Differential uptake, kinetics and mechanisms of intracellular trafficking of next-generation antisense oligonucleotides across human cancer cell lines von Linnane, Emily, Davey, Paul, Zhang, Pei, Puri, Sanyogitta, Edbrooke, Mark, Chiarparin, Elisabetta, Revenko, Alexey S, Macleod, A Robert, Norman, Jim C, Ross, Sarah J

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The Noncoding RNA MALAT1 Is a Critical Regulator of the Metastasis Phenotype of Lung Cancer Cells von GUTSCHNER, Tony, HÄMMERLE, Monika, ZÖRNIG, Martin, ROBERT MACLEOD, A, SPECTOR, David L, DIEDERICHS, Sven, EIBMANN, Moritz, HSU, Jeff, KIM, Youngsoo, HUNG, Gene, REVENKO, Alexey, ARUN, Gayatri, STENTRUP, Marion, GROSS, Matthias

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Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss von Arun, Gayatri, Diermeier, Sarah, Akerman, Martin, Chang, Kung-Chi, Wilkinson, J Erby, Hearn, Stephen, Kim, Youngsoo, MacLeod, A Robert, Krainer, Adrian R, Norton, Larry, Brogi, Edi, Egeblad, Mikala, Spector, David L

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Telomere length is key to hepatocellular carcinoma diversity and telomerase addiction is an actionable therapeutic target von Ningarhari, Massih, Caruso, Stefano, Hirsch, Théo Z., Bayard, Quentin, Franconi, Andrea, Védie, Anne-Laure, Noblet, Bénédicte, Blanc, Jean-Frédéric, Amaddeo, Giuliana, Ganne, Nathalie, Ziol, Marianne, Paradis, Valérie, Guettier, Catherine, Calderaro, Julien, Morcrette, Guillaume, Kim, Youngsoo, MacLeod, A. Robert, Nault, Jean-Charles, Rebouissou, Sandra, Zucman-Rossi, Jessica

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RNA Therapeutics in Oncology: Advances, Challenges, and Future Directions von MacLeod, A. Robert, Crooke, Stanley T.

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Targeting nuclear RNA for in vivo correction of myotonic dystrophy von Wheeler, Thurman M., Leger, Andrew J., Pandey, Sanjay K., MacLeod, A. Robert, Nakamori, Masayuki, Cheng, Seng H., Wentworth, Bruce M., Bennett, C. Frank, Thornton, Charles A.

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Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer’s disease von Baker, Sarah K., Chen, Zu-Lin, Norris, Erin H., Revenko, Alexey S., MacLeod, A. Robert, Strickland, Sidney

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Antisense STAT3 inhibitor decreases viability of myelodysplastic and leukemic stem cells von Shastri, Aditi, Choudhary, Gaurav, Teixeira, Margarida, Gordon-Mitchell, Shanisha, Ramachandra, Nandini, Bernard, Lumie, Bhattacharyya, Sanchari, Lopez, Robert, Pradhan, Kith, Giricz, Orsolya, Ravipati, Goutham, Wong, Li-Fan, Cole, Sally, Bhagat, Tushar D, Feld, Jonathan, Dhar, Yosman, Bartenstein, Matthias, Thiruthuvanathan, Victor J, Wickrema, Amittha, Ye, B Hilda, Frank, David A, Pellagatti, Andrea, Boultwood, Jacqueline, Zhou, Tianyuan, Kim, Youngsoo, MacLeod, A Robert, Epling-Burnette, P K, Ye, Minwei, McCoon, Patricia, Woessner, Richard, Steidl, Ulrich, Will, Britta, Verma, Amit

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Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding von Revenko, Alexey S., Gao, Dacao, Crosby, Jeff R., Bhattacharjee, Gourab, Zhao, Chenguang, May, Chris, Gailani, David, Monia, Brett P., MacLeod, A. Robert

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LncRNA PVT1 up-regulation is a poor prognosticator and serves as a therapeutic target in esophageal adenocarcinoma von Xu, Yan, Li, Yuan, Jin, Jiankang, Han, Guangchun, Sun, Chengcao, Pizzi, Melissa Pool, Huo, Longfei, Scott, Ailing, Wang, Ying, Ma, Lang, Lee, Jeffrey H, Bhutani, Manoop S, Weston, Brian, Vellano, Christopher, Yang, Liuqing, Lin, Chunru, Kim, Youngsoo, MacLeod, A Robert, Wang, Linghua, Wang, Zhenning, Song, Shumei, Ajani, Jaffer A

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Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma von Fox, Raymond G., Lytle, Nikki K., Jaquish, Dawn V., Park, Frederick D., Ito, Takahiro, Bajaj, Jeevisha, Koechlein, Claire S., Zimdahl, Bryan, Yano, Masato, Kopp, Janel L., Kritzik, Marcie, Sicklick, Jason K., Sander, Maike, Grandgenett, Paul M., Hollingsworth, Michael A., Shibata, Shinsuke, Pizzo, Donald, Valasek, Mark A., Sasik, Roman, Scadeng, Miriam, Okano, Hideyuki, Kim, Youngsoo, MacLeod, A. Robert, Lowy, Andrew M., Reya, Tannishtha

