p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade von Molkentine, David P, Molkentine, Jessica M, Bridges, Kathleen A, Valdecanas, David R, Dhawan, Annika, Bahri, Reshub, Hefner, Andrew J, Kumar, Manish, Yang, Liangpeng, Abdelhakiem, Mohamed, Pifer, Phillip M, Sandulache, Vlad, Sheth, Aakash, Beadle, Beth M, Thames, Howard D, Mason, Kathryn A, Pickering, Curtis R, Meyn, Raymond E, Skinner, Heath D

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Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function von Kumar, Manish, Molkentine, David, Molkentine, Jessica, Bridges, Kathleen, Xie, Tongxin, Yang, Liangpeng, Hefner, Andrew, Gao, Meng, Bahri, Reshub, Dhawan, Annika, Frederick, Mitchell J., Seth, Sahil, Abdelhakiem, Mohamed, Beadle, Beth M., Johnson, Faye, Wang, Jing, Shen, Li, Heffernan, Timothy, Sheth, Aakash, Ferris, Robert L., Myers, Jeffrey N., Pickering, Curtis R., Skinner, Heath D.

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Proteomic Profiling Identifies PTK2/FAK as a Driver of Radioresistance in HPV-negative Head and Neck Cancer von Skinner, Heath D, Giri, Uma, Yang, Liang, Woo, Sang Hyeok, Story, Michael D, Pickering, Curtis R, Byers, Lauren A, Williams, Michelle D, El-Naggar, Adel, Wang, Jing, Diao, Lixia, Shen, Li, Fan, You Hong, Molkentine, David P, Beadle, Beth M, Meyn, Raymond E, Myers, Jeffrey N, Heymach, John V

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BAP1 Is a Novel Target in HPV-Negative Head and Neck Cancer von Liu, Xiyou, Kumar, Manish, Yang, Liangpeng, Molkentine, David P, Valdecanas, David, Yu, Shiying, Meyn, Raymond E, Heymach, John V, Skinner, Heath D

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Integrative Analysis Identifies a Novel AXL-PI3 Kinase-PD-L1 Signaling Axis Associated with Radiation Resistance in Head and Neck Cancer von Skinner, Heath D, Giri, Uma, Yang, Liang P, Kumar, Manish, Liu, Ying, Story, Michael D, Pickering, Curtis R, Byers, Lauren A, Williams, Michelle D, Wang, Jing, Shen, Li, Yoo, Suk Y, Fan, You Hong, Molkentine, David P, Beadle, Beth M, Meyn, Raymond E, Myers, Jeffrey N, Heymach, John V

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Dasatinib, a multi-kinase inhibitor increased radiation sensitivity by interfering with nuclear localization of epidermal growth factor receptor and by blocking DNA repair pathways von Raju, Uma, Riesterer, Oliver, Wang, Zhi-Qiang, Molkentine, David P, Molkentine, Jessica M, Johnson, Faye M, Glisson, Bonnie, Milas, Luka, Ang, K. Kian

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Vandetanib Restores Head and Neck Squamous Cell Carcinoma Cells' Sensitivity to Cisplatin and Radiation In Vivo and In Vitro von SANO, Daisuke, MATSUMOTO, Fumihiko, MYERS, Jeffrey N, VALDECANAS, David R, MEI ZHAO, MOLKENTINE, David P, TAKAHASHI, Yoko, HANNA, Ehab Y, PAPADIMITRAKOPOULOU, Vali, HEYMACH, John, MILAS, Luka

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Proton versus photon radiation–induced cell death in head and neck cancer cells von Wang, Li, Han, Shichao, Zhu, Jinming, Wang, Xiaochun, Li, Yuting, Wang, Zeming, Lin, Eric, Wang, Xiaofang, Molkentine, David P., Blanchard, Pierre, Yang, Yining, Zhang, Ruiping, Sahoo, Narayan, Gillin, Michael, Zhu, Xiaorong Ronald, Zhang, Xiaodong, Myers, Jeffrey N., Frank, Steven J.

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Human papillomavirus status and the relative biological effectiveness of proton radiotherapy in head and neck cancer cells von Wang, Li, Wang, Xiaochun, Li, Yuting, Han, Shichao, Zhu, Jinming, Wang, Xiaofang, Molkentine, David P., Blanchard, Pierre, Yang, Yining, Zhang, Ruiping, Sahoo, Narayan, Gillin, Michael, Zhu, Xiaorong Ronald, Zhang, Xiaodong, Myers, Jeffrey N., Frank, Steven J.

