The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals von Torrence, Margaret E., MacArthur, Michael R., Hosios, Aaron M., Valvezan, Alexander J., Asara, John M., Mitchell, James R., Manning, Brendan D.

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Age and life expectancy clocks based on machine learning analysis of mouse frailty von Schultz, Michael B., Kane, Alice E., Mitchell, Sarah J., MacArthur, Michael R., Warner, Elisa, Vogel, David S., Mitchell, James R., Howlett, Susan E., Bonkowski, Michael S., Sinclair, David A.

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AI-Predicted mTOR Inhibitor Reduces Cancer Cell Proliferation and Extends the Lifespan of C. elegans von Vidovic, Tinka, Dakhovnik, Alexander, Hrabovskyi, Oleksii, MacArthur, Michael R, Ewald, Collin Y

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Optimizing preclinical models of ageing for translation to clinical trials von Mitchell, Sarah J., MacArthur, Michael R., Kane, Alice E.

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Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses von Langston, P. Kent, Nambu, Aya, Jung, Jonathan, Shibata, Munehiko, Aksoylar, H. Ibrahim, Lei, Jiahui, Xu, Peining, Doan, Mary T., Jiang, Helen, MacArthur, Michael R., Gao, Xia, Kong, Yong, Chouchani, Edward T., Locasale, Jason W., Snyder, Nathaniel W., Horng, Tiffany

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Interferon-α2b Treatment for COVID-19 Is Associated with Improvements in Lung Abnormalities von Zhou, Qiong, MacArthur, Michael R., He, Xinliang, Wei, Xiaoshan, Zarin, Payam, Hanna, Bola S., Wang, Zi-Hao, Xiang, Xuan, Fish, Eleanor N.

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Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production von Longchamp, Alban, Mirabella, Teodelinda, Arduini, Alessandro, MacArthur, Michael R., Das, Abhirup, Treviño-Villarreal, J. Humberto, Hine, Christopher, Ben-Sahra, Issam, Knudsen, Nelson H., Brace, Lear E., Reynolds, Justin, Mejia, Pedro, Tao, Ming, Sharma, Gaurav, Wang, Rui, Corpataux, Jean-Marc, Haefliger, Jacques-Antoine, Ahn, Kyo Han, Lee, Chih-Hao, Manning, Brendan D., Sinclair, David A., Chen, Christopher S., Ozaki, C. Keith, Mitchell, James R.

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General control nonderepressible 2 (GCN2) as a therapeutic target in age-related diseases von Altintas, Ozlem, MacArthur, Michael R

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Gut Microbiota Predicts Healthy Late-Life Aging in Male Mice von Ke, Shanlin, Mitchell, Sarah J., MacArthur, Michael R., Kane, Alice E., Sinclair, David A., Venable, Emily M., Chadaideh, Katia S., Carmody, Rachel N., Grodstein, Francine, Mitchell, James R., Liu, Yangyu

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The mitochondrial DNA common deletion as a potential biomarker of cancer-associated fibroblasts from skin basal and squamous cell carcinomas von Fontana, Gabriele A., MacArthur, Michael R., Rotankova, Nadezhda, Di Filippo, Michela, Beer, Hans-Dietmar, Gahlon, Hailey L.

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Preoperative methionine restriction induces perivascular adipose tissue browning and improves vein graft remodeling in male mice von Kip, Peter, Sluiter, Thijs J., MacArthur, Michael R., Tao, Ming, Kruit, Nicky, Mitchell, Sarah J., Jung, Jonathan, Kooijman, Sander, Gorham, Josh, Seidman, Jonathan G., Quax, Paul H. A., Decano, Julius L., Aikawa, Masanori, Ozaki, C. Keith, Mitchell, James R., de Vries, Margreet R.

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Calpain Inhibition Protects against UVB-Induced Degradation of Dermal–Epidermal Junction–Associated Proteins von Doleckova, Iva, Vidovic, Tinka, Jandova, Lenka, Gretzmeier, Christine, Navarini, Alexander A., MacArthur, Michael R., Goksel, Orcun, Nyström, Alexander, Ewald, Collin Y.

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Total protein, not amino acid composition, differs in plant-based versus omnivorous dietary patterns and determines metabolic health effects in mice von MacArthur, Michael R., Mitchell, Sarah J., Treviño-Villarreal, J. Humberto, Grondin, Yohann, Reynolds, Justin S., Kip, Peter, Jung, Jonathan, Trocha, Kaspar M., Ozaki, C. Keith, Mitchell, James R.

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Short-term hypercaloric carbohydrate loading increases surgical stress resilience by inducing FGF21 von Agius, Thomas, Emsley, Raffaella, Lyon, Arnaud, MacArthur, Michael R., Kiesworo, Kevin, Faivre, Anna, Stavart, Louis, Lambelet, Martine, Legouis, David, de Seigneux, Sophie, Golshayan, Déla, Lazeyras, Francois, Yeh, Heidi, Markmann, James F., Uygun, Korkut, Ocampo, Alejandro, Mitchell, Sarah J., Allagnat, Florent, Déglise, Sébastien, Longchamp, Alban

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Intracellular H2S production is an autophagy-dependent adaptive response to DNA damage von Jiang, Xiaofeng, MacArthur, Michael R., Treviño-Villarreal, J. Humberto, Kip, Peter, Ozaki, C. Keith, Mitchell, Sarah J., Mitchell, James R.

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Investigating trajectories of aging using high-dimensional phenotyping in mice von MacArthur, Michael R., Mitchell, Sarah J.

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Chronic polypharmacy, monotherapy, and deprescribing: Understanding complex effects on the hepatic proteome of aging mice von Winardi, Kevin, Mach, John, McKay, Matthew J, Molloy, Mark P, Mitchell, Sarah J, MacArthur, Michael R, McKenzie, Catriona, Le Couteur, David G, Hilmer, Sarah N

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The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth von Schrötter, Sandra, Yuskaitis, Christopher J., MacArthur, Michael R., Mitchell, Sarah J., Hosios, Aaron M., Osipovich, Maria, Torrence, Margaret E., Mitchell, James R., Hoxhaj, Gerta, Sahin, Mustafa, Manning, Brendan D.

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Sodium thiosulfate acts as a hydrogen sulfide mimetic to prevent intimal hyperplasia via inhibition of tubulin polymerisation von Macabrey, Diane, Longchamp, Alban, MacArthur, Michael R., Lambelet, Martine, Urfer, Severine, Deglise, Sebastien, Allagnat, Florent

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Supporting employers and their employees with Mental hEalth problems to remain eNgaged and producTive at wORk (MENTOR): A feasibility randomised controlled trial protocol von Prudenzi, Arianna, Jadhakhan, Feroz, Gill, Kiranpreet, MacArthur, Michael, Patel, Krishane, Moukhtarian, Talar, Kershaw, Charlotte, Norton-Brown, Errin, Johnston, Naomi, Daly, Guy, Russell, Sean, Thomson, Louise, Munir, Fehmidah, Blake, Holly, Meyer, Caroline, Marwaha, Steven

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