Global Nav1.7 knockout mice recapitulate the phenotype of human congenital indifference to pain von Gingras, Jacinthe, Smith, Sarah, Matson, David J, Johnson, Danielle, Nye, Kim, Couture, Lauren, Feric, Elma, Yin, Ruoyuan, Moyer, Bryan D, Peterson, Matthew L, Rottman, James B, Beiler, Rudolph J, Malmberg, Annika B, McDonough, Stefan I

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Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V von Moyer, Bryan D, Murray, Justin K, Ligutti, Joseph, Andrews, Kristin, Favreau, Philippe, Jordan, John B, Lee, Josie H, Liu, Dong, Long, Jason, Sham, Kelvin, Shi, Licheng, Stöcklin, Reto, Wu, Bin, Yin, Ruoyuan, Yu, Violeta, Zou, Anruo, Biswas, Kaustav, Miranda, Les P

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Genome-wide analysis of gene expression in primate taste buds reveals links to diverse processes von Hevezi, Peter, Moyer, Bryan D, Lu, Min, Gao, Na, White, Evan, Echeverri, Fernando, Kalabat, Dalia, Soto, Hortensia, Laita, Bianca, Li, Cherry, Yeh, Shaoyang Anthony, Zoller, Mark, Zlotnik, Albert

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Engineering Potent and Selective Analogues of GpTx-1, a Tarantula Venom Peptide Antagonist of the NaV1.7 Sodium Channel von Murray, Justin K, Ligutti, Joseph, Liu, Dong, Zou, Anruo, Poppe, Leszek, Li, Hongyan, Andrews, Kristin L, Moyer, Bryan D, McDonough, Stefan I, Favreau, Philippe, Stöcklin, Reto, Miranda, Les P

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Engineering potent and selective analogues of GpTx-1, a tarantula venom peptide antagonist of the Na(V)1.7 sodium channel von Murray, Justin K, Ligutti, Joseph, Liu, Dong, Zou, Anruo, Poppe, Leszek, Li, Hongyan, Andrews, Kristin L, Moyer, Bryan D, McDonough, Stefan I, Favreau, Philippe, Stöcklin, Reto, Miranda, Les P

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Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective NaV1.7 Inhibitors von DiMauro, Erin F, Altmann, Stephen, Berry, Loren M, Bregman, Howard, Chakka, Nagasree, Chu-Moyer, Margaret, Bojic, Elma Feric, Foti, Robert S, Fremeau, Robert, Gao, Hua, Gunaydin, Hakan, Guzman-Perez, Angel, Hall, Brian E, Huang, Hongbing, Jarosh, Michael, Kornecook, Thomas, Lee, Josie, Ligutti, Joseph, Liu, Dong, Moyer, Bryan D, Ortuno, Daniel, Rose, Paul E, Schenkel, Laurie B, Taborn, Kristin, Wang, Jean, Wang, Yan, Yu, Violeta, Weiss, Matthew M

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Single Residue Substitutions That Confer Voltage-Gated Sodium Ion Channel Subtype Selectivity in the NaV1.7 Inhibitory Peptide GpTx‑1 von Murray, Justin K, Long, Jason, Zou, Anruo, Ligutti, Joseph, Andrews, Kristin L, Poppe, Leszek, Biswas, Kaustav, Moyer, Bryan D, McDonough, Stefan I, Miranda, Les P

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Voltage-gated sodium channels in taste bud cells von Gao, Na, Lu, Min, Echeverri, Fernando, Laita, Bianca, Kalabat, Dalia, Williams, Mark E, Hevezi, Peter, Zlotnik, Albert, Moyer, Bryan D

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Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Viv... von Graceffa, Russell F, Boezio, Alessandro A, Able, Jessica, Altmann, Steven, Berry, Loren M, Boezio, Christiane, Butler, John R, Chu-Moyer, Margaret, Cooke, Melanie, DiMauro, Erin F, Dineen, Thomas A, Feric Bojic, Elma, Foti, Robert S, Fremeau, Robert T, Guzman-Perez, Angel, Gao, Hua, Gunaydin, Hakan, Huang, Hongbing, Huang, Liyue, Ilch, Christopher, Jarosh, Michael, Kornecook, Thomas, Kreiman, Charles R, La, Daniel S, Ligutti, Joseph, Milgram, Benjamin C, Lin, Min-Hwa Jasmine, Marx, Isaac E, Nguyen, Hanh N, Peterson, Emily A, Rescourio, Gwen, Roberts, John, Schenkel, Laurie, Shimanovich, Roman, Sparling, Brian A, Stellwagen, John, Taborn, Kristin, Vaida, Karina R, Wang, Jean, Yeoman, John, Yu, Violeta, Zhu, Dawn, Moyer, Bryan D, Weiss, Matthew M

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Expression of genes encoding multi-transmembrane proteins in specific primate taste cell populations von Moyer, Bryan D, Hevezi, Peter, Gao, Na, Lu, Min, Kalabat, Dalia, Soto, Hortensia, Echeverri, Fernando, Laita, Bianca, Yeh, Shaoyang Anthony, Zoller, Mark, Zlotnik, Albert

