Modeling Tumor Phenotypes In Vitro with Three-Dimensional Bioprinting von Langer, Ellen M., Allen-Petersen, Brittany L., King, Shelby M., Kendsersky, Nicholas D., Turnidge, Megan A., Kuziel, Genevra M., Riggers, Rachelle, Samatham, Ravi, Amery, Taylor S., Jacques, Steven L., Sheppard, Brett C., Korkola, James E., Muschler, John L., Thibault, Guillaume, Chang, Young Hwan, Gray, Joe W., Presnell, Sharon C., Nguyen, Deborah G., Sears, Rosalie C.

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3D-Imaging of Whole Neuronal and Vascular Networks of the Human Dental Pulp via CLARITY and Light Sheet Microscopy von França, Cristiane Miranda, Riggers, Rachelle, Muschler, John L., Widbiller, Matthias, Lococo, Peter Manning, Diogenes, Anibal, Bertassoni, Luiz Eduardo

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A multiplex implantable microdevice assay identifies synergistic combinations of cancer immunotherapies and conventional drugs von Tatarova, Zuzana, Blumberg, Dylan C., Korkola, James E., Heiser, Laura M., Muschler, John L., Schedin, Pepper J., Ahn, Sebastian W., Mills, Gordon B., Coussens, Lisa M., Jonas, Oliver, Gray, Joe W.

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Suppression of dystroglycan function accompanies pancreatic acinar-to-ductal metaplasia and favours dysplasia development von Huang, Ge, Ternes, Luke, Lanciault, Christian, MacPherson-Hawthorne, Kevin, Chang, Young Hwan, Sears, Rosalie C, Muschler, John L

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Longitudinal Analysis of Human Pancreatic Adenocarcinoma Development Reveals Transient Gene Expression Signatures von Kim, Jungsun, Ekstrom, Taelor, Yang, Wenli, Donahue, Greg, Grygoryev, Dmytro, Ngo, Thuy T M, Muschler, John L, Morgan, Terry, Zaret, Kenneth S

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The polymeric fluoropyrimidine CF10 overcomes limitations of 5-FU in pancreatic ductal adenocarcinoma cells through increased replication stress von Finan, Jennifer M., Di Niro, Roberto, Park, Soon Young, Jeong, Kang Jin, Hedberg, Madeline D., Smith, Alexander, McCarthy, Grace A., Haber, Alex O., Muschler, John, Sears, Rosalie C., Mills, Gordon B., Gmeiner, William H., Brody, Jonathan R.

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Sustained activation of STAT5 is essential for chromatin remodeling and maintenance of mammary-specific function von Xu, Ren, Nelson, Celeste M, Muschler, John L, Veiseh, Mandana, Vonderhaar, Barbara K, Bissell, Mina J

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Endocytic trafficking of laminin is controlled by dystroglycan and is disrupted in cancers von Leonoudakis, Dmitri, Huang, Ge, Akhavan, Armin, Fata, Jimmie E, Singh, Manisha, Gray, Joe W, Muschler, John L

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Loss of Cell-Surface Laminin Anchoring Promotes Tumor Growth and Is Associated with Poor Clinical Outcomes von AKHAVAN, Armin, GRIFFITH, Obi L, SOROCEANU, Liliana, LEONOUDAKIS, Dmitri, LUCIANI-TORRES, Maria Gloria, DAEMEN, Anneleen, GRAY, Joe W, MUSCHLER, John L

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Raf-induced MMP9 disrupts tissue architecture of human breast cells in three-dimensional culture and is necessary for tumor growth in vivo von Beliveau, Alain, Mott, Joni D, Lo, Alvin, Chen, Emily I, Koller, Antonius A, Yaswen, Paul, Muschler, John, Bissell, Mina J

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Accessible high-throughput single-cell whole-genome sequencing with paired chromatin accessibility von Queitsch, Konstantin, Moore, Travis W, O'Connell, Brendan L, Nichols, Ruth V, Muschler, John L, Keith, Dove, Lopez, Charles, Sears, Rosalie C, Mills, Gordon B, Yardımcı, Galip Gürkan, Adey, Andrew C

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Molecular Recognition by LARGE Is Essential for Expression of Functional Dystroglycan von Kanagawa, Motoi, Saito, Fumiaki, Kunz, Stefan, Yoshida-Moriguchi, Takako, Barresi, Rita, Kobayashi, Yvonne M, Muschler, John, Dumanski, Jan P, Michele, Daniel E, Oldstone, Michael B.A, Campbell, Kevin P

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SEA domain proteolysis determines the functional composition of dystroglycan von Akhavan, Armin, Crivelli, Silvia N., Singh, Manisha, Lingappa, Vishwanath R., Muschler, John L.

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Dystroglycan controls signaling of multiple hormones through modulation of STAT5 activity von Leonoudakis, Dmitri, Singh, Manisha, Mohajer, Roozbeh, Mohajer, Pouya, Fata, Jimmie E, Campbell, Kevin P, Muschler, John L

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Dystroglycan loss disrupts polarity and β-casein induction in mammary epithelial cells by perturbing laminin anchoring von Weir, M. Lynn, Oppizzi, Maria Luisa, Henry, Michael D, Onishi, Akiko, Campbell, Kevin P, Bissell, Mina J, Muschler, John L

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Proteolytic enzymes and altered glycosylation modulate dystroglycan function in carcinoma cells von SINGH, Jarnail, ITAHANA, Yoko, KNIGHT-KRAJEWSKI, Selena, KANAGAWA, Motoi, CAMPBELL, Kevin P, BISSELL, Mina J, MUSCHLER, John

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Nuclear Translocation of β-Dystroglycan Reveals a Distinctive Trafficking Pattern of Autoproteolyzed Mucins von Oppizzi, Maria Luisa, Akhavan, Armin, Singh, Manisha, Fata, Jimmie E, Muschler, John L

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Far-Red and Near-Infrared Seminaphthofluorophores for Targeted Pancreatic Cancer Imaging von Wang, Lei, Barth, Connor W., Sibrian-Vazquez, Martha, Escobedo, Jorge O., Lowry, Mark, Muschler, John, Li, Haiyan, Gibbs, Summer L., Strongin, Robert M.

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Cell-matrix interactions in mammary gland development and breast cancer von Muschler, John, Streuli, Charles H

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Abstract A34: Suppression of dystroglycan function is a hallmark of acinar-to-ductal metaplasia and favors the development of neoplasias and PDAC von Huang, Ge, Lanciault, Christian, Sears, Rosalie, Muschler, John

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