Sensory Transformations: Environments, Technologies, Sensobiographies von Järviluoma, Helmi, Murray, Lesley

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Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents von Degtyarev, Michael, De Mazière, Ann, Orr, Christine, Lin, Jie, Lee, Brian B, Tien, Janet Y, Prior, Wei W, van Dijk, Suzanne, Wu, Hong, Gray, Daniel C, Davis, David P, Stern, Howard M, Murray, Lesley J, Hoeflich, Klaus P, Klumperman, Judith, Friedman, Lori S, Lin, Kui

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In vivo Antitumor Activity of MEK and Phosphatidylinositol 3-Kinase Inhibitors in Basal-Like Breast Cancer Models von HOEFLICH, Klaus P, O'BRIEN, Carol, WEI ZHOU, BERRY, Leanne, MURRAY, Lesley, AMLER, Lukas, BELVIN, Marcia, FRIEDMAN, Lori S, LACKNER, Mark R, BOYD, Zachary, CAVET, Guy, GUERRERO, Steve, JUNG, Kenneth, JANUARIO, Tom, SAVAGE, Heidi, PUNNOOSE, Elizabeth, TRUONG, Tom

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SU11248 Inhibits KIT and Platelet-derived Growth Factor Receptor β in Preclinical Models of Human Small Cell Lung Cancer von Abrams, Tinya J, Lee, Leslie B, Murray, Lesley J, Pryer, Nancy K, Cherrington, Julie M

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Efficacy of erenumab and factors predicting response after 3 months in treatment resistant chronic migraine: a clinical service evaluation von Lowe, Michael, Murray, Lesley, Tyagi, Alok, Gorrie, George, Miller, Sarah, Dani, Krishna

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GDC-0449—A potent inhibitor of the hedgehog pathway von Robarge, Kirk D., Brunton, Shirley A., Castanedo, Georgette M., Cui, Yong, Dina, Michael S., Goldsmith, Richard, Gould, Stephen E., Guichert, Oivin, Gunzner, Janet L., Halladay, Jason, Jia, Wei, Khojasteh, Cyrus, Koehler, Michael F.T., Kotkow, Karen, La, Hank, LaLonde, Rebecca L., Lau, Kevin, Lee, Leslie, Marshall, Derek, Marsters, James C., Murray, Lesley J., Qian, Changgeng, Rubin, Lee L., Salphati, Laurent, Stanley, Mark S., Stibbard, John H.A., Sutherlin, Daniel P., Ubhayaker, Savita, Wang, Shumei, Wong, Susan, Xie, Minli

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Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152) von Flygare, John A, Beresini, Maureen, Budha, Nageshwar, Chan, Helen, Chan, Iris T, Cheeti, Sravanthi, Cohen, Frederick, Deshayes, Kurt, Doerner, Karl, Eckhardt, S. Gail, Elliott, Linda O, Feng, Bainian, Franklin, Matthew C, Reisner, Stacy Frankovitz, Gazzard, Lewis, Halladay, Jason, Hymowitz, Sarah G, La, Hank, LoRusso, Patricia, Maurer, Brigitte, Murray, Lesley, Plise, Emile, Quan, Clifford, Stephan, Jean-Philippe, Young, Shin G, Tom, Jeffrey, Tsui, Vickie, Um, Joanne, Varfolomeev, Eugene, Vucic, Domagoj, Wagner, Andrew J, Wallweber, Heidi J. A, Wang, Lan, Ware, Joseph, Wen, Zhaoyang, Wong, Harvey, Wong, Jonathan M, Wong, Melisa, Wong, Susan, Yu, Ron, Zobel, Kerry, Fairbrother, Wayne J

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Suppression of HER2/HER3-Mediated Growth of Breast Cancer Cells with Combinations of GDC-0941 PI3K Inhibitor, Trastuzumab, and Pertuzumab von Yao, Evelyn, Zhou, Wei, Lee-Hoeflich, Si Tuen, Truong, Tom, Haverty, Peter M, Eastham-Anderson, Jeffrey, Lewin-Koh, Nicholas, Gunter, Bert, Belvin, Marcia, Murray, Lesley J, Friedman, Lori S, Sliwkowski, Mark X, Hoeflich, Klaus P

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Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window von Rudolph, Joachim, Murray, Lesley J, Ndubaku, Chudi O, O’Brien, Thomas, Blackwood, Elizabeth, Wang, Weiru, Aliagas, Ignacio, Gazzard, Lewis, Crawford, James J, Drobnick, Joy, Lee, Wendy, Zhao, Xianrui, Hoeflich, Klaus P, Favor, David A, Dong, Ping, Zhang, Haiming, Heise, Christopher E, Oh, Angela, Ong, Christy C, La, Hank, Chakravarty, Paroma, Chan, Connie, Jakubiak, Diana, Epler, Jennifer, Ramaswamy, Sreemathy, Vega, Roxanne, Cain, Gary, Diaz, Dolores, Zhong, Yu

