Next-Generation Sequencing in the Field of Primary Immunodeficiencies: Current Yield, Challenges, and Future Perspectives von Vorsteveld, Emil E., Hoischen, Alexander, van der Made, Caspar I.

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Presence of Genetic Variants Among Young Men With Severe COVID-19 von van der Made, Caspar I, Simons, Annet, Schuurs-Hoeijmakers, Janneke, van den Heuvel, Guus, Mantere, Tuomo, Kersten, Simone, van Deuren, Rosanne C, Steehouwer, Marloes, van Reijmersdal, Simon V, Jaeger, Martin, Hofste, Tom, Astuti, Galuh, Corominas Galbany, Jordi, van der Schoot, Vyne, van der Hoeven, Hans, Hagmolen of ten Have, Wanda, Klijn, Eva, van den Meer, Catrien, Fiddelaers, Jeroen, de Mast, Quirijn, Bleeker-Rovers, Chantal P, Joosten, Leo A. B, Yntema, Helger G, Gilissen, Christian, Nelen, Marcel, van der Meer, Jos W. M, Brunner, Han G, Netea, Mihai G, van de Veerdonk, Frank L, Hoischen, Alexander

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Primary immunodeficiencies in cytosolic pattern‐recognition receptor pathways: Toward host‐directed treatment strategies von Made, Caspar I., Hoischen, Alexander, Netea, Mihai G., Veerdonk, Frank L.

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Clinical implications of host genetic variation and susceptibility to severe or critical COVID-19 von van der Made, Caspar I, Netea, Mihai G, van der Veerdonk, Frank L, Hoischen, Alexander

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Genetic Screening for TLR7 Variants in Young and Previously Healthy Men With Severe COVID-19 von Solanich, Xavier, Vargas-Parra, Gardenia, van der Made, Caspar I., Simons, Annet, Schuurs-Hoeijmakers, Janneke, Antoli, Arnau, del Valle, Jesus, Rocamora-Blanch, Gemma, Setien, Fernando, Esteller, Manel, van Reijmersdal, Simon V., Riera-Mestre, Antoni, Sabater-Riera, Joan, Capella, Gabriel, van de Veerdonk, Frank L., van der Hoven, Ben, Corbella, Xavier, Hoischen, Alexander, Lazaro, Conxi

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Genetic Predisposition to Neurological Complications in Patients with COVID-19 von Sahajpal, Nikhil Shri, Hastie, Alex R, Schieck, Maximilian, Mondal, Ashis K, Felde, Marc, van der Made, Caspar I, Chou, Janet S, Randolph, Adrienne G, Illig, Thomas, Zody, Michael C, Brownstein, Catherine A, Beggs, Alan H, Hoischen, Alexander, Chaubey, Alka, Kolhe, Ravindra

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SUsPECT: a pipeline for variant effect prediction based on custom long-read transcriptomes for improved clinical variant annotation von Salz, Renee, Saraiva-Agostinho, Nuno, Vorsteveld, Emil, van der Made, Caspar I, Kersten, Simone, Stemerdink, Merel, Allen, Jamie, Volders, Pieter-Jan, Hunt, Sarah E, Hoischen, Alexander, 't Hoen, Peter A C

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Dexamethasone attenuates interferon-related cytokine hyperresponsiveness in COVID-19 patients von Engel, Job J., van der Made, Caspar I., Keur, Nick, Setiabudiawan, Todia, Röring, Rutger J., Damoraki, Georgia, Dijkstra, Helga, Lemmers, Heidi, Ioannou, Sofia, Poulakou, Garyfallia, van der Meer, Jos W. M., Giamarellos-Bourboulis, Evangelos J., Kumar, Vinod, van de Veerdonk, Frank L., Netea, Mihai G., Ziogas, Athanasios

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Adult-onset autoinflammation caused by somatic mutations in UBA1: A Dutch case series of patients with VEXAS von van der Made, Caspar I., Potjewijd, Judith, Hoogstins, Annemiek, Willems, Huub P.J., Kwakernaak, Arjan J., de Sevaux, Ruud G.L., van Daele, Paul L.A., Simons, Annet, Heijstek, Marloes, Beck, David B., Netea, Mihai G., van Paassen, Pieter, Elizabeth Hak, A., van der Veken, Lars T., van Gijn, Marielle E., Hoischen, Alexander, van de Veerdonk, Frank L., Leavis, Helen L., Rutgers, Abraham

