Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial von Burn, John, Prof Sir, Gerdes, Anne-Marie, Prof, Macrae, Finlay, Prof, Mecklin, Jukka-Pekka, Prof, Moeslein, Gabriela, MD, Olschwang, Sylviane, MD, Eccles, Diane, Prof, Evans, D Gareth, Prof, Maher, Eamonn R, Prof, Bertario, Lucio, MD, Bisgaard, Marie-Luise, MD, Dunlop, Malcolm G, Prof, Ho, Judy WC, MD, Hodgson, Shirley V, Prof, Lindblom, Annika, Prof, Lubinski, Jan, Prof, Morrison, Patrick J, Prof, Murday, Victoria, MD, Ramesar, Raj, Prof, Side, Lucy, MD, Scott, Rodney J, Prof, Thomas, Huw JW, Prof, Vasen, Hans F, Prof, Barker, Gail, Crawford, Gillian, Elliott, Faye, Movahedi, Mohammad, PhD, Pylvanainen, Kirsi, Wijnen, Juul T, PhD, Fodde, Riccardo, Prof, Lynch, Henry T, Prof, Mathers, John C, Prof, Bishop, D Timothy, Prof

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Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome) von Mansour, Sahar, Ostergaard, Pia, Simpson, Michael A, Connell, Fiona C, Steward, Colin G, Brice, Glen, Woollard, Wesley J, Dafou, Dimitra, Kilo, Tatjana, Smithson, Sarah, Lunt, Peter, Murday, Victoria A, Hodgson, Shirley, Keenan, Russell, Pilz, Daniela T, Martinez-Corral, Ines, Makinen, Taija, Mortimer, Peter S, Jeffery, Steve, Trembath, Richard C

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Obesity, Aspirin, and Risk of Colorectal Cancer in Carriers of Hereditary Colorectal Cancer: A Prospective Investigation in the CAPP2 Study von Movahedi, Mohammad, Bishop, D Timothy, Macrae, Finlay, Mecklin, Jukka-Pekka, Moeslein, Gabriela, Olschwang, Sylviane, Eccles, Diana, Evans, D Gareth, Maher, Eamonn R, Bertario, Lucio, Bisgaard, Marie-Luise, Dunlop, Malcolm G, Ho, Judy W C, Hodgson, Shirley V, Lindblom, Annika, Lubinski, Jan, Morrison, Patrick J, Murday, Victoria, Ramesar, Raj S, Side, Lucy, Scott, Rodney J, Thomas, Huw J W, Vasen, Hans F, Burn, John, Mathers, John C

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Clinical Presentation and Penetrance of Pheochromocytoma/Paraganglioma Syndromes von Benn, Diana E., Gimenez-Roqueplo, Anne-Paule, Reilly, Jennifer R., Bertherat, Jérôme, Burgess, John, Byth, Karen, Croxson, Michael, Dahia, Patricia L. M., Elston, Marianne, Gimm, Oliver, Henley, David, Herman, Philippe, Murday, Victoria, Niccoli-Sire, Patricia, Pasieka, Janice L., Rohmer, Vincent, Tucker, Kathy, Jeunemaitre, Xavier, Marsh, Deborah J., Plouin, Pierre-François, Robinson, Bruce G.

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Novel SCN5A mutation in amiodarone-responsive multifocal ventricular ectopy-associated cardiomyopathy von Beckermann, Thomas M., PhD, McLeod, Karen, MD, Murday, Victoria, MD, Potet, Franck, PhD, George, Alfred L., MD

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Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial von Mathers, John C, Prof, Movahedi, Mohammad, PhD, Macrae, Finlay, Prof, Mecklin, Jukka-Pekka, MD, Moeslein, Gabriela, MD, Olschwang, Sylviane, MD, Eccles, Diana, Prof, Evans, Gareth, Prof, Maher, Eamonn R, Prof, Bertario, Lucio, MD, Bisgaard, Marie-Luise, MD, Dunlop, Malcolm, Prof, Ho, Judy WC, MD, Hodgson, Shirley, Prof, Lindblom, Annika, MD, Lubinski, Jan, Prof, Morrison, Patrick J, Prof, Murday, Victoria, MD, Ramesar, Raj, Prof, Side, Lucy, MD, Scott, Rodney J, PhD, Thomas, Huw JW, PhD, Vasen, Hans, MD, Gerdes, Anne-Marie, Prof, Barker, Gail, Crawford, Gillian, MSc, Elliott, Faye, MSc, Pylvanainen, Kirsi, CRA, Wijnen, Juul, PhD, Fodde, Riccardo, Prof, Lynch, Henry, Prof, Bishop, D Timothy, PhD, Burn, John, Prof Sir

