Comparative Analysis of Posiphen Pharmacokinetics across Different Species-Similar Absorption and Metabolism in Mouse, Rat, Dog and Human von Maccecchini, Maria L, Mould, Diane R

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Posiphen Reduces the Levels of Huntingtin Protein through Translation Suppression von Chen, Xu-Qiao, Barrero, Carlos A., Vasquez-Del Carpio, Rodrigo, Reddy, E. Premkumar, Fecchio, Chiara, Merali, Salim, Deglincerti, Alessia, Fang, Cheng, Rogers, Jack, Maccecchini, Maria L.

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Posiphen as a candidate drug to lower CSF amyloid precursor protein, amyloid-β peptide and τ levels: target engagement, tolerability and pharmacokinetics in humans von Maccecchini, Maria L, Chang, Mee Young, Pan, Catherine, John, Varghese, Zetterberg, Henrik, Greig, Nigel H

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Translational inhibition of APP by Posiphen: Efficacy, pharmacodynamics, and pharmacokinetics in the APP/PS1 mouse von Teich, Andrew F., Sharma, Ekta, Barnwell, Eliza, Zhang, Hong, Staniszewski, Agnieszka, Utsuki, Tadanobu, Padmaraju, Vasudevaraju, Mazell, Cheryl, Tzekou, Apostolia, Sambamurti, Kumar, Arancio, Ottavio, Maccecchini, Maria L.

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Do Mouse Data Lie? For Buntanetap, They Totally Predict Human Outcome von Maccecchini, Maria L., Fang, Cheng

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The alpha-synuclein 5'untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and Posiphen von Rogers, Jack T, Mikkilineni, Sohan, Cantuti-castelvetri, Ippolita, Smith, Deborah H, Huang, Xudong, Bandyopadhyay, Sanghamitra, Cahill, Catherine M, Maccecchini, Maria L, Lahiri, Debomoy K, Greig, Nigel H

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The alpha-synuclein 5′untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and Posiphen von Rogers, Jack T., Mikkilineni, Sohan, Cantuti-Castelvetri, Ippolita, Smith, Deborah H., Huang, Xudong, Bandyopadhyay, Sanghamitra, Cahill, Catherine M., Maccecchini, Maria L., Lahiri, Debomoy K., Greig, Nigel H.

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Posiphen'S Pharmacokinetics and Mechanism-of-action in Mildly Cognitive Impaired Patients von Maccecchini, Maria L

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INHIBITION OF APP/ABETA/CTF BY TRANSLATIONAL INHIBITION OF APP MRNA RESTORES VESICLE TRANSPORT IN TS65DN von Maccecchini, Maria L.

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Posiphen lowers amyloid precursor protein and amyloid β as well as acetylcholinesterase levels in culture, animals and humans von Maccecchini, Maria L, Roffman, Mark, Greig, Nigel

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Interim Analysis Results of Buntanetap in Phase 3 Clinical Studies in Alzheimer’s and Parkinson’s Disease von Fang, Cheng, Gaines, Melissa, Damiano, Eve, Nagy, Anne‐Marie, Ng, David, Maccecchini, Maria L.

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Translational Inhibition of Multiple Neurotoxic Proteins Leads to Improved Motor Function in Parkinson’s Disease von Fang, Cheng, Hernandez, Priscilla, Liow, Kore, Chen, Michael, Zetterberg, Henrik, Blennow, Kaj, Maccecchini, Maria L.

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Translational Inhibition of Multiple Neurotoxic Proteins Leads to Improved Cognition in Alzheimer’s Disease von Fang, Cheng, Hernandez, Priscilla, Liow, Kore, Chen, Michael, Zetterberg, Henrik, Blennow, Kaj, Maccecchini, Maria L.

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Positive clinical outcomes in two phase 2a studies: ADAS‐COG in Alzheimer’s and MDS‐UPDRS in Parkinson’s patients plus markers of toxic cascade that leads to nerve cell death... von Maccecchini, Maria L., Hernandez, Priscilla, Liow, Kore, Zetterberg, Henrik, Chen, Michael

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Stable Isotope Labelling Kinetics: Models and methods to evaluate APP production rates with Posiphen treatment in the DISCOVER clinical trial von Elbert, Donald L, Galasko, Douglas R., Farlow, Martin R., Aslanyan, Vahan, Pa, Judy, Lucey, Brendan, Honig, Lawrence S., Moghekar, Abhay, Bateman, Randall J., Momper, Jeremiah, Rissman, Robert A, Balasubramanian, Archana, Maccecchini, Maria L., Feldman, Howard H.

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SYM 2081, an agonist that desensitizes kainate receptors, attenuates capsaicin and inflammatory hyperalgesia von Turner, Michelle S., Hamamoto, Darryl T., Hodges, James S., Maccecchini, Maria L., Simone, Donald A.

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P4‐107: Posiphen'S Pharmacokinetics and Mechanism‐of‐action in Mildly Cognitive Impaired Patients von Maccecchini, Maria L.

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Translational inhibition of α-synuclein by Posiphen normalizes distal colon motility in transgenic Parkinson mice von Kuo, Yien-Ming, Nwankwo, Ejike Innocent, Nussbaum, Robert L, Rogers, Jack, Maccecchini, Maria L

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Posiphen as a candidate drug to lower CSF amyloid precursor protein, amyloid-[beta] peptide and [tau] levels: target engagement, tolerability and pharmacokinetics in humans von Maccecchini, Maria L, Chang, Mee Young, Pan, Catherine, John, Varghese, Zetterberg, Henrik, Greig, Nigel H

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P1‐243: Posiphen lowers amyloid precursor protein and amyloid β as well as acetylcholinesterase levels in culture, animals and humans von Maccecchini, Maria L., Roffman, Mark, Greig, Nigel

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