Potent, Orally Active Corticotropin-Releasing Factor Receptor-1 Antagonists Containing a Tricyclic Pyrrolopyridine or Pyrazolopyridine Core von Dyck, Brian, Grigoriadis, Dimitri E, Gross, Raymond S, Guo, Zhiqiang, Haddach, Mustapha, Marinkovic, Dragan, McCarthy, James R, Moorjani, Manisha, Regan, Collin F, Saunders, John, Schwaebe, Michael K, Szabo, Tomas, Williams, John P, Zhang, Xiaohu, Bozigian, Haig, Chen, Ta Kung

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Metabolites of RPC1063 Contribute to In Vivo Efficacy (P05.157) von Scott, Fiona, Timony, Gregg, Brooks, Jennifer, Peach, Robert, Clemons, Bryan, Desale, Hans, Moorjani, Manisha, Brahmachary, Engurthi, Powell, Rachel, Dedman, Harry, Martinborough, Esther, Boehm, Marcus

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Discovery of NBI-77860/GSK561679, a potent corticotropin-releasing factor (CRF 1) receptor antagonist with improved pharmacokinetic properties von Tellew, John E., Lanier, Marion, Moorjani, Manisha, Lin, Emily, Luo, Zhiyong, Slee, Deborah H., Zhang, Xiaohu, Hoare, Sam R.J., Grigoriadis, Dimitri E., Denis, Yves St, Fabio, Romano Di, Modugno, Enza Di, Saunders, John, Williams, John P.

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Identification of Novel, Water-Soluble, 2-Amino-N-pyrimidin-4-yl Acetamides as A2A Receptor Antagonists with In Vivo Efficacy von Slee, Deborah H, Zhang, Xiaohu, Moorjani, Manisha, Lin, Emily, Lanier, Marion C, Chen, Yongsheng, Rueter, Jaimie K, Lechner, Sandra M, Markison, Stacy, Malany, Siobhan, Joswig, Tanya, Santos, Mark, Gross, Raymond S, Williams, John P, Castro-Palomino, Julio C, Crespo, María I, Prat, Maria, Gual, Silvia, Díaz, José-Luis, Wen, Jenny, O’Brien, Zhihong, Saunders, John

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N -[6-Amino-2-(heteroaryl)pyrimidin-4-yl]acetamides as A 2A Receptor Antagonists with Improved Drug Like Properties and in Vivo Efficacy von Lanier, Marion C., Moorjani, Manisha, Luo, Zhiyong, Chen, Yongsheng, Lin, Emily, Tellew, John E., Zhang, Xiaohu, Williams, John P., Gross, Raymond S., Lechner, Sandra M., Markison, Stacy, Joswig, Tanya, Kargo, William, Piercey, Jaime, Santos, Mark, Malany, Siobhan, Zhao, Marilyn, Petroski, Robert, Crespo, María I., Díaz, José-Luis, Saunders, John, Wen, Jenny, O’Brien, Zhihong, Jalali, Kayvon, Madan, Ajay, Slee, Deborah H.

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Lead Optimization of 4-Acetylamino-2-(3,5-dimethylpyrazol-1-yl)-6-pyridylpyrimidines as A2A Adenosine Receptor Antagonists for the Treatment of Parkinson’s Disease von Zhang, Xiaohu, Tellew, John E, Luo, Zhiyong, Moorjani, Manisha, Lin, Emily, Lanier, Marion C, Chen, Yongsheng, Williams, John P, Saunders, John, Lechner, Sandra M, Markison, Stacy, Joswig, Tanya, Petroski, Robert, Piercey, Jaime, Kargo, William, Malany, Siobhan, Santos, Mark, Gross, Raymond S, Wen, Jenny, Jalali, Kayvon, O’Brien, Zhihong, Stotz, Carol E, Crespo, María I, Díaz, José-Luis, Slee, Deborah H