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Molecular Analysis of Pheochromocytoma after Maternal Transmission of SDHD Mutation Elucidates Mechanism of Parent-of-Origin Effect von Yeap, Phey M, Tobias, Edward S, Mavraki, Eleni, Fletcher, Alexander, Bradshaw, Nicola, Freel, E. Marie, Cooke, Alexander, Murday, Victoria A, Davidson, H. Rosemarie, Perry, Colin G, Lindsay, Robert S

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Recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by mutation of ROR2 von Jeffery, Steve, Afzal, Ali R, Rajab, Anna, Fenske, Christiane D, Oldridge, Michael, Elanko, Navaratnam, Ternes-Pereira, Eliana, Tüysüz, Beyhan, Murday, Victoria A, Patton, Michael A, Wilkie, Andrew O.M

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X-linked cataract and Nance-Horan syndrome are allelic disorders von Coccia, Margherita, Brooks, Simon P., Webb, Tom R., Christodoulou, Katja, Wozniak, Izabella O., Murday, Victoria, Balicki, Martha, Yee, Harris A., Wangensteen, Teresia, Riise, Ruth, Saggar, Anand K., Park, Soo-Mi, Kanuga, Naheed, Francis, Peter J., Maher, Eamonn R., Moore, Anthony T., Russell-Eggitt, Isabelle M., Hardcastle, Alison J.

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Gene for arrhythmogenic right ventricular cardiomyopathy with diffuse nonepidermolytic palmoplantar keratoderma and woolly hair (naxos disease) maps to 17q21 von COONAR, A. S, PROTONOTARIOS, N, TSATSOPOULOU, A, NEEDHAM, E. W. A, HOULSTON, R. S, CLIFF, S, OTTER, M. I, MURDAY, V. A, MATTU, R. K, MCKENNA, W. J

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Evidence for 28 genetic disorders discovered by combining healthcare and research data von Kaplanis, Joanna, Samocha, Kaitlin E., Wiel, Laurens, Zhang, Zhancheng, Arvai, Kevin J., Eberhardt, Ruth Y., Gallone, Giuseppe, Lelieveld, Stefan H., Martin, Hilary C., McRae, Jeremy F., Short, Patrick J., Torene, Rebecca I., de Boer, Elke, Danecek, Petr, Gardner, Eugene J., Huang, Ni, Lord, Jenny, Martincorena, Iñigo, Pfundt, Rolph, Reijnders, Margot R. F., Yeung, Alison, Yntema, Helger G., Vissers, Lisenka E. L. M., Juusola, Jane, Wright, Caroline F., Brunner, Han G., Firth, Helen V., FitzPatrick, David R., Barrett, Jeffrey C., Hurles, Matthew E., Gilissen, Christian, Retterer, Kyle

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Prevalence and architecture of de novo mutations in developmental disorders von McRae, Jeremy F, Clayton, Stephen, Mason, Laura E, Tivey, Adrian R, Ahmed, Munaza, Awada, Jana, Balasubramanian, Meena, Banka, Siddharth, Bennett, Chris, Bernhard, Birgitta, Bevan, A. Paul, Blair, Edward, Blyth, Moira, Burn, John, Castle, Bruce, Clasper, Susan, Collins, Amanda, Collinson, Morag N, Dabir, Tabib, Davidson, Rosemarie, Davies, Sally, Dean, John, Donnai, Dian, Ellard, Sian, Ellis, Ian, Everest, Sarah, Foulds, Nicola, Fryer, Alan, Gaunt, Lorraine, Goudie, David, Gray, Emma, Greene, Philip, Gribble, Susan, Henderson, Alex, Hildyard, Lucy, Holden, Simon, Holder, Muriel, Ingram, Stuart, Jackson, Andrew, Kaemba, Beckie, Kazembe, Sandra, Kinning, Esther, Kraus, Alison, Kumar, V. K. Ajith, Lachlan, Katherine, Lam, Wayne, Lim, Derek, Longman, Cheryl, Lynch, Sally A, Maher, Eddy, Maye, Una, McKay, Kirsten, McWilliam, Catherine, Metcalfe, Kay, Morgan, Sian, Murday, Victoria, Murphy, Helen, Nemeth, Andrea, Nevitt, Louise, Newbury-Ecob, Ruth, Park, Soo-Mi, Paterson, Joan, Payne, Stewart, Perrett, Daniel, Pratt, Norman, Quarrell, Oliver, Randall, Josh, Rankin, Julia, Raymond, Lucy, Robert, Leema, Roberts, Paul, Saggar, Anand, Samant, Shalaka, Sampson, Julian, Sandford, Richard, Selby, Ann, Sequeira, Cheryl, Shearing, Emma, Smith, Audrey, Smith, Kath, Splitt, Miranda, Suri, Mohnish, Sutton, Vivienne, Tatton-Brown, Kate, Temple, I. Karen, Turner, Claire, Varghese, Vinod, Vasudevan, Pradeep, Vogt, Julie, Wakeling, Emma, Wilcox, Sarah, Williams, Denise, Williams, Nicola, Wilson, Louise, Wright, Michael, Yates, Laura, Yau, Michael, Wright, Caroline F, FitzPatrick, David R, Barrett, Jeffrey C

