Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression von Ripke, Stephan, Trzaskowski, Maciej, Byrne, Enda M., Adams, Mark J., Andlauer, Till M. F., Bacanu, Silviu-Alin, Beekman, Aartjan F. T., Bigdeli, Tim B., Binder, Elisabeth B., Blackwood, Douglas R. H., Bybjerg-Grauholm, Jonas, Castelao, Enrique, Couvy-Duchesne, Baptiste, Craddock, Nick, Deary, Ian J., Finucane, Hilary K., Forstner, Andreas J., Frank, Josef, Gill, Michael, Goes, Fernando S., Grove, Jakob, Hall, Lynsey S., Hannon, Eilis, Hansen, Thomas F., Hickie, Ian B., Hoffmann, Per, Horn, Carsten, Hougaard, David M., Hyde, Craig L., Jorgenson, Eric, Knowles, James A., Kraft, Julia, Krogh, Jesper, Kutalik, Zoltán, Lane, Jacqueline M., Li, Yihan, Li, Yun, Liu, Xiaoxiao, Lu, Leina, MacIntyre, Donald J., MacKinnon, Dean F., Maier, Robert M., Marchini, Jonathan, Mbarek, Hamdi, McGrath, Patrick, Mehta, Divya, Montgomery, Grant W., Nauck, Matthias, Nivard, Michel G., Pedersen, Carsten Bøcker, Posthuma, Danielle, Purcell, Shaun M., Quiroz, Jorge A., Saeed Mirza, Saira, Schoevers, Robert, Schulte, Eva C., Shi, Jianxin, Shyn, Stanley I., Smit, Johannes H., Smith, Daniel J., Stockmeier, Craig A., Teumer, Alexander, Thompson, Wesley, Thomson, Pippa A., Thorgeirsson, Thorgeir E., Tian, Chao, Treutlein, Jens, van Hemert, Albert M., Viktorin, Alexander, Visscher, Peter M., Wang, Yunpeng, Weinsheimer, Shantel Marie, Wellmann, Jürgen, Witt, Stephanie H., Wu, Yang, Xi, Hualin S., Yang, Jian, Zhang, Futao, Baune, Bernhard T., Berger, Klaus, de Geus, E. C. J., Domschke, Katharina, Esko, Tõnu, Hinds, David A., Li, Qingqin S., McIntosh, Andrew M., Metspalu, Andres, Mors, Ole, Müller-Myhsok, Bertram, O’Donovan, Michael C., Paciga, Sara A., Pedersen, Nancy L., Perlis, Roy H., Potash, James B., Schaefer, Catherine, Schulze, Thomas G., Uher, Rudolf, Völzke, Henry, Winslow, Ashley R., Børglum, Anders D.

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Multi-site benchmark classification of major depressive disorder using machine learning on cortical and subcortical measures von Belov, Vladimir, Erwin-Grabner, Tracy, Aghajani, Moji, Aleman, Andre, Amod, Alyssa R., Basgoze, Zeynep, Benedetti, Francesco, Besteher, Bianca, Bülow, Robin, Ching, Christopher R. K., Connolly, Colm G., Cullen, Kathryn, Davey, Christopher G., Dima, Danai, Dols, Annemiek, Evans, Jennifer W., Fu, Cynthia H. Y., Gonul, Ali Saffet, Gotlib, Ian H., Grabe, Hans J., Groenewold, Nynke, Hamilton, J Paul, Harrison, Ben J., Ho, Tiffany C., Mwangi, Benson, Jaworska, Natalia, Jahanshad, Neda, Klimes-Dougan, Bonnie, Koopowitz, Sheri-Michelle, Lancaster, Thomas, Li, Meng, Linden, David E. J., MacMaster, Frank P., Mehler, David M. A., Melloni, Elisa, Mueller, Bryon A., Ojha, Amar, Oudega, Mardien L., Penninx, Brenda W. J. H., Poletti, Sara, Pomarol-Clotet, Edith, Portella, Maria J., Pozzi, Elena, Reneman, Liesbeth, Sacchet, Matthew D., Sämann, Philipp G., Schrantee, Anouk, Sim, Kang, Soares, Jair C., Stein, Dan J., Thomopoulos, Sophia I., Uyar-Demir, Aslihan, van der Wee, Nic J. A., van der Werff, Steven J. A., Völzke, Henry, Whittle, Sarah, Wittfeld, Katharina, Wright, Margaret J., Wu, Mon-Ju, Yang, Tony T., Zarate, Carlos, Veltman, Dick J., Schmaal, Lianne, Thompson, Paul M., Goya-Maldonado, Roberto

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Assessment of Bidirectional Relationships Between Physical Activity and Depression Among Adults: A 2-Sample Mendelian Randomization Study von Choi, Karmel W, Chen, Chia-Yen, Stein, Murray B, Klimentidis, Yann C, Wang, Min-Jung, Koenen, Karestan C, Smoller, Jordan W

