Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles von Eaton, John K., Furst, Laura, Ruberto, Richard A., Moosmayer, Dieter, Hilpmann, André, Ryan, Matthew J., Zimmermann, Katja, Cai, Luke L., Niehues, Michael, Badock, Volker, Kramm, Anneke, Chen, Sixun, Hillig, Roman C., Clemons, Paul A., Gradl, Stefan, Montagnon, Claire, Lazarski, Kiel E., Christian, Sven, Bajrami, Besnik, Neuhaus, Roland, Eheim, Ashley L., Viswanathan, Vasanthi S., Schreiber, Stuart L.

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Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia von Zhao, Xiao-Yan, Wilmen, Andreas, Wang, Dongli, Wang, Xinquan, Bauzon, Maxine, Kim, Ji-Yun, Linden, Lars, Li, Liang, Egner, Ursula, Marquardt, Tobias, Moosmayer, Dieter, Tebbe, Jan, Glück, Julian Marius, Ellinger, Philipp, McLean, Kirk, Yuan, Shujun, Yegneswaran, Subramanian, Jiang, Xiaoqiao, Evans, Vince, Gu, Jian-Ming, Schneider, Doug, Zhu, Ying, Xu, Yifan, Mallari, Cornell, Hesslein, Ashley, Wang, Yan, Schmidt, Nicole, Gutberlet, Katrin, Ruehl-Fehlert, Christine, Freyberger, Alexius, Hermiston, Terry, Patel, Chandra, Sim, Derek, Mosnier, Laurent O., Laux, Volker

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Differential activation of TRAIL-R1 and -2 by soluble and membrane TRAIL allows selective surface antigen-directed activation of TRAIL-R2 by a soluble TRAIL derivative von WAJANT, Harald, MOOSMAYER, Dieter, WÜEST, Thomas, BARTKE, Till, GERLACH, Elke, SCHÖNHERR, Ulrike, PETERS, Nathalie, SCHEURICH, Peter, PFIZENMAIER, Klaus

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Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS–SOS1 interaction von Hillig, Roman C., Sautier, Brice, Schroeder, Jens, Moosmayer, Dieter, Hilpmann, André, Stegmanna, Christian M., Werbeck, Nicolas D., Briem, Hans, Boemer, Ulf, Weiske, Joerg, Badock, Volker, Mastouri, Julia, Petersen, Kirstin, Siemeister, Gerhard, Kahmann, Jan D., Wegener, Dennis, Böhnke, Niels, Eis, Knut, Graham, Keith, Wortmann, Lars, von Nussbaum, Franz, Bader, Benjamin

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The Novel ATR Inhibitor BAY 1895344 Is Efficacious as Monotherapy and Combined with DNA Damage-Inducing or Repair-Compromising Therapies in Preclinical Cancer Models von Wengner, Antje M, Siemeister, Gerhard, Lücking, Ulrich, Lefranc, Julien, Wortmann, Lars, Lienau, Philip, Bader, Benjamin, Bömer, Ulf, Moosmayer, Dieter, Eberspächer, Uwe, Golfier, Sven, Schatz, Christoph A, Baumgart, Simon J, Haendler, Bernard, Lejeune, Pascale, Schlicker, Andreas, von Nussbaum, Franz, Brands, Michael, Ziegelbauer, Karl, Mumberg, Dominik

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The Tumor Necrosis Factor-related Apoptosis-inducing Ligand Receptors TRAIL-R1 and TRAIL-R2 Have Distinct Cross-linking Requirements for Initiation of Apoptosis and Are Non-redunda... von Mühlenbeck, Frank, Schneider, Pascal, Bodmer, Jean-Luc, Schwenzer, Ralph, Hauser, Angelika, Schubert, Gisela, Scheurich, Peter, Moosmayer, Dieter, Tschopp, Jürg, Wajant, Harald

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Crystal structures of the selenoprotein glutathione peroxidase 4 in its apo form and in complex with the covalently bound inhibitor ML162 von Moosmayer, Dieter, Hilpmann, André, Hoffmann, Jutta, Schnirch, Lennart, Zimmermann, Katja, Badock, Volker, Furst, Laura, Eaton, John K., Viswanathan, Vasanthi S., Schreiber, Stuart L., Gradl, Stefan, Hillig, Roman C.

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Bispecific Antibody Pretargeting of Tumor Neovasculature for Improved Systemic Radiotherapy of Solid Tumors von MOOSMAYER, Dieter, BERNDORFF, Dietmar, DINKELBORG, Ludger M, CHANG, Chien-Hsing, SHARKEY, Robert M, ROTHER, Axel, BORKOWSKI, Sandra, ROSSI, Edmund A, MCBRIDE, William J, CARDILLO, Thomas M, GOLDENBERG, David M

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Affinity Map of Bromodomain Protein 4 (BRD4) Interactions with the Histone H4 Tail and the Small Molecule Inhibitor JQ1 von Jung, Marie, Philpott, Martin, Müller, Susanne, Schulze, Jessica, Badock, Volker, Eberspächer, Uwe, Moosmayer, Dieter, Bader, Benjamin, Schmees, Norbert, Fernández-Montalván, Amaury, Haendler, Bernard

