PROTAC-Mediated Degradation of Bruton’s Tyrosine Kinase Is Inhibited by Covalent Binding von Tinworth, Christopher P, Lithgow, Hannah, Dittus, Lars, Bassi, Zuni I, Hughes, Sophie E, Muelbaier, Marcel, Dai, Han, Smith, Ian E. D, Kerr, William J, Burley, Glenn A, Bantscheff, Marcus, Harling, John D

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Differential Kinobeads Profiling for Target Identification of Irreversible Kinase Inhibitors von Dittus, Lars, Werner, Thilo, Muelbaier, Marcel, Bantscheff, Marcus

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Discovery of GSK8612, a Highly Selective and Potent TBK1 Inhibitor von Thomson, Douglas W, Poeckel, Daniel, Zinn, Nico, Rau, Christina, Strohmer, Katrin, Wagner, Anne J, Graves, Alan P, Perrin, Jessica, Bantscheff, Marcus, Duempelfeld, Birgit, Kasparcova, Viera, Ramanjulu, Joshi M, Pesiridis, G. Scott, Muelbaier, Marcel, Bergamini, Giovanna

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A caged E3 ligase ligand for PROTAC-mediated protein degradation with light von Kounde, Cyrille S, Shchepinova, Maria M, Saunders, Charlie N, Muelbaier, Marcel, Rackham, Mark D, Harling, John D, Tate, Edward W

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Design of amidobenzimidazole STING receptor agonists with systemic activity von Ramanjulu, Joshi M., Pesiridis, G. Scott, Yang, Jingsong, Concha, Nestor, Singhaus, Robert, Zhang, Shu-Yun, Tran, Jean-Luc, Moore, Patrick, Lehmann, Stephanie, Eberl, H. Christian, Muelbaier, Marcel, Schneck, Jessica L., Clemens, Jim, Adam, Michael, Mehlmann, John, Romano, Joseph, Morales, Angel, Kang, James, Leister, Lara, Graybill, Todd L., Charnley, Adam K., Ye, Guosen, Nevins, Neysa, Behnia, Kamelia, Wolf, Amaya I., Kasparcova, Viera, Nurse, Kelvin, Wang, Liping, Puhl, Ana C., Li, Yue, Klein, Michael, Hopson, Christopher B., Guss, Jeffrey, Bantscheff, Marcus, Bergamini, Giovanna, Reilly, Michael A., Lian, Yiqian, Duffy, Kevin J., Adams, Jerry, Foley, Kevin P., Gough, Peter J., Marquis, Robert W., Smothers, James, Hoos, Axel, Bertin, John

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Drug selectivity: Running in the family von Muelbaier, Marcel, Drewes, Gerard

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Running in the family von Muelbaier, Marcel, Drewes, Gerard

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Fragment-Based Covalent Ligand Screening Enables Rapid Discovery of Inhibitors for the RBR E3 Ubiquitin Ligase HOIP von Johansson, Henrik, Isabella Tsai, Yi-Chun, Fantom, Ken, Chung, Chun-Wa, Kümper, Sandra, Martino, Luigi, Thomas, Daniel A, Eberl, H. Christian, Muelbaier, Marcel, House, David, Rittinger, Katrin

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Thermal profiling reveals phenylalanine hydroxylase as an off-target of panobinostat von Becher, Isabelle, Werner, Thilo, Doce, Carola, Zaal, Esther A, Tögel, Ina, Khan, Crystal A, Rueger, Anne, Muelbaier, Marcel, Salzer, Elsa, Berkers, Celia R, Fitzpatrick, Paul F, Bantscheff, Marcus, Savitski, Mikhail M

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Multiplexed Proteome Dynamics Profiling Reveals Mechanisms Controlling Protein Homeostasis von Savitski, Mikhail M., Zinn, Nico, Faelth-Savitski, Maria, Poeckel, Daniel, Gade, Stephan, Becher, Isabelle, Muelbaier, Marcel, Wagner, Anne J., Strohmer, Katrin, Werner, Thilo, Melchert, Stephanie, Petretich, Massimo, Rutkowska, Anna, Vappiani, Johanna, Franken, Holger, Steidel, Michael, Sweetman, Gavain M., Gilan, Omer, Lam, Enid Y.N., Dawson, Mark A., Prinjha, Rab K., Grandi, Paola, Bergamini, Giovanna, Bantscheff, Marcus

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Discovery and Characterisation of Highly Cooperative FAK‐Degrading PROTACs von Law, Robert P., Nunes, Joao, Chung, Chun‐wa, Bantscheff, Marcus, Buda, Karol, Dai, Han, Evans, John P., Flinders, Adam, Klimaszewska, Diana, Lewis, Antonia J., Muelbaier, Marcel, Scott‐Stevens, Paul, Stacey, Peter, Tame, Christopher J., Watt, Gillian F., Zinn, Nico, Queisser, Markus A., Harling, John D., Benowitz, Andrew B.

