Differential uptake, kinetics and mechanisms of intracellular trafficking of next-generation antisense oligonucleotides across human cancer cell lines von Linnane, Emily, Davey, Paul, Zhang, Pei, Puri, Sanyogitta, Edbrooke, Mark, Chiarparin, Elisabetta, Revenko, Alexey S, Macleod, A Robert, Norman, Jim C, Ross, Sarah J

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The Noncoding RNA MALAT1 Is a Critical Regulator of the Metastasis Phenotype of Lung Cancer Cells von GUTSCHNER, Tony, HÄMMERLE, Monika, ZÖRNIG, Martin, ROBERT MACLEOD, A, SPECTOR, David L, DIEDERICHS, Sven, EIBMANN, Moritz, HSU, Jeff, KIM, Youngsoo, HUNG, Gene, REVENKO, Alexey, ARUN, Gayatri, STENTRUP, Marion, GROSS, Matthias

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Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss von Arun, Gayatri, Diermeier, Sarah, Akerman, Martin, Chang, Kung-Chi, Wilkinson, J Erby, Hearn, Stephen, Kim, Youngsoo, MacLeod, A Robert, Krainer, Adrian R, Norton, Larry, Brogi, Edi, Egeblad, Mikala, Spector, David L

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Antisense STAT3 inhibitor decreases viability of myelodysplastic and leukemic stem cells von Shastri, Aditi, Choudhary, Gaurav, Teixeira, Margarida, Gordon-Mitchell, Shanisha, Ramachandra, Nandini, Bernard, Lumie, Bhattacharyya, Sanchari, Lopez, Robert, Pradhan, Kith, Giricz, Orsolya, Ravipati, Goutham, Wong, Li-Fan, Cole, Sally, Bhagat, Tushar D, Feld, Jonathan, Dhar, Yosman, Bartenstein, Matthias, Thiruthuvanathan, Victor J, Wickrema, Amittha, Ye, B Hilda, Frank, David A, Pellagatti, Andrea, Boultwood, Jacqueline, Zhou, Tianyuan, Kim, Youngsoo, MacLeod, A Robert, Epling-Burnette, P K, Ye, Minwei, McCoon, Patricia, Woessner, Richard, Steidl, Ulrich, Will, Britta, Verma, Amit

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Targeting nuclear RNA for in vivo correction of myotonic dystrophy von Wheeler, Thurman M., Leger, Andrew J., Pandey, Sanjay K., MacLeod, A. Robert, Nakamori, Masayuki, Cheng, Seng H., Wentworth, Bruce M., Bennett, C. Frank, Thornton, Charles A.

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RNA Therapeutics in Oncology: Advances, Challenges, and Future Directions von MacLeod, A. Robert, Crooke, Stanley T.

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Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer’s disease von Baker, Sarah K., Chen, Zu-Lin, Norris, Erin H., Revenko, Alexey S., MacLeod, A. Robert, Strickland, Sidney

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Telomere length is key to hepatocellular carcinoma diversity and telomerase addiction is an actionable therapeutic target von Ningarhari, Massih, Caruso, Stefano, Hirsch, Théo Z., Bayard, Quentin, Franconi, Andrea, Védie, Anne-Laure, Noblet, Bénédicte, Blanc, Jean-Frédéric, Amaddeo, Giuliana, Ganne, Nathalie, Ziol, Marianne, Paradis, Valérie, Guettier, Catherine, Calderaro, Julien, Morcrette, Guillaume, Kim, Youngsoo, MacLeod, A. Robert, Nault, Jean-Charles, Rebouissou, Sandra, Zucman-Rossi, Jessica

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Abstract ND11: The discovery and characterization of ION-537: A next generation antisense oligonucleotide inhibitor of YAP1 in preclinical cancer models von Macleod, A. Robert

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Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding von Revenko, Alexey S., Gao, Dacao, Crosby, Jeff R., Bhattacharjee, Gourab, Zhao, Chenguang, May, Chris, Gailani, David, Monia, Brett P., MacLeod, A. Robert

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LncRNA PVT1 up-regulation is a poor prognosticator and serves as a therapeutic target in esophageal adenocarcinoma von Xu, Yan, Li, Yuan, Jin, Jiankang, Han, Guangchun, Sun, Chengcao, Pizzi, Melissa Pool, Huo, Longfei, Scott, Ailing, Wang, Ying, Ma, Lang, Lee, Jeffrey H, Bhutani, Manoop S, Weston, Brian, Vellano, Christopher, Yang, Liuqing, Lin, Chunru, Kim, Youngsoo, MacLeod, A Robert, Wang, Linghua, Wang, Zhenning, Song, Shumei, Ajani, Jaffer A

