Engineered Fc variant antibodies with enhanced ability to recruit complement and mediate effector functions von Moore, Gregory L., Chen, Hsing, Karki, Sher, Lazar, Greg A.

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Reduction of total IgE by targeted coengagement of IgE B-cell receptor and FcγRIIb with Fc-engineered antibody von Chu, Seung Y., PhD, Horton, Holly M., PhD, Pong, Erik, MS, Leung, Irene W.L., PhD, Chen, Hsing, MS, Nguyen, Duc-Hanh, BS, Bautista, Cristina, BS, Muchhal, Umesh S., PhD, Bernett, Matthew J., PhD, Moore, Gregory L., PhD, Szymkowski, David E., PhD, Desjarlais, John R., PhD

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A novel bispecific antibody format enables simultaneous bivalent and monovalent co-engagement of distinct target antigens von Moore, Gregory L., Bautista, Cristina, Pong, Erik, Nguyen, Duc-Hanh T., Jacinto, Jonathan, Eivazi, Araz, Muchhal, Umesh S., Karki, Sher, Chu, Seung Y., Lazar, Greg A.

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Targeting Multiple Myeloma with AMG 424, a Novel Anti-CD38/CD3 Bispecific T-cell-recruiting Antibody Optimized for Cytotoxicity and Cytokine Release von Zuch de Zafra, Christina L, Fajardo, Flordeliza, Zhong, Wendy, Bernett, Matthew J, Muchhal, Umesh S, Moore, Gregory L, Stevens, Jennitte, Case, Ryan, Pearson, Joshua T, Liu, Siyuan, McElroy, Patricia L, Canon, Jude, Desjarlais, John R, Coxon, Angela, Balazs, Mercedesz, Nolan-Stevaux, Olivier

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Creating Multiple-Crossover DNA Libraries Independent of Sequence Identity von Lutz, Stefan, Ostermeier, Marc, Moore, Gregory L., Maranas, Costas D., Benkovic, Stephen J.

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A robust heterodimeric Fc platform engineered for efficient development of bispecific antibodies of multiple formats von Moore, Gregory L., Bernett, Matthew J., Rashid, Rumana, Pong, Erik W., Nguyen, Duc-Hanh T., Jacinto, Jonathan, Eivazi, Araz, Nisthal, Alex, Diaz, Juan E., Chu, Seung Y., Muchhal, Umesh S., Desjarlais, John R.

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AMG 509 (Xaluritamig), an Anti-STEAP1 XmAb 2+1 T-cell Redirecting Immune Therapy with Avidity-Dependent Activity against Prostate Cancer von Nolan-Stevaux, Olivier, Li, Cong, Liang, Lingming, Zhan, Jinghui, Estrada, Juan, Osgood, Tao, Li, Fei, Zhang, Hanzhi, Case, Ryan, Murawsky, Christopher M, Estes, Bram, Moore, Gregory L, Bernett, Matthew J, Muchhal, Umesh, Desjarlais, John R, Staley, Binnaz K, Stevens, Jennitte, Cooke, Keegan S, Aeffner, Famke, Thomas, Oliver, Stieglmaier, Julia, Lee, Jae-Lyun, Coxon, Angela, Bailis, Julie M

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Identifying Residue-Residue Clashes in Protein Hybrids by Using a Second-Order Mean-Field Approach von Moore, Gregory L., Maranas, Costas D.

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Predicting Crossover Generation in DNA Shuffling von Moore, Gregory L., Maranas, Costas D., Lutz, Stefan, Benkovic, Stephen J.

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Inhibition of B cell receptor-mediated activation of primary human B cells by coengagement of CD19 and FcγRIIb with Fc-engineered antibodies von Chu, Seung Y., Vostiar, Igor, Karki, Sher, Moore, Gregory L., Lazar, Greg A., Pong, Erik, Joyce, Patrick F., Szymkowski, David E., Desjarlais, John R.

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1060 Optimally engineered IL18 Fc-fusion proteins balance potency and pharmacokinetics to promote strong anti-tumor activity von Nisthal, Alex, Lee, Sung-Hyung, Bonzon, Christine, Love, Ruschelle, Avery, Kendra N, Rashid, Rumana, Lertkiatmongkol, Panida, Rodriguez, Nicole, Leung, Irene, Karki, Sher, Barlow, Norman J, Chu, Seung Y, Moore, Gregory L, Desjarlais, John R

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Abstract 5000: Immunotherapy with anti-PSMA x anti-CD3 bispecific antibody stimulates potent killing of a human prostate cancer cell line and target-mediated T cell activation in m... von Chu, Seung Y., Pong, Erik W. K., Rashid, Rumana, Chen, Hsing, Chan, Emily W., Phung, Sheryl, Endo, Nancy A., Ardila, Maria C., Bonzon, Christine, Leung, Irene W. L., Muchhal, Umesh S., Moore, Gregory L., Bernett, Matthew J., Desjarlais, John R., Szymkowski, David E.

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Engineering Fully Human Monoclonal Antibodies from Murine Variable Regions von Bernett, Matthew J., Karki, Sher, Moore, Gregory L., Leung, Irene W.L., Chen, Hsing, Pong, Erik, Nguyen, Duc-Hanh T., Jacinto, Jonathan, Zalevsky, Jonathan, Muchhal, Umesh S., Desjarlais, John R., Lazar, Greg A.

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Suppression of mast cell degranulation through a dual-targeting tandem IgE–IgG Fc domain biologic engineered to bind with high affinity to FcγRIIb von Cemerski, Saso, Chu, Seung Y, Moore, Gregory L, Muchhal, Umesh S, Desjarlais, John R, Szymkowski, David E

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Immune suppression in cynomolgus monkeys by XPro9523: An improved CTLA4-Ig fusion with enhanced binding to CD80, CD86 and neonatal Fc receptor FcRn von Bernett, Matthew J., Chu, Seung Y., Leung, Irene, Moore, Gregory L., Lee, Sung-Hyung, Pong, Erik, Chen, Hsing, Phung, Sheryl, Muchhal, Umesh S., Horton, Holly M., Lazar, Greg A., Desjarlais, John R, Szymkowski, David E.

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IPRO: An Iterative Computational Protein Library Redesign and Optimization Procedure von Saraf, Manish C., Moore, Gregory L., Goodey, Nina M., Cao, Vania Y., Benkovic, Stephen J., Maranas, Costas D.

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Computational challenges in combinatorial library design for protein engineering von Moore, Gregory L., Maranas, Costas D.

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Finally in Color von Moore, Gregory L.

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Modeling DNA Mutation and Recombination for Directed Evolution Experiments von MOORE, GREGORY L, MARANAS, COSTAS D

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Abstract 1831: Affinity tuned XmAb®2+1 GPC3 x CD3 bispecific antibodies demonstrate selective activity in liver cancer models von Nisthal, Alex, Hassanzadeh-Kiabi, Nargess, Avery, Kendra N., Rashid, Rumana, Diaz, Juan E., Muchhal, Umesh S., Chu, Seung Y., Moore, Gregory L., Bykova, Katrina, Desjarlais, John R.

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