Clinical stage drugs targeting inhibitor of apoptosis proteins purge episomal Hepatitis B viral genome in preclinical models von Clark, Michelle P., Huynh, Thao, Rao, Shringar, Mackiewicz, Liana, Mason, Hugh, Romal, Shahla, Stutz, Michael D., Ahn, Sang H., Earnest, Linda, Sozzi, Vitina, Littlejohn, Margaret, Tran, Bang M., Wiedemann, Norbert, Vincan, Elizabeth, Torresi, Joseph, Netter, Hans J., Mahmoudi, Tokameh, Revill, Peter, Pellegrini, Marc, Ebert, Gregor

Volltext

Necroptosis does not drive disease pathogenesis in a mouse infective model of SARS-CoV-2 in vivo von M. Bader, Stefanie, Cooney, James P., Bhandari, Reet, Mackiewicz, Liana, Dayton, Merle, Sheerin, Dylan, Georgy, Smitha Rose, Murphy, James M., Davidson, Kathryn C., Allison, Cody C., Pellegrini, Marc, Doerflinger, Marcel

Volltext

Combinatorial Treatment of Birinapant and Zosuquidar Enhances Effective Control of HBV Replication In Vivo von Morrish, Emma, Mackiewicz, Liana, Silke, Natasha, Pellegrini, Marc, Silke, John, Brumatti, Gabriela, Ebert, Gregor

Volltext

Targeting the Extrinsic Pathway of Hepatocyte Apoptosis Promotes Clearance of Plasmodium Liver Infection von Ebert, Gregor, Lopaticki, Sash, O’Neill, Matthew T., Steel, Ryan W.J., Doerflinger, Marcel, Rajasekaran, Pravin, Yang, Annie S.P., Erickson, Sara, Ioannidis, Lisa, Arandjelovic, Philip, Mackiewicz, Liana, Allison, Cody, Silke, John, Pellegrini, Marc, Boddey, Justin A.

Volltext

A necroptosis-independent function of RIPK3 promotes immune dysfunction and prevents control of chronic LCMV infection von Preston, Simon P., Allison, Cody C., Schaefer, Jan, Clow, William, Bader, Stefanie M., Collard, Sophie, Forsyth, Wasan O., Clark, Michelle P., Garnham, Alexandra L., Li-Wai-Suen, Connie S. N., Peiris, Thanushi, Teale, Jack, Mackiewicz, Liana, Davidson, Sophia, Doerflinger, Marcel, Pellegrini, Marc

Volltext

Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors von Calleja, Dale J, Kuchel, Nathan, Lu, Bernadine G C, Birkinshaw, Richard W, Klemm, Theresa, Doerflinger, Marcel, Cooney, James P, Mackiewicz, Liana, Au, Amanda E, Yap, Yu Q, Blackmore, Timothy R, Katneni, Kasiram, Crighton, Elly, Newman, Janet, Jarman, Kate E, Call, Melissa J, Lechtenberg, Bernhard C, Czabotar, Peter E, Pellegrini, Marc, Charman, Susan A, Lowes, Kym N, Mitchell, Jeffrey P, Nachbur, Ueli, Lessene, Guillaume, Komander, David

Volltext

Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway von Simpson, Daniel S., Pang, Jiyi, Weir, Ashley, Kong, Isabella Y., Fritsch, Melanie, Rashidi, Maryam, Cooney, James P., Davidson, Kathryn C., Speir, Mary, Djajawi, Tirta M., Hughes, Sebastian, Mackiewicz, Liana, Dayton, Merle, Anderton, Holly, Doerflinger, Marcel, Deng, Yexuan, Huang, Allan Shuai, Conos, Stephanie A., Tye, Hazel, Chow, Seong H., Rahman, Arfatur, Norton, Raymond S., Naderer, Thomas, Nicholson, Sandra E., Burgio, Gaetan, Man, Si Ming, Groom, Joanna R., Herold, Marco J., Hawkins, Edwin D., Lawlor, Kate E., Strasser, Andreas, Silke, John, Pellegrini, Marc, Kashkar, Hamid, Feltham, Rebecca, Vince, James E.

