Nuphar Dimers: Crouching Sulfur, Hidden Reactivity von Marcaurelle, Lisa A, Mulvihill, Mark J

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The RON Receptor Tyrosine Kinase Promotes Metastasis by Triggering MBD4-Dependent DNA Methylation Reprogramming von Cunha, Stéphanie, Lin, Yi-Chun, Goossen, Elizabeth A., DeVette, Christa I., Albertella, Mark R., Thomson, Stuart, Mulvihill, Mark J., Welm, Alana L.

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Optimization of a Novel Mandelamide-Derived Pyrrolopyrimidine Series of PERK Inhibitors von Stokes, Michael E, Surman, Matthew D, Calvo, Veronica, Surguladze, David, Li, An-Hu, Gasparek, Jennifer, Betzenhauser, Matthew, Zhu, Guangyu, Du, Hongwen, Rigby, Alan C, Mulvihill, Mark J

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A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like grow... von Ji, Qun-sheng, Mulvihill, Mark J, Rosenfeld-Franklin, Maryland, Cooke, Andrew, Feng, Lixin, Mak, Gilda, O'Connor, Matthew, Yao, Yan, Pirritt, Caroline, Buck, Elizabeth, Eyzaguirre, Alexandra, Arnold, Lee D, Gibson, Neil W, Pachter, Jonathan A

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Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor von Wu, Jinhua, Li, Wanqing, Craddock, Barbara P, Foreman, Kenneth W, Mulvihill, Mark J, Ji, Qun-sheng, Miller, W Todd, Hubbard, Stevan R

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A highly effective one-pot synthesis of quinolines from o-nitroarylcarbaldehydes von Li, An-Hu, Ahmed, Eilaf, Chen, Xin, Cox, Matthew, Crew, Andrew P, Dong, Han-Qing, Jin, Meizhong, Ma, Lifu, Panicker, Bijoy, Siu, Kam W, Steinig, Arno G, Stolz, Kathryn M, Tavares, Paula A R, Volk, Brian, Weng, Qinghua, Werner, Doug, Mulvihill, Mark J

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PERK Inhibition by HC-5404 Sensitizes Renal Cell Carcinoma Tumor Models to Antiangiogenic Tyrosine Kinase Inhibitors von Stokes, Michael E, Calvo, Veronica, Fujisawa, Sho, Dudgeon, Crissy, Huang, Sharon, Ballal, Nupur, Shen, Leyi, Gasparek, Jennifer, Betzenhauser, Matthew, Taylor, Simon J, Staschke, Kirk A, Rigby, Alan C, Mulvihill, Mark J, Bose, Nandita, Lightcap, Eric S, Surguladze, David

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Modulation of insulin-like growth factor-1 receptor and its signaling network for the treatment of cancer: current status and future perspectives von Jin, Meizhong, Buck, Elizabeth, Mulvihill, Mark J

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Inhibition of the eukaryotic initiation factor-2-α kinase PERK decreases risk of autoimmune diabetes in mice von Muralidharan, Charanya, Huang, Fei, Enriquez, Jacob R, Wang, Jiayi E, Nelson, Jennifer B, Nargis, Titli, May, Sarah C, Chakraborty, Advaita, Figatner, Kayla T, Navitskaya, Svetlana, Anderson, Cara M, Calvo, Veronica, Surguladze, David, Mulvihill, Mark J, Yi, Xiaoyan, Sarkar, Soumyadeep, Oakes, Scott A, Webb-Robertson, Bobbie-Jo M, Sims, Emily K, Staschke, Kirk A, Eizirik, Decio L, Nakayasu, Ernesto S, Stokes, Michael E, Tersey, Sarah A, Mirmira, Raghavendra G

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Discovery of 2-amino-3-amido-5-aryl-pyridines as highly potent, orally bioavailable, and efficacious PERK kinase inhibitors von Calvo, Veronica, Surguladze, David, Li, An-Hu, Surman, Matthew D., Malibhatla, Srikanth, Bandaru, Madhavarao, Jonnalagadda, Suresh Krishna, Adarasandi, Ravi, Velmala, Madhusudhan, Singireddi, Durga Rama Prasad, Velpuri, Mahendar, Nareddy, Bhaskar Reddy, Sastry, Visweswara, Mandati, Chiranjeevi, Guguloth, Rambabu, Siddiqui, Shapi, Patil, Basanagoud S., Chad, Elena, Wolfley, Jennifer, Gasparek, Jennifer, Feldman, Kirsten, Betzenhauser, Matthew, Wiens, Brent, Koszelak-Rosenblum, Mary, Zhu, Guangyu, Du, Hongwen, Rigby, Alan C., Mulvihill, Mark J.

