Generation and Cross-Coupling of Organozinc Reagents in Flow von Herath, Ananda, Molteni, Valentina, Pan, Shifeng, Loren, Jon

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Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH) von Tully, David C, Rucker, Paul V, Chianelli, Donatella, Williams, Jennifer, Vidal, Agnès, Alper, Phil B, Mutnick, Daniel, Bursulaya, Badry, Schmeits, James, Wu, Xiangdong, Bao, Dingjiu, Zoll, Jocelyn, Kim, Young, Groessl, Todd, McNamara, Peter, Seidel, H. Martin, Molteni, Valentina, Liu, Bo, Phimister, Andrew, Joseph, Sean B, Laffitte, Bryan

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One-Pot Electrochemical Nickel-Catalyzed Decarboxylative Sp2–Sp3 Cross-Coupling von Koyanagi, Takaoki, Herath, Ananda, Chong, Ashley, Ratnikov, Maxim, Valiere, Andrew, Chang, Jim, Molteni, Valentina, Loren, Jon

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Recent Developments in Drug Discovery for Leishmaniasis and Human African Trypanosomiasis von Nagle, Advait S., Khare, Shilpi, Kumar, Arun Babu, Supek, Frantisek, Buchynskyy, Andriy, Mathison, Casey J. N., Chennamaneni, Naveen Kumar, Pendem, Nagendar, Buckner, Frederick S., Gelb, Michael H., Molteni, Valentina

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Tropifexor‐Mediated Abrogation of Steatohepatitis and Fibrosis Is Associated With the Antioxidative Gene Expression Profile in Rodents von Hernandez, Eloy D., Zheng, Lianxing, Kim, Young, Fang, Bin, Liu, Bo, Valdez, Reginald A., Dietrich, William F., Rucker, Paul V., Chianelli, Donatella, Schmeits, James, Bao, Dingjiu, Zoll, Jocelyn, Dubois, Claire, Federe, Glenn C., Chen, Lihao, Joseph, Sean B., Klickstein, Lloyd B., Walker, John, Molteni, Valentina, McNamara, Peter, Meeusen, Shelly, Tully, David C., Badman, Michael K., Xu, Jie, Laffitte, Bryan

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Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease von Khare, Shilpi, Roach, Steven L, Barnes, S Whitney, Hoepfner, Dominic, Walker, John R, Chatterjee, Arnab K, Neitz, R Jeffrey, Arkin, Michelle R, McNamara, Case W, Ballard, Jaime, Lai, Yin, Fu, Yue, Molteni, Valentina, Yeh, Vince, McKerrow, James H, Glynne, Richard J, Supek, Frantisek

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Doll therapy intervention for women with dementia living in nursing homes: a randomized single-blind controlled trial protocol von Vaccaro, Roberta, Ballabio, Roberta, Molteni, Valentina, Ceppi, Laura, Ferrari, Benedetta, Cantu, Marco, Zaccaria, Daniele, Vandoni, Carla, Ardito, Rita Bianca, Adenzato, Mauro, Poletti, Barbara, Guaita, Antonio, Pezzati, Rita

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Anti-trypanosomal proteasome inhibitors cure hemolymphatic and meningoencephalic murine infection models of African trypanosomiasis von Rao, Srinivasa P. S., Lakshminarayana, Suresh B., Jiricek, Jan, Kaiser, Marcel, Ritchie, Ryan, Myburgh, Elmarie, Supek, Frantisek, Tuntland, Tove, Nagle, Advait, Molteni, Valentina, Maeser, Pascal, Mottram, Jeremy C., Barrett, Michael P., Diagana, Thierry T.

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Discovery of 5‑(3,4-Difluorophenyl)-3-(pyrazol-4-yl)-7-azaindole (GNF3809) for β‑Cell Survival in Type 1 Diabetes von Huang, Zhihong, Tremblay, Matthew S, Wu, Tom Y.-H, Ding, Qiang, Hao, Xueshi, Baaten, Janine, Hill, Robert, Liu, Bo, Meeusen, Shelly, Zou, Yefen, Yan, Shanshan, Jia, Yong, Nguyen-Tran, Van, Shen, Weijun, Bhat, Ganesh, Glynne, Richard, Laffitte, Bryan, Li, Jing, Molteni, Valentina, Liu, Yahu A

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Identification of a small-molecule binding site at the dimer interface of the HIV integrase catalytic domain von Molteni, Valentina, Greenwald, Jason, Rhodes, Denise, Hwang, Young, Kwiatkowski, Witek, Bushman, Frederic D., Siegel, Jay S., Choe, Senyon

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The nuclear receptor LXR is a glucose sensor von Mitro, Nico, Molteni, Valentina, Saez, Enrique, Mak, Puiying A, Hampton, Eric, Kreusch, Andreas, Vargas, Leo, Godio, Cristina

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Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness von Khare, Shilpi, Nagle, Advait S., Biggart, Agnes, Lai, Yin H., Liang, Fang, Davis, Lauren C., Barnes, S. Whitney, Mathison, Casey J. N., Myburgh, Elmarie, Gao, Mu-Yun, Gillespie, J. Robert, Liu, Xianzhong, Tan, Jocelyn L., Stinson, Monique, Rivera, Ianne C., Ballard, Jaime, Yeh, Vince, Groessl, Todd, Federe, Glenn, Koh, Hazel X. Y., Venable, John D., Bursulaya, Badry, Shapiro, Michael, Mishra, Pranab K., Spraggon, Glen, Brock, Ansgar, Mottram, Jeremy C., Buckner, Frederick S., Rao, Srinivasa P. S., Wen, Ben G., Walker, John R., Tuntland, Tove, Molteni, Valentina, Glynne, Richard J., Supek, Frantisek