Volltext

Circulating BiP/Grp78 is a novel prognostic marker for sepsis‐mediated immune cell death von Doerflinger, Marcel, Reljic, Boris, Menassa, Joseph, Nedeva, Christina, Jose, Irvin, Faou, Pierre, Mackiewicz, Liana, Mansell, Ashley, Pellegrini, Marc, Hotchkiss, Richard, Puthalakath, Hamsa

Volltext

Epigenetic Silencing of RIPK3 in Hepatocytes Prevents MLKL-mediated Necroptosis From Contributing to Liver Pathologies von Preston, Simon P., Stutz, Michael D., Allison, Cody C., Nachbur, Ueli, Gouil, Quentin, Tran, Bang Manh, Duvivier, Valerie, Arandjelovic, Philip, Cooney, James P., Mackiewicz, Liana, Meng, Yanxiang, Schaefer, Jan, Bader, Stefanie M., Peng, Hongke, Valaydon, Zina, Rajasekaran, Pravin, Jennison, Charlie, Lopaticki, Sash, Farrell, Ann, Ryan, Marno, Howell, Jess, Croagh, Catherine, Karunakaran, Denuja, Schuster-Klein, Carole, Murphy, James M., Fifis, Theodora, Christophi, Christopher, Vincan, Elizabeth, Blewitt, Marnie E., Thompson, Alexander, Boddey, Justin A., Doerflinger, Marcel, Pellegrini, Marc

Volltext

SARS-CoV-2 mouse adaptation selects virulence mutations that cause TNF-driven age-dependent severe disease with human correlates von Bader, Stefanie M, Cooney, James P, Sheerin, Dylan, Taiaroa, George, Harty, Leigh, Davidson, Kathryn C, Mackiewicz, Liana, Dayton, Merle, Wilcox, Stephen, Whitehead, Lachlan, Rogers, Kelly L, Georgy, Smitha Rose, Coussens, Anna K, Grimley, Samantha L, Corbin, Vincent, Pitt, Miranda, Coin, Lachlan, Pickering, Raelene, Thomas, Merlin, Allison, Cody C, McAuley, Julie, Purcell, Damian F J, Doerflinger, Marcel, Pellegrini, Marc

Volltext

SAT-194-The utility of monomeric HBV genomes for interrogating the HBV cccDNA minichromosome, using in vitro and in vivo models of HBV replication von Huynh, Thao, Clark, Michelle, Mackiewicz, Liana, Sozzi, Vitini, Mason, Hugh, Pellegrini, Marc, Ebert, Greg, Netter, Hans J, Revill, Peter

Volltext

Endothelial Caspase-8 prevents fatal necroptotic hemorrhage caused by commensal bacteria von Bader, Stefanie M., Preston, Simon P., Saliba, Katie, Lipszyc, Adam, Grant, Zoe L., Mackiewicz, Liana, Baldi, Andrew, Hempel, Anne, Clark, Michelle P., Peiris, Thanushi, Clow, William, Bjelic, Jan, Stutz, Michael D., Arandjelovic, Philip, Teale, Jack, Du, Fashuo, Coultas, Leigh, Murphy, James M., Allison, Cody C., Pellegrini, Marc, Samson, Andre L.

Volltext

TARGETING MULTIDRUG RESISTANCE PROTEIN 1 (MDR1) POTENTIATES SMAC-MIMETIC THERAPY TO KILL LEUKEMIC STEM CELLS AND OVERCOME RESISTANCE IN ACUTE MYELOID LEUKEMIA von Morrish, Emma, Copeland, Anthony, Silke, Natasha, Beach, Jessica, Christie, Elizabeth, Sandow, Jarrod, Ebert, Gregor, Mackiewicz, Liana, Jarman, Kate, Moujalled, Donia, Pomilio, Giovanna, Fischer, Karla, Dawson, Mark, Bowtell, David, Pellegrini, Marc, Webb, Andrew, Wei, Andrew, Silke, John, Brumatti, Gabriela

Volltext

Clinical MDR1 inhibitors enhance Smac-mimetic bioavailability to kill murine LSCs and improve survival in AML models von Morrish, Emma, Copeland, Anthony, Moujalled, Donia M., Powell, Jason A., Silke, Natasha, Lin, Ann, Jarman, Kate E., Sandow, Jarrod J., Ebert, Gregor, Mackiewicz, Liana, Beach, Jessica A., Christie, Elizabeth L., Lewis, Alexander C., Pomilio, Giovanna, Fischer, Karla C., MacPherson, Laura, Bowtell, David D.L., Webb, Andrew I., Pellegrini, Marc, Dawson, Mark A., Pitson, Stuart M., Wei, Andrew H., Silke, John, Brumatti, Gabriela

Volltext