Projecting human pharmacokinetics of therapeutic antibodies from nonclinical data: What have we learned? von Deng, Rong, Iyer, Suhasini, Theil, Frank-Peter, Mortensen, Deborah L., Fielder, Paul J., Prabhu, Saileta

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An effector-reduced anti-β-amyloid (Aβ) antibody with unique aβ binding properties promotes neuroprotection and glial engulfment of Aβ von Adolfsson, Oskar, Pihlgren, Maria, Toni, Nicolas, Varisco, Yvan, Buccarello, Anna Lucia, Antoniello, Katia, Lohmann, Sophie, Piorkowska, Kasia, Gafner, Valerie, Atwal, Jasvinder K, Maloney, Janice, Chen, Mark, Gogineni, Alvin, Weimer, Robby M, Mortensen, Deborah L, Friesenhahn, Michel, Ho, Carole, Paul, Robert, Pfeifer, Andrea, Muhs, Andreas, Watts, Ryan J

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Dual mTORC1/mTORC2 Inhibition as a Host-Directed Therapeutic Target in Pathologically Distinct Mouse Models of Tuberculosis von Tasneen, Rokeya, Mortensen, Deborah S., Converse, Paul J., Urbanowski, Michael E., Upton, Anna, Fotouhi, Nader, Nuermberger, Eric, Hawryluk, Natalie

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CC-115, a dual inhibitor of mTOR kinase and DNA-PK, blocks DNA damage repair pathways and selectively inhibits ATM-deficient cell growth in vitro von Tsuji, Toshiya, Sapinoso, Lisa M, Tran, Tam, Gaffney, Bonny, Wong, Lilly, Sankar, Sabita, Raymon, Heather K, Mortensen, Deborah S, Xu, Shuichan

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Design and Synthesis of Novel Cereblon Binders for Use in Targeted Protein Degradation von Norris, Stephen, Ba, Xiaochu, Rhodes, Jayce, Huang, Dehua, Khambatta, Gody, Buenviaje, Jennifer, Nayak, Surendra, Meiring, Joseph, Reiss, Samantha, Xu, Shuichan, Shi, Lihong, Whitefield, Brandon, Alexander, Matt, Horn, Evan J., Correa, Matthew, Tehrani, Lida, Hansen, Joshua D., Papa, Patrick, Mortensen, Deborah S.

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Discovery of the c‑Jun N‑Terminal Kinase Inhibitor CC-90001 von Nagy, Mark A, Hilgraf, Robert, Mortensen, Deborah S, Elsner, Jan, Norris, Stephen, Tikhe, Jayashree, Yoon, Won, Paisner, David, Delgado, Mercedes, Erdman, Paul, Haelewyn, Jason, Khambatta, Godrej, Xu, Li, Romanow, William J, Condroski, Kevin, Bahmanyar, Sogole, McCarrick, Meg, Benish, Brent, Blease, Kate, LeBrun, Laurie, Moghaddam, Mehran F, Apuy, Julius, Canan, Stacie S, Bennett, Brydon L, Satoh, Yoshitaka

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Discovery of an Azabicyclo[2.1.1]hexane Piperazinium Salt and Its Application in Medicinal Chemistry via a Rearrangement von He, Chi, Ba, Xiaochu, Shunatona, Hunter P., Edwards, Jacob T., Li, Yi-Xin, Keller, Taylor M., Sommer, Roger D., Zapf, Christoph W., Mortensen, Deborah S.

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Correction to “Design and Synthesis of Novel Cereblon Binders for Use in Targeted Protein Degradation” von Norris, Stephen, Ba, Xiaochu, Rhodes, Jayce, Huang, Dehua, Khambatta, Gody, Buenviaje, Jennifer, Nayak, Surendra, Meiring, Joseph, Reiss, Samantha, Xu, Shuichan, Shi, Lihong, Whitefield, Brandon, Alexander, Matt, Horn, Evan J., Correa, Matthew, Tehrani, Lida, Hansen, Joshua D., Papa, Patrick, Mortensen, Deborah S., Brazeau, Jean-François