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Generation 2.5 antisense oligonucleotides targeting the androgen receptor and its splice variants suppress enzalutamide-resistant prostate cancer cell growth von Yamamoto, Yoshiaki, Loriot, Yohann, Beraldi, Eliana, Zhang, Fan, Wyatt, Alexander W, Al Nakouzi, Nader, Mo, Fan, Zhou, Tianyuan, Kim, Youngsoo, Monia, Brett P, MacLeod, A Robert, Fazli, Ladan, Wang, Yuzhuo, Collins, Colin C, Zoubeidi, Amina, Gleave, Martin

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STAT3 antisense oligonucleotide AZD9150 in a subset of patients with heavily pretreated lymphoma: results of a phase 1b trial von Reilley, Matthew J, McCoon, Patricia, Cook, Carl, Lyne, Paul, Kurzrock, Razelle, Kim, Youngsoo, Woessner, Richard, Younes, Anas, Nemunaitis, John, Fowler, Nathan, Curran, Michael, Liu, Qinying, Zhou, Tianyuan, Schmidt, Joanna, Jo, Minji, Lee, Samantha J, Yamashita, Mason, Hughes, Steven G, Fayad, Luis, Piha-Paul, Sarina, Nadella, Murali V P, Xiao, Xiaokun, Hsu, Jeff, Revenko, Alexey, Monia, Brett P, MacLeod, A Robert, Hong, David S

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Identification and characterization of modified antisense oligonucleotides targeting DMPK in mice and nonhuman primates for the treatment of myotonic dystrophy type 1 von Pandey, Sanjay K, Wheeler, Thurman M, Justice, Samantha L, Kim, Aneeza, Younis, Husam S, Gattis, Danielle, Jauvin, Dominic, Puymirat, Jack, Swayze, Eric E, Freier, Susan M, Bennett, C Frank, Thornton, Charles A, MacLeod, A Robert

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Antithrombotic Effect of Antisense Factor XI Oligonucleotide Treatment in Primates von Crosby, Jeffrey R, Marzec, Ulla, Revenko, Alexey S, Zhao, Chenguang, Gao, Dacao, Matafonov, Anton, Gailani, David, MacLeod, A Robert, Tucker, Erik I, Gruber, Andras, Hanson, Stephen R, Monia, Brett P

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MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo von Fournel, Marielle, Bonfils, Claire, Hou, Yu, Yan, Pu Theresa, Trachy-Bourget, Marie-Claude, Kalita, Ann, Liu, Jianhong, Lu, Ai-Hua, Zhou, Nancy Z, Robert, Marie-France, Gillespie, Jeffrey, Wang, James J, Ste-Croix, Hélène, Rahil, Jubrail, Lefebvre, Sylvain, Moradei, Oscar, Delorme, Daniel, Macleod, A Robert, Besterman, Jeffrey M, Li, Zuomei

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DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells von MacLeod, A. Robert, Robert, Marie-France, Morin, Steves, Beaulieu, Normand, Gauthier, France, Chute, Ian C, Barsalou, Annie

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The contact system proteases play disparate roles in streptococcal sepsis von Koehler, Juliane, Maletzki, Claudia, Koczan, Dirk, Frank, Marcus, Trepesch, Carolin, Revenko, Alexey S., Crosby, Jeffrey R., Macleod, A. Robert, Mikkat, Stefan, Oehmcke-Hecht, Sonja

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Interferon regulatory factor 4 as a therapeutic target in adult T-cell leukemia lymphoma von Rauch, Daniel A., Olson, Sydney L., Harding, John C., Sundaramoorthi, Hemalatha, Kim, Youngsoo, Zhou, Tianyuan, MacLeod, A. Robert, Challen, Grant, Ratner, Lee

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Direct targeting of FOXP3 in Tregs with AZD8701, a novel antisense oligonucleotide to relieve immunosuppression in cancer von Revenko, Alexey, Carnevalli, Larissa S, Sinclair, Charles, Johnson, Ben, Peter, Alison, Taylor, Molly, Hettrick, Lisa, Chapman, Melissa, Klein, Stephanie, Solanki, Anisha, Gattis, Danielle, Watt, Andrew, Hughes, Adina M, Magiera, Lukasz, Kar, Gozde, Ireland, Lucy, Mele, Deanna A, Sah, Vasu, Singh, Maneesh, Walton, Josephine, Mairesse, Maelle, King, Matthew, Edbrooke, Mark, Lyne, Paul, Barry, Simon T, Fawell, Stephen, Goldberg, Frederick W, MacLeod, A Robert

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