The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters von de Los Heros, Paola, Alessi, Dario R, Gourlay, Robert, Campbell, David G, Deak, Maria, Macartney, Thomas J, Kahle, Kristopher T, Zhang, Jinwei

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Cooperative control of holliday junction resolution and DNA repair by the SLX1 and MUS81-EME1 nucleases von Castor, Dennis, Nair, Nidhi, Déclais, Anne-Cécile, Lachaud, Christophe, Toth, Rachel, Macartney, Thomas J, Lilley, David M J, Arthur, J Simon C, Rouse, John

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PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65 von Kondapalli, Chandana, Kazlauskaite, Agne, Zhang, Ning, Woodroof, Helen I., Campbell, David G., Gourlay, Robert, Burchell, Lynn, Walden, Helen, Macartney, Thomas J., Deak, Maria, Knebel, Axel, Alessi, Dario R., Muqit, Miratul M. K.

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Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System von Simpson, Luke M., Macartney, Thomas J., Nardin, Alice, Fulcher, Luke J., Röth, Sascha, Testa, Andrea, Maniaci, Chiara, Ciulli, Alessio, Ganley, Ian G., Sapkota, Gopal P.

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The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt intera... von Ohta, Akihito, Schumacher, Frances-Rose, Mehellou, Youcef, Johnson, Clare, Knebel, Axel, Macartney, Thomas J, Wood, Nicola T, Alessi, Dario R, Kurz, Thimo

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Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1 von Lai, Yu-Chiang, Kondapalli, Chandana, Lehneck, Ronny, Procter, James B, Dill, Brian D, Woodroof, Helen I, Gourlay, Robert, Peggie, Mark, Macartney, Thomas J, Corti, Olga, Corvol, Jean-Christophe, Campbell, David G, Itzen, Aymelt, Trost, Matthias, Muqit, Miratul MK

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DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage von Davis, Emily J, Lachaud, Christophe, Appleton, Paul, Macartney, Thomas J, Näthke, Inke, Rouse, John

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Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling von Bustos, Francisco, Segarra-Fas, Anna, Nardocci, Gino, Cassidy, Andrew, Antico, Odetta, Davidson, Lindsay, Brandenburg, Lennart, Macartney, Thomas J., Toth, Rachel, Hastie, C. James, Moran, Jennifer, Gourlay, Robert, Varghese, Joby, Soares, Renata F., Montecino, Martin, Findlay, Greg M.

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Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2 von MacKay, Craig, Déclais, Anne-Cécile, Lundin, Cecilia, Agostinho, Ana, Deans, Andrew J., MacArtney, Thomas J., Hofmann, Kay, Gartner, Anton, West, Stephen C., Helleday, Thomas, Lilley, David M.J., Rouse, John

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The DUF1669 domain of FAM83 family proteins anchor casein kinase 1 isoforms von Fulcher, Luke J, Bozatzi, Polyxeni, Tachie-Menson, Theresa, Wu, Kevin Z L, Cummins, Timothy D, Bufton, Joshua C, Pinkas, Daniel M, Dunbar, Karen, Shrestha, Sabin, Wood, Nicola T, Weidlich, Simone, Macartney, Thomas J, Varghese, Joby, Gourlay, Robert, Campbell, David G, Dingwell, Kevin S, Smith, James C, Bullock, Alex N, Sapkota, Gopal P

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Targeting endogenous proteins for degradation through the affinity-directed protein missile system von Fulcher, Luke J., Hutchinson, Luke D., Macartney, Thomas J., Turnbull, Craig, Sapkota, Gopal P.

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A novel FAM83G variant from palmoplantar keratoderma patient disrupts WNT signalling via loss of FAM83G-CK1α interaction von Glennie, Lorraine, Solà, Marta Codina, Xunclà, Mar, Español, Gloria Aparicio, Garcia-Arumí, Elena, Tizzano, Eduardo Fidel, Wood, Nicola T, Macartney, Thomas J, Lasa-Aranzasti, Amaia, Sapkota, Gopal P

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Mapping the substrate landscape of protein phosphatase 2A catalytic subunit PPP2CA von Brewer, Abigail, Sathe, Gajanan, Pflug, Billie E., Clarke, Rosemary G., Macartney, Thomas J., Sapkota, Gopal P.

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Targeted dephosphorylation of TFEB promotes its nuclear translocation von Zhao, Jin-Feng, Shpiro, Natalia, Sathe, Gajanan, Brewer, Abigail, Macartney, Thomas J., Wood, Nicola T., Negoita, Florentina, Sakamoto, Kei, Sapkota, Gopal P.

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Targeted dephosphorylation of SMAD3 as an approach to impede TGF-β signaling von Brewer, Abigail, Zhao, Jin-Feng, Fasimoye, Rotimi, Shpiro, Natalia, Macartney, Thomas J., Wood, Nicola T., Wightman, Melanie, Alessi, Dario R., Sapkota, Gopal P.

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Kinase and channel activity of TRPM6 are co-ordinated by a dimerization motif and pocket interaction von van der Wijst, Jenny, Blanchard, Maxime G, Woodroof, Helen I, Macartney, Thomas J, Gourlay, Robert, Hoenderop, Joost G, Bindels, René J, Alessi, Dario R

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A conserved ATG2‐GABARAP family interaction is critical for phagophore formation von Bozic, Mihaela, van den Bekerom, Luuk, Milne, Beth A, Goodman, Nicola, Roberston, Lisa, Prescott, Alan R, Macartney, Thomas J, Dawe, Nina, McEwan, David G

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Identification of KLHDC2 as an efficient proximity-induced degrader of K-RAS, STK33, β-catenin, and FoxP3 von Röth, Sascha, Kocaturk, Nur Mehpare, Sathyamurthi, Preethi S., Carton, Bill, Watt, Matthew, Macartney, Thomas J., Chan, Kwok-Ho, Isidro-Llobet, Albert, Konopacka, Agnieszka, Queisser, Markus A., Sapkota, Gopal P.

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Pathogenic FAM83G palmoplantar keratoderma mutations inhibit the PAWS1:CK1α association and attenuate Wnt signalling von Wu, Kevin Z L, Jones, Rebecca A, Tachie-Menson, Theresa, Macartney, Thomas J, Wood, Nicola T, Varghese, Joby, Gourlay, Robert, Soares, Renata F, Smith, James C, Sapkota, Gopal P

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FAM83D directs protein kinase CK1α to the mitotic spindle for proper spindle positioning von Fulcher, Luke J, He, Zhengcheng, Mei, Lin, Macartney, Thomas J, Wood, Nicola T, Prescott, Alan R, Whigham, Arlene J, Varghese, Joby, Gourlay, Robert, Ball, Graeme, Clarke, Rosemary, Campbell, David G, Maxwell, Christopher A, Sapkota, Gopal P

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