Copper-catalyzed decarboxylative C–N coupling for N-arylation von Zhang, Yun, Patel, Sejal, Mainolfi, Nello

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Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma von Ducker, Gregory S., Ghergurovich, Jonathan M., Mainolfi, Nello, Suri, Vipin, Jeong, Stephanie K., Li, Sophia Hsin-Jung, Friedman, Adam, Manfredi, Mark G., Gitai, Zemer, Kim, Hahn, Rabinowitz, Joshua D.

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Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy von Tajan, Mylène, Hennequart, Marc, Cheung, Eric C., Zani, Fabio, Hock, Andreas K., Legrave, Nathalie, Maddocks, Oliver D. K., Ridgway, Rachel A., Athineos, Dimitris, Suárez-Bonnet, Alejandro, Ludwig, Robert L., Novellasdemunt, Laura, Angelis, Nikolaos, Li, Vivian S. W., Vlachogiannis, Georgios, Valeri, Nicola, Mainolfi, Nello, Suri, Vipin, Friedman, Adam, Manfredi, Mark, Blyth, Karen, Sansom, Owen J., Vousden, Karen H.

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Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition von Ngo, Bryan, Kim, Eugenie, Osorio-Vasquez, Victoria, Doll, Sophia, Bustraan, Sophia, Liang, Roger J, Luengo, Alba, Davidson, Shawn M, Ali, Ahmed, Ferraro, Gino B, Fischer, Grant M, Eskandari, Roozbeh, Kang, Diane S, Ni, Jing, Plasger, Ariana, Rajasekhar, Vinagolu K, Kastenhuber, Edward R, Bacha, Sarah, Sriram, Roshan K, Stein, Benjamin D, Bakhoum, Samuel F, Snuderl, Matija, Cotzia, Paolo, Healey, John H, Mainolfi, Nello, Suri, Vipin, Friedman, Adam, Manfredi, Mark, Sabatini, David M, Jones, Drew R, Yu, Min, Zhao, Jean J, Jain, Rakesh K, Keshari, Kayvan R, Davies, Michael A, Vander Heiden, Matthew G, Hernando, Eva, Mann, Matthias, Cantley, Lewis C, Pacold, Michael E

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The Intermolecular Pauson-Khand Reaction von Gibson, Susan E., Mainolfi, Nello

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Continuous Flow Coupling and Decarboxylation Reactions Promoted by Copper Tubing von Zhang, Yun, Jamison, Timothy F, Patel, Sejal, Mainolfi, Nello

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Serine Metabolism Supports Macrophage IL-1β Production von Rodriguez, Arianne E., Ducker, Gregory S., Billingham, Leah K., Martinez, Carlos A., Mainolfi, Nello, Suri, Vipin, Friedman, Adam, Manfredi, Mark G., Weinberg, Samuel E., Rabinowitz, Joshua D., Chandel, Navdeep S.

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Serine Is an Essential Metabolite for Effector T Cell Expansion von Ma, Eric H., Bantug, Glenn, Griss, Takla, Condotta, Stephanie, Johnson, Radia M., Samborska, Bozena, Mainolfi, Nello, Suri, Vipin, Guak, Hannah, Balmer, Maria L., Verway, Mark J., Raissi, Thomas C., Tsui, Harmony, Boukhaled, Giselle, Henriques da Costa, Sofia, Frezza, Christian, Krawczyk, Connie M., Friedman, Adam, Manfredi, Mark, Richer, Martin J., Hess, Christoph, Jones, Russell G.

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Targeted protein degradation mechanisms von Zhang, Yi, Loh, Christine, Chen, Jesse, Mainolfi, Nello

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54020 Potent and selective TYK2 degraders, devoid of JAK activity, potently and completely suppress IL12/23 and IFN-a signaling pathways von Slavin, Anthony, Marx, Isaac, Wang, Amy, Byrne, Fergus, Wilkinson, Alex, Harsch, Andreas, Hu, Kan-Nian, Walther, Dirk, Karnik, Rahul, Mainolfi, Nello, Weiss, Matt

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53901 Potent and selective oral STAT6 degraders inhibit IL-4 and IL-13 functions in human cells and block TH2 inflammation in a mouse model of atopic dermatitis von Wang, Amy, Yang, Bin, Ramanathan, Anand, Hossain, Alamgir, Dong, Huijun, Follows, Bruce, Browne, Chris, Harsch, Andreas, Sawant, Rupa, Slavin, Anthony, Mainolfi, Nello

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Tu1488 POTENT AND SELECTIVE ORAL STAT6 DEGRADERS INHIBIT IL-4 AND IL-13 FUNCTIONS IUN HUMAN CELLS AND BLOCK TH2 INFLAMMATION IN VIVO IN A MOUSE MODEL von Wang, Amy, Yang, Bin, Ramanathan, Anand, Hossain, Alamgir, Dong, Huijun, Follows, Bruce, Browne, Chris, Harsch, Andreas, Sawant, Rupa, Enerson, Bradley E., Slavin, Anthony, Mainolfi, Nello

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IRAK4 degrader in hidradenitis suppurativa and atopic dermatitis: a phase 1 trial von Ackerman, Lindsay, Acloque, Gerard, Bacchelli, Sandro, Schwartz, Howard, Feinstein, Brian J., La Stella, Phillip, Alavi, Afsaneh, Gollerkeri, Ashwin, Davis, Jeffrey, Campbell, Veronica, McDonald, Alice, Agarwal, Sagar, Karnik, Rahul, Shi, Kelvin, Mishkin, Aimee, Culbertson, Jennifer, Klaus, Christine, Enerson, Bradley, Massa, Virginia, Kuhn, Eric, Sharma, Kirti, Keaney, Erin, Barnes, Randy, Chen, Dapeng, Zheng, Xiaozhang, Rong, Haojing, Sabesan, Vijay, Ho, Chris, Mainolfi, Nello, Slavin, Anthony, Gollob, Jared A.