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DNA Repair Biomarker Profiling of Head and Neck Cancer: Ku80 Expression Predicts Locoregional Failure and Death following Radiotherapy von MOELLER, Benjamin J, YORDY, John S, STURGIS, Erich M, WEBER, Randal S, GARDEN, Adam S, KIAN ANG, K, SCHWARTZ, David L, WILLIAMS, Michelle D, GIRI, Uma, RAJU, Uma, MOLKENTINE, David P, BYERS, Lauren A, HEYMACH, John V, STORY, Michael D, LEE, J. Jack

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Biological responses of human solid tumor cells to X-ray irradiation within a 1.5-Tesla magnetic field generated by a magnetic resonance imaging-linear accelerator von Wang, Li, Hoogcarspel, Stan Jelle, Wen, Zhifei, van Vulpen, Marco, Molkentine, David P., Kok, Jan, Lin, Steven H., Broekhuizen, Roel, Ang, Kie-Kian, Bovenschen, Niels, Raaymakers, Bas W., Frank, Steven J.

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Inhibition of P-TEFb by DRB suppresses SIRT1/CK2α pathway and enhances radiosensitivity of human cancer cells von Wang, Zhi-Qiang, Johnson, Casey L, Kumar, Amit, Molkentine, David P, Molkentine, Jessica M, Rabin, Tatiana, Mason, Kathryn A, Milas, Luka, Raju, Uma

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Combination of Anti-IGF-1R Antibody A12 and Ionizing Radiation in Upper Respiratory Tract Cancers von Riesterer, Oliver, M.D, Yang, Qiuan, M.D, Raju, Uma, Ph.D, Torres, Mylin, M.D, Molkentine, David, B.S, Patel, Nalini, B.Sc, Valdecanas, David, B.S, Milas, Luka, M.D., Ph.D, Ang, K. Kian, M.D., Ph.D

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TRIP12 as a mediator of human papillomavirus/p16-related radiation enhancement effects von Wang, L, Zhang, P, Molkentine, D P, Chen, C, Molkentine, J M, Piao, H, Raju, U, Zhang, J, Valdecanas, D R, Tailor, R C, Thames, H D, Buchholz, T A, Chen, J, Ma, L, Mason, K A, Ang, K-K, Meyn, R E, Skinner, H D

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FAK Drives Resistance to Therapy in HPV-Negative Head and Neck Cancer in a p53-Dependent Manner von Pifer, Phillip M, Yang, Liangpeng, Kumar, Manish, Xie, Tongxin, Frederick, Mitchell, Hefner, Andrew, Beadle, Beth, Molkentine, David, Molkentine, Jessica, Dhawan, Annika, Abdelhakiem, Mohamed, Osman, Abdullah A, Leibowitz, Brian J, Myers, Jeffrey N, Pickering, Curtis R, Sandulache, Vlad C, Heymach, John, Skinner, Heath D

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Inhibition of EGFR or IGF‐1R signaling enhances radiation response in head and neck cancer models but concurrent inhibition has no added benefit von Raju, Uma, Molkentine, David P., Valdecanas, David R., Deorukhkar, Amit, Mason, Kathryn A., Buchholz, Thomas A., Meyn, Raymond E., Ang, Kie‐Kian, Skinner, Heath

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MCT4-dependent lactate secretion suppresses antitumor immunity in LKB1-deficient lung adenocarcinoma von Qian, Yu, Galan-Cobo, Ana, Guijarro, Irene, Dang, Minghao, Molkentine, David, Poteete, Alissa, Zhang, Fahao, Wang, Qi, Wang, Jing, Parra, Edwin, Panda, Apekshya, Fang, Jacy, Skoulidis, Ferdinandos, Wistuba, Ignacio I., Verma, Svena, Merghoub, Taha, Wolchok, Jedd D., Wong, Kwok-Kin, DeBerardinis, Ralph J., Minna, John D., Vokes, Natalie I., Meador, Catherine B., Gainor, Justin F., Wang, Linghua, Reuben, Alexandre, Heymach, John V.

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Imexon Augments Sensitivity of Human Lymphoma Cells to Ionizing Radiation: In Vitro Experimental Study von Cho, Heunglae, Koto, Masashi, Riesterer, Oliver, Molkentine, David P, Giri, Uma, Milas, Luka, Story, Michael D, Ha, Chul S, Raju, Uma

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Abstract 2919: p16 modulates a novel ubiquitin signaling cascade which regulates radioresponse and offers clinically relevant therapeutic targets in squamous cell carcinoma von Molkentine, David, Bridges, Kathleen, Sheth, Aakash, Valdecanas, David, Pickering, Curtis, Skinner, Heath D.

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ATM Mutations Associate with Distinct Co-Mutational Patterns and Therapeutic Vulnerabilities in NSCLC von Vokes, Natalie I, Galan Cobo, Ana, Fernandez-Chas, Margarita, Molkentine, David, Treviño, 3rd, Santiago, Druker, Vitaly, Qian, Yu, Patel, Sonia, Schmidt, Stephanie, Hong, Lingzhi, Lewis, Jeff, Rinsurongkawong, Waree, Rinsurongkawong, Vadeerat, Lee, J Jack, Negrao, Marcelo V, Gibbons, Don L, Vaporciyan, Ara, Le, Xiuning, Wu, Jia, Zhang, Jianjun, Rigney, Una, Iyer, Sonia, Dean, Emma, Heymach, John V

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