Cancer stem cells in glioblastoma von Lathia, Justin D, Mack, Stephen C, Mulkearns-Hubert, Erin E, Valentim, Claudia L L, Rich, Jeremy N

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A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer Stem Cell Heterogeneity of Tumors Found In Vivo von Hubert, Christopher G, Rivera, Maricruz, Spangler, Lisa C, Wu, Qiulian, Mack, Stephen C, Prager, Briana C, Couce, Marta, McLendon, Roger E, Sloan, Andrew E, Rich, Jeremy N

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Functional Enhancers Shape Extrachromosomal Oncogene Amplifications von Morton, Andrew R., Dogan-Artun, Nergiz, Faber, Zachary J., MacLeod, Graham, Bartels, Cynthia F., Piazza, Megan S., Allan, Kevin C., Mack, Stephen C., Wang, Xiuxing, Gimple, Ryan C., Wu, Qiulian, Rubin, Brian P., Shetty, Shashirekha, Angers, Stephane, Dirks, Peter B., Sallari, Richard C., Lupien, Mathieu, Rich, Jeremy N., Scacheri, Peter C.

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Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock von Dong, Zhen, Zhang, Guoxin, Qu, Meng, Gimple, Ryan C, Wu, Qiulian, Qiu, Zhixin, Prager, Briana C, Wang, Xiuxing, Kim, Leo J Y, Morton, Andrew R, Dixit, Deobrat, Zhou, Wenchao, Huang, Haidong, Li, Bin, Zhu, Zhe, Bao, Shideng, Mack, Stephen C, Chavez, Lukas, Kay, Steve A, Rich, Jeremy N

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Reciprocal Signaling between Glioblastoma Stem Cells and Differentiated Tumor Cells Promotes Malignant Progression von Wang, Xiuxing, Prager, Briana C., Wu, Qiulian, Kim, Leo J.Y., Gimple, Ryan C., Shi, Yu, Yang, Kailin, Morton, Andrew R., Zhou, Wenchao, Zhu, Zhe, Obara, Elisabeth Anne Adanma, Miller, Tyler E., Song, Anne, Lai, Sisi, Hubert, Christopher G., Jin, Xun, Huang, Zhi, Fang, Xiaoguang, Dixit, Deobrat, Tao, Weiwei, Zhai, Kui, Chen, Cong, Dong, Zhen, Zhang, Guoxin, Dombrowski, Stephen M., Hamerlik, Petra, Mack, Stephen C., Bao, Shideng, Rich, Jeremy N.

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AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells von Pei, Shanshan, Minhajuddin, Mohammad, Adane, Biniam, Khan, Nabilah, Stevens, Brett M., Mack, Stephen C., Lai, Sisi, Rich, Jeremy N., Inguva, Anagha, Shannon, Kevin M., Kim, Hyunmin, Tan, Aik-Choon, Myers, Jason R., Ashton, John M., Neff, Tobias, Pollyea, Daniel A., Smith, Clayton A., Jordan, Craig T.

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Glioma Stem Cell-Specific Superenhancer Promotes Polyunsaturated Fatty-Acid Synthesis to Support EGFR Signaling von Gimple, Ryan C, Kidwell, Reilly L, Kim, Leo J Y, Sun, Tengqian, Gromovsky, Anthony D, Wu, Qiulian, Wolf, Megan, Lv, Deguan, Bhargava, Shruti, Jiang, Li, Prager, Briana C, Wang, Xiuxing, Ye, Qing, Zhu, Zhe, Zhang, Guoxin, Dong, Zhen, Zhao, Linjie, Lee, Derrick, Bi, Junfeng, Sloan, Andrew E, Mischel, Paul S, Brown, J Mark, Cang, Hu, Huan, Tao, Mack, Stephen C, Xie, Qi, Rich, Jeremy N

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Purine synthesis promotes maintenance of brain tumor initiating cells in glioma von Wang, Xiuxing, Yang, Kailin, Xie, Qi, Wu, Qiulian, Mack, Stephen C, Shi, Yu, Kim, Leo J Y, Prager, Briana C, Flavahan, William A, Liu, Xiaojing, Singer, Meromit, Hubert, Christopher G, Miller, Tyler E, Zhou, Wenchao, Huang, Zhi, Fang, Xiaoguang, Regev, Aviv, Suvà, Mario L, Hwang, Tae Hyun, Locasale, Jason W, Bao, Shideng, Rich, Jeremy N