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Small-molecule factor B inhibitor for the treatment of complement-mediated diseases von Schubart, Anna, Anderson, Karen, Mainolfi, Nello, Sellner, Holger, Ehara, Takeru, Adams, Christopher M., Sweeney, Aengus Mac, Liao, Sha-Mei, Crowley, Maura, Littlewood-Evans, Amanda, Sarret, Sophie, Wieczorek, Grazyna, Perrot, Ludovic, Dubost, Valérie, Flandre, Thierry, Zhang, Yuzhou, Smith, Richard J. H., Risitano, Antonio M., Karki, Rajeshri G., Zhang, Chun, Valeur, Eric, Sirockin, Finton, Gerhartz, Bernd, Erbel, Paulus, Hughes, Nicola, Smith, Thomas M., Cumin, Frederic, Argikar, Upendra A., Haraldsson, Börje, Mogi, Muneto, Sedrani, Richard, Wiesmann, Christian, Jaffee, Bruce, Maibaum, Jürgen, Flohr, Stefanie, Harrison, Richard, Eder, Jörg

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STAT3 degraders inhibit cellular activation, cytokine production, and Th17 development, resulting in inhibition of autoimmunity in the MOG-EAE model of CNS inflammation von Sullivan, Jeffrey, Brown, Crystal, Mayo, Michele, Dixit, Vaishali, Enerson, Bradley, Rong, Haojing, Yang, Bin, De Savi, Chris, Gollob, Jared, Mainolfi, Nello, Slavin, Anthony, Hubeau, Cedric

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Discovery of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates Targeting MYD88 Mutant Diffuse Large B‑Cell Lymphoma von Weiss, Matthew M., Zheng, Xiaozhang, Ji, Nan, Browne, Chris M., Campbell, Veronica, Chen, Dapeng, Enerson, Brad, Fei, Xue, Huang, Xin, Klaus, Christine R., Li, Haoran, Mayo, Michele, McDonald, Alice A., Paul, Atanu, Rong, Haojing, Sharma, Kirti, Shi, Yatao, Slavin, Anthony, Walther, Dirk M., Yuan, Karen, Zhang, Yi, Zhu, Xiao, Kelleher, Joe, Walker, Duncan, Mainolfi, Nello

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Discovery of KT-474a Potent, Selective, and Orally Bioavailable IRAK4 Degrader for the Treatment of Autoimmune Diseases von Zheng, Xiaozhang, Ji, Nan, Campbell, Veronica, Slavin, Anthony, Zhu, Xiao, Chen, Dapeng, Rong, Haojing, Enerson, Brad, Mayo, Michele, Sharma, Kirti, Browne, Chris M., Klaus, Christine R., Li, Haoran, Massa, Ginny, McDonald, Alice A., Shi, Yatao, Sintchak, Mike, Skouras, Stephanie, Walther, Dirk M., Yuan, Karen, Zhang, Yi, Kelleher, Joe, Liu, Guang, Luo, Xinbo, Mainolfi, Nello, Weiss, Matthew M.

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Selective IRAK4 degradation, not kinase inhibition, blocks TLR-activated NF-Kb and p38 Signaling leading to broad cytokine inhibition von Skouras, Stephanie M, Massa, Virginia, Lurier, Emily, Hubeau, Cedric, Wang, Amy, Zheng, Xiaozhang, Sharma, Kirti, Walter, Dirk, Browne, Chris, Mayo, Michele, Fitzgerald, Michael, McDonald, Alice, Gollob, Jared, Mainolfi, Nello, Slavin, Anthony, Campbell, Veronica

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Ktx-120, a Novel Irakimid Degrader of IRAK4 and IMiD Substrates Shows Preferential Activity and Induces Regressions in MYD88-Mutant DLBCL CDX and PDX Models von Walker, Duncan, Mayo, Michele, Klaus, Christine, Chen, Dapeng, Bhaduri, Samyabrata, Sharma, Kirti, Rusin, Scott, McDonald, Alice, Gollob, Jared, Mainolfi, Nello, Weiss, Matt

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Targeting MYD88-Mutant DLBCL with IRAKIMiDs: A Comparison to IRAK4 Kinase Inhibition and Evaluation of Synergy with Rational Combinations von Lue, Jennifer Kimberly, Manavalan, John S, Klaus, Christine, Kanik, Rahul, Grilo, Andre M., McDonald, Alice, Gollob, Jared, Walker, Duncan, O'Connor, Owen A., Mainolfi, Nello

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