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Sa1221 Rpc1063, a Potent, Selective S1P1 Receptor Modulator, Is Active in a Therapeutic IBD Model and Exhibits Favorable PK/PD Properties in Healthy Volunteers von Brooks, Jennifer, Peach, Robert J, Boehm, Marcus, Brahmachary, Enugurthi, Clemons, Bryan, Dedman, Harry, Desale, Hans, Gujrathi, Sheila, Huang, Liming, Hartung, Jeffrey P, Martinborough, Esther, Moorjani, Manisha, Powell, Rachel, Reinhart, Greg, Scott, Fiona L, Tamiya, Junko, Yeager, Adam, Rosen, Hugh, Timony, Gregg

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2-Amino-N-pyrimidin-4-ylacetamides as A2A Receptor Antagonists: 1. Structure−Activity Relationships and Optimization of Heterocyclic Substituents von Slee, Deborah H, Chen, Yongsheng, Zhang, Xiaohu, Moorjani, Manisha, Lanier, Marion C, Lin, Emily, Rueter, Jaimie K, Williams, John P, Lechner, Sandra M, Markison, Stacy, Malany, Siobhan, Santos, Mark, Gross, Raymond S, Jalali, Kayvon, Sai, Yang, Zuo, Zhiyang, Yang, Chun, Castro-Palomino, Julio C, Crespo, María I, Prat, Maria, Gual, Silvia, Díaz, José-Luis, Saunders, John

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2-Amino-N-pyrimidin-4-ylacetamides as A2A Receptor Antagonists: 2. Reduction of hERG Activity, Observed Species Selectivity, and Structure−Activity Relationships von Slee, Deborah H, Moorjani, Manisha, Zhang, Xiaohu, Lin, Emily, Lanier, Marion C, Chen, Yongsheng, Rueter, Jaimie K, Lechner, Sandra M, Markison, Stacy, Malany, Siobhan, Joswig, Tanya, Santos, Mark, Gross, Raymond S, Williams, John P, Castro-Palomino, Julio C, Crespo, María I, Prat, Maria, Gual, Silvia, Díaz, José-Luis, Jalali, Kayvon, Sai, Yang, Zuo, Zhiyang, Yang, Chun, Wen, Jenny, O’Brien, Zhihong, Petroski, Robert, Saunders, John

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Design and Synthesis of Tricyclic Corticotropin-Releasing Factor-1 Antagonists von Gross, Raymond S, Guo, Zhiqiang, Dyck, Brian, Coon, Tim, Huang, Charles Q, Lowe, Richard F, Marinkovic, Dragan, Moorjani, Manisha, Nelson, Jodene, Zamani-Kord, Said, Grigoriadis, Dimitri E, Hoare, Sam R. J, Crowe, Paul D, Bu, Jane Han, Haddach, Mustapha, McCarthy, James, Saunders, John, Sullivan, Robert, Chen, Williams, John P

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Synthesis of N-pyrimidinyl-2-phenoxyacetamides as adenosine A2A receptor antagonists von XIAOHU ZHANG, RUETER, Jaimie K, MARKISON, Stacy, JOSWIG, Tanya, MALANY, Siobhan, SANTOS, Mark, CASTRO-PALOMINO, Julio C, CRESPO, Maria I, PRAT, Maria, GUAL, Silvia, DIAZ, José-Luis, SAUNDERS, John, YONGSHENG CHEN, SLEE, Deborah H, MOORJANI, Manisha, LANIER, Marion C, LIN, Emily, GROSS, Raymond S, TELLEW, John E, WILLIAMS, John P, LECHNER, Sandra M

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Discovery of NBI-77860/GSKS61679, a potent corticotropin-releasing factor (CRF1) receptor antagonist with improved pharmacokinetic properties von TELLEW, John E, LANIER, Marion, DI FABIO, Romano, DI MODUGNO, Enza, SAUNDERS, John, WILLIAMS, John P, MOORJANI, Manisha, LIN, Emily, ZHIYONG LUO, SLEE, Deborah H, XIAOHU ZHANG, HOARE, Sam R. J, GRIGORIADIS, Dimitri E, DENIS, Yves St

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Synthesis and Structure−Activity Relationships of 1-Arylmethyl-5-aryl-6-methyluracils as Potent Gonadotropin-Releasing Hormone Receptor Antagonists von Guo, Zhiqiang, Zhu, Yun-Fei, Gross, Timothy D, Tucci, Fabio C, Gao, Yinghong, Moorjani, Manisha, Connors, Patrick J, Rowbottom, Martin W, Chen, Yongsheng, Struthers, R. Scott, Xie, Qiu, Saunders, John, Reinhart, Greg, Chen, Ta Kung, Bonneville, Anne L. Killam, Chen