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Discovery of a Potent (4R,5S)‑4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modelin... von Chen, Huifen, Volgraf, Matthew, Do, Steven, Kolesnikov, Aleksandr, Shore, Daniel G, Verma, Vishal A, Villemure, Elisia, Wang, Lan, Chen, Yong, Hu, Baihua, Lu, Ai-Jun, Wu, Guosheng, Xu, Xiaofeng, Yuen, Po-wai, Zhang, Yamin, Erickson, Shawn D, Dahl, Martin, Brotherton-Pleiss, Christine, Tay, Suzanne, Ly, Justin Q, Murray, Lesley J, Chen, Jun, Amm, Desiree, Lange, Wienke, Hackos, David H, Reese, Rebecca M, Shields, Shannon D, Lyssikatos, Joseph P, Safina, Brian S, Estrada, Anthony A

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Discovery of Selective 4‑Amino-pyridopyrimidine Inhibitors of MAP4K4 Using Fragment-Based Lead Identification and Optimization von Crawford, Terry D, Ndubaku, Chudi O, Chen, Huifen, Boggs, Jason W, Bravo, Brandon J, DeLaTorre, Kelly, Giannetti, Anthony M, Gould, Stephen E, Harris, Seth F, Magnuson, Steven R, McNamara, Erin, Murray, Lesley J, Nonomiya, Jim, Sambrone, Amy, Schmidt, Stephen, Smyczek, Tanya, Stanley, Mark, Vitorino, Philip, Wang, Lan, West, Kristina, Wu, Ping, Ye, Weilan

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Oncogenic BRAF is required for tumor growth and maintenance in melanoma models von HOEFLICH, Klaus P, GRAY, Daniel C, MURRAY, Lesley J, DAVIS, David P, SESHAGIRI, Somasekar, EBY, Michael T, TIEN, Janet Y, LEO WONG, BOWER, Janeko, GOGINENI, Alvin, JIPING ZHA, COLE, Mary J, STERN, Howard M

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Preclinical evaluation of the tyrosine kinase inhibitor SU11248 as a single agent and in combination with “standard of care” therapeutic agents for the treatment of breast cancer... von Abrams, Tinya J, Murray, Lesley J, Pesenti, Enrico, Holway, Vicky Walker, Colombo, Tina, Lee, Leslie B, Cherrington, Julie M, Pryer, Nancy K

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In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of... von MENDEL, Dirk B, LAIRD, A. Douglas, MURRAY, Lesley J, CARVER, Jeremy, CHAN, Emily, MOSS, Katherine G, HAZNEDAR, Joshua Ö, SUKBUNTHERNG, Juthamas, BLAKE, Robert A, LI SUN, CHO TANG, MILLER, Todd, XIAOHUA XIN, SHIRAZIAN, Sheri, MCMAHON, Gerald, CHERRINGTON, Julie M, LOUIE, Sharianne G, CHRISTENSEN, James G, GUANGMIN LI, SCHRECK, Randall E, ABRAMS, Tinya J, NGAI, Theresa J, LEE, Leslie B

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Impact on stakeholders of a cultural adaptation of a social and emotional well-being intervention in an Aboriginal community von Donovan, Robert J., Drane, Catherine F., Owen, Julie, Murray, Lesley, Nicholas, Amberlee, Anwar‐McHenry, Julia

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SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo von O'Farrell, Anne-Marie, Abrams, Tinya J., Yuen, Helene A., Ngai, Theresa J., Louie, Sharianne G., Yee, Kevin W.H., Wong, Lily M., Hong, Weiru, Lee, Leslie B., Town, Ajia, Smolich, Beverly D., Manning, William C., Murray, Lesley J., Heinrich, Michael C., Cherrington, Julie M.

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Lead optimization of a pyrazolo[1,5-a]pyrimidin-7(4H)-one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studies von Liang, Jun, Zhang, Birong, Labadie, Sharada, Ortwine, Daniel F., Vinogradova, Maia, Kiefer, James R., Gehling, Victor S., Harmange, Jean-Christophe, Cummings, Richard, Lai, Tommy, Liao, Jiangpeng, Zheng, Xiaoping, Liu, Yichin, Gustafson, Amy, Van der Porten, Erica, Mao, Weifeng, Liederer, Bianca M., Deshmukh, Gauri, Classon, Marie, Trojer, Patrick, Dragovich, Peter S., Murray, Lesley

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Design of Selective PAK1 Inhibitor G‑5555: Improving Properties by Employing an Unorthodox Low‑pK a Polar Moiety von Ndubaku, Chudi O, Crawford, James J, Drobnick, Joy, Aliagas, Ignacio, Campbell, David, Dong, Ping, Dornan, Laura M, Duron, Sergio, Epler, Jennifer, Gazzard, Lewis, Heise, Christopher E, Hoeflich, Klaus P, Jakubiak, Diana, La, Hank, Lee, Wendy, Lin, Baiwei, Lyssikatos, Joseph P, Maksimoska, Jasna, Marmorstein, Ronen, Murray, Lesley J, O’Brien, Thomas, Oh, Angela, Ramaswamy, Sreemathy, Wang, Weiru, Zhao, Xianrui, Zhong, Yu, Blackwood, Elizabeth, Rudolph, Joachim

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Discourses of Mobility: Institutions, Everyday Lives and Embodiment von Doughty, Karolina, Murray, Lesley

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Illuminating urban street (u)topias von Murray, Lesley, Robertson, Susan

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