Selectively Nonselective Kinase Inhibition: Striking the Right Balance von Morphy, Richard

Volltext

Asymmetric nucleophilic fluorination under hydrogen bonding phase-transfer catalysis von Pupo, Gabriele, Ibba, Francesco, Ascough, David M H, Vicini, Anna Chiara, Ricci, Paolo, Christensen, Kirsten E, Pfeifer, Lukas, Morphy, John Richard, Brown, John M, Paton, Robert S, Gouverneur, Véronique

Volltext

Designed Multiple Ligands. An Emerging Drug Discovery Paradigm von Morphy, Richard, Rankovic, Zoran

Volltext

The dual role of thiourea in the thiotrifluoromethylation of alkenes von Ricci, Paolo, Khotavivattana, Tanatorn, Pfeifer, Lukas, Médebielle, Maurice, Morphy, John Richard, Gouverneur, Véronique

Volltext

The Influence of Target Family and Functional Activity on the Physicochemical Properties of Pre-Clinical Compounds von Morphy, Richard

Volltext

The Physicochemical Challenges of Designing Multiple Ligands von Morphy, Richard, Rankovic, Zoran

Volltext

Fragments, network biology and designing multiple ligands von Morphy, Richard, Rankovic, Zoran

Volltext

Identification and optimisation of novel sulfonamide, selective vasopressin V₁B receptor antagonists von Baker, James, Bingham, Matilda, Blackburn-Munro, Ruth, Cai, Jiaqiang, Craighead, Mark, Gilfillan, Robert, Goan, Kate, Jaap, David, Milne, Rachel, Richard Morphy, J, Napier, Susan, Presland, Jeremy, Spinks, Gayle, Thomson, Fiona

Volltext

From magic bullets to designed multiple ligands von Morphy, Richard, Kay, Corinne, Rankovic, Zoran

Volltext

Synthesis and SAR studies of novel 2-(6-aminomethylaryl-2-aryl-4-oxo-quinazolin-3(4H)-yl)acetamide Vasopressin V₁b receptor antagonists von Napier, Susan E, Letourneau, Jeffrey J, Ansari, Nasrin, Auld, Douglas S, Baker, James, Best, Stuart, Campbell-Wan, Leigh, Chan, Ray, Craighead, Mark, Desai, Hema, Ho, Koc-Kan, MacSweeney, Cliona, Milne, Rachel, Richard Morphy, J, Neagu, Irina, Ohlmeyer, Michael H.J, Pick, Jack, Presland, Jeremy, Riviello, Chris, Zanetakos, Heather A, Zhao, Jiuqiao, Webb, Maria L

Volltext

Design, synthesis, and structure–activity relationships of indole-3-carboxamides as novel water soluble cannabinoid CB1 receptor agonists von Adam, Julia M., Cairns, Jim, Caulfield, Wilson, Cowley, Phillip, Cumming, Iain, Easson, Morag, Edwards, Darren, Ferguson, Morag, Goodwin, Richard, Jeremiah, Fiona, Kiyoi, Takao, Mistry, Ashvin, Moir, Elizabeth, Morphy, Richard, Tierney, Jason, York, Mark, Baker, James, Cottney, Jean E., Houghton, Andrea K., Westwood, Paul J., Walker, Glenn

Volltext

Reagent concentration effects in the REM resin solid phase synthesis of tertiary amines von Richard Morphy, J, Rankovic, Zoran, York, Mark

Volltext

Synthesis and SAR studies of novel 2-(6-aminomethylaryl-2-aryl-4-oxo-quinazolin-3(4 H)-yl)acetamide Vasopressin V 1b receptor antagonists von Napier, Susan E., Letourneau, Jeffrey J., Ansari, Nasrin, Auld, Douglas S., Baker, James, Best, Stuart, Campbell-Wan, Leigh, Chan, Ray, Craighead, Mark, Desai, Hema, Ho, Koc-Kan, MacSweeney, Cliona, Milne, Rachel, Richard Morphy, J., Neagu, Irina, Ohlmeyer, Michael H.J., Pick, Jack, Presland, Jeremy, Riviello, Chris, Zanetakos, Heather A., Zhao, Jiuqiao, Webb, Maria L.

