Lenalidomide and CC-4047 inhibit the proliferation of malignant B cells while expanding normal CD34+ progenitor cells von VERHELLE, Dominique, CORRAL, Laura G, LOPEZ-GIRONA, Antonia, MUTTER, George W, BRADY, Helen A, CHAN, Kyle W. H, WONG, Kevin, MUELLER, Jessica H, MOUTOUH-DE PARSEVAL, Laure, JENSEN-PERGAKES, Kristen, SCHAFER, Peter H, CHEN, Roger, GLEZER, Emilia, FERGUSON, Gregory D

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The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions von Lu, Ling, Payvandi, Faribourz, Wu, Lei, Zhang, Ling-Hua, Hariri, Robert J, Man, Hon-Wah, Chen, Roger S., Muller, George W., Hughes, Christopher C.W., Stirling, David I., Schafer, Peter H., Bartlett, J. Blake

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Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma von Davies, Faith E., Raje, Noopur, Hideshima, Teru, Lentzsch, Suzanne, Young, Gloria, Tai, Yu-Tzu, Lin, Boris, Podar, Klaus, Gupta, Deepak, Chauhan, Dharminder, Treon, Steven P., Richardson, Paul G., Schlossman, Robert L., Morgan, Gareth J., Muller, George W., Stirling, David I., Anderson, Kenneth C.

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Thalidomide and Lenalidomide Extend Survival in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis von Kiaei, Mahmoud, Petri, Susanne, Kipiani, Khatuna, Gardian, Gabrielle, Choi, Dong-Kug, Chen, Junyu, Calingasan, Noel Y, Schafer, Peter, Muller, George W, Stewart, Charles, Hensley, Kenneth, Beal, M. Flint

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Isosteric analogs of lenalidomide and pomalidomide: Synthesis and biological activity von Ruchelman, Alexander L., Man, Hon-Wah, Zhang, Weihong, Chen, Roger, Capone, Lori, Kang, Jian, Parton, Anastasia, Corral, Laura, Schafer, Peter H., Babusis, Darius, Moghaddam, Mehran F., Tang, Yang, Shirley, Michael A., Muller, George W.

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1,1-Diarylalkenes as anticancer agents: Dual inhibitors of tubulin polymerization and phosphodiesterase 4 von Ruchelman, Alexander L., Man, Hon-Wah, Chen, Roger, Liu, Wei, Lu, Ling, Cedzik, Dorota, Zhang, Ling, Leisten, Jim, Collette, Alice, Narla, Rama Krishna, Raymon, Heather K., Muller, George W.

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Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiester... von Man, Hon-Wah, Schafer, Peter, Wong, Lu Min, Patterson, Rebecca T, Corral, Laura G, Raymon, Heather, Blease, Kate, Leisten, Jim, Shirley, Michael A, Tang, Yang, Babusis, Darius M, Chen, Roger, Stirling, Dave, Muller, George W

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CC-5079: A Small Molecule with MKP1, Antiangiogenic, and Antitumor Activity von Vu, Huan N., M.D, Miller, Walter J., D.O, O'Connor, Sarah A., B.S, He, Mei, M.S, Schafer, Peter H., Ph.D, Payvandi, Faribourz, Ph.D, Muller, George W., Ph.D, Stirling, David I, Libutti, Steven K., M.D

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Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiester... von MAN, Hon-Wah, SCHAFER, Peter, BABUSIS, Darius M, CHEN, Roger, STIRLING, Dave, MULLER, George W, LU MIN WONG, PATTERSON, Rebecca T, CORRAL, Laura G, RAYMON, Heather, BLEASE, Kate, LEISTEN, Jim, SHIRLEY, Michael A, YANG TANG

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Combination therapy targeting the tumor microenvironment is effective in a model of human ocular melanoma von Mangiameli, David P, Blansfield, Joseph A, Kachala, Stephan, Lorang, Dominique, Schafer, Peter H, Muller, George W, Stirling, David I, Libutti, Steven K

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Pomalidomide and Lenalidomide Induce p21WAF-1 Expression in Both Lymphoma and Multiple Myeloma through a LSD1-Mediated Epigenetic Mechanism von ESCOUBET-LOZACH, Laure, LIN, I-Lin, JENSEN-PERGAKES, Kristen, BRADY, Helen A, GANDHI, Anita K, SCHAFER, Peter H, MULLER, George W, WORLAND, Peter J, CHAN, Kyle W. H, VERHELLE, Dominique

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Protective Antitumor Immunity Induced by a Costimulatory Thalidomide Analog in Conjunction with Whole Tumor Cell Vaccination Is Mediated by Increased Th1-Type Immunity von Dredge, Keith, Marriott, J. Blake, Todryk, Stephen M, Muller, George W, Chen, Roger, Stirling, David I, Dalgleish, Angus G

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A novel technique for quantifying changes in vascular density, endothelial cell proliferation and protein expression in response to modulators of angiogenesis using the chick chori... von Miller, Walter J, Kayton, Mark L, Patton, Angela, O'Connor, Sarah, He, Mei, Vu, Huan, Baibakov, Galina, Lorang, Dominique, Knezevic, Vladimir, Kohn, Elise, Alexander, H Richard, Stirling, David, Payvandi, Faribourz, Muller, George W, Libutti, Steven K

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The synthetic compound CC-5079 is a potent inhibitor of tubulin polymerization and tumor necrosis factor-α production with antitumor activity von ZHANG, Ling-Hua, LEI WU, BARTLETT, J. Blake, SCHAFER, Peter H, PAWANDI, Faribourz, RAYMON, Heather K, CHEN, Roger S, CORRAL, Laura, SHIRLEY, Michael A, NARLA, Rama Krishna, GAMEZ, Jim, MULLER, George W, STIRLING, David I

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Chiral inversion of the second generation IMiD™ CC-4047 (ACTIMID™) in human plasma and phosphate-buffered saline von Teo, Steve K., Chen, Yong, Muller, George W., Chen, Roger S., D. Thomas, Steve, Stirling, David I., Chandula, Reddy S.

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A novel subclass of thalidomide analogue with anti-solid tumor activity in which caspase-dependent apoptosis is associated with altered expression of bcl-2 family proteins von MARRIOTT, J. Blake, CLARKE, Ian A, DALGLEISH, Angus G, CZAJKA, Anna, DREDGE, Keith, CHILDS, Kay, MAN, Hon-Wah, SCHAFER, Peter, GOVINDA, Sowmya, MULLER, George W, STIRLING, David I

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α-Fluoro-substituted thalidomide analogues von MAN, Hon-Wah, CORRAL, Laura G, STIRLING, David I, MULLER, George W

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Antiproliferative effects of CC-8062 and CC-8075 in pancreatic cancer cells von Mouratidis, Petros X E, Colston, Kay W, Bartlett, Jake Blake, Muller, George W, Man, Hon-Wah, Stirling, David, Dalgleish, Angus G

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Structural Modifications of Thalidomide Produce Analogs with Enhanced Tumor Necrosis Factor Inhibitory Activity von Muller, George W, Corral, Laura G, Shire, Mary G, Wang, Hua, Moreira, Andre, Kaplan, Gilla, Stirling, David I

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A Concise Two-Step Synthesis of Thalidomide von Muller, George W, Konnecke, William E, Smith, Alison M, Khetani, Vikram D

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