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Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas von Palles, Claire, Cazier, Jean-Baptiste, Howarth, Kimberley M, Domingo, Enric, Jones, Angela M, Broderick, Peter, Kemp, Zoe, Spain, Sarah L, Guarino, Estrella, Salguero, Israel, Sherborne, Amy, Chubb, Daniel, Carvajal-Carmona, Luis G, Ma, Yusanne, Kaur, Kulvinder, Dobbins, Sara, Barclay, Ella, Gorman, Maggie, Martin, Lynn, Kovac, Michal B, Humphray, Sean, Lucassen, Anneke, Holmes, Christopher C, Bentley, David, Donnelly, Peter, Taylor, Jenny, Petridis, Christos, Roylance, Rebecca, Sawyer, Elinor J, Kerr, David J, Clark, Susan, Grimes, Jonathan, Kearsey, Stephen E, Thomas, Huw J W, McVean, Gilean, Houlston, Richard S, Tomlinson, Ian

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Cancer Risks for BRCA1 and BRCA2 Mutation Carriers: Results From Prospective Analysis of EMBRACE von MAVADDAT, Nasim, PEOCK, Susan, DAVIDSON, Rosemarie, ECCLES, Diana, COLE, Trevor, COOK, Jackie, BREWER, Carole, TISCHKOWITZ, Marc, DOUGLAS, Fiona, HODGSON, Shirley, WALKER, Lisa, PORTEOUS, Mary E, FROST, Debra, MORRISON, Patrick J, SIDE, Lucy E, KENNEDY, M. John, HOUGHTON, Catherine, DONALDSON, Alan, ROGERS, Mark T, DORKINS, Huw, MIEDZYBRODZKA, Zosia, GREGORY, Helen, EASON, Jacqueline, ELLIS, Steve, BARWELL, Julian, MCCANN, Emma, MURRAY, Alex, ANTONIOU, Antonis C, EASTON, Douglas F, PLATTE, Radka, FINEBERG, Elena, EVANS, D. Gareth, IZATT, Louise, EELES, Rosalind A, ADLARD, Julian