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Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas von Pajtler, Kristian W., Wen, Ji, Sill, Martin, Lin, Tong, Orisme, Wilda, Tang, Bo, Hübner, Jens-Martin, Ramaswamy, Vijay, Jia, Sujuan, Dalton, James D., Haupfear, Kelly, Rogers, Hazel A., Punchihewa, Chandanamali, Lee, Ryan, Easton, John, Wu, Gang, Ritzmann, Timothy A., Chapman, Rebecca, Chavez, Lukas, Boop, Fredrick A., Klimo, Paul, Sabin, Noah D., Ogg, Robert, Mack, Stephen C., Freibaum, Brian D., Kim, Hong Joo, Witt, Hendrik, Jones, David T. W., Vo, Baohan, Gajjar, Amar, Pounds, Stan, Onar-Thomas, Arzu, Roussel, Martine F., Zhang, Jinghui, Taylor, J. Paul, Merchant, Thomas E., Grundy, Richard, Tatevossian, Ruth G., Taylor, Michael D., Pfister, Stefan M., Korshunov, Andrey, Kool, Marcel, Ellison, David W.

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Deubiquitinase USP13 maintains glioblastoma stem cells by antagonizing FBXL14-mediated Myc ubiquitination von Fang, Xiaoguang, Zhou, Wenchao, Wu, Qiulian, Huang, Zhi, Shi, Yu, Yang, Kailin, Chen, Cong, Xie, Qi, Mack, Stephen C, Wang, Xiuxing, Carcaboso, Angel M, Sloan, Andrew E, Ouyang, Gaoliang, McLendon, Roger E, Bian, Xiu-Wu, Rich, Jeremy N, Bao, Shideng

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MYC-Regulated Mevalonate Metabolism Maintains Brain Tumor-Initiating Cells von Wang, Xiuxing, Huang, Zhi, Wu, Qiulian, Prager, Briana C, Mack, Stephen C, Yang, Kailin, Kim, Leo J Y, Gimple, Ryan C, Shi, Yu, Lai, Sisi, Xie, Qi, Miller, Tyler E, Hubert, Christopher G, Song, Anne, Dong, Zhen, Zhou, Wenchao, Fang, Xiaoguang, Zhu, Zhe, Mahadev, Vaidehi, Bao, Shideng, Rich, Jeremy N

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Why haven't we solved intracranial pediatric ependymoma? Current questions and barriers to treatment advances von Hwang, Eugene I., Hanson, Derek, Filbin, Mariella G., Mack, Stephen C.

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Delineation of Two Clinically and Molecularly Distinct Subgroups of Posterior Fossa Ependymoma von Witt, Hendrik, Mack, Stephen C., Ryzhova, Marina, Bender, Sebastian, Sill, Martin, Isserlin, Ruth, Benner, Axel, Hielscher, Thomas, Milde, Till, Remke, Marc, Jones, David T.W., Northcott, Paul A., Garzia, Livia, Bertrand, Kelsey C., Wittmann, Andrea, Yao, Yuan, Roberts, Stephen S., Massimi, Luca, Van Meter, Tim, Weiss, William A., Gupta, Nalin, Grajkowska, Wiesia, Lach, Boleslaw, Cho, Yoon-Jae, von Deimling, Andreas, Kulozik, Andreas E., Witt, Olaf, Bader, Gary D., Hawkins, Cynthia E., Tabori, Uri, Guha, Abhijit, Rutka, James T., Lichter, Peter, Korshunov, Andrey, Taylor, Michael D., Pfister, Stefan M.

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Childhood Medulloblastoma: Current Therapies, Emerging Molecular Landscape and Newer Therapeutic Insights von Khatua, Soumen, Song, Anne, Sridhar, Divyaswathi Citla, Mack, Stephen C

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Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion-Positive Supratentorial Ependymomas von Zheng, Tuyu, Ghasemi, David R, Okonechnikov, Konstantin, Korshunov, Andrey, Sill, Martin, Maass, Kendra K, Benites Goncalves da Silva, Patricia, Ryzhova, Marina, Gojo, Johannes, Stichel, Damian, Arabzade, Amir, Kupp, Robert, Benzel, Julia, Taya, Shinichiro, Adachi, Toma, Shiraishi, Ryo, Gerber, Nicolas U, Sturm, Dominik, Ecker, Jonas, Sievers, Philipp, Selt, Florian, Chapman, Rebecca, Haberler, Christine, Figarella-Branger, Dominique, Reifenberger, Guido, Fleischhack, Gudrun, Rutkowski, Stefan, Donson, Andrew M, Ramaswamy, Vijay, Capper, David, Ellison, David W, Herold-Mende, Christel C, Schüller, Ulrich, Brandner, Sebastian, Driever, Pablo Hernáiz, Kros, Johan M, Snuderl, Matija, Milde, Till, Grundy, Richard G, Hoshino, Mikio, Mack, Stephen C, Gilbertson, Richard J, Jones, David T W, Kool, Marcel, von Deimling, Andreas, Pfister, Stefan M, Sahm, Felix, Kawauchi, Daisuke, Pajtler, Kristian W

