Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy von Chuang, Chihyuan, Collibee, Scott, Ashcraft, Luke, Wang, Wenyue, Vander Wal, Mark, Wang, Xiaolin, Hwee, Darren T, Wu, Yangsong, Wang, Jingying, Chin, Eva R, Cremin, Peadar, Zamora, Jeanelle, Hartman, James, Schaletzky, Julia, Wehri, Eddie, Robertson, Laura A, Malik, Fady I, Morgan, Bradley P

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Discovery of GBT440, an Orally Bioavailable R‑State Stabilizer of Sickle Cell Hemoglobin von Metcalf, Brian, Chuang, Chihyuan, Dufu, Kobina, Patel, Mira P, Silva-Garcia, Abel, Johnson, Carl, Lu, Qing, Partridge, James R, Patskovska, Larysa, Patskovsky, Yury, Almo, Steven C, Jacobson, Matthew P, Hua, Lan, Xu, Qing, Gwaltney, Stephen L, Yee, Calvin, Harris, Jason, Morgan, Bradley P, James, Joyce, Xu, Donghong, Hutchaleelaha, Athiwat, Paulvannan, Kumar, Oksenberg, Donna, Li, Zhe

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Cardiac myosin activation part 1: From concept to clinic von Malik, Fady I, Morgan, Bradley P

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Effects of Aficamten on cardiac contractility in a feline translational model of hypertrophic cardiomyopathy von Sharpe, Ashley N., Oldach, Maureen S., Rivas, Victor N., Kaplan, Joanna L., Walker, Ashley L., Kovacs, Samantha L., Hwee, Darren T., Cremin, Peadar, Morgan, Bradley P., Malik, Fady I., Harris, Samantha P., Stern, Joshua A.

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Cardiac myosin inhibitor, CK-586, minimally reduces systolic function and ameliorates obstruction in feline hypertrophic cardiomyopathy von Rivas, Victor N., Crofton, Amanda E., Jauregui, Carina E., Wouters, Jalena R., Yang, Betty S., Wittenburg, Luke A., Kaplan, Joanna L., Hwee, Darren T., Murphy, Anne N., Morgan, Bradley P., Malik, Fady I., Harris, Samantha P., Stern, Joshua A.

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Correction to “Discovery of Nelutroctiv (CK-136), a Selective Cardiac Troponin Activator for the Treatment of Cardiovascular Diseases Associated with Reduced Cardiac Contractility”... von Romero, Antonio, Ashcraft, Luke, Chandra, Aroop, DiMassa, Vincent, Cremin, Peadar, Collibee, Scott E., Chuang, Chihyuan, Hartman, James, Hwee, Darren T., St. Jean, David, Malinowski, Justin, DeBenedetto, Mikkel, Moebius, David C., Payette, Joshua, Vargas, Richard, Yeoman, John, Motani, Alykhan, Reagan, Jeffrey, Malik, Fady I., Morgan, Bradley P.

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Discovery of Nelutroctiv (CK-136), a Selective Cardiac Troponin Activator for the Treatment of Cardiovascular Diseases Associated with Reduced Cardiac Contractility von Romero, Antonio, Ashcraft, Luke, Chandra, Aroop, DiMassa, Vincent, Cremin, Peadar, Collibee, Scott E., Chuang, Chihyuan, Hartman, James, Hwee, Darren T., St. Jean, David, Malinowski, Justin, DeBenedetto, Mikkel, Moebius, David, Payette, Joshua, Vargas, Richard, Yeoman, John, Motani, Alykhan, Reagan, Jeffrey, Malik, Fady I., Morgan, Bradley P.

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Highly selective inhibition of myosin motors provides the basis of potential therapeutic application von Sirigu, Serena, Hartman, James J., Planelles-Herrero, Vicente José, Ropars, Virginie, Clancy, Sheila, Wang, Xi, Chuang, Grace, Qian, Xiangping, Lu, Pu-Ping, Barrett, Edward, Rudolph, Karin, Royer, Christopher, Morgan, Bradley P., Stura, Enrico A., Malik, Fady I., Houdusse, Anne M.

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Cardiac Troponin Activator CK-963 Increases Cardiac Contractility in Rats von Collibee, Scott E., Romero, Antonio, Muci, Alexander R., Hwee, Darren T., Chuang, Chihyuan, Hartman, James J., Motani, Alykhan S., Ashcraft, Luke, DeRosier, Andre, Grillo, Mark, Lu, Qing, Malik, Fady I., Morgan, Bradley P.