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Multi-Omics Integration Reveals Only Minor Long-Term Molecular and Functional Sequelae in Immune Cells of Individuals Recovered From COVID-19 von Liu, Zhaoli, Kilic, Gizem, Li, Wenchao, Bulut, Ozlem, Gupta, Manoj Kumar, Zhang, Bowen, Qi, Cancan, Peng, He, Tsay, Hsin-Chieh, Soon, Chai Fen, Mekonnen, Yonatan Ayalew, Ferreira, Anaísa Valido, van der Made, Caspar I, van Cranenbroek, Bram, Koenen, Hans J P M, Simonetti, Elles, Diavatopoulos, Dimitri, de Jonge, Marien I, Müller, Lisa, Schaal, Heiner, Ostermann, Philipp N, Cornberg, Markus, Eiz-Vesper, Britta, van de Veerdonk, Frank, van Crevel, Reinout, Joosten, Leo A B, Domínguez-Andrés, Jorge, Xu, Cheng-Jian, Netea, Mihai G, Li, Yang

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Multi-omic profiling of pathogen-stimulated primary immune cells von Salz, Renee, Vorsteveld, Emil E., van der Made, Caspar I., Kersten, Simone, Stemerdink, Merel, Riepe, Tabea V., Hsieh, Tsung-han, Mhlanga, Musa, Netea, Mihai G., Volders, Pieter-Jan, Hoischen, Alexander, ’t Hoen, Peter A.C.

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Optical genome mapping identifies rare structural variations as predisposition factors associated with severe COVID-19 von Sahajpal, Nikhil Shri, Jill Lai, Chi-Yu, Hastie, Alex, Mondal, Ashis K., Dehkordi, Siavash Raeisi, van der Made, Caspar I., Fedrigo, Olivier, Al-Ajli, Farooq, Jalnapurkar, Sawan, Byrska-Bishop, Marta, Kanagal-Shamanna, Rashmi, Levy, Brynn, Schieck, Maximilian, Illig, Thomas, Bacanu, Silviu-Alin, Chou, Janet S., Randolph, Adrienne G., Rojiani, Amyn M., Zody, Michael C., Brownstein, Catherine A., Beggs, Alan H., Bafna, Vineet, Jarvis, Erich D., Hoischen, Alexander, Chaubey, Alka, Kolhe, Ravindra

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Effect of exogenous IL-37 on immune cells from a patient carrying a potential IL37 loss-of-function variant: A case study von Teufel, Lisa U., van der Made, Caspar I., Klück, Viola, Simons, Annet, Hoischen, Alexander, Vernimmen, Vivian, Joosten, Leo A.B., Arts, Rob J.W.

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TLR9 ligand sequestration by chemokine CXCL4 negatively affects central B cell tolerance von Çakan, Elif, Ah Kioon, Marie Dominique, Garcia-Carmona, Yolanda, Glauzy, Salomé, Oliver, David, Yamakawa, Natsuko, Vega Loza, Andrea, Du, Yong, Schickel, Jean-Nicolas, Boeckers, Joshua M, Yang, Chao, Baldo, Alessia, Ivashkiv, Lionel B, Young, Ryan M, Staudt, Louis M, Moody, Krishna L, Nündel, Kerstin, Marshak-Rothstein, Ann, van der Made, Caspar I, Hoischen, Alexander, Hayward, Anthony, Rossato, Marzia, Radstake, Timothy R D J, Cunningham-Rundles, Charlotte, Ryu, Changwan, Herzog, Erica L, Barrat, Franck J, Meffre, Eric

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OTULIN Haploinsufficiency-Related Fasciitis and Skin Necrosis Treated by TNF Inhibition von Arts, Rob J. W., van der Linden, Tristan J., van der Made, Caspar I., Hendriks, Marianne M. C., van der Heijden, Wouter A., de Mast, Quirijn, Schuurs-Hoeijmakers, Janneke H. M., Simons, Annet, Spaan, András N., Mulders-Manders, Catharina M., van de Veerdonk, Frank L.

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Clinical exome sequencing data from patients with inborn errors of immunity: Cohort level diagnostic yield and the benefit of systematic reanalysis von Vorsteveld, Emil E., Van der Made, Caspar I., Smeekens, Sanne P., Schuurs-Hoeijmakers, Janneke H., Astuti, Galuh, Diepstra, Heleen, Gilissen, Christian, Hoenselaar, Evelien, Janssen, Alice, van Roozendaal, Kees, Engelen, Jettie Sikkema-van, Steyaert, Wouter, Weiss, Marjan M., Yntema, Helger G., Mantere, Tuomo, AlZahrani, Mofareh S., van Aerde, Koen, Derfalvi, Beata, Faqeih, Eissa Ali, Henriet, Stefanie S.V., van Hoof, Elise, Idressi, Eman, Issekutz, Thomas B., Jongmans, Marjolijn C.J., Keski-Filppula, Riikka, Krapels, Ingrid, te Loo, Maroeska, Mulders-Manders, Catharina M., ten Oever, Jaap, Potjewijd, Judith, Sarhan, Nora Tarig, Slot, Marjan C., Terhal, Paulien A., Thijs, Herman, Vandersteen, Anthony, Vanhoutte, Els K., van de Veerdonk, Frank, van Well, Gijs, Netea, Mihai G., Arts, Rob J.W., Bijker, Else M., Bruno, Mariolina, Hobo, Willemijn, Hoppenreijs, Esther, de Jonge, Marien I., van Laarhoven, Arjan, van der Molen, Renate, Oud, Manon, Schatorje, Ellen J.H., Smeets, Ruben, Sprenkeler, Evelien G.G., Stol, Kim, Verhagen, Lilly M., Zonneveld-Huijssoon, Evelien, Simons, Annet, Hoischen, Alexander

