Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease von Zhang, Bin, Gaiteri, Chris, Bodea, Liviu-Gabriel, Wang, Zhi, McElwee, Joshua, Podtelezhnikov, Alexei A., Zhang, Chunsheng, Xie, Tao, Tran, Linh, Dobrin, Radu, Fluder, Eugene, Clurman, Bruce, Melquist, Stacey, Narayanan, Manikandan, Suver, Christine, Shah, Hardik, Mahajan, Milind, Gillis, Tammy, Mysore, Jayalakshmi, MacDonald, Marcy E., Lamb, John R., Bennett, David A., Molony, Cliona, Stone, David J., Gudnason, Vilmundur, Myers, Amanda J., Schadt, Eric E., Neumann, Harald, Zhu, Jun, Emilsson, Valur

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The HTT CAG-Expansion Mutation Determines Age at Death but Not Disease Duration in Huntington Disease von Keum, Jae Whan, Shin, Aram, Gillis, Tammy, Mysore, Jayalakshmi Srinidhi, Abu Elneel, Kawther, Lucente, Diane, Hadzi, Tiffany, Holmans, Peter, Jones, Lesley, Orth, Michael, Kwak, Seung, MacDonald, Marcy E., Gusella, James F., Lee, Jong-Min

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RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression von Labadorf, Adam, Hoss, Andrew G, Lagomarsino, Valentina, Latourelle, Jeanne C, Hadzi, Tiffany C, Bregu, Joli, MacDonald, Marcy E, Gusella, James F, Chen, Jiang-Fan, Akbarian, Schahram, Weng, Zhiping, Myers, Richard H

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Genetic modifiers of Huntington's disease von Gusella, James F., MacDonald, Marcy E., Lee, Jong-Min

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Disruption of Neurexin 1 Associated with Autism Spectrum Disorder von Kim, Hyung-Goo, Kishikawa, Shotaro, Higgins, Anne W., Seong, Ihn-Sik, Donovan, Diana J., Shen, Yiping, Lally, Eric, Weiss, Lauren A., Najm, Juliane, Kutsche, Kerstin, Descartes, Maria, Holt, Lynn, Braddock, Stephen, Troxell, Robin, Kaplan, Lee, Volkmar, Fred, Klin, Ami, Tsatsanis, Katherine, Harris, David J., Noens, Ilse, Pauls, David L., Daly, Mark J., MacDonald, Marcy E., Morton, Cynthia C., Quade, Bradley J., Gusella, James F.

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A modifier of Huntington's disease onset at the MLH1 locus von Lee, Jong-Min, Chao, Michael J, Harold, Denise, Abu Elneel, Kawther, Gillis, Tammy, Holmans, Peter, Jones, Lesley, Orth, Michael, Myers, Richard H, Kwak, Seung, Wheeler, Vanessa C, MacDonald, Marcy E, Gusella, James F

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Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington’s disease knock-in mice is blocked by Mlh1 knock-out von Loupe, Jacob M, Pinto, Ricardo Mouro, Kim, Kyung-Hee, Gillis, Tammy, Mysore, Jayalakshmi S, Andrew, Marissa A, Kovalenko, Marina, Murtha, Ryan, Seong, IhnSik, Gusella, James F, Kwak, Seung, Howland, David, Lee, Ramee, Lee, Jong-Min, Wheeler, Vanessa C, MacDonald, Marcy E

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MicroRNAs located in the Hox gene clusters are implicated in huntington's disease pathogenesis von Hoss, Andrew G, Kartha, Vinay K, Dong, Xianjun, Latourelle, Jeanne C, Dumitriu, Alexandra, Hadzi, Tiffany C, Macdonald, Marcy E, Gusella, James F, Akbarian, Schahram, Chen, Jiang-Fan, Weng, Zhiping, Myers, Richard H

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Population-specific genetic modification of Huntington's disease in Venezuela von Chao, Michael J, Kim, Kyung-Hee, Shin, Jun Wan, Lucente, Diane, Wheeler, Vanessa C, Li, Hong, Roach, Jared C, Hood, Leroy, Wexler, Nancy S, Jardim, Laura B, Holmans, Peter, Jones, Lesley, Orth, Michael, Kwak, Seung, MacDonald, Marcy E, Gusella, James F, Lee, Jong-Min

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Complex reorganization and predominant non-homologous repair following chromosomal breakage in karyotypically balanced germline rearrangements and transgenic integration von Chiang, Colby, Jacobsen, Jessie C, Ernst, Carl, Hanscom, Carrie, Heilbut, Adrian, Blumenthal, Ian, Mills, Ryan E, Kirby, Andrew, Lindgren, Amelia M, Rudiger, Skye R, McLaughlan, Clive J, Bawden, C Simon, Reid, Suzanne J, Faull, Richard L M, Snell, Russell G, Hall, Ira M, Shen, Yiping, Ohsumi, Toshiro K, Borowsky, Mark L, Daly, Mark J, Lee, Charles, Morton, Cynthia C, MacDonald, Marcy E, Gusella, James F, Talkowski, Michael E

