Potent, Orally Active Corticotropin-Releasing Factor Receptor-1 Antagonists Containing a Tricyclic Pyrrolopyridine or Pyrazolopyridine Core von Dyck, Brian, Grigoriadis, Dimitri E, Gross, Raymond S, Guo, Zhiqiang, Haddach, Mustapha, Marinkovic, Dragan, McCarthy, James R, Moorjani, Manisha, Regan, Collin F, Saunders, John, Schwaebe, Michael K, Szabo, Tomas, Williams, John P, Zhang, Xiaohu, Bozigian, Haig, Chen, Ta Kung

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치환된 트리아졸 및 이와 관련된 방법 von ASHWEEK NEIL J, MOORJANI MANISHA, WILLIAMS JOHN P, SLEE DEBORAH

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Metabolites of RPC1063 Contribute to In Vivo Efficacy (P05.157) von Scott, Fiona, Timony, Gregg, Brooks, Jennifer, Peach, Robert, Clemons, Bryan, Desale, Hans, Moorjani, Manisha, Brahmachary, Engurthi, Powell, Rachel, Dedman, Harry, Martinborough, Esther, Boehm, Marcus

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Discovery of NBI-77860/GSK561679, a potent corticotropin-releasing factor (CRF 1) receptor antagonist with improved pharmacokinetic properties von Tellew, John E., Lanier, Marion, Moorjani, Manisha, Lin, Emily, Luo, Zhiyong, Slee, Deborah H., Zhang, Xiaohu, Hoare, Sam R.J., Grigoriadis, Dimitri E., Denis, Yves St, Fabio, Romano Di, Modugno, Enza Di, Saunders, John, Williams, John P.

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N -[6-Amino-2-(heteroaryl)pyrimidin-4-yl]acetamides as A 2A Receptor Antagonists with Improved Drug Like Properties and in Vivo Efficacy von Lanier, Marion C., Moorjani, Manisha, Luo, Zhiyong, Chen, Yongsheng, Lin, Emily, Tellew, John E., Zhang, Xiaohu, Williams, John P., Gross, Raymond S., Lechner, Sandra M., Markison, Stacy, Joswig, Tanya, Kargo, William, Piercey, Jaime, Santos, Mark, Malany, Siobhan, Zhao, Marilyn, Petroski, Robert, Crespo, María I., Díaz, José-Luis, Saunders, John, Wen, Jenny, O’Brien, Zhihong, Jalali, Kayvon, Madan, Ajay, Slee, Deborah H.

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Lead Optimization of 4-Acetylamino-2-(3,5-dimethylpyrazol-1-yl)-6-pyridylpyrimidines as A2A Adenosine Receptor Antagonists for the Treatment of Parkinson’s Disease von Zhang, Xiaohu, Tellew, John E, Luo, Zhiyong, Moorjani, Manisha, Lin, Emily, Lanier, Marion C, Chen, Yongsheng, Williams, John P, Saunders, John, Lechner, Sandra M, Markison, Stacy, Joswig, Tanya, Petroski, Robert, Piercey, Jaime, Kargo, William, Malany, Siobhan, Santos, Mark, Gross, Raymond S, Wen, Jenny, Jalali, Kayvon, O’Brien, Zhihong, Stotz, Carol E, Crespo, María I, Díaz, José-Luis, Slee, Deborah H

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Sa1221 Rpc1063, a Potent, Selective S1P1 Receptor Modulator, Is Active in a Therapeutic IBD Model and Exhibits Favorable PK/PD Properties in Healthy Volunteers von Brooks, Jennifer, Peach, Robert J, Boehm, Marcus, Brahmachary, Enugurthi, Clemons, Bryan, Dedman, Harry, Desale, Hans, Gujrathi, Sheila, Huang, Liming, Hartung, Jeffrey P, Martinborough, Esther, Moorjani, Manisha, Powell, Rachel, Reinhart, Greg, Scott, Fiona L, Tamiya, Junko, Yeager, Adam, Rosen, Hugh, Timony, Gregg

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Identification of Novel, Water-Soluble, 2-Amino-N-pyrimidin-4-yl Acetamides as A2A Receptor Antagonists with In Vivo Efficacy von Slee, Deborah H, Zhang, Xiaohu, Moorjani, Manisha, Lin, Emily, Lanier, Marion C, Chen, Yongsheng, Rueter, Jaimie K, Lechner, Sandra M, Markison, Stacy, Malany, Siobhan, Joswig, Tanya, Santos, Mark, Gross, Raymond S, Williams, John P, Castro-Palomino, Julio C, Crespo, María I, Prat, Maria, Gual, Silvia, Díaz, José-Luis, Wen, Jenny, O’Brien, Zhihong, Saunders, John

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2-Amino-N-pyrimidin-4-ylacetamides as A2A Receptor Antagonists: 1. Structure−Activity Relationships and Optimization of Heterocyclic Substituents von Slee, Deborah H, Chen, Yongsheng, Zhang, Xiaohu, Moorjani, Manisha, Lanier, Marion C, Lin, Emily, Rueter, Jaimie K, Williams, John P, Lechner, Sandra M, Markison, Stacy, Malany, Siobhan, Santos, Mark, Gross, Raymond S, Jalali, Kayvon, Sai, Yang, Zuo, Zhiyang, Yang, Chun, Castro-Palomino, Julio C, Crespo, María I, Prat, Maria, Gual, Silvia, Díaz, José-Luis, Saunders, John

