Unfolded Protein Response as a Compensatory Mechanism and Potential Therapeutic Target in PLN R14del Cardiomyopathy von Feyen, Dries A.M., Perea-Gil, Isaac, Maas, Renee G.C., Harakalova, Magdalena, Gavidia, Alexandra A., Arthur Ataam, Jennifer, Wu, Ting-Hsuan, Vink, Aryan, Pei, Jiayi, Vadgama, Nirmal, Suurmeijer, Albert J., te Rijdt, Wouter P., Vu, Michelle, Amatya, Prashila L., Prado, Maricela, Zhang, Yuan, Dunkenberger, Logan, Sluijter, Joost P.G., Sallam, Karim, Asselbergs, Folkert W., Mercola, Mark, Karakikes, Ioannis

Volltext

Distinct fibrosis pattern in desmosomal and phospholamban mutation carriers in hereditary cardiomyopathies von Sepehrkhouy, Shahrzad, MD, Gho, Johannes M.I.H., MD, van Es, René, MSc, Harakalova, Magdalena, MD, PhD, de Jonge, Nicolaas, MD, PhD, Dooijes, Dennis, PhD, van der Smagt, Jasper J., MD, PhD, Buijsrogge, Marc P., MD, PhD, Hauer, Richard N.W., MD, PhD, Goldschmeding, Roel, MD, PhD, de Weger, Roel A., PhD, Asselbergs, Folkert W., MD, PhD, Vink, Aryan, MD, PhD

Volltext

Characteristic adaptations of the extracellular matrix in dilated cardiomyopathy von Louzao-Martinez, Laura, Vink, Aryan, Harakalova, Magdalena, Asselbergs, Folkert W, Verhaar, Marianne C, Cheng, Caroline

Volltext

Locational memory of macrovessel vascular cells is transcriptionally imprinted von Spanjersberg, Talitha C. F., Oosterhoff, Loes A., Kruitwagen, Hedwig S., van den Dungen, Noortje A. M., Vernooij, Johannes C. M., Asselbergs, Folkert W., Mokry, Michal, Spee, Bart, Harakalova, Magdalena, van Steenbeek, Frank G.

Volltext

Metabolomics in Severe Aortic Stenosis Reveals Intermediates of Nitric Oxide Synthesis as Most Distinctive Markers von van Driel, Beau Olivier, Schuldt, Maike, Algul, Sila, Levin, Evgeni, Guclu, Ahmet, Germans, Tjeerd, van Rossum, Albert C., Pei, Jiayi, Harakalova, Magdalena, Baas, Annette, Jans, Judith J. M., van der Velden, Jolanda

Volltext

Systematic analysis of chromatin interactions at disease associated loci links novel candidate genes to inflammatory bowel disease von Meddens, Claartje A, Harakalova, Magdalena, van den Dungen, Noortje A M, Foroughi Asl, Hassan, Hijma, Hemme J, Cuppen, Edwin P J G, Björkegren, Johan L M, Asselbergs, Folkert W, Nieuwenhuis, Edward E S, Mokry, Michal

Volltext

Generation and characterization of novel human induced pluripotent stem cell (iPSC) lines originating from five asymptomatic individuals carrying the PLN-R14del pathogenic variant... von Balducci, Valentina, Scardigli, Francesco, Harakalova, Magdalena, Peter. van Tintelen, J., Doevendans, Pieter A., Costa, Kevin D., Turnbull, Irene C., P. G. Sluijter, Joost, Stillitano, Francesca

Volltext

Generation of human induced pluripotent stem cell (iPSC) lines derived from five patients carrying the pathogenic phospholamban-R14del (PLN-R14del) variant and three non-carrier fa... von Mittal, Nishka, Dave, Jaydev, Harakalova, Magdalena, van Tintelen, J. Peter, Asselbergs, Folkert W., Doevendans, Pieter A., Costa, Kevin D., Turnbull, Irene C., Stillitano, Francesca

Volltext

Multiplexed array-based and in-solution genomic enrichment for flexible and cost-effective targeted next-generation sequencing von Harakalova, Magdalena, Mokry, Michal, Hrdlickova, Barbara, Renkens, Ivo, Duran, Karen, van Roekel, Henk, Lansu, Nico, van Roosmalen, Mark, de Bruijn, Ewart, Nijman, Isaac J, Kloosterman, Wigard P, Cuppen, Edwin

Volltext

Indoxyl Sulfate Stimulates Angiogenesis by Regulating Reactive Oxygen Species Production via CYP1B1 von Pei, Jiayi, Juni, Rio, Harakalova, Magdalena, Duncker, Dirk J, Asselbergs, Folkert W, Koolwijk, Pieter, Hinsbergh, Victor van, Verhaar, Marianne C, Mokry, Michal, Cheng, Caroline

Volltext

Sex-based differences in cardiovascular proteomic profiles and their associations with adverse outcomes in patients with chronic heart failure von de Bakker, Marie, Petersen, Teun B, Akkerhuis, K Martijn, Harakalova, Magdalena, Umans, Victor A, Germans, Tjeerd, Caliskan, Kadir, Katsikis, Peter D, van der Spek, Peter J, Suthahar, Navin, de Boer, Rudolf A, Rizopoulos, Dimitris, Asselbergs, Folkert W, Boersma, Eric, Kardys, Isabella

Volltext

Targeting lipid metabolism as a new therapeutic strategy for inherited cardiomyopathies von Gaar-Humphreys, Karen R, van den Brink, Alyssa, Wekking, Mark, Asselbergs, Folkert W, van Steenbeek, Frank G, Harakalova, Magdalena, Pei, Jiayi

Volltext

Extensive Association of Common Disease Variants with Regulatory Sequence von Mokry, Michal, Harakalova, Magdalena, Asselbergs, Folkert W, de Bakker, Paul I W, Nieuwenhuis, Edward E S

Volltext

Massive expansion and cryopreservation of functional human induced pluripotent stem cell-derived cardiomyocytes von Maas, Renee G.C., Lee, Soah, Harakalova, Magdalena, Snijders Blok, Christian J.B., Goodyer, William R., Hjortnaes, Jesper, Doevendans, Pieter A.F.M., Van Laake, Linda W., van der Velden, Jolanda, Asselbergs, Folkert W., Wu, Joseph C., Sluijter, Joost P.G., Wu, Sean M., Buikema, Jan W.