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Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis von Chianelli, Donatella, Rucker, Paul V, Roland, Jason, Tully, David C, Nelson, John, Liu, Xiaodong, Bursulaya, Badry, Hernandez, Eloy D, Wu, Jane, Prashad, Mahavir, Schlama, Thierry, Liu, Yugang, Chu, Alan, Schmeits, James, Huang, David J, Hill, Robert, Bao, Dingjiu, Zoll, Jocelyn, Kim, Young, Groessl, Todd, McNamara, Peter, Liu, Bo, Richmond, Wendy, Sancho-Martinez, Ignacio, Phimister, Andrew, Seidel, H. Martin, Badman, Michael K, Joseph, Sean B, Laffitte, Bryan, Molteni, Valentina

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Antitrypanosomal Treatment with Benznidazole Is Superior to Posaconazole Regimens in Mouse Models of Chagas Disease von Khare, Shilpi, Liu, Xianzhong, Stinson, Monique, Rivera, Ianne, Groessl, Todd, Tuntland, Tove, Yeh, Vince, Wen, Ben, Molteni, Valentina, Glynne, Richard, Supek, Frantisek

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Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases von Nagle, Advait, Biggart, Agnes, Be, Celine, Srinivas, Honnappa, Hein, Andreas, Caridha, Diana, Sciotti, Richard J, Pybus, Brandon, Kreishman-Deitrick, Mara, Bursulaya, Badry, Lai, Yin H, Gao, Mu-Yun, Liang, Fang, Mathison, Casey J. N, Liu, Xiaodong, Yeh, Vince, Smith, Jeffrey, Lerario, Isabelle, Xie, Yongping, Chianelli, Donatella, Gibney, Michael, Berman, Ashley, Chen, Yen-Liang, Jiricek, Jan, Davis, Lauren C, Liu, Xianzhong, Ballard, Jaime, Khare, Shilpi, Eggimann, Fabian Kurt, Luneau, Alexandre, Groessl, Todd, Shapiro, Michael, Richmond, Wendy, Johnson, Kevin, Rudewicz, Patrick J, Rao, Srinivasa P. S, Thompson, Christopher, Tuntland, Tove, Spraggon, Glen, Glynne, Richard J, Supek, Frantisek, Wiesmann, Christian, Molteni, Valentina

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One-Pot Electrochemical Nickel-Catalyzed Decarboxylative Sp 2 -Sp 3 Cross-Coupling von Koyanagi, Takaoki, Herath, Ananda, Chong, Ashley, Ratnikov, Maxim, Valiere, Andrew, Chang, Jim, Molteni, Valentina, Loren, Jon

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Efficacy of doll therapy intervention on behavioral and psychological symptoms of dementia: A randomized single‐blind controlled trial von Vaccaro, Roberta, Molteni, Valentina, Ballabio, Roberta, Ceppi, Laura, Ardito, Rita Bianca, Adenzato, Mauro, Guaita, Antonio, Pezzati, Rita

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Selective DYRK1A Inhibitor for the Treatment of Type 1 Diabetes: Discovery of 6‑Azaindole Derivative GNF2133 von Liu, Yahu A, Jin, Qihui, Zou, Yefen, Ding, Qiang, Yan, Shanshan, Wang, Zhicheng, Hao, Xueshi, Nguyen, Bao, Zhang, Xiaoyue, Pan, Jianfeng, Mo, Tingting, Jacobsen, Kate, Lam, Thanh, Wu, Tom Y.-H, Petrassi, H. Michael, Bursulaya, Badry, DiDonato, Michael, Gordon, W. Perry, Liu, Bo, Baaten, Janine, Hill, Robert, Nguyen-Tran, Vân, Qiu, Minhua, Zhang, You-Qing, Kamireddy, Anwesh, Espinola, Sheryll, Deaton, Lisa, Ha, Sukwon, Harb, George, Jia, Yong, Li, Jing, Shen, Weijun, Schumacher, Andrew M, Colman, Karyn, Glynne, Richard, Pan, Shifeng, McNamara, Peter, Laffitte, Bryan, Meeusen, Shelly, Molteni, Valentina, Loren, Jon

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GS07 - Nidufexor, a non-bile acid FXR agonist, decreases ALT and hepatic fat fraction in patients with NASH after 12 weeks dosing von Aspinall, Richard, Shennak, Mustafa, Stocia, George, Quinn, Dean, Javashvili, Lali, Molteni, Valentina, Ukomadu, Chinweike, Sohal, Bindi, Zhang, Yiming, Martic, Miljen, Avrameas, Alexandre, Kao, Sheena, Herve, Jacques, Soon, Rachel, Badman, Michael

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Nidufexor, a non-bile acid FXR agonist, decreases ALT and hepatic fat fraction in patients with NASH after 12 weeks dosing von Aspinall, Richard, Shennak, Mustafa, Stocia, George, Quinn, Dean, Javashvili, Lali, Molteni, Valentina, Ukomadu, Chinweike, Sohal, Bindi, Zhang, Yiming, Martic, Miljen, Avrameas, Alexandre, Kao, Sheena, Herve, Jacques, Soon, Rachel, Badman, Michael

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