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Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma von Fox, Raymond G., Lytle, Nikki K., Jaquish, Dawn V., Park, Frederick D., Ito, Takahiro, Bajaj, Jeevisha, Koechlein, Claire S., Zimdahl, Bryan, Yano, Masato, Kopp, Janel L., Kritzik, Marcie, Sicklick, Jason K., Sander, Maike, Grandgenett, Paul M., Hollingsworth, Michael A., Shibata, Shinsuke, Pizzo, Donald, Valasek, Mark A., Sasik, Roman, Scadeng, Miriam, Okano, Hideyuki, Kim, Youngsoo, MacLeod, A. Robert, Lowy, Andrew M., Reya, Tannishtha

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Are drivers recurring or ephemeral? observations from serial mapping of persistent atrial fibrillation von Hunt, Bram, Kwan, Eugene, Paccione, Eric, Orkild, Benjamin, Yazaki, Kyoichiro, Bergquist, Jake, Dong, Jiawei, MacLeod, Robert S, Dosdall, Derek J, Ranjan, Ravi

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Generation 2.5 antisense oligonucleotides targeting the androgen receptor and its splice variants suppress enzalutamide-resistant prostate cancer cell growth von Yamamoto, Yoshiaki, Loriot, Yohann, Beraldi, Eliana, Zhang, Fan, Wyatt, Alexander W, Al Nakouzi, Nader, Mo, Fan, Zhou, Tianyuan, Kim, Youngsoo, Monia, Brett P, MacLeod, A Robert, Fazli, Ladan, Wang, Yuzhuo, Collins, Colin C, Zoubeidi, Amina, Gleave, Martin

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Identification and characterization of modified antisense oligonucleotides targeting DMPK in mice and nonhuman primates for the treatment of myotonic dystrophy type 1 von Pandey, Sanjay K, Wheeler, Thurman M, Justice, Samantha L, Kim, Aneeza, Younis, Husam S, Gattis, Danielle, Jauvin, Dominic, Puymirat, Jack, Swayze, Eric E, Freier, Susan M, Bennett, C Frank, Thornton, Charles A, MacLeod, A Robert

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STAT3 antisense oligonucleotide AZD9150 in a subset of patients with heavily pretreated lymphoma: results of a phase 1b trial von Reilley, Matthew J, McCoon, Patricia, Cook, Carl, Lyne, Paul, Kurzrock, Razelle, Kim, Youngsoo, Woessner, Richard, Younes, Anas, Nemunaitis, John, Fowler, Nathan, Curran, Michael, Liu, Qinying, Zhou, Tianyuan, Schmidt, Joanna, Jo, Minji, Lee, Samantha J, Yamashita, Mason, Hughes, Steven G, Fayad, Luis, Piha-Paul, Sarina, Nadella, Murali V P, Xiao, Xiaokun, Hsu, Jeff, Revenko, Alexey, Monia, Brett P, MacLeod, A Robert, Hong, David S

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Antithrombotic Effect of Antisense Factor XI Oligonucleotide Treatment in Primates von Crosby, Jeffrey R, Marzec, Ulla, Revenko, Alexey S, Zhao, Chenguang, Gao, Dacao, Matafonov, Anton, Gailani, David, MacLeod, A Robert, Tucker, Erik I, Gruber, Andras, Hanson, Stephen R, Monia, Brett P

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Knockdown of circulating C1 inhibitor induces neurovascular impairment, glial cell activation, neuroinflammation, and behavioral deficits von Farfara, Dorit, Feierman, Emily, Richards, Allison, Revenko, Alexey S., MacLeod, Robert A., Norris, Erin H., Strickland, Sidney

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DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells von MacLeod, A. Robert, Robert, Marie-France, Morin, Steves, Beaulieu, Normand, Gauthier, France, Chute, Ian C, Barsalou, Annie

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Identifying locations of re-entrant drivers from patient-specific distribution of fibrosis in the left atrium von Roy, Aditi, Varela, Marta, Chubb, Henry, MacLeod, Robert, Hancox, Jules C, Schaeffter, Tobias, Aslanidi, Oleg

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