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GLP-1 GLP-1 RECEPTOR MODULATORS von TAMIYA JUNKO, MOORJANI MANISHA, YEAGER ADAM R, BRAHMACHARY ENUGURTHI, MILLS MARK, MEGHANI PREMJI, FOWLER THOMAS, KNAGGS MICHAEL, MARTINBOROUGH ESTHER, HUANG LIMING, NOVAK ANDREW, BOEHM MARCUS F, GLYNN DANIEL

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GLP-1 NOVEL GLP-1 RECEPTOR MODULATORS von TAMIYA JUNKO, MOORJANI MANISHA, FOWLER THOMAS, KNAGGS MICHAEL, MARTINBOROUGH ESTHER, YEAGER ADAM R, HUANG LIMING, BRAHMACHARY ENUGURTHI, NOVAK ANDREW, BOEHM MARCUS F, MEGHANI PREMJI

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2-Amino-N-pyrimidin-4-ylacetamides as A2A Receptor Antagonists: 2. Reduction of hERG Activity, Observed Species Selectivity, and Structure−Activity Relationships von Slee, Deborah H, Moorjani, Manisha, Zhang, Xiaohu, Lin, Emily, Lanier, Marion C, Chen, Yongsheng, Rueter, Jaimie K, Lechner, Sandra M, Markison, Stacy, Malany, Siobhan, Joswig, Tanya, Santos, Mark, Gross, Raymond S, Williams, John P, Castro-Palomino, Julio C, Crespo, María I, Prat, Maria, Gual, Silvia, Díaz, José-Luis, Jalali, Kayvon, Sai, Yang, Zuo, Zhiyang, Yang, Chun, Wen, Jenny, O’Brien, Zhihong, Petroski, Robert, Saunders, John

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NOVEL GLP-1 RECEPTOR MODULATORS von TAMIYA JUNKO, MOORJANI MANISHA, FOWLER THOMAS, KNAGGS MICHAEL, MARTINBOROUGH ESTHER, YEAGER ADAM R, HUANG LIMING, BRAHMACHARY ENUGURTHI, NOVAK ANDREW, BOEHM MARCUS F, MEGHANI PREMJI

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1 SELECTIVE SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYSTHESIS von TAMIYA JUNKO, BROOKS JENNIFER L, YEAGER ADAM RICHARD, MOORJANI MANISHA, MARTINBOROUGH ESTHER, PEACH ROBERT, HUANG LIMING, SCOTT FIONA LORRAINE, BRAHMACHARY ENUGURTHI, BOEHM MARCUS F, TIMONY GREGG ALAN, HANSON MICHAEL ALLEN

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Synthesis of N-pyrimidinyl-2-phenoxyacetamides as adenosine A2A receptor antagonists von XIAOHU ZHANG, RUETER, Jaimie K, MARKISON, Stacy, JOSWIG, Tanya, MALANY, Siobhan, SANTOS, Mark, CASTRO-PALOMINO, Julio C, CRESPO, Maria I, PRAT, Maria, GUAL, Silvia, DIAZ, José-Luis, SAUNDERS, John, YONGSHENG CHEN, SLEE, Deborah H, MOORJANI, Manisha, LANIER, Marion C, LIN, Emily, GROSS, Raymond S, TELLEW, John E, WILLIAMS, John P, LECHNER, Sandra M

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Design and Synthesis of Tricyclic Corticotropin-Releasing Factor-1 Antagonists von Gross, Raymond S, Guo, Zhiqiang, Dyck, Brian, Coon, Tim, Huang, Charles Q, Lowe, Richard F, Marinkovic, Dragan, Moorjani, Manisha, Nelson, Jodene, Zamani-Kord, Said, Grigoriadis, Dimitri E, Hoare, Sam R. J, Crowe, Paul D, Bu, Jane Han, Haddach, Mustapha, McCarthy, James, Saunders, John, Sullivan, Robert, Chen, Williams, John P

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Discovery of NBI-77860/GSKS61679, a potent corticotropin-releasing factor (CRF1) receptor antagonist with improved pharmacokinetic properties von TELLEW, John E, LANIER, Marion, DI FABIO, Romano, DI MODUGNO, Enza, SAUNDERS, John, WILLIAMS, John P, MOORJANI, Manisha, LIN, Emily, ZHIYONG LUO, SLEE, Deborah H, XIAOHU ZHANG, HOARE, Sam R. J, GRIGORIADIS, Dimitri E, DENIS, Yves St

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2,6-Diaryl-4-acylaminopyrimidines as potent and selective adenosine A(2A) antagonists with improved solubility and metabolic stability von Moorjani, Manisha, Luo, Zhiyong, Lin, Emily, Vong, Binh G, Chen, Yongsheng, Zhang, Xiaohu, Rueter, Jaimie K, Gross, Raymond S, Lanier, Marion C, Tellew, John E, Williams, John P, Lechner, Sandra M, Malany, Siobhan, Santos, Mark, Crespo, María I, Díaz, José-Luis, Saunders, John, Slee, Deborah H

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SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS von TAMIYA JUNKO, YEAGER ADAM RICHARD, MOORJANI MANISHA, MARTINBOROUGH ESTHER, HUANG LIMING, BRAHMACHARY ENUGURTHI, BOEHM MARCUS F

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SELECTIVE HETEROCYCLIC SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS von TAMIYA JUNKO, MOORJANI MANISHA, YEAGER ADAM RICHARD, MARTINBOROUGH ESTHER, HUANG LIMING, BRAHMACHARY ENUGURTHI, BOEHM MARCUS F

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