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Discovery of 2,4‑1H‑Imidazole Carboxamides as Potent and Selective TAK1 Inhibitors von Veerman, Johan J. N, Bruseker, Yorik B, Damen, Eddy, Heijne, Erik H, van Bruggen, Wendy, Hekking, Koen F. W, Winkel, Rob, Hupp, Christopher D, Keefe, Anthony D, Liu, Julie, Thomson, Heather A, Zhang, Ying, Cuozzo, John W, McRiner, Andrew J, Mulvihill, Mark J, van Rijnsbergen, Peter, Zech, Birgit, Renzetti, Louis M, Babiss, Lee, Müller, Gerhard

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Discovery of 2,4-1 H -Imidazole Carboxamides as Potent and Selective TAK1 Inhibitors von Veerman, Johan J N, Bruseker, Yorik B, Damen, Eddy, Heijne, Erik H, van Bruggen, Wendy, Hekking, Koen F W, Winkel, Rob, Hupp, Christopher D, Keefe, Anthony D, Liu, Julie, Thomson, Heather A, Zhang, Ying, Cuozzo, John W, McRiner, Andrew J, Mulvihill, Mark J, van Rijnsbergen, Peter, Zech, Birgit, Renzetti, Louis M, Babiss, Lee, Müller, Gerhard

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Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: Optimization of kinase selectivity and pharmacokinetics von Hornberger, Keith R., Chen, Xin, Crew, Andrew P., Kleinberg, Andrew, Ma, Lifu, Mulvihill, Mark J., Wang, Jing, Wilde, Victoria L., Albertella, Mark, Bittner, Mark, Cooke, Andrew, Kadhim, Salam, Kahler, Jennifer, Maresca, Paul, May, Earl, Meyn, Peter, Romashko, Darlene, Tokar, Brianna, Turton, Roy

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Palladium-Catalyzed Direct Heck Arylation of Dual π-Deficient/π-Excessive Heteroaromatics. Synthesis of C-5 Arylated Imidazo[1,5-a]pyrazines von Wang, Jian-Xin, McCubbin, J. Adam, Jin, Meizhong, Laufer, Radoslaw S, Mao, Yunyu, Crew, Andrew P, Mulvihill, Mark J, Snieckus, Victor

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Discovery of potent, selective and orally bioavailable imidazo[1,5-a]pyrazine derived ACK1 inhibitors von Jin, Meizhong, Wang, Jing, Kleinberg, Andrew, Kadalbajoo, Mridula, Siu, Kam W., Cooke, Andrew, Bittner, Mark A., Yao, Yan, Thelemann, April, Ji, Qunsheng, Bhagwat, Shripad, Mulvihill, Kristen M., Rechka, Josef A., Pachter, Jonathan A., Crew, Andrew P., Epstein, David, Mulvihill, Mark J.

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Enzymatic Resolution of Aminocyclopentenols as Precursors to d- and l-Carbocyclic Nucleosides von Mulvihill, Mark J, Gage, Jennifer L, Miller, Marvin J

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The Crystal Structure of a Constitutively Active Mutant RON Kinase Suggests an Intramolecular Autophosphorylation Hypothesis von Wang, Jing, Steinbacher, Stefan, Augustin, Martin, Schreiner, Patrick, Epstein, David, Mulvihill, Mark J, Crew, Andrew P

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Novel 2-phenylquinolin-7-yl-derived imidazo[1,5- a]pyrazines as potent insulin-like growth factor-I receptor (IGF-IR) inhibitors von Mulvihill, Mark J., Ji, Qun-Sheng, Coate, Heather R., Cooke, Andrew, Dong, Hanqing, Feng, Lixin, Foreman, Kenneth, Rosenfeld-Franklin, Maryland, Honda, Ayako, Mak, Gilda, Mulvihill, Kristen M., Nigro, Anthony I., O’Connor, Matthew, Pirrit, Caroline, Steinig, Arno G., Siu, Kam, Stolz, Kathryn M., Sun, Yingchuan, Tavares, Paula A.R., Yao, Yan, Gibson, Neil W.

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Novel 6-aminofuro[3,2-c]pyridines as potent, orally efficacious inhibitors of cMET and RON kinases von Steinig, Arno G., Li, An-Hu, Wang, Jing, Chen, Xin, Dong, Hanqing, Ferraro, Caterina, Jin, Meizhong, Kadalbajoo, Mridula, Kleinberg, Andrew, Stolz, Kathryn M., Tavares-Greco, Paula A., Wang, Ti, Albertella, Mark R., Peng, Yue, Crew, Linda, Kahler, Jennifer, Kan, Julie, Schulz, Ryan, Cooke, Andy, Bittner, Mark, Turton, Roy W., Franklin, Maryland, Gokhale, Prafulla, Landfair, Darla, Mantis, Christine, Workman, Jen, Wild, Robert, Pachter, Jonathan, Epstein, David, Mulvihill, Mark J.

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Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1 von Hornberger, Keith R., Berger, Dan M., Crew, Andrew P., Dong, Hanqing, Kleinberg, Andrew, Li, An-Hu, Medeiros, Matthew R., Mulvihill, Mark J., Siu, Kam, Tarrant, James, Wang, Jing, Weng, Felix, Wilde, Victoria L., Albertella, Mark, Bittner, Mark, Cooke, Andrew, Gray, Michael J., Maresca, Paul, May, Earl, Meyn, Peter, Peick, William, Romashko, Darlene, Tanowitz, Michael, Tokar, Brianna

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