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2,6-Diaryl-4-acylaminopyrimidines as potent and selective adenosine A(2A) antagonists with improved solubility and metabolic stability von Moorjani, Manisha, Luo, Zhiyong, Lin, Emily, Vong, Binh G, Chen, Yongsheng, Zhang, Xiaohu, Rueter, Jaimie K, Gross, Raymond S, Lanier, Marion C, Tellew, John E, Williams, John P, Lechner, Sandra M, Malany, Siobhan, Santos, Mark, Crespo, María I, Díaz, José-Luis, Saunders, John, Slee, Deborah H

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2,6-Diaryl-4-acylaminopyrimidines as potent and selective adenosine A2A antagonists with improved solubility and metabolic stability von MOORJANI, Manisha, ZHIYONG LUO, WILLIAMS, John P, LECHNER, Sandra M, MALANY, Siobhan, SANTOS, Mark, CRESPO, Maria I, DIAZ, José-Luis, SAUNDERS, John, SLEE, Deborah H, LIN, Emily, VONG, Binh G, YONGSHENG CHEN, XIAOHU ZHANG, RUETER, Jaimie K, GROSS, Raymond S, LANIER, Marion C, TELLEW, John E

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Design and Synthesis of Tricyclic Imidazo[4,5-b]pyridin-2-ones as Corticotropin-Releasing Factor-1 Antagonists von Guo, Zhiqiang, Tellew, John E, Gross, Raymond S, Dyck, Brian, Grey, Jonathan, Haddach, Mustapha, Kiankarimi, Mehrak, Lanier, Marion, Li, Bin-Feng, Luo, Zhiyong, McCarthy, James R, Moorjani, Manisha, Saunders, John, Sullivan, Robert, Zhang, Xiaohu, Zamani-Kord, Said, Grigoriadis, Dimitri E, Crowe, Paul D, Chen, Ta Kung, Williams, John P

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Substituted triazoles and methods relating thereto von Moorjani, Manisha, Williams, John, Slee, Deborah, Ashweek, Neil

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N-[6-Amino-2-(heteroaryl)pyrimidin-4-yl]acetamides as A2AReceptor Antagonists with Improved Drug Like Properties and in Vivo Efficacy von LANIER, Marion C, MOORJANI, Manisha, MARKISON, Stacy, JOSWIG, Tanya, KARGO, William, PIERCEY, Jaime, SANTOS, Mark, MALANY, Siobhan, ZHAO, Marilyn, PETROSKI, Robert, CRESPO, Maria I, DIAZ, Jose-Luis, ZHIYONG LUO, SAUNDERS, John, WEN, Jenny, O'BRIEN, Zhihong, JALALI, Kayvon, MADAN, Ajay, SLEE, Deborah H, YONGSHENG CHEN, LIN, Emily, TELLEW, John E, XIAOHU ZHANG, WILLIAMS, John P, GROSS, Raymond S, LECHNER, Sandra M

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Lead Optimization of 4-Acetylamino-2-(3,5-dimethylpyrazol-1-yl)-6-pyridylpyrimidines as A 2A Adenosine Receptor Antagonists for the Treatment of Parkinson’s Disease von Zhang, Xiaohu, Tellew, John E., Luo, Zhiyong, Moorjani, Manisha, Lin, Emily, Lanier, Marion C., Chen, Yongsheng, Williams, John P., Saunders, John, Lechner, Sandra M., Markison, Stacy, Joswig, Tanya, Petroski, Robert, Piercey, Jaime, Kargo, William, Malany, Siobhan, Santos, Mark, Gross, Raymond S., Wen, Jenny, Jalali, Kayvon, O’Brien, Zhihong, Stotz, Carol E., Crespo, María I., Díaz, José-Luis, Slee, Deborah H.

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SUBSTITUTED TRIAZOLES AND METHODS RELATING THERETO von MOORJANI, MANISHA, ASHWEEK, NEIL J, WILLIAMS, JOHN P, SLEE, DEBORAH

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