Proteases as therapeutics von Craik, Charles S, Page, Michael J, Madison, Edwin L

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CVS-3983, a selective matriptase inhibitor, suppresses the growth of androgen independent prostate tumor xenografts von Galkin, Anna V., Mullen, Lynne, Fox, William D., Brown, Jason, Duncan, David, Moreno, Ofir, Madison, Edwin L., Agus, David B.

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Catalytic Domain Structures of MT-SP1/Matriptase, a Matrix-degrading Transmembrane Serine Proteinase von Friedrich, Rainer, Fuentes-Prior, Pablo, Ong, Edgar, Coombs, Gary, Hunter, Michael, Oehler, Ryan, Pierson, Diane, Gonzalez, Richard, Huber, Robert, Bode, Wolfram, Madison, Edwin L.

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Crystal structure of the catalytic domain of DESC1, a new member of the type II transmembrane serine proteinase family von Kyrieleis, Otto J. P., Huber, Robert, Ong, Edgar, Oehler, Ryan, Hunter, Mike, Madison, Edwin L., Jacob, Uwe

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Membrane anchored serine proteases: a rapidly expanding group of cell surface proteolytic enzymes with potential roles in cancer von Netzel-Arnett, Sarah, Hooper, John D, Szabo, Roman, Madison, Edwin L, Quigley, James P, Bugge, Thomas H, Antalis, Toni M

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The Kringle V-Protease Domain Is a Fibrinogen Binding Region within Apo(a) von Xue, Song, Madison, Edwin L., Miles, Lindsey A.

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Serpin-resistant mutants of human tissue-type plasminogen activator von Madison, Edwin L, Goldsmith, Elizabeth J, Gerard, Robert D, Gething, Mary-Jane H, Sambrook, Joseph F

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Converting Tissue Plasminogen Activator to a Zymogen: A Regulatory Triad of Asp-His-Ser von Madison, Edwin L., Kobe, Andreja, Gething, Mary-Jane, Sambrook, Joseph F., Goldsmith, Elizabeth J.

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Identification of Efficiently Cleaved Substrates for HIV-1 Protease Using a Phage Display Library and Use in Inhibitor Development von Beck, Zachary Q., Hervio, Laurence, Dawson, Philip E., Elder, John H., Madison, Edwin L.

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Optimal Subsite Occupancy and Design of a Selective Inhibitor of Urokinase von Ke, Song-Hua, Coombs, Gary S., Tachias, Kathy, Corey, David R., Madison, Edwin L.

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Revisiting Catalysis by Chymotrypsin Family Serine Proteases Using Peptide Substrates and Inhibitors with Unnatural Main Chains von Coombs, Gary S., Rao, Mohan S., Olson, Arthur J., Dawson, Philip E., Madison, Edwin L.

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Converting Tissue-type Plasminogen Activator into a Zymogen von Tachias, K, Madison, E L

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Binding of Nonphysiological Protein and Peptide Substrates to Proteases:  Differences between Urokinase-Type Plasminogen Activator and Trypsin and Contributions to the Evolution of... von Bergstrom, Robert C, Coombs, Gary S, Ye, Sheng, Madison, Edwin L, Goldsmith, Elizabeth J, Corey, David R

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Variants of Tissue-type Plasminogen Activator Which Display Substantially Enhanced Stimulation by Fibrin von Tachias, Kathy, Madison, Edwin L.

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Distinct Mechanisms Contribute to Stringent Substrate Specificity of Tissue-type Plasminogen Activator (∗) von Coombs, Gary S., Dang, Alphonsus T., Madison, Edwin L., Corey, David R.

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Variants of Tissue-type Plasminogen Activator That Display Extraordinary Resistance to Inhibition by the Serpin Plasminogen Activator Inhibitor Type 1 von Tachias, K, Madison, E L

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Converting Tissue Type Plasminogen Activator into a Zymogen von Tachias, Kathy, Madison, Edwin L.

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Variants of Tissue-type Plasminogen Activator with Substantially Enhanced Response and Selectivity toward Fibrin Co-factors (∗) von Strandberg, Leif, Madison, Edwin L.

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Distinct Contributions of Residue 192 to the Specificity of Coagulation and Fibrinolytic Serine Proteases von Zhang, Yan-Liang, Hervio, Laurence, Strandberg, Leif, Madison, Edwin L.

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Rapid and efficient site-directed mutagenesis by single-tube ‘megaprimer’ PCR method von Ke, Song-Hua, Madison, Edwin L.

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