Design and Synthesis of Piperazine Sulfonamide Cores Leading to Highly Potent HIV‑1 Protease Inhibitors von Bungard, Christopher J, Williams, Peter D, Schulz, Jurgen, Wiscount, Catherine M, Holloway, M. Katharine, Loughran, H. Marie, Manikowski, Jesse J, Su, Hua-Poo, Bennett, David J, Chang, Lehua, Chu, Xin-Jie, Crespo, Alejandro, Dwyer, Michael P, Keertikar, Kartik, Morriello, Gregori J, Stamford, Andrew W, Waddell, Sherman T, Zhong, Bin, Hu, Bin, Ji, Tao, Diamond, Tracy L, Bahnck-Teets, Carolyn, Carroll, Steven S, Fay, John F, Min, Xu, Morris, William, Ballard, Jeanine E, Miller, Michael D, McCauley, John A

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Development of Scalable Routes to 1‑Bicyclo[1.1.1]pentylpyrazoles von Zarate, Cayetana, Ardolino, Michael, Morriello, Gregori J, Logan, Kaitlyn M, Kaplan, William P, Torres, Luis, Li, Derun, Chen, Meng, Li, Hongming, Su, Jing, Fuller, Peter, Maddess, Matthew L, Song, Zhiguo Jake

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Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors von Keylor, Mitchell H, Gulati, Anmol, Kattar, Solomon D, Johnson, Rebecca E, Chau, Ryan W, Margrey, Kaila A, Ardolino, Michael J, Zarate, Cayetana, Poremba, Kelsey E, Simov, Vladimir, Morriello, Gregori J, Acton, John J, Pio, Barbara, Yan, Xin, Palte, Rachel L, McMinn, Spencer E, Nogle, Lisa, Lesburg, Charles A, Adpressa, Donovon, Lin, Shishi, Neelamkavil, Santhosh, Liu, Ping, Su, Jing, Hegde, Laxminarayan G, Woodhouse, Janice D, Faltus, Robert, Xiong, Tina, Ciaccio, Paul J, Piesvaux, Jennifer, Otte, Karin M, Wood, Harold B, Kennedy, Matthew E, Bennett, David Jonathan, DiMauro, Erin F, Fell, Matthew J, Fuller, Peter H

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Discovery and Optimization of N‑Heteroaryl Indazole LRRK2 Inhibitors von Logan, Kaitlyn M., Kaplan, Will, Simov, Vladimir, Zhou, Hua, Li, Derun, Torres, Luis, Morriello, Gregori J., Acton, John J., Pio, Barbara, Chen, Yi-Heng, Keylor, Mitchell H., Johnson, Rebecca, Kattar, Solomon D., Chau, Ryan, Yan, Xin, Ardolino, Michael, Zarate, Cayetana, Otte, Karin M., Palte, Rachel L., Xiong, Tina, McMinn, Spencer E., Lin, Shishi, Neelamkavil, Santhosh F., Liu, Ping, Su, Jing, Hegde, Laxminarayan G., Woodhouse, Janice D., Moy, Lily Y., Ciaccio, Paul J., Piesvaux, Jennifer, Zebisch, Matthias, Henry, Clare, Barker, John, Wood, Harold B., Kennedy, Matthew E., DiMauro, Erin F., Fell, Matthew J., Fuller, Peter H.