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Discovery of Reldesemtiv, a Fast Skeletal Muscle Troponin Activator for the Treatment of Impaired Muscle Function von Collibee, Scott E, Bergnes, Gustave, Chuang, Chihyuan, Ashcraft, Luke, Gardina, Jeffrey, Garard, Marc, Jamison, Chris R, Lu, Kevin, Lu, Pu-Ping, Muci, Alexander, Romero, Antonio, Valkevich, Ellen, Wang, Wenyue, Warrington, Jeffrey, Yao, Bing, Durham, Nickie, Hartman, James, Marquez, Anna, Hinken, Aaron, Schaletzky, Julia, Xu, Donghong, Hwee, Darren T, Morgans, David, Malik, Fady I, Morgan, Bradley P

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Preclinical characterization of CK-4021586, a new class of cardiac myosin inhibitors for the treatment of hypertrophic cardiomyopathy von Sankar Sarkar, Saswata, Hartman, James J., Hwee, Darren T., Chuang, Chihyuan, Cremin, Peadar, deRosier, Andre, Edell, Samantha, Madhvani, Roshni, Wu, Yangsong, Yco, Lisette, Zamora, Jeanelle, Murphy, Anne, Morgan, Bradley P., Malik, Fady I.

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Pharmacokinetics of a single dose of Aficamten (CK‐274) on cardiac contractility in a A31P MYBPC3 hypertrophic cardiomyopathy cat model von Sharpe, Ashley N., Oldach, Maureen S., Kaplan, Joanna L., Rivas, Victor, Kovacs, Samantha L., Hwee, Darren T., Morgan, Bradley P., Malik, Fady I., Harris, Samantha P., Stern, Joshua A.

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Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases von Russell, Alan J, Hartman, James J, Hinken, Aaron C, Muci, Alexander R, Kawas, Raja, Driscoll, Lena, Godinez, Guillermo, Lee, Kenneth H, Marquez, David, Browne, William F, Chen, Michael M, Clarke, David, Collibee, Scott E, Garard, Marc, Hansen, Richard, Jia, Zhiheng, Lu, Pu-Ping, Rodriguez, Hector, Saikali, Khalil G, Schaletzky, Julia, Vijayakumar, Vipin, Albertus, Daniel L, Claflin, Dennis R, Morgans, David J, Morgan, Bradley P, Malik, Fady I

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Medical Malpractice Lawsuits Involving Pediatric Trainees von Bradley, Morgan T, Golan, Roei, Agudelo, Vanessa, Thomas, Nicholas D, Donches, Katherine

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Preventive interventions for children of parents with depression: international perspectives von Beardslee, William R, Solantaus, Tytti S, Morgan, Bradley S, Gladstone, Tracy R, Kowalenko, Nicholas M

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Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure von Malik, Fady I., Hartman, James J., Elias, Kathleen A., Morgan, Bradley P., Rodriguez, Hector, Brejc, Katjuša, Anderson, Robert L., Sueoka, Sandra H., Lee, Kenneth H., Finer, Jeffrey T., Sakowicz, Roman, Baliga, Ramesh, Cox, David R., Garard, Marc, Godinez, Guillermo, Kawas, Raja, Kraynack, Erica, Lenzi, David, Lu, Pu Ping, Muci, Alexander, Niu, Congrong, Qian, Xiangping, Pierce, Daniel W., Pokrovskii, Maria, Suehiro, Ion, Sylvester, Sheila, Tochimoto, Todd, Valdez, Corey, Wang, Wenyue, Katori, Tatsuo, Kass, David A., Shen, You-Tang, Vatner, Stephen F., Morgans, David J.

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Aficamten is a small-molecule cardiac myosin inhibitor designed to treat hypertrophic cardiomyopathy von Hartman, James J, Hwee, Darren T, Robert-Paganin, Julien, Chuang, Chihyuan, Chin, Eva R, Edell, Samantha, Lee, Ken H, Madhvani, Roshni, Paliwal, Preeti, Pernier, Julien, Sarkar, Saswata Sankar, Schaletzky, Julia, Schauer, Kristine, Taheri, Khanha D, Wang, Jingying, Wehri, Eddie, Wu, Yangsong, Houdusse, Anne, Morgan, Bradley P, Malik, Fady I

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Preventive interventions for children of parents with depression: international perspectives. [Paper in special issue: Parental Mental Illness is a Family Matter. Reupert, Andrea E... von Beardslee, William R, Solantaus, Tytti S, Morgan, Bradley S, Gladstone, Tracy R, Kowalenko, Nicholas M

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Flat epithelial atypia with and without atypical ductal hyperplasia: to re-excise or not. Results of a 5-year prospective study von Uzoaru, Ikechukwu, Morgan, Bradley R., Liu, Zheng G., Bellafiore, Frank J., Gaudier, Farah S., Lo, Jeanne V., Pakzad, Kourosh

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Development of a Factory Process for Omecamtiv Mecarbil, a Novel Cardiac Myosin Activator von Caille, Seb, Allgeier, Alan M, Bernard, Charles, Correll, Tiffany L, Cosbie, Andrew, Crockett, Richard D, Cui, Sheng, Faul, Margaret M, Hansen, Karl B, Huggins, Seth, Langille, Neil, Mennen, Steven M, Morgan, Bradley P, Morrison, Henry, Muci, Alexander, Nagapudi, Karthik, Quasdorf, Kyle, Ranganathan, Krishnakumar, Roosen, Philipp, Shi, Xianqing, Thiel, Oliver R, Wang, Fang, Tvetan, Justin T, Woo, Jacqueline C. S, Wu, Steven, Walker, Shawn D

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