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Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics While Mitigating Metabolic Liabilities von Weiss, Matthew M, Dineen, Thomas A, Marx, Isaac E, Altmann, Steven, Boezio, Alessandro, Bregman, Howard, Chu-Moyer, Margaret, DiMauro, Erin F, Feric Bojic, Elma, Foti, Robert S, Gao, Hua, Graceffa, Russell, Gunaydin, Hakan, Guzman-Perez, Angel, Huang, Hongbing, Huang, Liyue, Jarosh, Michael, Kornecook, Thomas, Kreiman, Charles R, Ligutti, Joseph, La, Daniel S, Lin, Min-Hwa Jasmine, Liu, Dong, Moyer, Bryan D, Nguyen, Hanh N, Peterson, Emily A, Rose, Paul E, Taborn, Kristin, Youngblood, Beth D, Yu, Violeta, Fremeau, Robert T

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Discovery of pyridyl urea sulfonamide inhibitors of NaV1.7 von Butler, John R., Rescourio, Gwenaella, Milgram, Benjamin C., Foti, Robert S., Kornecook, Thomas, Ligutti, Joseph, Moyer, Bryan D., Taborn, Kristin, Youngblood, Beth D., Yu, Violeta, Shimanovich, Roman, Boezio, Alessandro, Weiss, Matthew

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PAC1 receptor blockade reduces central nociceptive activity: new approach for primary headache? von Hoffmann, Jan, Miller, Silke, Martins-Oliveira, Margarida, Akerman, Simon, Supronsinchai, Weera, Sun, Hong, Shi, Licheng, Wang, Judy, Zhu, Dawn, Lehto, Sonya, Liu, Hantao, Yin, Ruoyuan, Moyer, Bryan D., Xu, Cen, Goadsby, Peter J.

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Discovery of Tarantula Venom-Derived NaV1.7-Inhibitory JzTx‑V Peptide 5‑Br-Trp24 Analogue AM-6120 with Systemic Block of Histamine-Induced Pruritis von Wu, Bin, Murray, Justin K, Andrews, Kristin L, Sham, Kelvin, Long, Jason, Aral, Jennifer, Ligutti, Joseph, Amagasu, Shanti, Liu, Dong, Zou, Anruo, Min, Xiaoshan, Wang, Zhulun, Ilch, Christopher P, Kornecook, Thomas J, Lin, Min-Hwa Jasmine, Be, Xuhai, Miranda, Les P, Moyer, Bryan D, Biswas, Kaustav

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The discovery of benzoxazine sulfonamide inhibitors of NaV1.7: Tools that bridge efficacy and target engagement von La, Daniel S., Peterson, Emily A., Bode, Christiane, Boezio, Alessandro A., Bregman, Howard, Chu-Moyer, Margaret Y., Coats, James, DiMauro, Erin F., Dineen, Thomas A., Du, Bingfan, Gao, Hua, Graceffa, Russell, Gunaydin, Hakan, Guzman-Perez, Angel, Fremeau, Robert, Huang, Xin, Ilch, Christopher, Kornecook, Thomas J., Kreiman, Charles, Ligutti, Joseph, Jasmine Lin, Min-Hwa, McDermott, Jeff S., Marx, Isaac, Matson, David J., McDonough, Stefan I., Moyer, Bryan D., Nho Nguyen, Hanh, Taborn, Kristin, Yu, Violeta, Weiss, Matthew M.

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Endoplasmic Reticulum Retention, Degradation, and Aggregation of Olfactory G‐Protein Coupled Receptors von Lu, Min, Echeverri, Fernando, Moyer, Bryan D.

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Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement von Marx, Isaac E, Dineen, Thomas A, Able, Jessica, Bode, Christiane, Bregman, Howard, Chu-Moyer, Margaret, DiMauro, Erin F, Du, Bingfan, Foti, Robert S, Fremeau, Robert T, Gao, Hua, Gunaydin, Hakan, Hall, Brian E, Huang, Liyue, Kornecook, Thomas, Kreiman, Charles R, La, Daniel S, Ligutti, Joseph, Lin, Min-Hwa Jasmine, Liu, Dong, McDermott, Jeff S, Moyer, Bryan D, Peterson, Emily A, Roberts, Jonathan T, Rose, Paul, Wang, Jean, Youngblood, Beth D, Yu, Violeta, Weiss, Matthew M

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Sustained inhibition of the NaV1.7 sodium channel by engineered dimers of the domain II binding peptide GpTx-1 von Murray, Justin K., Biswas, Kaustav, Holder, J. Ryan, Zou, Anruo, Ligutti, Joseph, Liu, Dong, Poppe, Leszek, Andrews, Kristin L., Lin, Fen-Fen, Meng, Shi-Yuan, Moyer, Bryan D., McDonough, Stefan I., Miranda, Les P.

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1,2,4-Triazolsulfone: A novel isosteric replacement of acylsulfonamides in the context of NaV1.7 inhibition von Boezio, Alessandro A., Andrews, Kristin, Boezio, Christiane, Chu-Moyer, Margaret, Copeland, Katrina W., DiMauro, Erin F., Foti, Robert S., Fremeau, Robert T., Gao, Hua, Geuns-Meyer, Stephanie, Graceffa, Russell F., Gunaydin, Hakan, Huang, Hongbing, La, Daniel S., Ligutti, Joseph, Moyer, Bryan D., Peterson, Emily A., Yu, Violeta, Weiss, Matthew M.

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Rab1 Recruitment of p115 into a cis-SNARE Complex: Programming Budding COPII Vesicles for Fusion von Allan, Bernard B., Moyer, Bryan D., Balch, William E.

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