The search for novel TRPV1-antagonists: From carboxamides to benzimidazoles and indazolones von Robert Fletcher, Stephen, McIver, Edward, Lewis, Stephen, Burkamp, Frank, Leech, Clare, Mason, Glenn, Boyce, Susan, Morrison, Denise, Richards, Gillian, Sutton, Kathy, Brian Jones, Anthony

Volltext

Prediction of Human Oral Plasma Concentration-Time Profiles Using Preclinical Data von Van den Bergh, An, Sinha, Vikash, Gilissen, Ron, Straetemans, Roel, Wuyts, Koen, Morrison, Denise, Bijnens, Luc, Mackie, Claire

Volltext

A Symbolic Regression Model for the Prediction of Drug Binding to Human Liver Microsomes von Van Rompaey, Dries, Morrison, Denise, Van Den Bergh, An, Wegner, Joerg Kurt

Volltext

Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain—a Game Changing Parameter for CNS Drug Discovery and Development von Loryan, Irena, Reichel, Andreas, Feng, Bo, Bundgaard, Christoffer, Shaffer, Christopher, Kalvass, Cory, Bednarczyk, Dallas, Morrison, Denise, Lesuisse, Dominique, Hoppe, Edmund, Terstappen, Georg C., Fischer, Holger, Di, Li, Colclough, Nicola, Summerfield, Scott, Buckley, Stephen T., Maurer, Tristan S., Fridén, Markus

Volltext

Mechanistic Understanding of Brain Drug Disposition to Optimize the Selection of Potential Neurotherapeutics in Drug Discovery von Loryan, Irena, Sinha, Vikash, Mackie, Claire, Van Peer, Achiel, Drinkenburg, Wilhelmus, Vermeulen, An, Morrison, Denise, Monshouwer, Mario, Heald, Donald, Hammarlund-Udenaes, Margareta

Volltext

Development and implementation of an enterprise-wide predictive model for early absorption, distribution, metabolism and excretion properties von Kumar, Kiran, Chupakhin, Vladimir, Vos, Ann, Morrison, Denise, Rassokhin, Dmitrii, Dellwo, Martin J, McCormick, Keith, Paternoster, Eric, Ceulemans, Hugo, DesJarlais, Renee L

Volltext

Approaches to higher-throughput pharmacokinetics (HTPK) in drug discovery von Watt, Alan P, Morrison, Denise, Evans, David C

Volltext

Unbound Brain-to-Plasma Partition Coefficient, K-p,K-uu,K-brain-a Game Changing Parameter for CNS Drug Discovery and Development von Loryan, Irena, Reichel, Andreas, Feng, Bo, Bundgaard, Christoffer, Shaffer, Christopher, Kalvass, Cory, Bednarczyk, Dallas, Morrison, Denise, Lesuisse, Dominique, Hoppe, Edmund, Terstappen, Georg C., Fischer, Holger, Di, Li, Colclough, Nicola, Summerfield, Scott, Buckley, Stephen T., Maurer, Tristan S., Fridén, Markus

Volltext

The Main Ingredient of Change von Morrison, Denise M

Volltext

Prediction of Human Oral Plasma Concentration-Time Profiles Using Preclinical Data: Comparative Evaluation of Prediction Approaches in Early Pharmaceutical Discovery von Van den Bergh, An, Sinha, Vikash, Gilissen, Ron, Straetemans, Roel, Wuyts, Koen, Morrison, Denise, Bijnens, Luc, Mackie, Claire

Volltext

Unbound Brain-to-Plasma Partition Coefficient, K p,uu,brain -a Game Changing Parameter for CNS Drug Discovery and Development von Loryan, Irena, Reichel, Andreas, Feng, Bo, Bundgaard, Christoffer, Shaffer, Christopher, Kalvass, Cory, Bednarczyk, Dallas, Morrison, Denise, Lesuisse, Dominique, Hoppe, Edmund, Terstappen, Georg C, Fischer, Holger, Di, Li, Colclough, Nicola, Summerfield, Scott, Buckley, Stephen T, Maurer, Tristan S, Fridén, Markus

Volltext

The Fluorescent Two-Hybrid Assay to Screen for Protein–Protein Interaction Inhibitors in Live Cells: Targeting the Interaction of p53 with Mdm2 and Mdm4 von Yurlova, Larisa, Derks, Maarten, Buchfellner, Andrea, Hickson, Ian, Janssen, Marc, Morrison, Denise, Stansfield, Ian, Brown, Christopher J., Ghadessy, Farid J., Lane, David P., Rothbauer, Ulrich, Zolghadr, Kourosh, Krausz, Eberhard

Volltext

Ultra-performance liquid chromatography coupled to time-of-flight mass spectrometry for robust, high-throughput quantitative analysis of an automated metabolic stability assay, wit... von O'Connor, Desmond, Mortishire-Smith, Russell, Morrison, Denise, Davies, Amy, Dominguez, Maria

Volltext

Higher Throughput Bioanalysis by Automation of a Protein Precipitation Assay Using a 96-Well Format with Detection by LC−MS/MS von Watt, Alan P, Morrison, Denise, Locker, Karen L, Evans, David C

Volltext

An Evaluation of a Four-Channel Multiplexed Electrospray Tandem Mass Spectrometry for Higher Throughput Quantitative Analysis von Morrison, Denise, Davies, Amy E, Watt, Alan P

Volltext

2-Aryl indole NK1 receptor antagonists : Optimisation of indole substitution von COOPER, Laura C, CHICCHI, Gary G, WATT, Alan P, WILLIAMS, Angela R, SWAIN, Christopher J, DINNELL, Kevin, ELLIOTT, Jason M, HOLLINGWORTH, Gregory J, KURTZ, Mare M, LOCKER, Karen L, MORRISON, Denise, SHAW, Duncan E, TSAO, Kwei-Lan

Volltext

Determination of drug concentrations in plasma by a highly automated, generic and flexible protein precipitation and liquid chromatography/tandem mass spectrometry method applicabl... von O'Connor, Desmond, Clarke, Dawn E., Morrison, Denise, Watt, Alan P.

Volltext

Strategic and technical challenges for drug discovery von Watt, Alan, Morrison, Denise

Volltext

Development and Validation of a Higher-Throughput Equilibrium Dialysis Assay for Plasma Protein Binding von van Liempd, Sebastiaan, Morrison, Denise, Sysmans, Leen, Nelis, Paul, Mortishire-Smith, Russell

Volltext

Unbound Brain-to-Plasma Partition Coefficient, K-p,K-uu,K-brain-a Game Changing Parameter for CNS Drug Discovery and Development von Loryan, Irena, Reichel, Andreas, Feng, Bo, Bundgaard, Christoffer, Shaffer, Christopher, Kalvass, Cory, Bednarczyk, Dallas, Morrison, Denise, Lesuisse, Dominique, Hoppe, Edmund, Terstappen, Georg C, Fischer, Holger, Di, Li, Colclough, Nicola, Summerfield, Scott, Buckley, Stephen T, Maurer, Tristan S, Fridén, Markus

Volltext bestellen