgina, Nye, Clemency, Britten, Vianne, Broad, Lauren, Frayling, Sharon, Gray, Laura, Haynes, Matthew, Oliver, Catherine, Ahmed, Tanwir, Byrne, Natalie, Hernan-Sancho, Elena, Stockley, Louise, Templin, Heike, Fisk, Marie, Gray, Joanna, Gudu, Tania, Kulkarni, Spoorthy, Masters, Peta, Mir, Fraz, Stober, Carmel, Abercrombie, Donna, Bermperi, Areti, Burns, Stella, Canna, Laura, Hodges, Kathy, Jose, Sherly, Kourampa, Evgenia, Meadows, Anne, Nacorda, Aileen, Pasquale, Ciro, Read, Debbie, Rowlands, Jane, Ruffulo, Valentina, Soave, Carlotta, Tordesillas, Hugo, Wright, Samantha, Scott, Kathryn, Cathcart, Susanne, Rimmer, Dominic, Semple, Gary, Sheeran, Tom, Phiri, Laurence, Bhagat, Shweta, Kellett, Jo, Bukhari, Marwan, Simpson, Kerry, Makkuni, Damodar, Patrick, Jean, Kavanagh, David, Barr, Andrew, Baldwin, Kelly, McAlinden, Paul, McCormack, Louise, Stephenson, Elaine, Cross, Elizabeth L A, Musiol, Monika, Cope, Andrew, Koduri, Gouri, Mercioniu, Mihaela, Kunhunny, Swapna, Pollard, Louise, Coakley, Gerald, Gupta, Sunil, Pilgrim, Samia, Treus, Estefania, Boehmer, Gabriele, Beranova, Eva, Knight, Alicia, Tilbey, Sorrell, Willis, Joanna, Putensen, Daniel, Dimitriadis, Georgios K, Gogoi, Sukanya, Griffiths, Nicola, Rajasekaran, Arvind, Nisar, Muhammad, Ustianowski, Andrew, Lindergard, Gabriella, Uriel, Alison, Hey, Samuel, Bruce, Michelle, Flaherty, Jan, Fox, Claire, Parfrey, Helen

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PF691 SPLENECTOMY IN IMMUNE THROMBOCYTOPENIA: DO CHANGING TREATMENT PATTERNS FOR ITP AFFECT OUTCOMES? DATA FROM THE UK ITP REGISTRY von Todd, S., Infirri, S. Sardo, Miah, H., Miah, A., Zaidi, A., Taylor, L., Chen, F., Allsup, D., Biss, T., Bagot, C., Scully, M., Garcia, S., Cooper, N., Hill, Q., Mahalakshmi, M., Hall, C., Garg, M., Chattree, S., Wilson, J., Chapman, O., Vadher, B., Greig, S., Johns, S., Jackson, H., Austin, S., Chacko, J., Mushkbar, M., Martlew, V., Munro, L., Seale, J., Rinaldi, C., Matthias, G., Rayment, R., Jack, F., Sargant, N., Bradbury, C., Sivakumaram, M., Crowe, J., Dang, R., Evans, G., Robinson, S., Makkuni, S., Cooke, L., Kilner, M., Murphy, M., Lester, W., Alobaidi, M., Jaggia, A., Coppell, J., Almusawy, M., Lyall, H., Robinson, L., Davies, S., Ahmad, H., Karanth, M., Newland, A., Provan, D., McDonald, V.

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Mathematical validation of a biological model for unlinking replication catenanes by recombination von Jayaram, Makkuni

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E019 A case of RS3PE triggered by immune check point inhibitor von Ramachandran, Deepak, Mushtaq, Warda, Makkuni, Damodar

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E028 Seronegative arthritis in the context of CHIP: is this a new entity that needs further investigation? von Mohamed, Sarah, McKerrell, Thomas, Makkuni, Damodaran

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300. PONCET'S ARTHRITIS: A FORGOTTEN ENTITY von Nair, Saptha, Makkuni, Damodar

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E005 The impact of hypogammaglobulinaemia with rituximab treatment von Ghosh, Suchi A, Makkuni, Damodar

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Disintegration promotes protospacer integration by the Cas1-Cas2 complex von Ma, Chien-Hui, Javanmardi, Kamyab, Finkelstein, Ilya J., Jayaram, Makkuni

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E031 A rare case of diffuse osteosclerosis von Mohamed, Sarah, Phillips, Abimbola, Thomas, Joegi, Makkuni, Damodaran

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E007 Is there an urgent need to change the methotrexate monitoring guidelines to incorporate fibroscan? von Ramalingam, Satheekshan, Sayed, Mostafa, Alam, Syed, Makkuni, Damodar

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P46 Takotsubo cardiomyopathy in a GPA patient receiving rituximab therapy von Jayanti, Santhosh P, Nair, Sulfi, Makkuni, Damodar

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P042 Spontaneous gallbladder perforation: a rare complication of eosinophilic granulomatosis with polyangiitis von Ochogwu, Joanna, Madathil, Afsar, Mazin, Hamed, Makkuni, Damodar

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A bipartite thermodynamic-kinetic contribution by an activating mutation to RDF-independent excision by a phage serine integrase von Fan, Hsiu-Fang, Su, Bo-Yu, Ma, Chien-Hui, Rowley, Paul A, Jayaram, Makkuni

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105 Predicting cirrhosis in methotrexate-treated patients: is elastography the answer? von Manning, Charelle, Williams, Matthew, Makkuni, Damodar

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The selfish yeast plasmid exploits a SWI/SNF-type chromatin remodeling complex for hitchhiking on chromosomes and ensuring high-fidelity propagation von Ma, Chien-Hui, Kumar, Deepanshu, Jayaram, Makkuni, Ghosh, Santanu K, Iyer, Vishwanath R

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A case of skin rash associated with spontaneous pneumomediastinum von Ghaffar, Muhammad Tauseef, Warda, Mushtaq, Afsar, Madathil, Damodar, Makkuni

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Acute Arterial Occlusion Following ChAdOx1 nCov-19 (Oxford–AstraZeneca) Vaccination von Ali, Azhar, Rabouhans, Jeremy, Salar, Tooba, Moghul, Sakib, Makkuni, Sudhakaran, Browne, Tom, Ahmed, Rumman, Syed, Imran, Zaman, Ali

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Spectrum of interstitial lung disease in rheumatic diseases von Koduri, Gouri, Makkuni, Damodar, Jubber, Ameen, Moorthy, Arumugam

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