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Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions von Howard, David M., Adams, Mark J., Clarke, Toni-Kim, Hafferty, Jonathan D., Gibson, Jude, Shirali, Masoud, Coleman, Jonathan R. I., Hagenaars, Saskia P., Ward, Joey, Wigmore, Eleanor M., Alloza, Clara, Shen, Xueyi, Barbu, Miruna C., Xu, Eileen Y., Whalley, Heather C., Marioni, Riccardo E., Porteous, David J., Davies, Gail, Deary, Ian J., Hemani, Gibran, Berger, Klaus, Teismann, Henning, Rawal, Rajesh, Arolt, Volker, Baune, Bernhard T., Dannlowski, Udo, Domschke, Katharina, Tian, Chao, Hinds, David A., Trzaskowski, Maciej, Byrne, Enda M., Ripke, Stephan, Smith, Daniel J., Sullivan, Patrick F., Wray, Naomi R., Breen, Gerome, Lewis, Cathryn M., McIntosh, Andrew M.

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Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group von Schmaal, L, Veltman, D J, van Erp, T G M, Sämann, P G, Frodl, T, Jahanshad, N, Loehrer, E, Tiemeier, H, Hofman, A, Niessen, W J, Vernooij, M W, Ikram, M A, Wittfeld, K, Grabe, H J, Block, A, Hegenscheid, K, Völzke, H, Hoehn, D, Czisch, M, Lagopoulos, J, Hatton, S N, Hickie, I B, Goya-Maldonado, R, Krämer, B, Gruber, O, Couvy-Duchesne, B, Rentería, M E, Strike, L T, Mills, N T, de Zubicaray, G I, McMahon, K L, Medland, S E, Martin, N G, Gillespie, N A, Wright, M J, Hall, G B, MacQueen, G M, Frey, E M, Carballedo, A, van Velzen, L S, van Tol, M J, van der Wee, N J, Veer, I M, Walter, H, Schnell, K, Schramm, E, Normann, C, Schoepf, D, Konrad, C, Zurowski, B, Nickson, T, McIntosh, A M, Papmeyer, M, Whalley, H C, Sussmann, J E, Godlewska, B R, Cowen, P J, Fischer, F H, Rose, M, Penninx, B W J H, Thompson, P M, Hibar, D P

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The association between lower educational attainment and depression owing to shared genetic effects? Results in ~25 000 subjects von Peyrot, W J, Lee, S H, Milaneschi, Y, Abdellaoui, A, Byrne, E M, Esko, T, de Geus, E J C, Hemani, G, Hottenga, J J, Kloiber, S, Levinson, D F, Lucae, S, Martin, N G, Medland, S E, Metspalu, A, Milani, L, Noethen, M M, Potash, J B, Rietschel, M, Rietveld, C A, Ripke, S, Shi, J, Willemsen, G, Zhu, Z, Boomsma, D I, Wray, N R, Penninx, B W J H

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Metabolic activity of CYP2C19 and CYP2D6 on antidepressant response from 13 clinical studies using genotype imputation: a meta-analysis von Li, Danyang, Pain, Oliver, Fabbri, Chiara, Wong, Win Lee Edwin, Lo, Chris Wai Hang, Ripke, Stephan, Cattaneo, Annamaria, Souery, Daniel, Dernovsek, Mojca Z., Henigsberg, Neven, Hauser, Joanna, Lewis, Glyn, Mors, Ole, Perroud, Nader, Rietschel, Marcella, Uher, Rudolf, Maier, Wolfgang, Baune, Bernhard T., Biernacka, Joanna M., Bondolfi, Guido, Domschke, Katharina, Kato, Masaki, Liu, Yu-Li, Serretti, Alessandro, Tsai, Shih-Jen, Weinshilboum, Richard, McIntosh, Andrew M., Lewis, Cathryn M.

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A direct test of the diathesis–stress model for depression von Colodro-Conde, L, Couvy-Duchesne, B, Zhu, G, Coventry, W L, Byrne, E M, Gordon, S, Wright, M J, Montgomery, G W, Madden, P A F, Ripke, S, Eaves, L J, Heath, A C, Wray, N R, Medland, S E, Martin, N G

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Genetic Associations Between Childhood Psychopathology and Adult Depression and Associated Traits in 42 998 Individuals: A Meta-analysis von Akingbuwa, Wonuola A, Hammerschlag, Anke R, Jami, Eshim S, Allegrini, Andrea G, Karhunen, Ville, Sallis, Hannah, Ask, Helga, Askeland, Ragna B, Baselmans, Bart, Diemer, Elizabeth, Hagenbeek, Fiona A, Havdahl, Alexandra, Hottenga, Jouke-Jan, Mbarek, Hamdi, Rivadeneira, Fernando, Tesli, Martin, van Beijsterveldt, Catharina, Breen, Gerome, Lewis, Cathryn M, Thapar, Anita, Boomsma, Dorret I, Kuja-Halkola, Ralf, Reichborn-Kjennerud, Ted, Magnus, Per, Rimfeld, Kaili, Ystrom, EIVIND, Jarvelin, Marjo-Riitta, Lichtenstein, Paul, Lundstrom, Sebastian, Munafò, Marcus R, Plomin, Robert, Tiemeier, Henning, Nivard, Michel G, Bartels, Meike, Middeldorp, Christel M

