The delivery challenge: fulfilling the promise of therapeutic genome editing von van Haasteren, Joost, Li, Jie, Scheideler, Olivia J., Murthy, Niren, Schaffer, David V.

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Detection of unamplified target genes via CRISPR–Cas9 immobilized on a graphene field-effect transistor von Hajian, Reza, Balderston, Sarah, Tran, Thanhtra, deBoer, Tara, Etienne, Jessy, Sandhu, Mandeep, Wauford, Noreen A., Chung, Jing-Yi, Nokes, Jolie, Athaiya, Mitre, Paredes, Jacobo, Peytavi, Regis, Goldsmith, Brett, Murthy, Niren, Conboy, Irina M., Aran, Kiana

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Synthetically modified guide RNA and donor DNA are a versatile platform for CRISPR-Cas9 engineering von Lee, Kunwoo, Mackley, Vanessa A, Rao, Anirudh, Chong, Anthony T, Dewitt, Mark A, Corn, Jacob E, Murthy, Niren

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A synthetic hydrogel for the high-throughput study of cell–ECM interactions von Rape, Andrew D., Zibinsky, Mikhail, Murthy, Niren, Kumar, Sanjay

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Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair von Lee, Kunwoo, Conboy, Michael, Park, Hyo Min, Jiang, Fuguo, Kim, Hyun Jin, Dewitt, Mark A., Mackley, Vanessa A., Chang, Kevin, Rao, Anirudh, Skinner, Colin, Shobha, Tamanna, Mehdipour, Melod, Liu, Hui, Huang, Wen-chin, Lan, Freeman, Bray, Nicolas L., Li, Song, Corn, Jacob E., Kataoka, Kazunori, Doudna, Jennifer A., Conboy, Irina, Murthy, Niren

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Nanoparticle delivery of CRISPR into the brain rescues a mouse model of fragile X syndrome from exaggerated repetitive behaviours von Lee, Bumwhee, Lee, Kunwoo, Panda, Shree, Gonzales-Rojas, Rodrigo, Chong, Anthony, Bugay, Vladislav, Park, Hyo Min, Brenner, Robert, Murthy, Niren, Lee, Hye Young

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End-point immobilization of heparin on plasma-treated surface of electrospun polycarbonate-urethane vascular graft von Qiu, Xuefeng, Lee, Benjamin Li-Ping, Ning, Xinghai, Murthy, Niren, Dong, Nianguo, Li, Song

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Dissolving polymer microneedle patches for influenza vaccination von del Pilar Martin, Maria, Murthy, Niren, Prausnitz, Mark R, Lee, Jeong Woo, Zarnitsyn, Vladimir, Choi, Seong-O, Skountzou, Ioanna, Sullivan, Sean P, Koutsonanos, Dimitrios G, Compans, Richard W

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Extension of the crRNA enhances Cpf1 gene editing in vitro and in vivo von Park, Hyo Min, Liu, Hui, Wu, Joann, Chong, Anthony, Mackley, Vanessa, Fellmann, Christof, Rao, Anirudh, Jiang, Fuguo, Chu, Hunghao, Murthy, Niren, Lee, Kunwoo

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Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway von Murthy, Niren, Pulendran, Bali, Kasturi, Sudhir Pai, Cao, Weiping, Tang, Hua, Pirani, Ali, Manicassamy, Santhakumar

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Polyketal Nanoparticles:  A New pH-Sensitive Biodegradable Drug Delivery Vehicle von Heffernan, Michael J, Murthy, Niren

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Enteric commensal bacteria potentiate epithelial restitution via reactive oxygen species-mediated inactivation of focal adhesion kinase phosphatases von Swanson, Phillip A. II, Kumar, Amrita, Samarin, Stanislav, Vijay-Kumar, Matam, Kundu, Kousik, Murthy, Niren, Hansen, Jason, Nusrat, Asma, Neish, Andrew S

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In utero delivery of mRNA to the heart, diaphragm and muscle with lipid nanoparticles von Gao, Kewa, Li, Jie, Song, Hengyue, Han, Hesong, Wang, Yongheng, Yin, Boyan, Farmer, Diana L., Murthy, Niren, Wang, Aijun

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Nanomedicine in GI von Laroui, Hamed, Wilson, David S, Dalmasso, Guillaume, Salaita, Khalid, Murthy, Niren, Sitaraman, Shanthi V, Merlin, Didier

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Maltohexaose-indocyanine green (MH-ICG) for near infrared imaging of endocarditis von Takemiya, Kiyoko, Røise, Joachim J, He, Maomao, Taing, Chung, Rodriguez, Alexander G, Murthy, Niren, Goodman, Mark M, Taylor, W Robert

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Peptide-enhanced mRNA transfection in cultured mouse cardiac fibroblasts and direct reprogramming towards cardiomyocyte-like cells von Lee, Kunwoo, Yu, Pengzhi, Lingampalli, Nithya, Kim, Hyun Jin, Tang, Richard, Murthy, Niren

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Dimensionless parameter predicts bacterial prodrug success von Holt, Brandon Alexander, Tuttle, McKenzie, Xu, Yilin, Su, Melanie, Røise, Joachim J, Wang, Xioajian, Murthy, Niren, Kwong, Gabriel A

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All-in-One Nanowire-Decorated Multifunctional Membrane for Rapid Cell Lysis and Direct DNA Isolation von So, Hongyun, Lee, Kunwoo, Murthy, Niren, Pisano, Albert P

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Making gene editing a therapeutic reality [version 1; peer review: 2 approved] von Conboy, Irina, Murthy, Niren, Etienne, Jessy, Robinson, Zachery

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Rapidly polymerizing injectable click hydrogel therapy to delay bone growth in a murine re-synostosis model von Hermann, Christopher D, Wilson, David S, Lawrence, Kelsey A, Ning, Xinghai, Olivares-Navarrete, Rene, Williams, Joseph K, Guldberg, Robert E, Murthy, Niren, Schwartz, Zvi, Boyan, Barbara D

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