Evolution of Novartis’ Small Molecule Screening Deck Design von Schuffenhauer, Ansgar, Schneider, Nadine, Hintermann, Samuel, Auld, Douglas, Blank, Jutta, Cotesta, Simona, Engeloch, Caroline, Fechner, Nikolas, Gaul, Christoph, Giovannoni, Jerome, Jansen, Johanna, Joslin, John, Krastel, Philipp, Lounkine, Eugen, Manchester, John, Monovich, Lauren G, Pelliccioli, Anna Paola, Schwarze, Manuel, Shultz, Michael D, Stiefl, Nikolaus, Baeschlin, Daniel K

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Design of Thioether Cyclic Peptide Scaffolds with Passive Permeability and Oral Exposure von Golosov, Andrei A, Flyer, Alec N, Amin, Jakal, Babu, Charles, Gampe, Christian, Li, Jingzhou, Liu, Eugene, Nakajima, Katsumasa, Nettleton, David, Patel, Tajesh J, Reid, Patrick C, Yang, Lihua, Monovich, Lauren G

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Total Synthesis of (+)-Isoschizandrin Utilizing a Samarium(II) Iodide-Promoted 8-Endo Ketyl−Olefin Cyclization von Molander, Gary A, George, Kelly M, Monovich, Lauren G

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Identification of a PCSK9-LDLR disruptor peptide with in vivo function von Brousseau, Margaret E., Clairmont, Kevin B., Spraggon, Glen, Flyer, Alec N., Golosov, Andrei A., Grosche, Philipp, Amin, Jakal, Andre, Jerome, Burdick, Debra, Caplan, Shari, Chen, Guanjing, Chopra, Raj, Ames, Lisa, Dubiel, Diana, Fan, Li, Gattlen, Raphael, Kelly-Sullivan, Dawn, Koch, Alexander W., Lewis, Ian, Li, Jingzhou, Liu, Eugene, Lubicka, Danuta, Marzinzik, Andreas, Nakajima, Katsumasa, Nettleton, David, Ottl, Johannes, Pan, Meihui, Patel, Tajesh, Perry, Lauren, Pickett, Stephanie, Poirier, Jennifer, Reid, Patrick C., Pelle, Xavier, Seepersaud, Mohindra, Subramanian, Vanitha, Vera, Victoria, Xu, Mei, Yang, Lihua, Yang, Qing, Yu, Jinghua, Zhu, Guoming, Monovich, Lauren G.

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Clearance of plasma PCSK9 via the asialoglycoprotein receptor mediated by heterobifunctional ligands von Bagdanoff, Jeffrey T., Smith, Thomas M., Allan, Martin, O’Donnell, Peter, Nguyen, Zachary, Moore, Elizabeth A., Baird, Jason, Wang, Shuangxi, Subramanian, Vanitha, Tigani, Bruno, Nettleton, David O., Monovich, Lauren G., Lewis, Ian, Flyer, Alec N., Granda, Brian, Blankenship, John W., Barnes-Seeman, David, Clairmont, Kevin B.

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Discovery of Truncated Cyclic Peptides Targeting an Induced‐Fit Pocket on PCSK9 von Grosche, Philipp, Flyer, Alec N., Gattlen, Raphael, Xu, Mei, Golosov, Andrei A., Vera, Victoria, Pickett, Stephanie, Brousseau, Margaret E., Chopra, Rajiv, Clairmont, Kevin B., Koch, Alexander, Liu, Eugene, Reid, Patrick, Perry, Lauren, Yang, Lihua, Yang, Qing, Monovich, Lauren G.

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Total Synthesis of (−)-Steganone Utilizing a Samarium(II) Iodide Promoted 8-Endo Ketyl−Olefin Cyclization von Monovich, Lauren G, Le Huérou, Yvan, Rönn, Magnus, Molander, Gary A

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Identification of Orally Available Naphthyridine Protein Kinase D Inhibitors von Meredith, Erik L, Ardayfio, Ophelia, Beattie, Kimberly, Dobler, Markus R, Enyedy, Istvan, Gaul, Christoph, Hosagrahara, Vinayak, Jewell, Charles, Koch, Keith, Lee, Wendy, Lehmann, HansJoerg, McKinsey, Timothy A, Miranda, Karl, Pagratis, Nikos, Pancost, Margaret, Patnaik, Anup, Phan, Dillon, Plato, Craig, Qian, Ming, Rajaraman, Vasumathy, Rao, Chang, Rozhitskaya, Olga, Ruppen, Thomas, Shi, Jie, Siska, Sarah J, Springer, Clayton, van Eis, Maurice, Vega, Richard B, von Matt, Anette, Yang, Lihua, Yoon, Taeyoung, Zhang, Ji-Hu, Zhu, Na, Monovich, Lauren G