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Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115 von Mortensen, Deborah S., Perrin-Ninkovic, Sophie M., Shevlin, Graziella, Elsner, Jan, Zhao, Jingjing, Whitefield, Brandon, Tehrani, Lida, Sapienza, John, Riggs, Jennifer R., Parnes, Jason S., Papa, Patrick, Packard, Garrick, Lee, Branden G.S., Harris, Roy, Correa, Matthew, Bahmanyar, Sogole, Richardson, Samantha J., Peng, Sophie X., Leisten, Jim, Khambatta, Godrej, Hickman, Matt, Gamez, James C., Bisonette, René R., Apuy, Julius, Cathers, Brian E., Canan, Stacie S., Moghaddam, Mehran F., Raymon, Heather K., Worland, Peter, Narla, Rama Krishna, Fultz, Kimberly E., Sankar, Sabita

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Amyloid positron emission tomography and cerebrospinal fluid results from a crenezumab anti-amyloid-beta antibody double-blind, placebo-controlled, randomized phase II study in mil... von Salloway, Stephen, Honigberg, Lee A, Cho, William, Ward, Michael, Friesenhahn, Michel, Brunstein, Flavia, Quartino, Angelica, Clayton, David, Mortensen, Deborah, Bittner, Tobias, Ho, Carole, Rabe, Christina, Schauer, Stephen P, Wildsmith, Kristin R, Fuji, Reina N, Suliman, Shehnaaz, Reiman, Eric M, Chen, Kewei, Paul, Robert

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A phase I dose‐escalation study to assess safety, tolerability, pharmacokinetics, and preliminary efficacy of the dual mTORC1/mTORC2 kinase inhibitor CC‐223 in patients with advanc... von Bendell, Johanna C., Kelley, Robin K., Shih, Kent C., Grabowsky, Jennifer A., Bergsland, Emily, Jones, Suzanne, Martin, Thomas, Infante, Jeffrey R., Mischel, Paul S., Matsutani, Tomoo, Xu, Shuichan, Wong, Lilly, Liu, Yong, Wu, Xiaoling, Mortensen, Deborah S., Chopra, Rajesh, Hege, Kristen, Munster, Pamela N.

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SMG1, a nonsense‐mediated mRNA decay (NMD) regulator, as a candidate therapeutic target in multiple myeloma von Leeksma, Alexander C., Derks, Ingrid A. M., Garrick, Brett, Jongejan, Aldo, Colombo, Martino, Bloedjes, Timon, Trowe, Torsten, Leisten, Jim C., Howarth, Michelle, Malek, Mehnaz, Mortensen, Deborah S., Blease, Kate, Groza, Mathew C., Narla, Rama Krishna, Loos, Remco, Kersten, Marie‐José, Moerland, Perry D., Guikema, Jeroen E. J., Kater, Arnon P., Eldering, Eric, Filvaroff, Ellen H.

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Discovery of the Selective Protein Kinase C-theta Kinase Inhibitor, CC-90005 von Papa, Patrick, Whitefield, Brandon, Mortensen, Deborah S., Cashion, Dan, Huang, Dehua, Torres, Eduardo, Parnes, Jason, Sapienza, John, Hansen, Joshua, Correa, Matthew, Delgado, Mercedes, Harris, Roy, Hegde, Sayee, Norris, Stephen, Bahmanyar, Sogole, Plantevin-Krenitsky, Veronique, Liu, Zheng, Leftheris, Katerina, Kulkarni, Ashutosh, Bennett, Brydon, Hur, Eun Mi, Ringheim, Garth, Khambatta, Godrej, Chan, Henry, Muir, Jeffrey, Blease, Kate, Burnett, Kelven, LeBrun, Laurie, Morrison, Lisa, Celeridad, Maria, Khattri, Roli, Cathers, Brian E.