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Histone Lysine Methylases and Demethylases in the Landscape of Human Developmental Disorders von Faundes, Víctor, Demos, Michelle K., Goldman, Amy, Lehman, Anna, McKee, Shane, Morton, Jenny, Rankin, Julia, Temple, I. Karen, Adam, Shelin, van Karnebeek, Clara, Aitken, Stuart, Alvi, Mohsan, Ambridge, Kirsty, Jones, Philip, Jones, Wendy D., Mason, Laura E., Tivey, Adrian R., Ahmed, Munaza, Balasubramanian, Meena, Barnicoat, Angela, Bitner-Glindzicz, Maria, Bourdon, Louise, Bradley, Lisa, Burn, John, Colgiu, Irina, Collins, Amanda, Collinson, Morag N., Connell, Fiona, Crow, Yanick, Dabir, Tabib, Davidson, Rosemarie, de Vries, Dylan, Deshpande, Charu, Dixit, Abhijit, Dobbie, Angus, Douzgou, Sofia, Duncan, Alexis, Eason, Jacqueline, Ellard, Sian, Elmslie, Frances, Evans, Karenza, Everest, Sarah, Flinter, Frances, Foulds, Nicola, Ghali, Neeti, Gibbons, Richard, Gill, Harinder, Greene, Philip, Gribble, Susan, Holder, Muriel, Hollingsworth, Georgina, Ingram, Stuart, Jenkins, Lucy, Joss, Shelagh, Kerr, Bronwyn, Kini, Usha, Kraus, Alison, Lachlan, Katherine, Marks, Karen, McConnell, Vivienne, McEntagart, Meriel, McGowan, Ruth, Middleton, Anna, Mohammed, Shehla, O’Shea, Rosie, Ogilvie, Caroline, Ong, Kai-Ren, Parker, Michael J., Patel, Chirag, Paterson, Joan, Payne, Stewart, Prescott, Katrina, Procter, Annie, Purnell, Hellen, Randall, Josh, Rankin, Julia, Raymond, Lucy, Rice, Debbie, Robert, Leema, Samant, Shalaka, Selby, Ann, Sequeira, Cheryl, Shears, Debbie, Smith, Audrey, Smith, Kath, Splitt, Miranda, Squires, Miranda, Tomkins, Susan, Treacy, Becky, Tysoe, Carolyn, Vasudevan, Pradeep, Vijayarangakannan, Parthiban, Vogt, Julie, Wakeling, Emma, Whiteford, Margo, Wilcox, Sarah, Wilkinson, Emily, Firth, Helen V., Wright, Caroline F., FitzPatrick, David R.

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Irbesartan in Marfan syndrome (AIMS): a double-blind, placebo-controlled randomised trial von Child, Anne, Stuart, A Graham, Aragon-Martin, José Antonio, Yuan, Li, Hu, Jiangting, Van Dyck, Laura, Knight, Rosemary, Clayton, Tim, Flather, Marcus, Dean, John, Gow, Heather, Murray, Jane, D'Allessandro, Mariella, Burns, Sharon, Paterson, Yvonne, Cotter, Catherine, Barclay, Justin, Prentice, Scott, O'Sullivan, John, Head-Baister, Alison, Crossland, D, Oliver, Jack, Wake, Jill, Quinn, Louise, Wealleans, Vera, Walker, Niki, Khambadkone, Sachin, Brady, Cassie, Szepezvary, Eszter, Titmus, Heather, Bo, Ilaria, Green, Loren, Jones, Nigel, Banks, Rebecca, Kiesewetter, Christopher, Mathur, Sujeev, Savis, Alex, Guzman, Josephine, Harris, Julia, Peacock, Kelly, Gibson, Kirsty, Kabir, Saleha, Mushemi, Sitali, Richardson, Cath, Leng, Elaine, Brennan, Paul, Nixon, Annabel, Turner, Louise, Bainbridge, Samantha, Kerr, Heather, Mordi, Ify, Duff, Jackie, Berg, Jonathan, Armory, Pauline, Freeman, Leisa, Anwar, Amir, Healey, Gail, Ilsley, Mary, Wood, Sheila, Wheeldon, Nigel, Middle, Janet, Walker, Rachel, Bennett, Tina, Clift, Paul, Alvior, Amor Mia, Green, Carole, West, Cathy, Naqvi, Nitha, Welch, Sophie, Farzad, Zohreh, Smith, Ben, Murday, Victoria, Murtagh, Eamonn, Adams, Emma, Richards, Amy, Andiapen, Mervyn, Hutchinson, Carmel, Newman, William G, Breen, Catherine, Kumar, Dhavendra, Wilson, Dirk G, Farrugia, Adele, Powell, Jessie, Hale, Terese, Boult, Zoe, Carroll, Aisling, Veldtman, Gruschen, Fletcher, Lisa, Mapstone, Sue, Marsh, Gary, Jones, Joanne, Sheehan, Karen, Stevenson, Kirsty, Nelson, Martin, Fairweather, Rebecca, Simpson, Sue, Steven, Jill, Munro, Joanna, Petrou, Mario, MacAllister, Raymond