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Expanding the PRAAS spectrum: De novo mutations of immunoproteasome subunit β-type 10 in six infants with SCID-Omenn syndrome von van der Made, Caspar I., Kersten, Simone, Chorin, Odelia, Engelhardt, Karin R., Ramakrishnan, Gayatri, Griffin, Helen, Schim van der Loeff, Ina, Venselaar, Hanka, Rothschild, Annick Raas, Segev, Meirav, Schuurs-Hoeijmakers, Janneke H.M., Mantere, Tuomo, Essers, Rick, Esteki, Masoud Zamani, Avital, Amir L., Loo, Peh Sun, Simons, Annet, Pfundt, Rolph, Warris, Adilia, Seyger, Marieke M., van de Veerdonk, Frank L., Netea, Mihai G., Slatter, Mary A., Flood, Terry, Gennery, Andrew R., Simon, Amos J., Lev, Atar, Frizinsky, Shirley, Barel, Ortal, van der Burg, Mirjam, Somech, Raz, Hambleton, Sophie, Henriet, Stefanie S.V., Hoischen, Alexander

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“Deficiency in ELF4, X-Linked”: a Monogenic Disease Entity Resembling Behçet’s Syndrome and Inflammatory Bowel Disease von Olyha, Sam J., O’Connor, Shannon K., Kribis, Marat, Bucklin, Molly L., Uthaya Kumar, Dinesh Babu, Tyler, Paul M., Alam, Faiad, Jones, Kate M., Sheikha, Hassan, Konnikova, Liza, Lakhani, Saquib A., Montgomery, Ruth R., Catanzaro, Jason, Du, Hongqiang, DiGiacomo, Daniel V., Rothermel, Holly, Moran, Christopher J., Fiedler, Karoline, Warner, Neil, Hoppenreijs, Esther P.A.H., van der Made, Caspar I., Hoischen, Alexander, Olbrich, Peter, Neth, Olaf, Rodríguez-Martínez, Alejandro, Lucena Soto, José Manuel, van Rossum, Annemarie M.C., Dalm, Virgil A.S.H., Muise, Aleixo M., Lucas, Carrie L.

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Trio-based whole exome sequencing in patients with suspected sporadic inborn errors of immunity: A retrospective cohort study von Hebert, Anne, Simons, Annet, Schuurs-Hoeijmakers, Janneke H M, Koenen, Hans J P M, Zonneveld-Huijssoon, Evelien, Henriet, Stefanie S V, Schatorjé, Ellen J H, Hoppenreijs, Esther P A H, Leenders, Erika K S M, Janssen, Etienne J M, Santen, Gijs W E, de Munnik, Sonja A, van Reijmersdal, Simon V, van Rijssen, Esther, Kersten, Simone, Netea, Mihai G, Smeets, Ruben L, van de Veerdonk, Frank L, Hoischen, Alexander, van der Made, Caspar I

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Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency von Block, Jana, Rashkova, Christina, Castanon, Irinka, Zoghi, Samaneh, Platon, Jessica, Ardy, Rico C., Fujiwara, Mitsuhiro, Chaves, Beatriz, Schoppmeyer, Rouven, van der Made, Caspar I., Jimenez Heredia, Raul, Harms, Frederike L., Alavi, Samin, Alsina, Laia, Sanchez Moreno, Paula, Ávila Polo, Rainiero, Cabrera-Pérez, Rocío, Kostel Bal, Sevgi, Pfajfer, Laurène, Ransmayr, Bernhard, Mautner, Anna-Katharina, Kondo, Ryohei, Tinnacher, Anna, Caldera, Michael, Schuster, Michael, Domínguez Conde, Cecilia, Platzer, René, Salzer, Elisabeth, Boyer, Thomas, Brunner, Han G., Nooitgedagt-Frons, Judith E., Iglesias, Estíbaliz, Deyà-Martinez, Angela, Camacho-Lovillo, Marisol, Menche, Jörg, Bock, Christoph, Huppa, Johannes B., Pickl, Winfried F., Distel, Martin, Yoder, Jeffrey A., Traver, David, Engelhardt, Karin R., Linden, Tobias, Kager, Leo, Hannich, J. Thomas, Hoischen, Alexander, Hambleton, Sophie, Illsinger, Sabine, Da Costa, Lydie, Kutsche, Kerstin, Chavoshzadeh, Zahra, van Buul, Jaap D., Antón, Jordi, Calzada-Hernández, Joan, Neth, Olaf, Viaud, Julien, Nishikimi, Akihiko, Dupré, Loïc, Boztug, Kaan

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