Intratumoral IL12 mRNA Therapy Promotes TH1 Transformation of the Tumor Microenvironment von Hewitt, Susannah L., Bailey, Dyane, Zielinski, John, Apte, Ameya, Musenge, Faith, Karp, Russell, Burke, Shannon, Garcon, Fabien, Mishra, Ankita, Gurumurthy, Sushma, Watkins, Amanda, Arnold, Kristen, Moynihan, James, Clancy-Thompson, Eleanor, Mulgrew, Kathy, Adjei, Grace, Deschler, Katharina, Potz, Darren, Moody, Gordon, Leinster, David A., Novick, Steve, Sulikowski, Michal, Bagnall, Chris, Martin, Philip, Lapointe, Jean-Martin, Si, Han, Morehouse, Chris, Sedic, Maja, Wilkinson, Robert W., Herbst, Ronald, Frederick, Joshua P., Luheshi, Nadia

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DIALing-up the preclinical characterization of gene-modified adoptive cellular immunotherapies von Giardino Torchia, Maria Letizia, Moody, Gordon

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Bispecific T cell engager (BiTE®) antibody constructs can mediate bystander tumor cell killing von Ross, Sandra L, Sherman, Marika, McElroy, Patricia L, Lofgren, Julie A, Moody, Gordon, Baeuerle, Patrick A, Coxon, Angela, Arvedson, Tara

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Antitumor activity of AZD0754, a dnTGFβRII-armored, STEAP2-targeted CAR-T cell therapy, in prostate cancer von Zanvit, Peter, van Dyk, Dewald, Fazenbaker, Christine, McGlinchey, Kelly, Luo, Weichuan, Pezold, Jessica M, Meekin, John, Chang, Chien-Ying, Carrasco, Rosa A, Breen, Shannon, Cheung, Crystal Sao-Fong, Endlich-Frazier, Ariel, Clark, Benjamin, Chu, Nina J, Vantellini, Alessio, Martin, Philip L, Hoover, Clare E, Riley, Kenesha, Sweet, Steve M, Chain, David, Kim, Yeoun Jin, Tu, Eric, Harder, Nathalie, Phipps, Sandrina, Damschroder, Melissa, Gilbreth, Ryan N, Cobbold, Mark, Moody, Gordon, Bosco, Emily E

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432 Pharmacological inhibition with anti-CD38 mAb protects NK-mediated off-the-shelf CAR T cells allorejection von Rhoo, Jules, Steinhardt, James, Davies, Owanaemi, Simon, Carl, Bondanza, Attilio, Moody, Gordon, Cobbold, Mark, Carlesso, Gianluca, Vian, Laura

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281 Development of syngeneic mouse models to study the therapeutic efficacy of chimeric antigen receptor T cells against solid tumors von Lee, Ping-Hsien, Breen, Shannon, Merlino, Ashley, Ortiz, Lorenzo, Carrasco, Rosa, Moody, Gordon, Barrett, Allison, Giardino, Letizia

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325 Armored STEAP2 CAR-T (AZD0754) alone and in combination with enzalutamide demonstrates anti-tumor activity across a range of STEAP2 expressing prostate cancer PDX models von Zanvit, Peter, McGlinchey, Kelly, Fazenbaker, Christine, Luo, Weichuan, Pezold, Jessica, Hoover, Clare, Cobbold, Mark, Moody, Gordon, Bosco, Emily

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235 Preclinical evaluation and anti-tumor activity of AZD6422, a CLDN18.2 targeting armored CAR-T for gastric, esophageal and pancreatic cancers von Britton, Zachary, Breen, Shannon, Carrasco, Rosa, Clark, Benjamin, Broggi, Maria AS, Lapointe, Jean-Martin, Giraldo, Nicolas, Rao Attili, Bala NN, Hatke, Amy, Grigoriadou, Christina, Damschroder, Melissa, Cobbold, Mark, Bosco, Emily, Moody, Gordon, Barrett, Allison

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112 Rational design of chimeric antigen receptor T cells against glypican 3 decouples toxicity from therapeutic efficacy von Giardino, Letizia, Gilbreth, Ryan, Chen, Cui, Sult, Erin, Monks, Noel, Tammali, Ravinder, Chesebrough, Jon, Schifferli, Kevin, Chu, Nina, Tong, Jessica, Clarke, Lori, Gesse, Christina, Yao, Xiao-Tao, DaCosta, Karma, Vashisht, Kapil, Moody, Gordon

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Rational design of TGFbRII dominant negative armored GPC3 CAR-T cells for the treatment of hepatocellular carcinoma von Merlino, Ashley, Tu, Eric, Overstreet, Michael, Gilbreth, Ryan, Clarke, Lori, Cobbold, Mark, Moody, Gordon, Giardino, Letizia, Chu, Nina