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Hotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome von Cohen, Andrea J., Saiakhova, Alina, Corradin, Olivia, Luppino, Jennifer M., Lovrenert, Katreya, Bartels, Cynthia F., Morrow, James J., Mack, Stephen C., Dhillon, Gursimran, Beard, Lydia, Myeroff, Lois, Kalady, Matthew F., Willis, Joseph, Bradner, James E., Keri, Ruth A., Berger, Nathan A., Pruett-Miller, Shondra M., Markowitz, Sanford D., Scacheri, Peter C.

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A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor von Sin-Chan, Patrick, Mumal, Iqra, Suwal, Tannu, Ho, Ben, Fan, Xiaolian, Singh, Irtisha, Du, Yuchen, Lu, Mei, Patel, Neilket, Torchia, Jonathon, Popovski, Dean, Fouladi, Maryam, Guilhamon, Paul, Hansford, Jordan R., Leary, Sarah, Hoffman, Lindsey M., Mulcahy Levy, Jean M., Lassaletta, Alvaro, Solano-Paez, Palma, Rivas, Eloy, Reddy, Alyssa, Gillespie, G. Yancey, Gupta, Nalin, Van Meter, Timothy E., Nakamura, Hideo, Wong, Tai-Tong, Ra, Young-Shin, Kim, Seung-Ki, Massimi, Luca, Grundy, Richard G., Fangusaro, Jason, Johnston, Donna, Chan, Jennifer, Lafay-Cousin, Lucie, Hwang, Eugene I., Wang, Yin, Catchpoole, Daniel, Michaud, Jean, Ellezam, Benjamin, Ramanujachar, Ramya, Lindsay, Holly, Taylor, Michael D., Hawkins, Cynthia E., Bouffet, Eric, Jabado, Nada, Singh, Sheila K., Kleinman, Claudia L., Barsyte-Lovejoy, Dalia, Li, Xiao-Nan, Dirks, Peter B., Lin, Charles Y., Mack, Stephen C., Rich, Jeremy N., Huang, Annie

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ZFTA-RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma von Arabzade, Amir, Zhao, Yanhua, Varadharajan, Srinidhi, Chen, Hsiao-Chi, Jessa, Selin, Rivas, Bryan, Stuckert, Austin J, Solis, Minerva, Kardian, Alisha, Tlais, Dana, Golbourn, Brian J, Stanton, Ann-Catherine J, Chan, Yuen San, Olson, Calla, Karlin, Kristen L, Kong, Kathleen, Kupp, Robert, Hu, Baoli, Injac, Sarah G, Ngo, Madeline, Wang, Peter R, De León, Luz A, Sahm, Felix, Kawauchi, Daisuke, Pfister, Stefan M, Lin, Charles Y, Hodges, H Courtney, Singh, Irtisha, Westbrook, Thomas F, Chintagumpala, Murali M, Blaney, Susan M, Parsons, Donald W, Pajtler, Kristian W, Agnihotri, Sameer, Gilbertson, Richard J, Yi, Joanna, Jabado, Nada, Kleinman, Claudia L, Bertrand, Kelsey C, Deneen, Benjamin, Mack, Stephen C

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The Meningioma Enhancer Landscape Delineates Novel Subgroups and Drives Druggable Dependencies von Prager, Briana C, Vasudevan, Harish N, Dixit, Deobrat, Bernatchez, Jean A, Wu, Qiulian, Wallace, Lisa C, Bhargava, Shruti, Lee, Derrick, King, Bradley H, Morton, Andrew R, Gimple, Ryan C, Pekmezci, Melike, Zhu, Zhe, Siqueira-Neto, Jair L, Wang, Xiuxing, Xie, Qi, Chen, Clark, Barnett, Gene H, Vogelbaum, Michael A, Mack, Stephen C, Chavez, Lukas, Perry, Arie, Raleigh, David R, Rich, Jeremy N

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RBPJ maintains brain tumor-initiating cells through CDK9-mediated transcriptional elongation von Xie, Qi, Wu, Qiulian, Kim, Leo, Miller, Tyler E, Liau, Brian B, Mack, Stephen C, Yang, Kailin, Factor, Daniel C, Fang, Xiaoguang, Huang, Zhi, Zhou, Wenchao, Alazem, Kareem, Wang, Xiuxing, Bernstein, Bradley E, Bao, Shideng, Rich, Jeremy N

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