Volltext

Genetic Basis of Dilated Cardiomyopathy in Dogs and Its Potential as a Bidirectional Model von Gaar-Humphreys, Karen R., Spanjersberg, Talitha C. F., Santarelli, Giorgia, Grinwis, Guy C. M., Szatmári, Viktor, Roelen, Bernard A. J., Vink, Aryan, van Tintelen, J. Peter, Asselbergs, Folkert W., Fieten, Hille, Harakalova, Magdalena, van Steenbeek, Frank G.

Volltext

High resolution systematic digital histological quantification of cardiac fibrosis and adipose tissue in phospholamban p.Arg14del mutation associated cardiomyopathy von Gho, Johannes M I H, van Es, René, Stathonikos, Nikolas, Harakalova, Magdalena, te Rijdt, Wouter P, Suurmeijer, Albert J H, van der Heijden, Jeroen F, de Jonge, Nicolaas, Chamuleau, Steven A J, de Weger, Roel A, Asselbergs, Folkert W, Vink, Aryan

Volltext

Sarcomere Disassembly and Transfection Efficiency in Proliferating Human iPSC-Derived Cardiomyocytes von Yuan, Qianliang, Maas, Renee G C, Brouwer, Ellen C J, Pei, Jiayi, Blok, Christian Snijders, Popovic, Marko A, Paauw, Nanne J, Bovenschen, Niels, Hjortnaes, Jesper, Harakalova, Magdalena, Doevendans, Pieter A, Sluijter, Joost P G, van der Velden, Jolanda, Buikema, Jan W

Volltext

Genomic DNA Pooling Strategy for Next-Generation Sequencing-Based Rare Variant Discovery in Abdominal Aortic Aneurysm Regions of Interest—Challenges and Limitations von Harakalova, Magdalena, Nijman, Isaäc J., Medic, Jelena, Mokry, Michal, Renkens, Ivo, Blankensteijn, Jan D., Kloosterman, Wigard, Baas, Annette F., Cuppen, Edwin

Volltext

Gene expression profiling of hypertrophic cardiomyocytes identifies new players in pathological remodelling von Vigil-Garcia, Marta, Demkes, Charlotte J, Eding, Joep E C, Versteeg, Danielle, de Ruiter, Hesther, Perini, Ilaria, Kooijman, Lieneke, Gladka, Monika M, Asselbergs, Folkert W, Vink, Aryan, Harakalova, Magdalena, Bossu, Alexander, van Veen, Toon A B, Boogerd, Cornelis J, van Rooij, Eva

Volltext

Genome-wide association analysis in dilated cardiomyopathy reveals two new players in systolic heart failure on chromosomes 3p25.1 and 22q11.23 von Garnier, Sophie, Harakalova, Magdalena, Weiss, Stefan, Mokry, Michal, Regitz-Zagrosek, Vera, Hengstenberg, Christian, Cappola, Thomas P, Isnard, Richard, Arbustini, Eloisa, Cook, Stuart A, van Setten, Jessica, Calis, Jorg J A, Hakonarson, Hakon, Morley, Michael P, Stark, Klaus, Prasad, Sanjay K, Li, Jin, O'Regan, Declan P, Grasso, Maurizia, Müller-Nurasyid, Martina, Meitinger, Thomas, Empana, Jean-Philippe, Strauch, Konstantin, Waldenberger, Melanie, Marguiles, Kenneth B, Seidman, Christine E, Kararigas, Georgios, Meder, Benjamin, Haas, Jan, Boutouyrie, Pierre, Lacolley, Patrick, Jouven, Xavier, Erdmann, Jeanette, Blankenberg, Stefan, Wichter, Thomas, Ruppert, Volker, Tavazzi, Luigi, Dubourg, Olivier, Roizes, Gérard, Dorent, Richard, de Groote, Pascal, Fauchier, Laurent, Trochu, Jean-Noël, Aupetit, Jean-François, Bilinska, Zofia T, Germain, Marine, Völker, Uwe, Hemerich, Daiane, Raji, Ibticem, Bacq-Daian, Delphine, Proust, Carole, Remior, Paloma, Gomez-Bueno, Manuel, Lehnert, Kristin, Maas, Renee, Olaso, Robert, Saripella, Ganapathi Varma, Felix, Stephan B, McGinn, Steven, Duboscq-Bidot, Laëtitia, van Mil, Alain, Besse, Céline, Fontaine, Vincent, Blanché, Hélène, Ader, Flavie, Keating, Brendan, Curjol, Angélique, Boland, Anne, Komajda, Michel, Cambien, François, Deleuze, Jean-François, Dörr, Marcus, Asselbergs, Folkert W, Villard, Eric, Trégouët, David-Alexandre, Charron, Philippe

Volltext