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Damage Incorporated: Discovery of the Potent, Highly Selective, Orally Available ATR Inhibitor BAY 1895344 with Favorable Pharmacokinetic Properties and Promising Efficacy in Monot... von Lücking, Ulrich, Wortmann, Lars, Wengner, Antje M, Lefranc, Julien, Lienau, Philip, Briem, Hans, Siemeister, Gerhard, Bömer, Ulf, Denner, Karsten, Schäfer, Martina, Koppitz, Marcus, Eis, Knut, Bartels, Florian, Bader, Benjamin, Bone, Wilhelm, Moosmayer, Dieter, Holton, Simon J, Eberspächer, Uwe, Grudzinska-Goebel, Joanna, Schatz, Christoph, Deeg, Gesa, Mumberg, Dominik, von Nussbaum, Franz

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Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2‑d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5 von Nguyen, Duy, Lemos, Clara, Wortmann, Lars, Eis, Knut, Holton, Simon J, Boemer, Ulf, Moosmayer, Dieter, Eberspaecher, Uwe, Weiske, Joerg, Lechner, Christian, Prechtl, Stefan, Suelzle, Detlev, Siegel, Franziska, Prinz, Florian, Lesche, Ralf, Nicke, Barbara, Nowak-Reppel, Katrin, Himmel, Herbert, Mumberg, Dominik, von Nussbaum, Franz, Nising, Carl F, Bauser, Marcus, Haegebarth, Andrea

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TNF-selectokine: a novel prodrug generated for tumor targeting and site-specific activation of tumor necrosis factor von WÜEST, Thomas, GERLACH, Elke, BANERJEE, Debola, GERSPACH, Jeannette, MOOSMAYER, Dieter, PFIZENMAIER, Klaus

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Discovery of BAY-298 and BAY-899: Tetrahydro-1,6-naphthyridine-Based, Potent, and Selective Antagonists of the Luteinizing Hormone Receptor Which Reduce Sex Hormone Levels in Vivo von Wortmann, Lars, Lindenthal, Bernhard, Muhn, Peter, Walter, Alexander, Nubbemeyer, Reinhard, Heldmann, Dieter, Sobek, Lothar, Morandi, Federica, Schrey, Anna K, Moosmayer, Dieter, Günther, Judith, Kuhnke, Joachim, Koppitz, Marcus, Lücking, Ulrich, Röhn, Ulrike, Schäfer, Martina, Nowak-Reppel, Katrin, Kühne, Ronald, Weinmann, Hilmar, Langer, Gernot

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BAY-8400: A Novel Potent and Selective DNA-PK Inhibitor which Shows Synergistic Efficacy in Combination with Targeted Alpha Therapies von Berger, Markus, Wortmann, Lars, Buchgraber, Philipp, Lücking, Ulrich, Zitzmann-Kolbe, Sabine, Wengner, Antje M, Bader, Benjamin, Bömer, Ulf, Briem, Hans, Eis, Knut, Rehwinkel, Hartmut, Bartels, Florian, Moosmayer, Dieter, Eberspächer, Uwe, Lienau, Philip, Hammer, Stefanie, Schatz, Christoph A, Wang, Qiuwen, Wang, Qi, Mumberg, Dominik, Nising, Carl F, Siemeister, Gerhard

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Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor von Ferreira de Freitas, Renato, Eram, Mohammad S, Szewczyk, Magdalena M, Steuber, Holger, Smil, David, Wu, Hong, Li, Fengling, Senisterra, Guillermo, Dong, Aiping, Brown, Peter J, Hitchcock, Marion, Moosmayer, Dieter, Stegmann, Christian M, Egner, Ursula, Arrowsmith, Cheryl, Barsyte-Lovejoy, Dalia, Vedadi, Masoud, Schapira, Matthieu

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Cell-Based Protein Stabilization Assays for the Detection of Interactions between Small-Molecule Inhibitors and BRD4 von Schulze, Jessica, Moosmayer, Dieter, Weiske, Joerg, Fernández-Montalván, Amaury, Herbst, Christopher, Jung, Marie, Haendler, Bernard, Bader, Benjamin

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Procaryotic Expression of Single-Chain Variable-Fragment (scFv) Antibodies: Secretion in L-Form Cells of Proteus mirabilis Leads to Active Product and Overcomes the Limitations of... von RIPPMANN, J. F, KLEIN, M, HOISCHEN, C, BROCKS, B, RETTIG, W. J, GUMPERT, J, PFIZENMAIER, K, MATTES, R, MOOSMAYER, D

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Computationally Empowered Workflow Identifies Novel Covalent Allosteric Binders for KRASG12C von Mortier, Jérémie, Friberg, Anders, Badock, Volker, Moosmayer, Dieter, Schroeder, Jens, Steigemann, Patrick, Siegel, Franziska, Gradl, Stefan, Bauser, Marcus, Hillig, Roman C., Briem, Hans, Eis, Knut, Bader, Benjamin, Nguyen, Duy, Christ, Clara D.

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Computationally Empowered Workflow Identifies Novel Covalent Allosteric Binders for KRAS G12C von Mortier, Jérémie, Friberg, Anders, Badock, Volker, Moosmayer, Dieter, Schroeder, Jens, Steigemann, Patrick, Siegel, Franziska, Gradl, Stefan, Bauser, Marcus, Hillig, Roman C, Briem, Hans, Eis, Knut, Bader, Benjamin, Nguyen, Duy, Christ, Clara D

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Front Cover: Computationally Empowered Workflow Identifies Novel Covalent Allosteric Binders for KRAS G12C (ChemMedChem 10/2020) von Mortier, Jérémie, Friberg, Anders, Badock, Volker, Moosmayer, Dieter, Schroeder, Jens, Steigemann, Patrick, Siegel, Franziska, Gradl, Stefan, Bauser, Marcus, Hillig, Roman C., Briem, Hans, Eis, Knut, Bader, Benjamin, Nguyen, Duy, Christ, Clara D.

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