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Chemical proteomics reveals target selectivity of clinical Jak inhibitors in human primary cells von Eberl, H. Christian, Werner, Thilo, Reinhard, Friedrich B., Lehmann, Stephanie, Thomson, Douglas, Chen, Peiling, Zhang, Cunyu, Rau, Christina, Muelbaier, Marcel, Drewes, Gerard, Drewry, David, Bantscheff, Marcus

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A Modular Probe Strategy for Drug Localization, Target Identification and Target Occupancy Measurement on Single Cell Level von Rutkowska, Anna, Thomson, Douglas W, Vappiani, Johanna, Werner, Thilo, Mueller, Katrin M, Dittus, Lars, Krause, Jana, Muelbaier, Marcel, Bergamini, Giovanna, Bantscheff, Marcus

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Characterization of Apo‐Form Selective Inhibition of Indoleamine 2,3‐Dioxygenase von Ortiz‐Meoz, Rodrigo F., Wang, Liping, Matico, Rosalie, Rutkowska‐Klute, Anna, De la Rosa, Martha, Bedard, Sabrina, Midgett, Robert, Strohmer, Katrin, Thomson, Douglas, Zhang, Cunyu, Mebrahtu, Makda, Guss, Jeffrey, Totoritis, Rachel, Consler, Thomas, Campobasso, Nino, Taylor, David, Lewis, Tia, Weaver, Kurt, Muelbaier, Marcel, Seal, John, Dunham, Richard, Kazmierski, Wieslaw, Favre, David, Bergamini, Giovanna, Shewchuk, Lisa, Rendina, Alan, Zhang, Guofeng

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Deoxycytidine kinase (dCK) inhibition is synthetic lethal with BRCA2 deficiency von Guantay, Laura, Garro, Cintia, Siri, Sebastián, Pansa, María Florencia, Ghidelli-Disse, Sonja, Paviolo, Natalia, Racca, Ana, Nicotra, Viviana, Radu, Caius, Bocco, José Luis, Felice, Rosana, Jansson, Keith H., Remlinger, Katja, Amador, Alejandro, Stronach, Euan, Coleman, Kevin, Muelbaier, Marcel, Drewes, Gerard, Gloger, Isro, Madauss, Kevin, García, Manuela, Gottifredi, Vanesa, Soria, Gastón

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amTCO, a new trans-cyclooctene derivative to study drug-target interactions in cells von Echalier, Cécile, Rutkowska, Anna, Kojic, Ana, Thomson, Douglas W, Edwards, Lee J, McKay, Blandine S J, Mülbaier, Marcel, Schultz, Carsten, Bergamini, Giovanna

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Discovery of a Highly Selective Tankyrase Inhibitor Displaying Growth Inhibition Effects against a Diverse Range of Tumor Derived Cell Lines von Thomson, Douglas W, Wagner, Anne J, Bantscheff, Marcus, Benson, R. Edward, Dittus, Lars, Duempelfeld, Birgit, Drewes, Gerard, Krause, Jana, Moore, John T, Mueller, Katrin, Poeckel, Daniel, Rau, Christina, Salzer, Elsa, Shewchuk, Lisa, Hopf, Carsten, Emery, John G, Muelbaier, Marcel

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Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 1. 3‑Amino-4-pyridine Carboxylate Derivatives von Westaway, Susan M, Preston, Alex G. S, Barker, Michael D, Brown, Fiona, Brown, Jack A, Campbell, Matthew, Chung, Chun-wa, Diallo, Hawa, Douault, Clement, Drewes, Gerard, Eagle, Robert, Gordon, Laurie, Haslam, Carl, Hayhow, Thomas G, Humphreys, Philip G, Joberty, Gerard, Katso, Roy, Kruidenier, Laurens, Leveridge, Melanie, Liddle, John, Mosley, Julie, Muelbaier, Marcel, Randle, Rebecca, Rioja, Inma, Rueger, Anne, Seal, Gail A, Sheppard, Robert J, Singh, Onkar, Taylor, Joanna, Thomas, Pamela, Thomson, Douglas, Wilson, David M, Lee, Kevin, Prinjha, Rab K

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Interrogating the Druggability of the 2‑Oxoglutarate-Dependent Dioxygenase Target Class by Chemical Proteomics von Joberty, Gérard, Boesche, Markus, Brown, Jack A, Eberhard, Dirk, Garton, Neil S, Humphreys, Philip G, Mathieson, Toby, Muelbaier, Marcel, Ramsden, Nigel G, Reader, Valérie, Rueger, Anne, Sheppard, Robert J, Westaway, Susan M, Bantscheff, Marcus, Lee, Kevin, Wilson, David M, Prinjha, Rab K, Drewes, Gerard

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Abstract P4-08-09: Deoxycytidine kinase (dCK) inhibition is synthetic lethal with BRCA2-deficiency von Guantay, María L., Garro, Cintia A., Siri, Sebastian, Pansa, María, Ghidelli-Disse, Sonja, Paviolo, Natalia, Racca, Ana, Nicotra, Viviana, Radu, Caius, Bocco, José L., Felice, Rosana, Gloger, Israel, Muelbaier, Marcel, Drewes, Gerard, Madauss, Kevin, García, Manuela, Gottifredi, Vanesa, Soria, Gastón

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