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AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies von Caenepeel, Sean, Brown, Sean P, Belmontes, Brian, Moody, Gordon, Keegan, Kathleen S, Chui, Danny, Whittington, Douglas A, Huang, Xin, Poppe, Leszek, Cheng, Alan C, Cardozo, Mario, Houze, Jonathan, Li, Yunxiao, Lucas, Brian, Paras, Nick A, Wang, Xianghong, Taygerly, Joshua P, Vimolratana, Marc, Zancanella, Manuel, Zhu, Liusheng, Cajulis, Elaina, Osgood, Tao, Sun, Jan, Damon, Leah, Egan, Regina K, Greninger, Patricia, McClanaghan, Joseph D, Gong, Jianan, Moujalled, Donia, Pomilio, Giovanna, Beltran, Pedro, Benes, Cyril H, Roberts, Andrew W, Huang, David C, Wei, Andrew, Canon, Jude, Coxon, Angela, Hughes, Paul E

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Abstract 4720: TIGIT blockade enhances cytolytic function in antigen-specific CTLs in a manner non-redundant to PD1 blockade von Malhotra, Deepali, Moody, Gordon, Overstreet, Michael, Mumm, John

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Antitumor activity of AZD0754, a dnTGF[beta]RII-armored, STEAP2-targeted CAR-T cell therapy, in prostate cancer von Zanvit, Peter, van Dyk, Dewald, Fazenbaker, Christine, McGlinchey, Kelly, Luo, Weichuan, Pezold, Jessica M, Meekin, John, Chang, Chien-ying, Carrasco, Rosa A, Breen, Shannon, Cheung, Crystal Sao-Fong, Endlich-Frazier, Ariel, Clark, Benjamin, Chu, Nina J, Vantellini, Alessio, Martin, Philip L, Hoover, Clare E, Riley, Kenesha, Sweet, Steve M, Chain, David, Kim, Yeoun Jin, Tu, Eric, Harder, Nathalie, Phipps, Sandrina, Damschroder, Melissa, Gilbreth, Ryan N, Cobbold, Mark, Moody, Gordon, Bosco, Emily E

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Abstract 1695: Activation of B cells by CD73 blocking antibodies von Hair, James, Garcon, Fabien, Hsueh, Michelle, Dallaway, Laura, Bibikova, Elena, Torchia, Maria Letizia Giardino, Moody, Gordon, Schuller, Alwin, Dovedi, Simon J., Cooper, Zachary A., Sachsenmeier, Kris, Kumar, Rakesh, Eyles, Jim, Wilkinson, Robert W.

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Abstract 2027: Preclinical evaluation of AMG 176, a novel, potent and selective Mcl-1 inhibitor with robust anti-tumor activity in Mcl-1 dependent cancer models von Caenepeel, Sean R., Belmontes, Brian, Sun, Jan, Coxon, Angela, Moody, Gordon, Hughes, Paul E.

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Abstract 2978: The utilization of a human MCL1 knockin mouse suggests that reductions in B-cells and monocytes may serve as clinically relevant pharmacodynamic markers of MCL1 inhi... von Belmontes, Brian, Caenepeel, Sean R., Sun, Jan, Chui, Danny, Coxon, Angela, Moody, Gordon, Canon, Jude, Hughes, Paul

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Molecular Mechanism of Hepcidin-Mediated Ferroportin Internalization Requires Ferroportin Lysines, Not Tyrosines or JAK-STAT von Ross, Sandra L., Tran, Lynn, Winters, Aaron, Lee, Ki-Jeong, Plewa, Cherylene, Foltz, Ian, King, Chadwick, Miranda, Les P., Allen, Jennifer, Beckman, Holger, Cooke, Keegan S., Moody, Gordon, Sasu, Barbra J., Nemeth, Elizabeta, Ganz, Tomas, Molineux, Graham, Arvedson, Tara L.

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Antibody‐mediated neutralization of autocrine Gas6 inhibits the growth of pancreatic ductal adenocarcinoma tumors in vivo von Moody, Gordon, Belmontes, Brian, Masterman, Stephanie, Wang, Wei, King, Chadwick, Murawsky, Chris, Tsuruda, Trace, Liu, Shuying, Radinsky, Robert, Beltran, Pedro J.

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Bispecific T cell engager von Ross, Sandra L, Sherman, Marika, McElroy, Patricia L, Lofgren, Julie A, Moody, Gordon, Baeuerle, Patrick A, Coxon, Angela, Arvedson, Tara

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Discovery and in Vivo Evaluation of Macrocyclic Mcl‑1 Inhibitors Featuring an α‑Hydroxy Phenylacetic Acid Pharmacophore or Bioisostere von Rescourio, Gwenaella, Gonzalez, Ana Z, Jabri, Salman, Belmontes, Brian, Moody, Gordon, Whittington, Doug, Huang, Xin, Caenepeel, Sean, Cardozo, Mario, Cheng, Alan C, Chow, David, Dou, Hannah, Jones, Adrie, Kelly, Ron C, Li, Yihong, Lizarzaburu, Mike, Lo, Mei-Chu, Mallari, Rommel, Meleza, Cesar, Rew, Yosup, Simonovich, Scott, Sun, Daqing, Turcotte, Simon, Yan, Xuelei, Wong, Simon G, Yanez, Evelyn, Zancanella, Manuel, Houze, Jonathan, Medina, Julio C, Hughes, Paul E, Brown, Sean P

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