Kynurenines in the mammalian brain: when physiology meets pathology von Schwarcz, Robert, Bruno, John P., Muchowski, Paul J., Wu, Hui-Qiu

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The Kynurenine Pathway Modulates Neurodegeneration in a Drosophila Model of Huntington's Disease von Campesan, Susanna, Green, Edward W., Breda, Carlo, Sathyasaikumar, Korrapati V., Muchowski, Paul J., Schwarcz, Robert, Kyriacou, Charalambos P., Giorgini, Flaviano

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Flanking sequences profoundly alter polyglutamine toxicity in yeast von Duennwald, M.L, Jagadish, S, Muchowski, P.J, Lindquist, S

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Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration von Zwilling, Daniel, Huang, Shao-Yi, Sathyasaikumar, Korrapati V., Notarangelo, Francesca M., Guidetti, Paolo, Wu, Hui-Qiu, Lee, Jason, Truong, Jennifer, Andrews-Zwilling, Yaisa, Hsieh, Eric W., Louie, Jamie Y., Wu, Tiffany, Scearce-Levie, Kimberly, Patrick, Christina, Adame, Anthony, Giorgini, Flaviano, Moussaoui, Saliha, Laue, Grit, Rassoulpour, Arash, Flik, Gunnar, Huang, Yadong, Muchowski, Joseph M., Masliah, Eliezer, Schwarcz, Robert, Muchowski, Paul J.

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Adaptive and Behavioral Changes in Kynurenine 3-monooxygenase Knockout Mice: Relevance to Psychotic Disorders von Erhardt, Sophie, Pocivavsek, Ana, Repici, Mariaelena, Liu, Xi-Cong, Imbeault, Sophie, Maddison, Daniel C, Thomas, Marian A.R, Smalley, Joshua L, Larsson, Markus K, Muchowski, Paul J, Giorgini, Flaviano, Schwarcz, Robert

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Green tea (−)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models von Ehrnhoefer, Dagmar E., Duennwald, Martin, Markovic, Phoebe, Wacker, Jennifer L., Engemann, Sabine, Roark, Margaret, Legleiter, Justin, Marsh, J. Lawrence, Thompson, Leslie M., Lindquist, Susan, Muchowski, Paul J., Wanker, Erich E.

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Methylene blue modulates huntingtin aggregation intermediates and is protective in Huntington's disease models von Sontag, Emily Mitchell, Lotz, Gregor P, Agrawal, Namita, Tran, Andrew, Aron, Rebecca, Yang, Guocheng, Necula, Mihaela, Lau, Alice, Finkbeiner, Steven, Glabe, Charles, Marsh, J Lawrence, Muchowski, Paul J, Thompson, Leslie M

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Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer von Wacker, Jennifer L, Zareie, M Hadi, Fong, Hanson, Sarikaya, Mehmet, Muchowski, Paul J

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Identification of Novel Potentially Toxic Oligomers Formed in Vitro from Mammalian-derived Expanded huntingtin Exon-1 Protein von Nucifora, Leslie G., Burke, Kathleen A., Feng, Xia, Arbez, Nicolas, Zhu, Shanshan, Miller, Jason, Yang, Guocheng, Ratovitski, Tamara, Delannoy, Michael, Muchowski, Paul J., Finkbeiner, Steven, Legleiter, Justin, Ross, Christopher A., Poirier, Michelle A.

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Bone marrow transplantation confers modest benefits in mouse models of Huntington's disease von Kwan, Wanda, Magnusson, Anna, Chou, Austin, Adame, Anthony, Carson, Monica J, Kohsaka, Shinichi, Masliah, Eliezer, Möller, Thomas, Ransohoff, Richard, Tabrizi, Sarah J, Björkqvist, Maria, Muchowski, Paul J

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A Network of Protein Interactions Determines Polyglutamine Toxicity von Duennwald, Martin L., Jagadish, Smitha, Giorgini, Flaviano, Muchowski, Paul J., Lindquist, Susan

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Monoclonal Antibodies Recognize Distinct Conformational Epitopes Formed by Polyglutamine in a Mutant Huntingtin Fragment von Legleiter, Justin, Lotz, Gregor P., Miller, Jason, Ko, Jan, Ng, Cheping, Williams, Geneva L., Finkbeiner, Steve, Patterson, Paul H., Muchowski, Paul J.

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Hsp70 and Hsp40 Chaperones Can Inhibit Self-Assembly of Polyglutamine Proteins into Amyloid-Like Fibrils von Muchowski, Paul J., Schaffar, Gregor, Sittler, Annie, Wanker, Erich E., Hayer-Hartl, Manajit K., Hartl, F. Ulrich

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Chaperone Functions of the E3 Ubiquitin Ligase CHIP von Rosser, Meredith F.N., Washburn, Erin, Muchowski, Paul J., Patterson, Cam, Cyr, Douglas M.

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Modulation of neurodegeneration by molecular chaperones von Muchowski, Paul J., Wacker, Jennifer L.

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Histone Deacetylase Inhibition Modulates Kynurenine Pathway Activation in Yeast, Microglia, and Mice Expressing a Mutant Huntingtin Fragment von Giorgini, Flaviano, Möller, Thomas, Kwan, Wanda, Zwilling, Daniel, Wacker, Jennifer L., Hong, Soyon, Tsai, Li-Chun L., Cheah, Christine S., Schwarcz, Robert, Guidetti, Paolo, Muchowski, Paul J.

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Cannabinoid receptor 2 signaling in peripheral immune cells modulates disease onset and severity in mouse models of Huntington's disease von Bouchard, Jill, Truong, Jennifer, Bouchard, Kristofer, Dunkelberger, Diana, Desrayaud, Sandrine, Moussaoui, Saliha, Tabrizi, Sarah J, Stella, Nephi, Muchowski, Paul J

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Requirement of an Intact Microtubule Cytoskeleton for Aggregation and Inclusion Body Formation by a Mutant Huntingtin Fragment von Muchowski, Paul J., Ning, Ke, D'Souza-Schorey, Crislyn, Fields, Stanley

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Of mice, rats and men: Revisiting the quinolinic acid hypothesis of Huntington's disease von Schwarcz, Robert, Guidetti, Paolo, Sathyasaikumar, Korrapati V, Muchowski, Paul J

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Mutant Huntingtin Fragments Form Oligomers in a Polyglutamine Length-dependent Manner in Vitro and in Vivo von Legleiter, Justin, Mitchell, Emily, Lotz, Gregor P., Sapp, Ellen, Ng, Cheping, DiFiglia, Marian, Thompson, Leslie M., Muchowski, Paul J.

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