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Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders von Writing Committee for the Attention-Deficit/Hyperactivity Disorder, Autism Spectrum Disorder, Bipolar Disorder, Major Depressive Disorder, Obsessive-Compulsive Disorder, and Schizophrenia ENIGMA Working Groups

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Reproducibility of functional brain alterations in major depressive disorder: Evidence from a multisite resting-state functional MRI study with 1,434 individuals von Xia, Mingrui, Si, Tianmei, Sun, Xiaoyi, Ma, Qing, Liu, Bangshan, Wang, Li, Meng, Jie, Chang, Miao, Huang, Xiaoqi, Chen, Ziqi, Tang, Yanqing, Xu, Ke, Gong, Qiyong, Wang, Fei, Qiu, Jiang, Xie, Peng, Li, Lingjiang, He, Yong

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Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders von Vieta i Pascual, Eduard, 1963, Writing Committee for the Attention-Deficit/Hyperactivity Disorder, Autism Spectrum Disorder, Bipolar Disorder, Major Depressive Disorder, Obsessive-Compulsive Disorder, and Schizophrenia ENIGMA Working Groups

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META-ANALYSIS OF RARE CNV GENOME-WIDE ASSOCIATION STUDIES ACROSS MAJOR PSYCHIATRIC DISORDERS IN EUR, AFR/AFAM, AND ASN/ASAM POPULATIONS von Shanta, Omar, Engchuan, Worrawat, MacDonald, Jeff, Klein, Marieke, Thiruvahindrapuram, Bhooma, Maihofer, Adam, Sacks, Molly, Ahangari, Mohammad, Jacquemont, Sebastien, Kendall, Kimberley, Sonderby, Ida, Huguet, Guillaume, Scherer, Steven H., Sebat, Jonathan

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COLLABORATIVE STUDY OF THE COMBINED EFFECTS OF RARE CNVS AND POLYGENIC RISK ON PSYCHIATRIC TRAITS von Sacks, Molly, Klein, Marieke, Shanta, Omar, Ahangari, Mohammad, Hong, Oanh, MacDonald, Jeff, Thiruvahindrapuram, Bhooma, Jacquemont, Sebastien, Bigdeli, Tim, Oetjens, Matthew, Kals, Mart, Scherer, Stephen H., Sebat, Jonathan

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FUNCTIONAL-BASED ASSOCIATION STUDY OF RARE CNVS ACROSS SIX PSYCHIATRIC DISORDERS IN EUROPEAN, AFRICAN, AND EAST ASIAN POPULATIONS von Engchuan, Worrawat, Shanta, Omar, Macdonald, Jeffrey R, Thiruvahindrapuram, Bhooma, Kumar, Kuldeep, Huguet, Guillaume, Wang, Zhuozhi, Pellecchia, Giovanna, Yuen, Ryan K.C., Merico, Daniele, Jacquemont, Sebastien, Scherer, Stephen W, Sebat, Jonathan

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Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis von Grotzinger, Andrew D., Mallard, Travis T., Akingbuwa, Wonuola A., Ip, Hill F., Adams, Mark J., Lewis, Cathryn M., McIntosh, Andrew M., Grove, Jakob, Dalsgaard, Søren, Lesch, Klaus-Peter, Strom, Nora, Meier, Sandra M., Mattheisen, Manuel, Børglum, Anders D., Mors, Ole, Breen, Gerome, Lee, Phil H., Kendler, Kenneth S., Smoller, Jordan W., Tucker-Drob, Elliot M., Nivard, Michel G.

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Genetic Association of Major Depression With Atypical Features and Obesity-Related Immunometabolic Dysregulations von Milaneschi, Yuri, Lamers, Femke, Peyrot, Wouter J, Baune, Bernhard T, Breen, Gerome, Dehghan, Abbas, Forstner, Andreas J, Grabe, Hans J, Homuth, Georg, Kan, Carol, Lewis, Cathryn, Mullins, Niamh, Nauck, Matthias, Pistis, Giorgio, Preisig, Martin, Rivera, Margarita, Rietschel, Marcella, Streit, Fabian, Strohmaier, Jana, Teumer, Alexander, Van der Auwera, Sandra, Wray, Naomi R, Boomsma, Dorret I, Penninx, Brenda W. J. H

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DNA methylation and inflammation marker profiles associated with a history of depression von Crawford, Bethany, Craig, Zoe, Mansell, Georgina, White, Isobel, Smith, Adam, Spaull, Steve, Imm, Jennifer, Hannon, Eilis, Wood, Andrew, Yaghootkar, Hanieh, Ji, Yingjie, Mullins, Niamh, Lewis, Cathryn M, Mill, Jonathan, Murphy, Therese M

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Genetic risk of major depressive disorder: the moderating and mediating effects of neuroticism and psychological resilience on clinical and self-reported depression von Navrady, L. B., Adams, M. J., Chan, S. W. Y., Ritchie, S. J., McIntosh, A. M.

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A gene co-expression network-based analysis of multiple brain tissues reveals novel genes and molecular pathways underlying major depression von Gerring, Zachary F, Gamazon, Eric R, Derks, Eske M

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