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The mTOR Kinase Inhibitors, CC214-1 and CC214-2, Preferentially Block the Growth of EGFRvIII-Activated Glioblastomas von GINI, Beatrice, ZANCA, Ciro, SHAOJUN ZHU, TANAKA, Kazuhiro, BABIC, Ivan, AKHAVAN, David, LIN, Kelly, ASSUNCAO, Alvaro, YUCHAO GU, BONETTI, Bruno, MORTENSEN, Deborah S, SHUICHAN XU, DELIANG GUO, RAYMON, Heather K, CAVENEE, Webster K, FURNARI, Frank B, JAMES, C. David, KROEMER, Guido, HEATH, James R, HEGE, Kristen, CHOPRA, Rajesh, CLOUGHESY, Timothy F, MISCHEL, Paul S, MATSUTANI, Tomoo, MASUI, Kenta, IKEGAMI, Shiro, HUIJUN YANG, NATHANSON, David, VILLA, Genaro R, SHACKELFORD, David

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CC-223, a Potent and Selective Inhibitor of mTOR Kinase: In Vitro and In Vivo Characterization von Mortensen, Deborah S, Fultz, Kimberly E, Xu, Shuichan, Xu, Weiming, Packard, Garrick, Khambatta, Godrej, Gamez, James C, Leisten, Jim, Zhao, Jingjing, Apuy, Julius, Ghoreishi, Kamran, Hickman, Matt, Narla, Rama Krishna, Bissonette, Rene, Richardson, Samantha, Peng, Sophie X, Perrin-Ninkovic, Sophie, Tran, Tam, Shi, Tao, Yang, Wen Qing, Tong, Zeen, Cathers, Brian E, Moghaddam, Mehran F, Canan, Stacie S, Worland, Peter, Sankar, Sabita, Raymon, Heather K

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Structure-based optimization of aminothiadiazole inhibitors of AKT von Mortensen, Deborah S., Hegde, Sayee G., Perrin-Ninkovic, Sophie M., Bahmanyar, Sogole, McCarrick, Meg, Harris, Roy, Hilgraf, Robert, Lee, Branden G. S., McKie, Jeff, Nadolny, Lisa, Sapienza, John, Collette, Alice, Cox, Sarah, Gamez, James C., Hensel, Jennifer L., Hua, Xuequn Helen, Leisten, Jim, Raymon, Heather K., Tran, Tam, Narla, Rama Krishna

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Discovery of Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor CC-223 von Mortensen, Deborah S, Perrin-Ninkovic, Sophie M, Shevlin, Graziella, Zhao, Jingjing, Packard, Garrick, Bahmanyar, Sogole, Correa, Matthew, Elsner, Jan, Harris, Roy, Lee, Branden G. S, Papa, Patrick, Parnes, Jason S, Riggs, Jennifer R, Sapienza, John, Tehrani, Lida, Whitefield, Brandon, Apuy, Julius, Bisonette, René R, Gamez, James C, Hickman, Matt, Khambatta, Godrej, Leisten, Jim, Peng, Sophie X, Richardson, Samantha J, Cathers, Brian E, Canan, Stacie S, Moghaddam, Mehran F, Raymon, Heather K, Worland, Peter, Narla, Rama Krishna, Fultz, Kimberly E, Sankar, Sabita

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Synthesis and Biological Evaluation of a Novel Series of Furans:  Ligands Selective for Estrogen Receptor α von Mortensen, Deborah S, Rodriguez, Alice L, Carlson, Kathryn E, Sun, Jun, Katzenellenbogen, Benita S, Katzenellenbogen, John A

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Use of core modification in the discovery of CC214-2, an orally available, selective inhibitor of mTOR kinase von Mortensen, Deborah S., Sapienza, John, Lee, Branden G.S., Perrin-Ninkovic, Sophie M., Harris, Roy, Shevlin, Graziella, Parnes, Jason S., Whitefield, Brandon, Hickman, Matt, Khambatta, Gody, Bisonette, Rene R., Peng, Sophie, Gamez, Jim C., Leisten, Jim, Narla, Rama Krishna, Fultz, Kimberly E., Sankar, Sabita

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Discovery and SAR exploration of a novel series of imidazo[4,5- b]pyrazin-2-ones as potent and selective mTOR kinase inhibitors von Mortensen, Deborah S., Perrin-Ninkovic, Sophie M., Harris, Roy, Lee, Branden G.S., Shevlin, Graziella, Hickman, Matt, Khambatta, Gody, Bisonette, Rene R., Fultz, Kimberly E., Sankar, Sabita

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