A selective GPR40 (FFAR1) agonist LY2881835 provides immediate and durable glucose control in rodent models of type 2 diabetes von Chen, Yanyun, Song, Min, Riley, Jonathan P., Hu, Charlie C., Peng, Xianbu, Scheuner, Donalyn, Bokvist, Krister, Maiti, Pranab, Kahl, Steven D., Montrose‐Rafizadeh, Chahrzad, Hamdouchi, Chafiq, Miller, Anne Reifel

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Structural basis for GPR40 allosteric agonism and incretin stimulation von Ho, Joseph D., Chau, Betty, Rodgers, Logan, Lu, Frances, Wilbur, Kelly L., Otto, Keith A., Chen, Yanyun, Song, Min, Riley, Jonathan P., Yang, Hsiu-Chiung, Reynolds, Nichole A., Kahl, Steven D., Lewis, Anjana Patel, Groshong, Christopher, Madsen, Russell E., Conners, Kris, Lineswala, Jayana P., Gheyi, Tarun, Saflor, Melbert-Brian Decipulo, Lee, Matthew R., Benach, Jordi, Baker, Kenton A., Montrose-Rafizadeh, Chahrzad, Genin, Michael J., Miller, Anne R., Hamdouchi, Chafiq

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Discovery of 6‑(4-{[5-Cyclopropyl-3-(2,6-dichlorophenyl)­isoxazol-4-yl]methoxy}­piperidin-1-yl)-1-methyl‑1H‑indole-3-carboxylic Acid: A Novel FXR Agonist for the Treatment of Dysli... von Genin, Michael J, Bueno, Ana B, Agejas Francisco, Javier, Manninen, Peter R, Bocchinfuso, Wayne P, Montrose-Rafizadeh, Chahrzad, Cannady, Ellen A, Jones, Timothy M, Stille, John R, Raddad, Eyas, Reidy, Charles, Cox, Amy, Michael, M. Dodson, Michael, Laura F

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A Novel Aldosterone Antagonist Limits Renal Injury in 5/6 Nephrectomy von Fujihara, Clarice K., Kowala, M. C., Breyer, M. D., Sena, Claudia R., Rodrigues, Mariliza V., Arias, Simone C. A., Fanelli, Camilla, Malheiros, Denise M., Jadhav, P. K., Montrose-Rafizadeh, Chahrzad, Krieger, Jose E., Zatz, Roberto

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Identification of potent and selective retinoic acid receptor gamma (RARγ) antagonists for the treatment of osteoarthritis pain using structure based drug design von Hughes, Norman E., Bleisch, Thomas J., Jones, Scott A., Richardson, Timothy I., Doti, Robert A., Wang, Yong, Stout, Stephanie L., Durst, Gregory L., Chambers, Mark G., Oskins, Jennifer L., Lin, Chaohua, Adams, Lisa A., Page, Todd J., Barr, Robert J., Zink, Richard W., Osborne, Harold, Montrose-Rafizadeh, Chahrzad, Norman, Bryan H.

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Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method von Dai, Susie Y, Chalmers, Michael J, Bruning, John, Bramlett, Kelli S, Osborne, Harold E, Montrose-Rafizadeh, Chahrzad, Barr, Robert J, Wang, Yong, Wang, Minmin, Burris, Thomas P, Dodge, Jeffrey A, Griffin, Patrick R

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A nonsecosteroidal vitamin D receptor ligand with improved therapeutic window of bone efficacy over hypercalcemia von Sato, Masahiko, Lu, Jianliang, Iturria, Stephen, Stayrook, Keith R, Burris, Lorri L, Zeng, Qing Qiang, Schmidt, Allen, Barr, Robert J, Montrose‐Rafizadeh, Chahrzad, Bryant, Henry U, Ma, Yanfei L

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Biological Characterization of a Heterodimer-Selective Retinoid X Receptor Modulator: Potential Benefits for the Treatment of Type 2 Diabetes von Leibowitz, Mark D, Ardecky, Robert J, Boehm, Marcus F, Broderick, Carol L, Carfagna, Mark A, Crombie, Diane L, D’Arrigo, Jennifer, Etgen, Garrett J, Faul, Margaret M, Grese, Timothy A, Havel, Henry, Hein, Nancy I, Heyman, Richard A, Jolley, Diane, Klausing, Kay, Liu, Sha, Mais, Dale E, Mapes, Christopher M, Marschke, Keith B, Michellys, Pierre-Yves, Montrose-Rafizadeh, Chahrzad, Ogilvie, Kathleen M, Pascual, Bernadette, Rungta, Deepa, Tyhonas, John S, Urcan, Mary S, Wardlow, Marilyn, Yumibe, Nathan, Reifel-Miller, Anne

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Pancreatic Glucagon-Like Peptide-1 Receptor Couples to Multiple G Proteins and Activates Mitogen-Activated Protein Kinase Pathways in Chinese Hamster Ovary Cells von Montrose-Rafizadeh, Chahrzad, Avdonin, Pavel, Garant, Michael J., Rodgers, Buel D., Kole, Sutapa, Yang, Huan, Levine, Michael A., Schwindinger, William, Bernier, Michel

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High Potency Antagonists of the Pancreatic Glucagon-like Peptide-1 Receptor von Montrose-Rafizadeh, Chahrzad, Yang, Huan, Rodgers, Buel D., Beday, Alvie, Pritchette, Louella A., Eng, John

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2-Alkoxydihydrocinnamates as PPAR agonists. Activity modulation by the incorporation of phenoxy substituents von Martín, José A., Brooks, Dawn A., Prieto, Lourdes, González, Rosario, Torrado, Alicia, Rojo, Isabel, López de Uralde, Beatriz, Lamas, Carlos, Ferritto, Rafael, Dolores Martín-Ortega, María, Agejas, Javier, Parra, Francisco, Rizzo, John R., Rhodes, Gary A., Robey, Roger L., Alt, Charles A., Wendel, Samuel R., Zhang, Tony Y., Reifel-Miller, Anne, Montrose-Rafizadeh, Chahrzad, Brozinick, Joseph T., Hawkins, Eric, Misener, Elizabeth A., Briere, Daniel A., Ardecky, Robert, Fraser, James D., Warshawsky, Alan M.