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Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors von Meredith, Erik L, Ksander, Gary, Monovich, Lauren G, Papillon, Julien P. N, Liu, Qian, Miranda, Karl, Morris, Patrick, Rao, Chang, Burgis, Robin, Capparelli, Michael, Hu, Qi-Ying, Singh, Alok, Rigel, Dean F, Jeng, Arco Y, Beil, Michael, Fu, Fumin, Hu, Chii-Whei, LaSala, Daniel

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Discovery of Potent, Selective, and Orally Active Carboxylic Acid Based Inhibitors of Matrix Metalloproteinase-13 von Monovich, Lauren G, Tommasi, Ruben A, Fujimoto, Roger A, Blancuzzi, Vincent, Clark, Kirk, Cornell, Wendy D, Doti, Robert, Doughty, John, Fang, James, Farley, David, Fitt, John, Ganu, Vishwas, Goldberg, Ronald, Goldstein, Robert, Lavoie, Stacey, Kulathila, Raviraj, Macchia, William, Parker, David T, Melton, Richard, O’Byrne, Elizabeth, Pastor, Gary, Pellas, Theodore, Quadros, Elizabeth, Reel, Noela, Roland, Dennis M, Sakane, Yumi, Singh, Hem, Skiles, Jerry, Somers, Joseph, Toscano, Karen, Wigg, Andrew, Zhou, Siyuan, Zhu, Lijuan, Shieh, Wen-Chung, Xue, Song, McQuire, Leslie W

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Identification of Potent and Selective Amidobipyridyl Inhibitors of Protein Kinase D von Meredith, Erik L, Beattie, Kimberly, Burgis, Robin, Capparelli, Michael, Chapo, Joseph, DiPietro, Lucian, Gamber, Gabriel, Enyedy, Istvan, Hood, David B, Hosagrahara, Vinayak, Jewell, Charles, Koch, Keith A, Lee, Wendy, Lemon, Douglas D, McKinsey, Timothy A, Miranda, Karl, Pagratis, Nikos, Phan, Dillon, Plato, Craig, Rao, Chang, Rozhitskaya, Olga, Soldermann, Nicolas, Springer, Clayton, van Eis, Maurice, Vega, Richard B, Yan, Wanlin, Zhu, Qingming, Monovich, Lauren G

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Abstract 10516: Identification of a PCSK9-LDLR Disruptor Macrocycle with in vivo Function von Brousseau, Margaret E, Clairmont, Kevin B, Spraggon, Glen, Flyer, Alec N, Golosov, Andrei A, Grosche, Philipp, André, Jérôme, Caplan, Shari, Chen, Guanjing, Fan, Li, Gattlen, Raphael, Koch, Alexander, Lewis, Ian, Li, Jingzhou, Liu, Eugene, Lubicka, Danuta, Marzinzik, Andreas, Nakajima, Katsumasa, Nettleton, David, Ottl, Johannes, Pan, Meihui, Patel, Tajesh, Pickett, Stephanie, Poirier, Jennifer, Reid, Patrick C, Pelle, Xavier, Subramanian, Vanitha, Vera, Victoria, Xu, Mei, Yang, Lihua, Yang, Qing, yu, jinghua, Zhu, Guoming, Monovich, Lauren G

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USE OF ADRENAL HORMONE-MODIFYING AGENT von PAPILLON JULIEN, HU QI-YING, MEREDITH ERIK, CHRISTOPH SCHUMACHER, GARY KSANDER, MONOVICH LAUREN G

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USE OF ADRENAL HORMONE MODIFYING AGENT von PAPILLON JULIEN, HU QI-YING, MEREDITH ERIK, CHRISTOPH SCHUMACHER, GARY KSANDER, MONOVICH LAUREN G

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USE OF AN ADRENAL HORMONE-MODIFYING AGENT von KSANDER, Gary, SCHUMACHER, Christoph, HU, Qi-Ying, PAPILLON, Julien, MONOVICH, Lauren G, MEREDITH, Erik

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USE OF AN ADRENAL HORMONE-MODIFYING AGENT von KSANDER, Gary, SCHUMACHER, Christoph, HU, Qi-Ying, PAPILLON, Julien, MONOVICH, Lauren G, MEREDITH, Erik

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Uso de un agente modificador de hormonas suprarrenales von KSANDER, Gary, SCHUMACHER, Christoph, HU, Qi-Ying, PAPILLON, Julien, MONOVICH, Lauren G, MEREDITH, Erik

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USE OF AN ADRENAL HORMONE-MODIFYING AGENT von Schumacher, Christoph, Ksander, Gary, Hu, Qi-Ying, Meredith, Erik, Papillon, Julien, Monovich, Lauren G

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USE OF AN ADRENAL HORMONE-MODIFYING AGENT von KSANDER Gary, MONOVICH Lauren G, PAPILLON Julien, SCHUMACHER Christoph, HU Qi-Ying, MEREDITH Erik

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USE OF AN ADRENAL HORMONE-MODIFYING AGENT von KSANDER, Gary, SCHUMACHER, Christoph, HU, Qi-Ying, PAPILLON, Julien, MONOVICH, Lauren G, MEREDITH, Erik

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