Differentiating the mTOR inhibitors everolimus and sirolimus in the treatment of tuberous sclerosis complex von MacKeigan, Jeffrey P, Krueger, Darcy A

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Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy von Nicklin, Paul, Bergman, Philip, Zhang, Bailin, Triantafellow, Ellen, Wang, Henry, Nyfeler, Beat, Yang, Haidi, Hild, Marc, Kung, Charles, Wilson, Christopher, Myer, Vic E., MacKeigan, Jeffrey P., Porter, Jeffrey A., Wang, Y. Karen, Cantley, Lewis C., Finan, Peter M., Murphy, Leon O.

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The genomic landscape of tuberous sclerosis complex von Martin, Katie R., Zhou, Wanding, Bowman, Megan J., Shih, Juliann, Au, Kit Sing, Dittenhafer-Reed, Kristin E., Sisson, Kellie A., Koeman, Julie, Weisenberger, Daniel J., Cottingham, Sandra L., DeRoos, Steven T., Devinsky, Orrin, Winn, Mary E., Cherniack, Andrew D., Shen, Hui, Northrup, Hope, Krueger, Darcy A., MacKeigan, Jeffrey P.

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Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1 von Düvel, Katrin, Yecies, Jessica L., Menon, Suchithra, Raman, Pichai, Lipovsky, Alex I., Souza, Amanda L., Triantafellow, Ellen, Ma, Qicheng, Gorski, Regina, Cleaver, Stephen, Vander Heiden, Matthew G., MacKeigan, Jeffrey P., Finan, Peter M., Clish, Clary B., Murphy, Leon O., Manning, Brendan D.

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STAT3 is activated by JAK2 independent of key oncogenic driver mutations in non-small cell lung carcinoma von Looyenga, Brendan D, Hutchings, Danielle, Cherni, Irene, Kingsley, Chris, Weiss, Glen J, Mackeigan, Jeffrey P

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Mitochondrial morphological features are associated with fission and fusion events von Westrate, Laura M, Drocco, Jeffrey A, Martin, Katie R, Hlavacek, William S, MacKeigan, Jeffrey P

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Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance von Blenis, John, MacKeigan, Jeffrey P, Murphy, Leon O

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Morphological and behavioral impact of AAV2/5-mediated overexpression of human wildtype alpha-synuclein in the rat nigrostriatal system von Gombash, Sara E, Manfredsson, Fredric P, Kemp, Christopher J, Kuhn, Nathan C, Fleming, Sheila M, Egan, Ann E, Grant, Laura M, Ciucci, Michelle R, MacKeigan, Jeffrey P, Sortwell, Caryl E

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Computational analysis of an autophagy/translation switch based on mutual inhibition of MTORC1 and ULK1 von Szymańska, Paulina, Martin, Katie R, MacKeigan, Jeffrey P, Hlavacek, William S, Lipniacki, Tomasz

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A Potent and Selective ULK1 Inhibitor Suppresses Autophagy and Sensitizes Cancer Cells to Nutrient Stress von Martin, Katie R, Celano, Stephanie L, Solitro, Abigail R, Gunaydin, Hakan, Scott, Mark, O'Hagan, Ronan C, Shumway, Stuart D, Fuller, Peter, MacKeigan, Jeffrey P

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Persistent mitochondrial hyperfusion promotes G2/M accumulation and caspase-dependent cell death von Westrate, Laura M, Sayfie, Aaron D, Burgenske, Danielle M, MacKeigan, Jeffrey P

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A Mitochondrial RNAi Screen Defines Cellular Bioenergetic Determinants and Identifies an Adenylate Kinase as a Key Regulator of ATP Levels von Lanning, Nathan J., Looyenga, Brendan D., Kauffman, Audra L., Niemi, Natalie M., Sudderth, Jessica, DeBerardinis, Ralph J., MacKeigan, Jeffrey P.

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DDK Has a Primary Role in Processing Stalled Replication Forks to Initiate Downstream Checkpoint Signaling von Sasi, Nanda Kumar, Coquel, Flavie, Lin, Yea-Lih, MacKeigan, Jeffrey P, Pasero, Philippe, Weinreich, Michael

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PI3K-C2α knockdown decreases autophagy and maturation of endocytic vesicles von Merrill, Nathan M, Schipper, Joshua L, Karnes, Jonathan B, Kauffman, Audra L, Martin, Katie R, MacKeigan, Jeffrey P

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Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing von Stark, Mitchell S, Woods, Susan L, Gartside, Michael G, Bonazzi, Vanessa F, Dutton-Regester, Ken, Aoude, Lauren G, Chow, Donald, Sereduk, Chris, Niemi, Natalie M, Tang, Nanyun, Ellis, Jonathan J, Reid, Jeffrey, Zismann, Victoria, Tyagi, Sonika, Muzny, Donna, Newsham, Irene, Wu, YuanQing, Palmer, Jane M, Pollak, Thomas, Youngkin, David, Brooks, Bradford R, Lanagan, Catherine, Schmidt, Christopher W, Kobe, Bostjan, MacKeigan, Jeffrey P, Yin, Hongwei, Brown, Kevin M, Gibbs, Richard, Trent, Jeffrey, Hayward, Nicholas K

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A Network of Immediate Early Gene Products Propagates Subtle Differences in Mitogen-Activated Protein Kinase Signal Amplitude and Duration von Murphy, Leon O., MacKeigan, Jeffrey P., Blenis, John

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Metabolic profiling of triple-negative breast cancer cells reveals metabolic vulnerabilities von Lanning, Nathan J, Castle, Joshua P, Singh, Simar J, Leon, Andre N, Tovar, Elizabeth A, Sanghera, Amandeep, MacKeigan, Jeffrey P, Filipp, Fabian V, Graveel, Carrie R

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DDK Promotes Tumor Chemoresistance and Survival via Multiple Pathways von Sasi, Nanda Kumar, Bhutkar, Arjun, Lanning, Nathan J, MacKeigan, Jeffrey P, Weinreich, Michael

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Mitochondrial phosphorylation in apoptosis: flipping the death switch von Niemi, Natalie M, MacKeigan, Jeffrey P

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Kinase targets in renal-cell carcinomas: reassessing the old and discovering the new von Furge, Kyle A, PhD, MacKeigan, Jeffrey P, PhD, Teh, Bin T, Dr

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