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Design, Synthesis, and Structure−Activity Relationship Studies of Novel 6,7-Locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic Acids von Michellys, Pierre-Yves, Ardecky, Robert J, Chen, Jyun-Hung, D'Arrigo, Jennifer, Grese, Timothy A, Karanewsky, Donald S, Leibowitz, Mark D, Liu, Sha, Mais, Dale A, Mapes, Christopher M, Montrose-Rafizadeh, Chahrzad, Ogilvie, Katheen M, Reifel-Miller, Anne, Rungta, Deepa, Thompson, Anthony W, Tyhonas, John S, Boehm, Marcus F

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Novel signal transduction and peptide specificity of glucagon-like peptide receptor in 3T3-L1 adipocytes von Montrose-Rafizadeh, Chahrzad, Yang, Huan, Wang, Yihong, Roth, Jesse, Montrose, Marshall H., Adams, Lisa G.

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The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470... von Hamdouchi, Chafiq, Kahl, Steven D, Patel Lewis, Anjana, Cardona, Guemalli R, Zink, Richard W, Chen, Keyue, Eessalu, Thomas E, Ficorilli, James V, Marcelo, Marialuisa C, Otto, Keith A, Wilbur, Kelly L, Lineswala, Jayana P, Piper, Jared L, Coffey, D. Scott, Sweetana, Stephanie A, Haas, Joseph V, Brooks, Dawn A, Pratt, Edward J, Belin, Ruth M, Deeg, Mark A, Ma, Xiaosu, Cannady, Ellen A, Johnson, Jason T, Yumibe, Nathan P, Chen, Qi, Maiti, Pranab, Montrose-Rafizadeh, Chahrzad, Chen, Yanyun, Reifel Miller, Anne

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Discovery of LY3104607: A Potent and Selective G Protein-Coupled Receptor 40 (GPR40) Agonist with Optimized Pharmacokinetic Properties to Support Once Daily Oral Treatment in Patie... von Hamdouchi, Chafiq, Maiti, Pranab, Warshawsky, Alan M, DeBaillie, Amy C, Otto, Keith A, Wilbur, Kelly L, Kahl, Steven D, Patel Lewis, Anjana, Cardona, Guemalli R, Zink, Richard W, Chen, Keyue, CR, Siddaramaiah, Lineswala, Jayana P, Neathery, Grace L, Bouaichi, Cecilia, Diseroad, Benjamin A, Campbell, Alison N, Sweetana, Stephanie A, Adams, Lisa A, Cabrera, Over, Ma, Xiaosu, Yumibe, Nathan P, Montrose-Rafizadeh, Chahrzad, Chen, Yanyun, Miller, Anne Reifel

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Unique Ligand Binding Patterns between Estrogen Receptor α and β Revealed by Hydrogen−Deuterium Exchange von Dai, Susie Y, Burris, Thomas P, Dodge, Jeffrey A, Montrose-Rafizadeh, Chahrzad, Wang, Yong, Pascal, Bruce D, Chalmers, Michael J, Griffin, Patrick R

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Discovery of 6-(4-{[5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl]methoxy}piperidin-1-yl)-1-methyl-1 H -indole-3-carboxylic Acid: A Novel FXR Agonist for the Treatment of Dysli... von Genin, Michael J., Bueno, Ana B., Agejas Francisco, Javier, Manninen, Peter R., Bocchinfuso, Wayne P., Montrose-Rafizadeh, Chahrzad, Cannady, Ellen A., Jones, Timothy M., Stille, John R., Raddad, Eyas, Reidy, Charles, Cox, Amy, Michael, M. Dodson, Michael, Laura F.

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Glucagon-like peptide-1 does not mediate amylase release from AR42J cells von Zhou, Jie, Montrose-Rafizadeh, Chahrzad, Janczewski, Andrzej M., Pineyro, Marco A., Sollott, Steven J., Wang, Yihong, Egan, Josephine M.

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Discrete region of the insulin receptor carboxyl terminus plays key role in insulin action von Bernier, Michel, Kole, Hemanta K., Montrose-Rafizadeh, Chahrzad, Kole, Sutapa

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Identification of potent and selective retinoic acid receptor gamma (RARγ) antagonists for the treatment of osteoarthritis pain using structure based drug design von Hughes, Norman E., Bleisch, Thomas J., Jones, Scott A., Richardson, Timothy I., Doti, Robert A., Wang, Yong, Stout, Stephanie L., Durst, Gregory L., Chambers, Mark G., Oskins, Jennifer L., Lin, Chaohua, Adams, Lisa A., Page, Todd J., Barr, Robert J., Zink, Richard W., Osborne, Harold, Montrose-Rafizadeh, Chahrzad, Norman, Bryan H.

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