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Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1‑Heteroaryl‑1H‑Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson’s Disease von Candito, David A., Simov, Vladimir, Gulati, Anmol, Kattar, Solomon, Chau, Ryan W., Lapointe, Blair T., Methot, Joey L., DeMong, Duane E., Graham, Thomas H., Kurukulasuriya, Ravi, Keylor, Mitchell H., Tong, Ling, Morriello, Gregori J., Acton, John J., Pio, Barbara, Liu, Weiguo, Scott, Jack D., Ardolino, Michael J., Martinot, Theodore A., Maddess, Matthew L., Yan, Xin, Gunaydin, Hakan, Palte, Rachel L., McMinn, Spencer E., Nogle, Lisa, Yu, Hongshi, Minnihan, Ellen C., Lesburg, Charles A., Liu, Ping, Su, Jing, Hegde, Laxminarayan G., Moy, Lily Y., Woodhouse, Janice D., Faltus, Robert, Xiong, Tina, Ciaccio, Paul, Piesvaux, Jennifer A., Otte, Karin M., Kennedy, Matthew E., Bennett, David Jonathan, DiMauro, Erin F., Fell, Matthew J., Neelamkavil, Santhosh, Wood, Harold B., Fuller, Peter H., Ellis, J. Michael

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Discovery of novel N-1 substituted pyrazolopyrimidinones as potent, selective PDE2 inhibitors von Morriello, Gregori J., Dwyer, Michael P., Chen, Yili, Ginetti, Anthony T., Xu, Shimin, Lu, Jun, Abeywickrema, Pravien, Wang, Deping, Crespo, Alejandro, Cabalu, Tamara D., Wilson, Jonathan E., Stachel, Shawn J., Paone, Daniel V., Sinz, Christopher

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Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1 H -Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease von Candito, David A, Simov, Vladimir, Gulati, Anmol, Kattar, Solomon, Chau, Ryan W, Lapointe, Blair T, Methot, Joey L, DeMong, Duane E, Graham, Thomas H, Kurukulasuriya, Ravi, Keylor, Mitchell H, Tong, Ling, Morriello, Gregori J, Acton, John J, Pio, Barbara, Liu, Weiguo, Scott, Jack D, Ardolino, Michael J, Martinot, Theodore A, Maddess, Matthew L, Yan, Xin, Gunaydin, Hakan, Palte, Rachel L, McMinn, Spencer E, Nogle, Lisa, Yu, Hongshi, Minnihan, Ellen C, Lesburg, Charles A, Liu, Ping, Su, Jing, Hegde, Laxminarayan G, Moy, Lily Y, Woodhouse, Janice D, Faltus, Robert, Xiong, Tina, Ciaccio, Paul, Piesvaux, Jennifer A, Otte, Karin M, Kennedy, Matthew E, Bennett, David Jonathan, DiMauro, Erin F, Fell, Matthew J, Neelamkavil, Santhosh, Wood, Harold B, Fuller, Peter H, Ellis, J Michael

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Synthesis of the Liposidomycin Diazepanone Nucleoside von Knapp, Spencer, Morriello, Gregori J, Doss, George A

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Ligand Activation Domain of Human Orphan Growth Hormone (GH) Secretagogue Receptor (GHS-R) Conserved from Pufferfish to Humans von Palyha, Oksana C, Feighner, Scott D, Tan, Carina P, McKee, Karen Kulju, Hreniuk, Donna L, Gao, Ying-Duo, Schleim, Klaus D, Yang, Lihu, Morriello, Gregori J, Nargund, Ravi, Patchett, Arthur A, Howard, Andrew D, Smith, Roy G

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Assignment of the Liposidomycin Diazepanone Stereochemistry von Knapp, Spencer, Morriello, Gregori J, Nandan, Santosh R, Emge, Thomas J, Doss, George A, Mosley, Ralph T, Chen, Lijian

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Fused tricyclic pyrrolizinones that exhibit pseudo-irreversible blockade of the NK1 receptor von MORRIELLO, Gregori J, CHICCHI, Gary, TOWNSON, Karen, WHEELDON, Alan, BOYCE, Susan, COLLINSON, Neil, RUPNIAK, Nadia, DEVITA, Robert J, JOHNSON, Tricia, MILLS, Sander G, DEMARTINO, Julie, KURTZ, Marc, TSAO, K. L. C, SONG ZHENG, XINCHUN TONG, CARLSON, Emma