Volltext

The First Potent and Selective Inhibitors of the Glycine Transporter Type 2 von Caulfield, Wilson L, Collie, Iain T, Dickins, Rachel S, Epemolu, Ola, McGuire, Ross, Hill, David R, McVey, Gillian, Morphy, J. Richard, Rankovic, Zoran, Sundaram, Hardy

Volltext

Identification and optimisation of novel sulfonamide, selective vasopressin V 1B receptor antagonists von Baker, James, Bingham, Matilda, Blackburn-Munro, Ruth, Cai, Jiaqiang, Craighead, Mark, Gilfillan, Robert, Goan, Kate, Jaap, David, Milne, Rachel, Richard Morphy, J., Napier, Susan, Presland, Jeremy, Spinks, Gayle, Thomson, Fiona

Volltext

Synthesis of Tertiary Amines Using a Polystyrene (REM) Resin von Brown, Angus R, Rees, David C, Rankovic, Zoran, Morphy, J. Richard

Volltext

Defining Target Engagement Required for Efficacy In Vivo at the Retinoic Acid Receptor-Related Orphan Receptor C2 (RORγt) von Lugar, Charles W, Clarke, Christian A, Morphy, Richard, Rudyk, Helene, Sapmaz, Selma, Stites, Ryan E, Vaught, Grant M, Furness, Kelly, Broughton, Howard B, Durst, Greg L, Clawson, David K, Stout, Stephanie L, Guo, Sherry Y, Durbin, Jim D, Stayrook, Keith R, Edmondson, Denise D, Kikly, Kristy, New, Nicole E, Bina, Holly A, Chambers, Mark G, Shetler, Pamela, Chang, William Y, Chang, Veavi Ching-Yun, Barr, Rob, Gough, Wendy H, Steele, Jimmy P, Getman, Brian, Patel, Nita, Mathes, Brian M, Richardson, Timothy I

Volltext

Synthesis and SAR studies of 3-phenoxypropyl piperidine analogues as ORL1 (NOP) receptor agonists von Palin, Ronald, Barn, David R., Clark, John K., Cottney, Jean E., Cowley, Phillip M., Crockatt, Marc, Evans, Louise, Feilden, Helen, Goodwin, Richard R., Griekspoor, Frank, Grove, Simon J.A., Houghton, Andrea K., Jones, Philip S., Morphy, Richard J., Smith, Alasdair R.C., Sundaram, Hardy, Vrolijk, David, Weston, Mark A., Wishart, Grant, Wren, Paul

Volltext

Discovery and optimisation of a selective non-steroidal glucocorticoid receptor antagonist von Brown, Angus R., Bosies, Michael, Cameron, Helen, Clark, John, Cowley, Angela, Craighead, Mark, Elmore, Moira A., Firth, Alistair, Goodwin, Richard, Goutcher, Susan, Grant, Emma, Grassie, Morag, Grove, Simon J.A., Hamilton, Niall M., Hampson, Hannah, Hillier, Alison, Ho, Koc-Kan, Kiczun, Michael, Kingsbury, Celia, Kultgen, Steven G., Littlewood, Peter T.A., Lusher, Scott J., MacDonald, Susan, McIntosh, Lorraine, McIntyre, Theresa, Mistry, Ashvin, Morphy, J. Richard, Nimz, Olaf, Ohlmeyer, Michael, Pick, Jack, Rankovic, Zoran, Sherborne, Brad, Smith, Alasdair, Speake, Michael, Spinks, Gayle, Thomson, Fiona, Watson, Lynn, Weston, Mark

Volltext

Identification and optimization of novel 2-(4-oxo-2-aryl-quinazolin-3(4 H)-yl)acetamide vasopressin V3 (V1b) receptor antagonists von Letourneau, Jeffrey J., Riviello, Christopher M., Li, Hong, Cole, Andrew G., Ho, Koc-Kan, Zanetakos, Heather A., Desai, Hema, Zhao, Jiuqiao, Auld, Douglas S., Napier, Susan E., Thomson, Fiona J., Goan, Katharine A., Morphy, J. Richard, Ohlmeyer, Michael H.J., Webb, Maria L.

Volltext