The role of sodium channels in neuropathic pain von Rogers, Marc, Tang, Lam, Madge, David J., Stevens, Edward B.

Volltext

New pharmacological approaches to atrial fibrillation von Milnes, James T., Madge, David J., Ford, John W.

Volltext

Medicinal Chemistry of Neuronal Voltage-Gated Sodium Channel Blockers von Anger, Thorsten, Madge, David J, Mulla, Mushtaq, Riddall, Dieter

Volltext

Ubiquitin-specific protease 7 inhibitors reveal a differentiated mechanism of p53-driven anti-cancer activity von Futran, Alan S., Lu, Tao, Amberg-Johnson, Katherine, Xu, Jiayi, Yang, Xiaoxiao, He, Saidi, Boyce, Sarah, Bell, Jeffrey A., Pelletier, Robert, Suzuki, Takao, Huang, Xianhai, Qian, Heng, Fang, Liping, Xing, Li, Xu, Zhaowu, Kurtz, Stephen E., Tyner, Jeffrey W., Tang, Wayne, Guo, Tao, Akinsanya, Karen, Madge, David, Jensen, Kristian K.

Volltext

Ligand- and Structure-Based Virtual Screening for Clathrodin-Derived Human Voltage-Gated Sodium Channel Modulators von Tomašić, Tihomir, Hartzoulakis, Basil, Zidar, Nace, Chan, Fiona, Kirby, Robert W, Madge, David J, Peigneur, Steve, Tytgat, Jan, Kikelj, Danijel

Volltext

Substituted 4-phenyl-2-aminoimidazoles and 4-phenyl-4,5-dihydro-2-aminoimidazoles as voltage-gated sodium channel modulators von Zidar, Nace, Jakopin, Žiga, Madge, David J., Chan, Fiona, Tytgat, Jan, Peigneur, Steve, Dolenc, Marija Sollner, Tomašić, Tihomir, Ilaš, Janez, Mašič, Lucija Peterlin, Kikelj, Danijel

Volltext

Novel state-dependent voltage-gated sodium channel modulators, based on marine alkaloids from Agelas sponges von Hodnik, Žiga, Tomašić, Tihomir, Mašič, Lucija Peterlin, Chan, Fiona, Kirby, Robert W., Madge, David J., Kikelj, Danijel

Volltext

Action of clathrodin and analogues on voltage-gated sodium channels von Peigneur, Steve, Zula, Aleš, Zidar, Nace, Chan-Porter, Fiona, Kirby, Robert, Madge, David, Ilaš, Janez, Kikelj, Danijel, Tytgat, Jan

Volltext

Prediction of Ion Channel Activity Using Binary Kernel Discrimination von Willett, Peter, Wilton, David, Hartzoulakis, Basil, Tang, Raymond, Ford, John, Madge, David

Volltext

Synthesis and analysis of conjugates of the major vitamin E metabolite, alpha-CEHC von Pope, Simon A S, Burtin, Guillaume E, Clayton, Peter T, Madge, David J, Muller, David P R

Volltext

Deep learning enables rapid identification of potent DDR1 kinase inhibitors von Zhavoronkov, Alex, Ivanenkov, Yan A., Aliper, Alex, Veselov, Mark S., Aladinskiy, Vladimir A., Aladinskaya, Anastasiya V., Terentiev, Victor A., Polykovskiy, Daniil A., Kuznetsov, Maksim D., Asadulaev, Arip, Volkov, Yury, Zholus, Artem, Shayakhmetov, Rim R., Zhebrak, Alexander, Minaeva, Lidiya I., Zagribelnyy, Bogdan A., Lee, Lennart H., Soll, Richard, Madge, David, Xing, Li, Guo, Tao, Aspuru-Guzik, Alán

Volltext

A comparative study of sildenafil, NCX-911 and BAY41-2272 on the anococcygeus muscle of diabetic rats von KALSI, Jasjit S, RALPH, David J, MADGE, David J, KELL, Phil D, CELLEK, Selim

Volltext

Abstract 1338: Discovery of novel, potent USP7 inhibitors that upregulate p53 leading to anti-proliferative effects in cancer cells von Futran, Alan, Lu, Tao, Amberg-Johnson, Katherine, Yang, Xiaoxiao, He, Saidi, Bell, Jeffrey, Boyce, Sarah, Dahlgren, Markus, Dingley, Karen, Fang, Liping, Koldsoe, Heidi, Konst, Zef, Lin, Fang-Yu, Pelleltier, Robert, Qian, Heng, Svensson, Mats, Trzoss, Michael, Xu, Jie, Xu, Shuping, Xu, Zhaowu, Yapici, Engin, Zhang, Yan, Xing, Li, Suzuki, Takao, Huang, Xianhai, Xu, Jiayi, Wright, Hamish, Jensen, Kristian, Tang, Wayne, Guo, Tao, Akinsanya, Karen, Madge, David

Volltext

Human Electrophysiological and Pharmacological Properties of XEN-D0101: A Novel Atrial-Selective Kv1.5/IKur Inhibitor von Ford, John, Milnes, James, Wettwer, Erich, Christ, Torsten, Rogers, Marc, Sutton, Kathy, Madge, David, Virag, Laszlo, Jost, Norbert, Horvath, Zoltan, Matschke, Klaus, Varro, Andras, Ravens, Ursula

Volltext

New synthesis of (±)-α-CMBHC and its confirmation as a metabolite of α-tocopherol (vitamin E) von Pope, Simon A.S, Burtin, Guillaume E, Clayton, Peter T, Madge, David J, Muller, David P.R

Volltext

The effects of a novel and selective inhibitor of tryptophan 2,3-dioxygenase on tryptophan and serotonin metabolism in the rat von Salter, Mark, Hazelwood, Robert, Pogson, Christopher I., Iyer, Ramachandran, Madge, David J.

Volltext

Near-Thorough QT Study as Part of a First-In-Man Study von Malik, Marek, Hnatkova, Katerina, Ford, John, Madge, David

Volltext

Ligand- and structure-based virtual screening for clathrodin-derived human voltage-gated sodium channel modulators von Tomašić, Tihomir, Hartzoulakis, Basil, Zidar, Nace, Chan, Fiona, Kirby, Robert W, Madge, David J, Peigneur, Steve, Tytgat, Jan, Kikelj, Danijel

Volltext

Abstract 18632: The Potent, Selective Cardiac Acetylcholine-Activated Potassium Current Inhibitor XEN-R0706 Prolongs Human Atrial Action Potential Duration von Milnes, James, Loose, Simone, Poulet, Claire, Kuenzel, Stephan, El-Haou, Said, Jackson, Claire, Tang, Raymond, Madge, David, Ford, John, Ravens, Ursula

Volltext

Substituted 4-phenyl-2-aminoimidazoles and 4-phenyl-4,5-dihydro-2-aminoimidazoles as voltage-gated sodium channel modulators von Zidar, Nace, Jakopin, Ziga, Madge, David J, Chan, Fiona, Tytgat, Jan, Peigneur, Steve, Dolenc, Marija Sollner, Tomašić, Tihomir, Ilaš, Janez, Mašič, Lucija Peterlin, Kikelj, Danijel

Volltext