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4-Amino-2-alkyl-butyramides as small molecule CCR2 antagonists with favorable pharmacokinetic properties von Butora, Gabor, Morriello, Gregori J., Kothandaraman, Shankaran, Guiadeen, Deodialsingh, Pasternak, Alexander, Parsons, William H., MacCoss, Malcolm, Vicario, Pasquale P., Cascieri, Margaret A., Yang, Lihu

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Design, synthesis, and structure–activity relationship of novel CCR2 antagonists von Kothandaraman, Shankaran, Donnely, Karla L., Butora, Gabor, Jiao, Richard, Pasternak, Alexander, Morriello, Gregori J., Goble, Stephen D., Zhou, Changyou, Mills, Sander G., MacCoss, Malcolm, Vicario, Pasquale P., Ayala, Julia M., DeMartino, Julie A., Struthers, Mary, Cascieri, Margaret A., Yang, Lihu

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Design of a novel pyrrolidine scaffold utilized in the discovery of potent and selective human β₃ adrenergic receptor agonists von Morriello, Gregori J, Wendt, Harvey R, Bansal, Alka, Salvo, Jerry Di, Feighner, Scott, He, Jiafang, Hurley, Amanda L, Hreniuk, Donna L, Salituro, Gino M, Reddy, Marat Vijay, Galloway, Sheila M, McGettigan, Katherine K, Laws, George, McKnight, Crystal, Doss, George A, Tsou, Nancy N, Black, Regina M, Morris, Judy, Ball, Richard G, Sanfiz, Anthony T, Streckfuss, Eric, Struthers, Mary, Edmondson, Scott D

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Fused bicyclic pyrrolizinones as new scaffolds for human NK1 antagonists von Morriello, Gregori J, Devita, Robert J, Mills, Sander G, Young, Jonathan R, Lin, Peter, Doss, George, Chicchi, Gary G, Demartino, Julie, Kurtz, Marc M, Tsao, Kwei-Lan C, Carlson, Emma, Townson, Karen, Wheeldon, Alan, Boyce, Susan, Collinson, Neil, Rupniak, Nadia, Moore, Stephen

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Substituted fused bicyclic pyrrolizinones as potent, orally bioavailable hNK1 antagonists von MORRIELLO, Gregori J, MILLS, Sander G, XINCHUN TONG, CARLSON, Emma, TOWNSON, Karen, TATTERSALL, F. D, WHEELDON, Alan, BOYCE, Susan, COLLINSON, Neil, RUPNIAK, Nadia, MOORE, Stephen, DEVITA, Robert J, JOHNSON, Tricia, REIBARKH, Mikhail, CHICCHI, Gary, DEMARTINO, Julie, KURTZ, Marc, DAVIES, P, TSAO, K. L. C, SONG ZHENG

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Tetrahydroindolizinone NK1 antagonists von JIANMING BAO, HUAGANG LU, MILLS, Sander G, DEVITA, Robert J, MORRIELLO, Gregori J, CARLSON, Emma J, WHEELDON, Alan, CHICCHI, Gary G, KURTZ, Marc M, TSAO, Kwei-Lan C, SONG ZHENG, XINCHUN TONG

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Short Synthesis of Octosyl Nucleosides von Knapp, Spencer, Thakur, Vinay V, Madduru, Machender R, Malolanarasimhan, Krishnan, Morriello, Gregori J, Doss, George A

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Synthesis of Griseolic Acid B by π-Face-Dependent Radical Cyclization von Knapp, Spencer, Madduru, Machender R, Lu, Zhijian, Morriello, Gregori J, Emge, Thomas J, Doss, George A

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Tetrahydroindolizinone NK sub(1) antagonists von Bao, Jianming, Lu, Huagang, Morriello, Gregori J, Carlson, Emma J, Wheeldon, Alan, Chicchi, Gary G, Kurtz, Marc M, Tsao, Kwei-Lan C, Zheng, Song, Tong, Xinchun, Mills, Sander G, DeVita, Robert J

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