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Pathology of Breast and Ovarian Cancers among BRCA1 and BRCA2 Mutation Carriers: Results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) von MAVADDAT, Nasim, BARROWDALE, Daniel, MULLIGAN, Anna Marie, COUCH, Fergus J, ENGEL, Christoph, MCGUFFOG, Lesley, HEALER, Sue, SINILNIKOVA, Olga M, SOUTHEY, Melissa C, TERRY, Mary Beth, GOLDGAR, David, O'MALLEY, Frances, ANDRULIS, Irene L, JOHN, Esther M, JANAVICIUS, Ramunas, TIHOMIROVA, Laima, HANSEN, Thomas V. O, NIELSEN, Finn C, OSORIO, Ana, STAVROPOULOU, Alexandra, BENITEZ, Javier, MANOUKIAN, Siranoush, PEISSEL, Bernard, DOMCHEK, Susan M, BARILE, Monica, VOLORIO, Sara, PASIN, Barbara, DOLCETTI, Riccardo, PUTIGNANO, Anna Laura, OTTINI, Laura, RADICE, Paolo, HAMANN, Ute, RASHID, Muhammad U, HOGERVORST, Frans B, ECCLES, Diana, KRIEGE, Mieke, VAN DER LUIJT, Rob B, HEBON, PEOCK, Susan, FROST, Debra, GARETH EVANS, D, BREWER, Carole, WALKER, Lisa, ROGERS, Mark T, SIDE, Lucy E, NEVANLINNA, Heli, HOUGHTON, Catherine, EMBRACE, WEAVER, Joellen, GODWIN, Andrew K, SCHMUTZLER, Rita K, WAPPENSCHMIDT, Barbara, MEINDL, Alfons, KAST, Karin, RAMUS, Susan J, SPURDLE, Amanda, ROBSON, Mark, SHERMAN, Mark

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CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language von Snijders Blok, Lot, Rousseau, Justine, Twist, Joanna, Ehresmann, Sophie, Takaku, Motoki, Venselaar, Hanka, Rodan, Lance H., Nowak, Catherine B., Douglas, Jessica, Swoboda, Kathryn J., Steeves, Marcie A., Sahai, Inderneel, Stumpel, Connie T. R. M., Stegmann, Alexander P. A., Wheeler, Patricia, Willing, Marcia, Fiala, Elise, Kochhar, Aaina, Gibson, William T., Cohen, Ana S. A., Agbahovbe, Ruky, Innes, A. Micheil, Au, P. Y. Billie, Rankin, Julia, Anderson, Ilse J., Skinner, Steven A., Louie, Raymond J., Warren, Hannah E., Afenjar, Alexandra, Keren, Boris, Nava, Caroline, Buratti, Julien, Isapof, Arnaud, Rodriguez, Diana, Lewandowski, Raymond, Propst, Jennifer, van Essen, Ton, Choi, Murim, Lee, Sangmoon, Chae, Jong H., Price, Susan, Schnur, Rhonda E., Douglas, Ganka, Wentzensen, Ingrid M., Zweier, Christiane, Reis, André, Bialer, Martin G., Moore, Christine, Koopmans, Marije, Brilstra, Eva H., Monroe, Glen R., van Gassen, Koen L. I., van Binsbergen, Ellen, Newbury-Ecob, Ruth, Bownass, Lucy, Bader, Ingrid, Mayr, Johannes A., Wortmann, Saskia B., Jakielski, Kathy J., Strand, Edythe A., Kloth, Katja, Bierhals, Tatjana, Roberts, John D., Petrovich, Robert M., Machida, Shinichi, Kurumizaka, Hitoshi, Lelieveld, Stefan, Pfundt, Rolph, Jansen, Sandra, Deriziotis, Pelagia, Faivre, Laurence, Thevenon, Julien, Assoum, Mirna, Shriberg, Lawrence, Kleefstra, Tjitske, Brunner, Han G., Wade, Paul A., Fisher, Simon E., Campeau, Philippe M.

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The contribution of X-linked coding variation to severe developmental disorders von Martin, Hilary C., Gardner, Eugene J., Samocha, Kaitlin E., Kaplanis, Joanna, Akawi, Nadia, Sifrim, Alejandro, Eberhardt, Ruth Y., Tavares, Ana Lisa Taylor, Neville, Matthew D. C., Niemi, Mari E. K., Gallone, Giuseppe, McRae, Jeremy, Wright, Caroline F., FitzPatrick, David R., Firth, Helen V., Hurles, Matthew E.

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147 Elevated Serum Troponin I Is Associated with Increased Risk in HCM von Connelly, Andrew, Coats, Caroline, Hunter, Amanda, Murday, Victoria, Findlay, Iain

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