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Splice modulators target PMS1 to reduce somatic expansion of the Huntington’s disease-associated CAG repeat von McLean, Zachariah L., Gao, Dadi, Correia, Kevin, Roy, Jennie C. L., Shibata, Shota, Farnum, Iris N., Valdepenas-Mellor, Zoe, Kovalenko, Marina, Rapuru, Manasa, Morini, Elisabetta, Ruliera, Jayla, Gillis, Tammy, Lucente, Diane, Kleinstiver, Benjamin P., Lee, Jong-Min, MacDonald, Marcy E., Wheeler, Vanessa C., Mouro Pinto, Ricardo, Gusella, James F.

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Genetic Modification of Huntington Disease Acts Early in the Prediagnosis Phase von Long, Jeffrey D., Lee, Jong-Min, Aylward, Elizabeth H., Gillis, Tammy, Mysore, Jayalakshmi Srinidhi, Abu Elneel, Kawther, Chao, Michael J., Paulsen, Jane S., MacDonald, Marcy E., Gusella, James F.

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Transcriptional regulatory networks underlying gene expression changes in Huntington's disease von Ament, Seth A, Pearl, Jocelynn R, Cantle, Jeffrey P, Bragg, Robert M, Skene, Peter J, Coffey, Sydney R, Bergey, Dani E, Wheeler, Vanessa C, MacDonald, Marcy E, Baliga, Nitin S, Rosinski, Jim, Hood, Leroy E, Carroll, Jeffrey B, Price, Nathan D

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Rrs1 Is Involved in Endoplasmic Reticulum Stress Response in Huntington Disease von Carnemolla, Alisia, Fossale, Elisa, Agostoni, Elena, Michelazzi, Silvia, Calligaris, Raffaella, De Maso, Luca, Del Sal, Giannino, MacDonald, Marcy E., Persichetti, Francesca

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Huntingtin Controls Neurotrophic Support and Survival of Neurons by Enhancing BDNF Vesicular Transport along Microtubules von Gauthier, Laurent R, Charrin, Bénédicte C, Borrell-Pagès, Maria, Dompierre, Jim P, Rangone, Hélène, Cordelières, Fabrice P, De Mey, Jan, MacDonald, Marcy E, Leßmann, Volkmar, Humbert, Sandrine, Saudou, Frédéric

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A Homozygous Mutation in KCTD7 Links Neuronal Ceroid Lipofuscinosis to the Ubiquitin-Proteasome System von Staropoli, John F., Karaa, Amel, Lim, Elaine T., Kirby, Andrew, Elbalalesy, Naser, Romansky, Stephen G., Leydiker, Karen B., Coppel, Scott H., Barone, Rosemary, Xin, Winnie, MacDonald, Marcy E., Abdenur, Jose E., Daly, Mark J., Sims, Katherine B., Cotman, Susan L.

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Intergenerational and striatal CAG repeat instability in Huntington's disease knock-in mice involve different DNA repair genes von Dragileva, Ella, Hendricks, Audrey, Teed, Allison, Gillis, Tammy, Lopez, Edith T, Friedberg, Errol C, Kucherlapati, Raju, Edelmann, Winfried, Lunetta, Kathryn L, MacDonald, Marcy E, Wheeler, Vanessa C

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Hypomorphic mutation of the mouse Huntington's disease gene orthologue von Murthy, Vidya, Tebaldi, Toma, Yoshida, Toshimi, Erdin, Serkan, Calzonetti, Teresa, Vijayvargia, Ravi, Tripathi, Takshashila, Kerschbamer, Emanuela, Seong, Ihn Sik, Quattrone, Alessandro, Talkowski, Michael E, Gusella, James F, Georgopoulos, Katia, MacDonald, Marcy E, Biagioli, Marta

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Huntingtin facilitates polycomb repressive complex 2 von Seong, Ihn Sik, Woda, Juliana M., Song, Ji-Joon, Lloret, Alejandro, Abeyrathne, Priyanka D., Woo, Caroline J., Gregory, Gillian, Lee, Jong-Min, Wheeler, Vanessa C., Walz, Thomas, Kingston, Robert E., Gusella, James F., Conlon, Ronald A., MacDonald, Marcy E.

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Autophagy Is Disrupted in a Knock-in Mouse Model of Juvenile Neuronal Ceroid Lipofuscinosis von Cao, Yi, Espinola, Janice A., Fossale, Elisa, Massey, Ashish C., Cuervo, Ana Maria, MacDonald, Marcy E., Cotman, Susan L.

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